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Search Results: 1 - 10 of 1201 matches for " Katrine Dahl Madsen "
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Unfolding Education for Sustainable Development as Didactic Thinking and Practice
Katrine Dahl Madsen
Sustainability , 2013, DOI: 10.3390/su5093771
Abstract: This article’s primary objective is to unfold how teachers translate education for sustainable development (ESD) in a school context. The article argues that exploring tensions, ruptures and openings apparent in this meeting is crucial for the development of existing teaching practices in relation to ESD. The article draws on doctoral research involving interviews with researchers and teachers who have collaborated in ESD research and development projects at primary and secondary schools in two different countries, Denmark and Ireland. It is the teachers’ perspectives on the projects which form the analytical foundation; thus, it is the practices as seen from the ‘inside’. Furthermore, ESD practices are considered in a broader societal perspective, pointing to the critical power of the practice lens.
Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels
Katrine R. Laub,Katja Witschas,Andreas Blicher,Soren B. Madsen,Andreas Luckhoff,Thomas Heimburg
Physics , 2011, DOI: 10.1016/j.bbamem.2012.01.014
Abstract: In this article we compare electrical conductance events from single channel recordings of three TRP channel proteins (TRPA1, TRPM2 and TRPM8) expressed in human embryonic kidney cells with channel events recorded on synthetic lipid membranes close to melting transitions. Ion channels from the TRP family are involved in a variety of sensory processes including thermo- and mechano-reception. Synthetic lipid membranes close to phase transitions display channel-like events that respond to stimuli related to changes in intensive thermodynamic variables such as pressure and temperature. TRP channel activity is characterized by typical patterns of current events dependent on the type of protein expressed. Synthetic lipid bilayers show a wide spectrum of electrical phenomena that are considered typical for the activity of protein ion channels. We find unitary currents, burst behavior, flickering, multistep-conductances, and spikes behavior in both preparations. Moreover, we report conductances and lifetimes for lipid channels as described for protein channels. Non-linear and asymmetric current-voltage relationships are seen in both systems. Without further knowledge of the recording conditions, no easy decision can be made whether short current traces originate from a channel protein or from a pure lipid membrane
Immunohistochemical Expression of Platelet-Derived Growth Factor Receptors in Ovarian Cancer Patients with Long-Term Follow-Up
Christine Vestergaard Madsen,Karina Dahl Steffensen,Marianne Waldstr?m,Anders Jakobsen
Pathology Research International , 2012, DOI: 10.1155/2012/851432
Abstract: Introduction. The well-documented role of the PDGF system in tumor growth and angiogenesis has prompted the development of new biological agents targeting the PDGF system. The aim of the present study was to analyze the expression of the PDGF-receptors in ovarian cancer and to investigate its relation to histopathological parameters and long-term overall survival. Methods. The immunohistochemical expression of PDGFR-α and PDGFR-β was investigated in tumor and stromal cells in 170 patients with histologically verified epithelial ovarian cancer. Results. Almost half of the tumor specimens showed high expression of PDGFR-α and PDGFR-β in tumor cells (43% and 41%) and in stromal compartments (32% and 44%). There was a significant association between high expression of PDGFR-α and high expression of PDGFR-β in both tumor and stromal cells. Coexpression of PDGFR-α and PDGFR-β in stromal cells was seen more often in serous adenocarcinomas than in nonserous adenocarcinomas. No clear correlation between PDGFR expression and longterm overall survival or clinical parameters was found. Conclusions. PDGFR-α and PDGFR-β were expressed in a subset of ovarian carcinomas but did not show significant prognostic importance in this material. 1. Introduction Epithelial ovarian cancer is the most deadly gynecologic cancer in the Western world. The majority of patients are diagnosed in advanced stage which is a contributory factor to the poor prognosis of the disease. The current state- of-art in front-line treatment is aggressive surgical debulking followed by a combination of chemotherapy with platinum/taxane [1, 2]. Even though high response rates are seen, relapse often occurs within few years, and, in most cases, the therapy will then change from a curative to a palliative perspective. A higher degree of individualized treatment strategies based on validated prognostic or predictive markers may help improve the outcome and are therefore highly warranted in ovarian cancer. Results from recently published studies have shown that the addition of antivascular endothelial growth factor (VEGF) treatment to first-line chemotherapy may be beneficial for a fraction of ovarian cancer patients [3, 4], also in the treatment of the recurrent disease [5–7]. However, several other growth factors are involved in angiogenesis [8], among them the platelet-derived growth factor (PDGF) system. It plays a role in cell growth [9], chemotaxis [9, 10], pericytes recruitment, and stabilization of microvasculature [11, 12] as well as in the recruitment of fibroblast in tumor stroma [13, 14]. The
Human Development V: Biochemistry Unable to Explain the Emergence of Biological Form (Morphogenesis) and Therefore a New Principle as Source of Biological Information is Needed
Søren Ventegodt,Tyge Dahl Hermansen,Trine Flensborg-Madsen,Maj Lyck Nielsen
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.234
Abstract:
Human Development VI: Supracellular Morphogenesis. The Origin of Biological and Cellular Order
Søren Ventegodt,Tyge Dahl Hermansen,Trine Flensborg-Madsen,Maj Lyck Nielsen
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.255
Abstract:
Human development IV: The Living Cell has Information-Directed Self-Organisation
Søren Ventegodt,Tyge Dahl Hermansen,Trine Flensborg-Madsen,Maj Lyck Nielsen
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.177
Abstract:
Human development III: Bridging Brain-Mind and Body-Mind. Introduction to “Deep” (Fractal, Poly-Ray) Cosmology
Søren Ventegodt,Tyge Dahl Hermansen,Erik Rald,Trine Flensborg-Madsen
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.157
Abstract:
Human Development VII: A Spiral Fractal Model of Fine Structure of Physical Energy Could Explain Central Aspects of Biological Information, Biological Organization and Biological Creativity
Søren Ventegodt,Tyge Dahl Hermansen,Trine Flensborg-Madsen,Erik Rald
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.256
Abstract:
Human Development VIII: A Theory of Deep Quantum Chemistry and Cell Consciousness: Quantum Chemistry Controls Genes and Biochemistry to Give Cells and Higher Organisms Consciousness and Complex Behavior
Søren Ventegodt,Tyge Dahl Hermansen,Trine Flensborg-Madsen,Maj Lyck Nielsen
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.257
Abstract:
Human Development IX: A Model of the Wholeness of Man, His Consciousness, and Collective Consciousness
Søren Ventegodt,Tyge Dahl Hermansen,Trine Flensborg-Madsen,Erik Rald
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.258
Abstract:
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