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Search Results: 1 - 10 of 1213 matches for " Kaushik Avinash "
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Kaushik Avinash,Dwivedi Abha,Sunda Mukesh
International Research Journal of Pharmacy , 2011,
Abstract: Now a days, The novel drug delivery system is creating a new interest in development of drug deliveries. Vesicular drug delivery system in also a part of this novel drug delivery system which is designed according to the recent demands of treatment like sustain release of drug in systemic circulation, definite dosing interval. Transferosomes are part of this vesicular drug delivery system which are altered deformable vesicles used to enhance skin penetration. It is also a controlled & targeted drug delivery system which is used to increase the existence of drug in systemic circulation & decrease the toxicity.Transferosomes are proposed for variety of applications in humans like as carrier for insulin & vaccines. In this review, we mainly focus on transferosome with its applications, limitations, advantages & preparation.
Kaushik Avinash,Dwivedi Abha,Sharma Ganesh N.
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Due to changes in life style and eating habits an increase in frequency to be affected by ulceration in gastric contents can be observed now a day. At the same time a number of semisynthetic and synthetic drugs like proton pump inhibitors, H2 receptor antagonists, mucosal defensive agents along with various antimicrobial agents are available for the treatment of ulcer, but clinical evaluation of these drugs has shown side effects, and drug interactions. Recently a number of approaches have been made for the development of newer ulcer healing or ulcer protective using herbal sources, as they are easily available, of low cost and have no or less side effects. This review aim to compile data on plants from cucurbetaceae family reported for their anti-ulcer or ulcer healing properties.
Sharma Ganesh N.,Sanadya Jyotsana,Kaushik Avinash,Dwivedi Abha
International Research Journal of Pharmacy , 2012,
Abstract: Many current therapeutic agents like antibiotics, ionizable and peptide drugs are impermeable or do not possess the requisite physicochemical properties for efficient transport through outer tissue barrier to attain therapeutic blood level. For this reason the delivery of such drugs through barriers is currently one of the major interests in pharmaceutical research. Penetration enhancers or promoters are agents that have no therapeutic properties of their own but can transport the sorption of drugs from drug delivery system onto the skin and / or their subsequent transdermal permeation through skin. Numerous harmless and non-toxic penetration-enhancing compounds were found from both natural substances and synthetic products. Penetration enhancers are used to maintain the drug level in blood and to improve the efficacy of drugs.
Kaushik Avinash Yogendraji,Lokwani Priyanka,Singh Nisha,Sharma Ritu
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Insulin is a proteinaceous hormone produced in the islets of Langerhans in the pancreas and used as a treatment in the diabetes mellitus. Successful oral insulin delivery involves overcoming the enzymatic and physical barriers and taking steps to conserve bioactivity during formulation processing. Newer strategies for insulin delivery include insulin pen injector, Refillable insulin injection pen, Insulin Syringe, Transfersome and Implantable insulin pumps.
Open Journal of Applied Biosensor: Point-of-Care Biosensing and Environment Monitoring  [PDF]
Ajeet Kaushik
Open Journal of Applied Biosensor (OJAB) , 2013, DOI: 10.4236/ojab.2013.24012
Abstract: Open Journal of Applied Biosensor: Point-of-Care Biosensing and Environment Monitoring
The Mode of Inhibitor Binding to Peptidyl-tRNA Hydrolase: Binding Studies and Structure Determination of Unbound and Bound Peptidyl-tRNA Hydrolase from Acinetobacter baumannii
Sanket Kaushik, Nagendra Singh, Shavait Yamini, Avinash Singh, Mau Sinha, Ashish Arora, Punit Kaur, Sujata Sharma, Tej P. Singh
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0067547
Abstract: The incidences of infections caused by an aerobic Gram-negative bacterium, Acinetobacter baumannii are very common in hospital environments. It usually causes soft tissue infections including urinary tract infections and pneumonia. It is difficult to treat due to acquired resistance to available antibiotics is well known. In order to design specific inhibitors against one of the important enzymes, peptidyl-tRNA hydrolase from Acinetobacter baumannii, we have determined its three-dimensional structure. Peptidyl-tRNA hydrolase (AbPth) is involved in recycling of peptidyl-tRNAs which are produced in the cell as a result of premature termination of translation process. We have also determined the structures of two complexes of AbPth with cytidine and uridine. AbPth was cloned, expressed and crystallized in unbound and in two bound states with cytidine and uridine. The binding studies carried out using fluorescence spectroscopic and surface plasmon resonance techniques revealed that both cytidine and uridine bound to AbPth at nanomolar concentrations. The structure determinations of the complexes revealed that both ligands were located in the active site cleft of AbPth. The introduction of ligands to AbPth caused a significant widening of the entrance gate to the active site region and in the process of binding, it expelled several water molecules from the active site. As a result of interactions with protein atoms, the ligands caused conformational changes in several residues to attain the induced tight fittings. Such a binding capability of this protein makes it a versatile molecule for hydrolysis of peptidyl-tRNAs having variable peptide sequences. These are the first studies that revealed the mode of inhibitor binding in Peptidyl-tRNA hydrolases which will facilitate the structure based ligand design.
