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Search Results: 1 - 10 of 1885 matches for " Kazuhiro Imai "
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Trochanteric Fracture of a Congenital/Developmental Dislocation of the Hip in an Elderly Woman: A Case Report  [PDF]
Kazuhiro Imai
Open Journal of Orthopedics (OJO) , 2011, DOI: 10.4236/ojo.2011.11001
Abstract: An 87-year-old woman with a residual dislocated hip suffered a trochanteric fracture on the ipsilateral side. The fracture was treated by open reduction and internal fixation surgery with good results. To treat a proximal femoral fracture of the residual dislocated hip in an elderly patient, the patient’s overall status, pre-fracture ability, hip joint configuration, and fracture pattern should be considered.
In Vivo Investigation of Zr-Based Bulk Metallic Glasses Sub-Periosteally Implanted on the Bone Surface  [PDF]
Kazuhiro Imai
Journal of Materials Science and Chemical Engineering (MSCE) , 2016, DOI: 10.4236/msce.2016.41009

Bulk metallic glasses (BMG) show higher strength and lower Young’s modulus than SUS 316L stainless steel and Ti-6Al-4V alloys. This study aimed to investigate the reaction of Zr-based BMG sub-periosteally implanted on the surface of the rat femur, thereby evaluate the possibility of the BMG as biomaterials for osteosynthetic devices. Zr65Al7.5Ni10Cu17.5 BMG ribbons with 10 mm length, 2 mm width and 0.5 mm thickness were implanted sub-periosteally on the femur surface in three male Wistar rats for 6 weeks. Systemic effects were evaluated by measuring Cu and Ni levels in the blood, and local effects were evaluated by the histological observation of the surrounding soft tissues in contact with the BMG. The reaction of the surface of the BMG was examined with scanning electron microscopy. No increase of Cu and Ni levels in the blood was recognized. In the scanning electron microscopy observation, spherical deposits which were considered as sodium chloride crystals were observed. Neither breakage nor pitting corrosion was noted. BMG will be a promising metallic biomaterial for osteosynthetic device that must be removed.

Strategies for Synchronous and Multiple Metastatic Liver Tumors Designed from Epithelial-Mesenchymal Transition Concept  [PDF]
Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki, Kazuhiro Yoshida
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.33029
Abstract: At some point in the natural course of colorectal cancer up to 50% of patients will develop metastasis to the liver and it is one of the most critical effects for patient prognosis. The incidence of synchronous liver metastasis has been detected at around 20% - 25%, but the optimal timing of surgical resection remains controversial. Neoadjuvant chemotherapy has also been found to be beneficial not only for initially unresectable but also resectable synchronous metastases. Then, traditional surgical strategies of hepatic resection in accordance with past chemotherapeutic regimens have been used decreasingly over the past several years. This review will primarily discuss treatments in association with the recent developed chemotherapeutic regimens and surgical procedure from the clinical data and the concept for epithetlial-mesenchymal transition, which has recently been studied to elucidate mechanisms of the liver metastatic process.
The Best Choice to Achieve Zero Complications after Pancreatoduodenectomy  [PDF]
Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki, Itaru Yasufuku, Ryuichi Asai, Yoshihisa Tokumaru, Takuji Sakuratani, Kazuhiro Yoshida
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.22010
Abstract: Pancreatoduodenectomy (PD) has been performed commonly, but the occurrence of pancreatic fistula (PF) is a critical trigger of complications, which are potentially life threatening, and is also associated with markedly prolonged hospitalization. Many techniques have been proposed for connecting the pancreatic stump with the gastrointestinal tract, stomach vs. jejunum, etc. Among the risk factors for PF, such as general patient factors or disease-related factors, the most important is the texture of the remnant pancreas. Surgical technique might be one improvable aspect that can reduce the pancreatic leakage rate, therefore; various methods of managing the pancreatic remnant have been studied. Methods of reconstruction between the remnant pancreas and the intestine include end-to-side with/without duct-to-mucosa anastomosis or end-to-end invagination styles, has been argued. Here, we review several trials for safety and methods of treating the pancreatic stump after PD, and demonstrate our experiences.
