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Search Results: 1 - 10 of 1221 matches for " Kazunari Murakami "
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Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test
Masaaki Kodama,Kazunari Murakami,Tadayoshi Okimoto,Yoshihiro Fukuda
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i1.44
Abstract: AIM: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration. RESULTS: Using the UBT as the standard, the sensitivity, specificity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were significantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A450/630) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099). CONCLUSION: The stool antigen test was equally sensitive to the UBT, making it a useful and reliable diagnostic method, even during PPI administration.
Aspirin-induced small bowel injuries and the preventive effect of rebamipide
Kazuhiro Mizukami,Kazunari Murakami,Takashi Abe,Kunimitsu Inoue
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i46.5117
Abstract: AIM: To evaluate the influence of taking low-dose aspirin for 4 wk on small intestinal complications and to examine the preventive effect of rebamipide. METHODS: This study was conducted as a single-center, randomized, double-blind, cross-over, placebo-controlled study. Eleven healthy male subjects were enrolled. Each subject underwent video capsule endoscopy after 1 and 4 wk of taking aspirin and omeprazole, along with either rebamipide or placebo therapy. The primary endpoint was to evaluate small bowel damage in healthy subjects before and after taking low-dose aspirin for 4 wk. RESULTS: The number of subjects with mucosal breaks (defined as multiple erosions and/or ulcers) were 1 at 1 wk and 1 at 4 wk on the jejunum, and 6 at 1 wk (P = 0.0061) and 7 at 4 wk on the ileum (P = 0.0019). Rebamipide significantly prevented mucosal breaks on the ileum compared with the placebo group (P = 0.0173 at 1 wk and P = 0.0266 at 4 wk). CONCLUSION: Longer-term, low-dose aspirin administration induced damage in the small bowel. Rebamipide prevented this damage, and may be a candidate drug for treating aspirin-induced small bowel complications.
Distribution of Myxomycetes on Varied Leaf Litter Types in a Mixed Forest in Warm-Temperate Western Japan  [PDF]
Kazunari Takahashi
Open Journal of Forestry (OJF) , 2015, DOI: 10.4236/ojf.2015.57061
Abstract: Myxomycete assemblages were compared on various leaf litters of different vegetation types in a local mixed forest consisting of deciduous and evergreen trees in western Japan. A total of 33 myxomycete species were recorded and associated with the chemical and biological environments of leaf litters under natural condition of the forest floor. Different myxomycete assemblages were found on different sites under the dominant trees in a short distance apart (300 m). A site of Prunus jamasakura tree yielded 21 species, a Quercus glauca tree yielded 20 species, an Ilex pedunculosa tree yielded 12 species, and two Quercus serrata trees yielded 13 and 14 species, respectively. Non-metric multidimensional scaling demonstrated that the myxomycete assemblages were closely related to the litter types of deciduous and evergreen trees, and both litter pH and cellulolytic activity influenced distribution of myxomycete species. Species richness was higher in leaf litters with higher pH than in leaf litters with more acidic pH such as I. pedunculosa litter. The dominant tree litter and litter pH strongly influenced the species distribution of foliicolous myxomycetes in a local mixed forest.
Sport Skill Evaluation with Wearable Sensors and Statistical Analysis  [PDF]
Kazunari Ishida
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.73019
This research discusses sport skill evaluation with wearable sensor and statistical analysis. Skateboarding is selected as the target sport to analyze because it will be an official competition in Tokyo 2020 Olympic Games. Skateboarding is one of the difficult sports because of controlling balance to move forward and to get speed on flat ground. The balance control is a basic trick named Tic-Tac, while the trick is difficult for beginners. To make data set for analyzing Tic-Tac skill, we have provided a basic lesson to research participants. After giving them enough self-training time, we put two inertial sensors on a skateboard and waist of a research participant and got total 41 running data with Tic-Tac. According to the result of statistical analysis on the data, we confirmed that swinging a skateboard left and right is the most important motion to generate moving forward driving forth. This result means that inertial sensors are one of the effective tools to evaluate sport skill for sports science and physical education.