Genetic diversity among Indian phytopathogenic isolates of Fusarium semitectum Berkeley and Ravenel  [PDF]
Avinash Ingle, Mahendra Rai
Advances in Bioscience and Biotechnology (ABB) , 2011, DOI: 10.4236/abb.2011.23023
Abstract: We report total ten isolates of F. semitectum recovered from different hosts. Identity of these isolates was determined by morphological and cultural characteristics and confirmed by RAPD-PCR analysis using forty random primers. Morphologically all the ten isolates showed similarity, but based on RAPD-PCR analysis, these isolates can be categorized in three groups depending upon similarity co-efficient. Genetic similarity coefficients between pair wise isolates varied from 0.00 to 1.95 based on an unweighted paired group method of arithmetic average (UPGMA) cluster analysis. RAPD-PCR technique can be used as an important tool for the genetic differentiation among isolates of F. semitectum.
Ab-Initio Structural Study of SrMoO3 Perovskite  [PDF]
Avinash Daga, Smita Sharma
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.312238
Abstract: The equilibrium crystal structure parameter and bulk modulus of the SrMoO3 perovskite has been calculated with ab-initio method based on density functional theory (DFT) using both local density approximation (LDA) and generalized gradient approximation (GGA). The corresponding total free energy along with its various components for SrMoO3 was obtained. The lattice parameter and bulk modulus calculated for SrMoO3 within LDA are 3.99 A and 143.025 GPa respectively whereas within GGA are 4.04 A and 146.14 GPa respectively, both agree well with the available experimental data. The total energy calculated within LDA and GGA is almost the same however lower results are obtained for GGA. All calculations have been carried out using ABINIT computer code.
Effect of calcium and diltiazem on phenylhydrazine-induced oxidative injury in goat erythrocytes  [PDF]
Kaushik Das, Jharna Bhattacharyya
Health (Health) , 2010, DOI: 10.4236/health.2010.210181
Abstract: Lipid peroxidation, hemolysis and thiol contents were studied in intact goat erythrocytes exposed to phenylhydrazine. An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. Extracellular Ca2+ potentiates the phenylhydrazine-induced lipid peroxidation and hemoly- sis of erythrocytes significantly. Ca2+ does not influence much the thiol content of phenylhydrazine treated erythrocytes. No effect of Ca2+ on control lipid peroxidation, hemolysis and thiol contents of erythrocytes was observed. Diltiazem and EDTA inhibited the increased responses of lipid peroxidation and hemolysis due to Ca2+. However the thiol content was not much influenced by either diltiazem or EDTA. The results suggest that oxidative damage of erythrocyte caused by phenyl hydrazine could be prevented by calcium channel antagonist, diltiazem, which may act as antioxidant also.
Evaluation of Various Crude Extracts of Zingiber officinale Rhizome for Potential Antibacterial Activity: A Study in Vitro  [PDF]
Purshotam Kaushik, Pankaj Goyal
Advances in Microbiology (AiM) , 2011, DOI: 10.4236/aim.2011.11002
Abstract: In vitro antibacterial activity of crude aqueous and organic extracts of rhizome of Zingiber officinaleRoscoe (ginger) was studied against both Gram-negative (Escherichia coli and Salmonella typhi) and Gram-positive (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus and Streptococcus pyogenes) bacterial strains. The present study reveals that the pattern of inhibition varied with the solvent used for extraction and the organism tested. Plant extracts prepared in organic solvents provided more consistent antibacterial activity as compared to aqueous extracts. Methanol extract was the most active against maximum number of bacterial species tested. Gram-positive bacteria were found the most sensitive as compared to Gram-negative bacteria. Staphylococcus aureus was significantly inhibited by almost all the extracts even in very low MIC followed by other Gram-positives. Escherichia coli (a Gram-negative bacterium) was showing the least inhibition with highest MIC values, while Salmonella typhi was found completely resistant. Methanol extract yielded the presence of terpenoids, flavonoids, alkaloids and tannins in phytochemical screening. Results of the present study sign the interesting assurance of designing a potentially active antibacterial agent from Zingiber officinale.
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