Cryoablation-Induced Anti-Cancer Immune Reaction—Immune Reaction Induced By Cryoablation  [PDF]
Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki, Kazuhiro Yoshida, Itaru Yasufuku, Ryuichi Asai, Yoshihisa Tokumaru, Takuji Sakuratani
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.22015
Abstract: Among the ablation procedures used against advanced liver cancer, thermal ablation therapy is widely applied, and the safety and efficacy of this technique have been well characterized. In contrast, the principle of cryosurgery is not only to control local recurrence, but also to stimulate the immune system into initiating an anti-tumor response. In recent years, we have developed a treatment method for patients with advanced liver tumors. From these experiences, repeated treatment was demonstrated to induce anti-cancer immune reaction-related factors. In the present review, mechanisms for anti-tumor immune reaction will be argued with introducing a novel strategy of a cryoablation.
Impact of improved bottom hypoxia on zooplankton community in shallow eutrophic lake L’impact de la correction de l’hypoxie benthique sur la communauté de zooplancton dans un lac eutrophe peu profond
Chang Kwang-Hyeon,Imai Hiroyuki,Ayukawa Kazuhiro,Sugahara Shogo
Knowledge and Management of Aquatic Ecosystems , 2013, DOI: 10.1051/kmae/2013038
Abstract: We followed changes in the abundance of meso- and microzooplankton after an existing bottom hypoxia improved by the introduction of water with high oxygen content into the bottom. Mesozooplankton, calanoid copepod Acartia hudsonica showed ten times higher abundance under high oxygen condition at the bottom than under control where there was less oxygen at the bottom. On the other hand, during summer when microzooplankton such as rotifers and small cyclopoid species Oithona spp. were dominant, no difference in their distribution pattern and abundance was observed. Results have suggested that oxygen concentration at the bottom is one important factor determining the abundance and distribution of mesozooplankton even in local-scale probably by providing bottom refuge, but not for microzoooplankton. Since spring season is important for recruitment of many commercial fish juveniles, the distribution of oxygen in the lake seems very important for the fish stock in the lake. Nous avons suivi les changements dans l’abondance des méso- et micro-zooplanctons après une correction de l’hypoxie benthique par l’introduction d’eau à forte teneur en oxygène dans le fond. Le mésozooplancton, copépode calano de Acartia hudsonica, a présenté une abondance dix fois plus élevée, dans des conditions de haute teneur en oxygène sur le fond, que dans une zone témoin où il y a moins d’oxygène au fond. D’autre part, pendant l’été lorsque le microzooplancton tel que les rotifères et les petites espèces cyclopo des Oithona spp. sont dominantes, aucune différence dans leur mode de distribution et l’abondance n’a été observée. Les résultats suggérent que la concentration en oxygène au fond est un facteur important pour déterminer l’abondance et la distribution de mésozooplancton même à l’échelle locale probablement en fournissant un refuge, mais pas pour le microzoooplankton. Comme la saison du printemps est importante pour le recrutement de nombreux jeunes poissons commerciaux, la distribution de l’oxygène dans le lac semble très importante pour les stocks de poissons dans le lac.
Nonlinear Modulation of Travelling Rolls in Magnetoconvection
Ken-ichi Matsuba,Kenji Imai,Kazuhiro Nozaki
Physics , 1996, DOI: 10.1016/S0167-2789(97)00034-1
Abstract: Modulational dynamics of oscillatory travelling rolls in magnetoconvection is studied near the onset of a Hopf bifurcation. Using weakly nonlinear analysis, we derive an envelope equation of oscillatory travelling rolls in the plane perpendicular to an ambient vertical magnetic field.The envelope equation is the Davey-Stewartson (DS) equation with complex coefficients, from which we obtain criteria for the modulational (Benjamin-Feir) instability of oscillatory travelling rolls.
An FD-LC-MS/MS Proteomic Strategy for Revealing Cellular Protein Networks: A Conditional Superoxide Dismutase 1 Knockout Cells
Tomoko Ichibangase, Yasuhiro Sugawara, Akio Yamabe, Akiyo Koshiyama, Akari Yoshimura, Takemi Enomoto, Kazuhiro Imai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045483
Abstract: Systems biology aims to understand biological phenomena in terms of complex biological and molecular interactions, and thus proteomics plays an important role in elucidating protein networks. However, many proteomic methods have suffered from their high variability, resulting in only showing altered protein names. Here, we propose a strategy for elucidating cellular protein networks based on an FD-LC-MS/MS proteomic method. The strategy permits reproducible relative quantitation of differences in protein levels between different cell populations and allows for integration of the data with those obtained through other methods. We demonstrate the validity of the approach through a comparison of differential protein expression in normal and conditional superoxide dismutase 1 gene knockout cells and believe that beginning with an FD-LC-MS/MS proteomic approach will enable researchers to elucidate protein networks more easily and comprehensively.