Association between Helicobacter pylori cagA-related genes and clinical outcomes in Colombia and Japan
Masahide Watada, Seiji Shiota, Osamu Matsunari, Rumiko Suzuki, Kazunari Murakami, Toshio Fujioka, Yoshio Yamaoka
BMC Gastroenterology , 2011, DOI: 10.1186/1471-230x-11-141
Abstract: cagA-associated genes were selected based on previous H. pylori genome microarray data. A total of 343 strains (174 from Colombia and 169 from Japan) were examined for the status of cagA, vacA, and candidate genes by polymerase chain reaction and dot blot.Microarray data showed that 9 genes were significantly correlated with the presence of cagA. Among the 9 genes, the functions of 4 were known, and we selected these 4 genes as candidate genes (hp0967, jhp0045, jhp0046, and jhp0951). The prevalences of cagA, vacA s1/m1 genotype, and hp0967 were significantly higher in Japan than Colombia, whereas those of jhp0045 and jhp0046 were more prevalent in Colombia than Japan. The prevalences of jhp0045 and jhp0046 in cagA-positive cases of gastric cancer were significantly higher than those from gastritis in Colombia (P = 0.015 and 0.047, respectively). In contrast, the prevalence of 4 candidate genes was independent of clinical outcomes in Japan.jhp0045 and jhp0046 might be novel markers for predicting gastric cancer in cagA-positive cases in Colombia, but not in Japan.Helicobacter pylori (H. pylori) infection is now accepted as the major cause of chronic gastritis. In addition, several epidemiological studies have shown that H. pylori infection is linked to severe gastritis-associated diseases, including peptic ulcer and gastric cancer (GC) [1]. In 1994, the International Agency for Research on Cancer categorized H. pylori infection as a group I carcinogen [2]. Although GC is one of the most common cancers, only a minority of individuals with H. pylori infection ever develop it. The prevalence of GC is approximately 3% in H. pylori-positive patients [3].In addition to environmental factors (eg, diet) and host factors, virulence factors of H. pylori, such as cagA, vacA, oipA, babA, hopQ, and homA/B, have been demonstrated to be predictors of gastric atrophy, intestinal metaplasia, and severe clinical outcomes [4-10]. The most studied virulence factor of H. pylori is cagA,
Dynamic Effect of Low-Cost Entry on the Conduct Parameter: An Early-Stage Analysis of Southwest Airlines and America West Airlines  [PDF]
Hideki Murakami
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.44032

The purpose of this research is to investigate the dynamic changes in the competition between air carriers by applying a revised conduct parameter method. We examine the cases of Southwest Airlines and America West Airlines due to the availability of data. Our interests are in what fashion a low-cost carrier entered the market, how the rival reacted, and whether the fashions of competition between two types of air carrier remained stable as time passed. Our empirical results show that the fashions of competition fell between Cournot and “P = MC” competition, and competitive fashions were sometimes stable but sometimes not.