Morphological and Functional Changes in the Retina after Chronic Oxygen-Induced Retinopathy
Shinsuke Nakamura, Shunsuke Imai, Hiromi Ogishima, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0032167
Abstract: The mouse model of oxygen-induced retinopathy (OIR) has been widely used for studies of retinopathy of prematurity (ROP). This disorder, characterized by abnormal vascularization of the retina, tends to occur in low birth weight neonates after exposure to high supplemental oxygen. Currently, the incidence of ROP is increasing because of increased survival of these infants due to medical progress. However, little is known about changes in the chronic phase after ROP. Therefore, in this study, we examined morphological and functional changes in the retina using a chronic OIR model. Both the a- and b-waves in the OIR model recovered in a time-dependent manner at 4 weeks (w), 6 w, and 8 w, but the oscillatory potential (OP) amplitudes remained depressed following a return to normoxic conditions. Furthermore, decrease in the thicknesses of the inner plexiform layer (IPL) and inner nuclear layer (INL) at postnatal day (P) 17, 4 w, and 8 w and hyperpermeability of blood vessels were observed in conjunction with the decrease in the expression of claudin-5 and occludin at 8 w. The chronic OIR model revealed the following: (1) a decrease in OP amplitudes, (2) morphological abnormalities in the retinal cells (limited to the IPL and INL) and blood vessels, and (3) an increase in retinal vascular permeability via the impairment of the tight junction proteins. These findings suggest that the experimental animal model used in this study is suitable for elucidating the pathogenesis of ROP and may lead to the development of potential therapeutic agents for ROP treatment.
Inhibition of dendritic cell migration by transforming growth factor-β1 increases tumor-draining lymph node metastasis
Kazuhiro Imai, Yoshihiro Minamiya, Souichi Koyota, Manabu Ito, Hajime Saito, Yusuke Sato, Satoru Motoyama, Toshihiro Sugiyama, Jun-ichi Ogawa
Journal of Experimental & Clinical Cancer Research , 2012, DOI: 10.1186/1756-9966-31-3
Abstract: To address that issue and investigate the mechanism by which TGF-β1 suppresses DC activity, we subdermally inoculated mouse ears with squamous cell carcinoma cells stably expressing TGF-β1 or empty vector (mock).The numbers of DCs within lymph nodes draining the resultant TGF-β1-expressing tumors was significantly lower than within nodes draining tumors not expressing TGF-β1. We then injected fluorescently labeled bone marrow-derived dendritic cells into the tumors, and subsequent analysis confirmed that the tumors were the source of the DCs within the tumor-draining lymph nodes, and that there were significantly fewer immature DCs within the nodes draining TGF-β1-expressing tumors than within nodes draining tumors not expressing TGF-β1. In addition, 14 days after tumor cell inoculation, lymph node metastasis occurred more frequently in mice inoculated with TGF-β1 transfectants than in those inoculated with the mock transfectants.These findings provide new evidence that tumor-derived TGF-β1 inhibits migration of DCs from tumors to their draining lymph nodes, and this immunosuppressive effect of TGF-β1 increases the likelihood of metastasis in the affected nodes.Transforming growth factor (TGF) -β can reportedly promote cancer metastasis by affecting the tumor microenvironment in a manner that facilitates tumor cell invasion [1,2] and by inhibiting immune cell function [3]. Consistent with those reports, overproduction of TGF-β by tumors is frequently associated with metastasis [4-6] and a poor prognosis in patients with cancer [7-10]. Among the three highly homologous TGF-β isoforms, TGF-β1 is the most abundant and most extensively studied [11]. We previously showed that tumor-derived TGF-β1 causes a reduction in the number of dendritic cells (DCs) within tumor-draining lymph nodes (TDLNs) [12]. It also has been shown that TGF-β1 is produced by progressor tumors and that it immobilizes the DCs within those tumors [13]. This is noteworthy because DCs are highly speci
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