Risk Factors for Dysmotility, Acid Reflux Symptoms, and Overlap Using FSSG in Japan
Seiji Shiota,Kazunari Murakami,Kunimitsu Inoue,Kyoko Yamamoto,Akiko Kuroda,Kazuhiro Mizukami,Tadayoshi Okimoto,Aoi Yoshiiwa,Masaaki Kodama,Koh Abe,Yoshio Yamaoka,Toshio Fujioka
Epidemiology Research International , 2012, DOI: 10.1155/2012/984039
Abstract: Aims. FSSG {frequency scale for the symptoms of gastroesophageal reflux disease (GERD)} was developed as a diagnostic tool for dysmotility and acid reflux symptoms. We first used FSSG to investigate the prevalence and risk factors for dysmotility and acid reflux symptoms and overlap of the two symptoms in a Japanese population. Methods. A cross-sectional survey was performed in Japanese underwent the routine medical examination. Dysmotility and acid reflux symptom were diagnosed by using FSSG. Subjects met both criteria were considered as overlap group. Results. Among 778 subjects, 395 persons were included in the final analyses. Dysmotility symptoms were found in 32.6% and acid reflux symptoms in 20.5%. Their overlap was found in 13.9% of all 395 subjects, which in 42.6% of dysmotility symptoms and 67.9% of acid reflux symptoms. Multiple logistic analysis showed that female gender was significantly associated with dysmotility symptoms compared with controls. Female gender, smoking, and hiatus hernia were significantly associated with overlap. Smoking was significantly associated with overlap compared with dysmotility symptoms alone and acid reflux symptoms alone. Conclusions. Overlap between dysmotility and acid reflux symptoms was common in Japan. Smoking was an independent risk factor for overlap among two symptoms. 1. Introduction Dyspepsia such as dysmotility and epigastric pain and acid reflux symptoms including heartburn are common gastrointestinal symptoms and major symptoms for functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) in general population [1, 2]. Several studies showed that there is a significant overlap between dyspepsia and acid reflux symptoms [1, 3, 4]. As disturbances of gastrointestinal sensory and motor function are commonly accepted as the underlying pathogenesis of both dyspepsia and acid reflux symptoms, it is possible that the overlap induces by common risk factors. However, the risk factors for overlap of dyspepsia and acid reflux symptoms have not been enough elucidated. Regarding dyspepsia, dysmotility symptoms are the major type in Japan [5, 6]. In 2004, Kusano et al. developed a screening tool for dysmotility symptoms and acid reflux symptoms, named frequency scale for the symptoms of GERD (FSSG) [7]. Although several studies reported the usefulness of FSSG regarding GERD [7, 8], there is no epidemiological study examined the prevalence of dysmotility symptoms by using FSSG. Recently, many reports have shown that metabolic risk factors including obesity were related with gastrointestinal diseases
Supersymmetric Structure of Spacetime and Matter -Superon Quintet Hypothesis-
Kazunari Shima
Physics , 1998,
Abstract: A unified description of spacetime and matter at the Planck scale is proposed by using the irreducible representation of N=10 extended Super-Poincar\'e algebra, where all matters and all forces except the graviton are the supersymmetric composites made of the fundamental objects with spin 1/2, superon quintet. All the local gauge interactions in GUTs are investigated systematically by using the superon diagrams. The proton is stable and the flavor changing neutral current process is suppressed in the superon pictures of GUTs. The fundamental action of the superon model is proposed. The characteristic predictions which can be tested in the (coming) high energy experiments are discussed briefly.
New Einstein-Hilbert Type Action for Unity of Nature
Kazunari Shima
Physics , 2001, DOI: 10.1002/1521-3978(200205)50:5/7<717::AID-PROP717>3.0.CO;2-B
Abstract: The fundamental action of superon-graviton model(SGM) for space-time and matter is written down explicitly in terms of the fields of the graviton and superons by using the affine and the spin connection formalisms, alternatively. Some characteristic structures including some hidden symmetries of the gravitational coupling of superons are manifested (in two dimensional space-time) with some details of the calculations. SGM cosmology is discussed briefly.
Supersymmetric structure of spacetime and matter -superon-graviton model-
Kazunari Shima
Physics , 2000, DOI: 10.1016/S0370-2693(01)00121-6
Abstract: A unified description of spacetime and matter is proposed by using a single irreducible representation of SO(10) Super-Poincare algebra(SO(10)SPA). All (observed) elementary particles except the graviton are the (massless) eigenstates of SO10)SPA composed of fundamental Nambu-Goldstone fermions with spin 1/2, superons, associating with the spontaneous breakdown of the supertranslation of the spacetime. The systematic investigations of the standard model(SM) and SU(5)GUT by using superon diagrams may reveal the generation structure, the stability of the proton, K-, B-, D- mixings, CP-violation, the atmospheric and solar neutrino deficits and the absence of the electroweak lepton-flavor-mixing. The fundamental action of the superon-graviton model(SGM) for spacetime and matter is proposed, which is invariant under a new supersymmetry.
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