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Search Results: 1 - 10 of 10013 matches for " Katharina Anne Scherf "
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Electrochemical Immunosensors for the Diagnosis of Celiac Disease  [PDF]
Katharina Anne Scherf, Peter Koehler, Herbert Wieser
Advances in Chemical Engineering and Science (ACES) , 2015, DOI: 10.4236/aces.2015.51009
Abstract: Celiac disease is a permanent intolerance to gluten proteins of wheat, rye, barley, and oats in genetically susceptible individuals. The clinical picture is characterized by inflammation and damage of the small intestinal mucosa and malabsorption of essential nutrients. Therapeutically, a lifelong strict gluten-free diet is necessary. The diagnosis of celiac disease is complex and includes symptomatology, serology, small intestinal histology, and genetic status. Serological testing plays a central role within the diagnostic procedure and is based on the measurement of disease-specific antibodies against gluten proteins (antigen) and tissue transglutaminase (autoantigen). Immunofluorescence detection and enzyme-linked immunosorbent assays are currently most often applied for antibody testing. However, these tests are expensive and time-consuming. Therefore, simple and rapid alternative methods have been developed during the last years, and electro-chemical immunosensors seem to be the most promising analytical tools. The architecture of these sensors may comprise the following elements: working and reference electrodes, covalent or noncovalent binding of the antigen to the surface of the working electrode by means of a functional monolayer, and blocking of unreacted binding sites. The analytical procedure is initiated by adding the analyte (serum antibodies) and an analyte-specific second antibody, which is usually labeled with an enzyme. The special reaction of the enzyme with an appropriate substrate results in a product that initiates a current that can be measured by different electrical methods. A number of different electrochemical immunosensors variable in different electrodes, binding systems, secondary antibodies, and current measurements have been developed. Most of them have been tested with real human serum samples of celiac patients and healthy individuals, and some of them reached disease sensitivity and specificity comparable with traditional analytical systems. Thus, electrochemical immunosensors can be promising alternatives to existing diagnostic tests in the future. They are simple, reliable, robust, user-friendly, and cost-effective tools with short operation times.
Implicit Multisensory Associations Influence Voice Recognition
Katharina von Kriegstein,Anne-Lise Giraud
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040326
Abstract: Natural objects provide partially redundant information to the brain through different sensory modalities. For example, voices and faces both give information about the speech content, age, and gender of a person. Thanks to this redundancy, multimodal recognition is fast, robust, and automatic. In unimodal perception, however, only part of the information about an object is available. Here, we addressed whether, even under conditions of unimodal sensory input, crossmodal neural circuits that have been shaped by previous associative learning become activated and underpin a performance benefit. We measured brain activity with functional magnetic resonance imaging before, while, and after participants learned to associate either sensory redundant stimuli, i.e. voices and faces, or arbitrary multimodal combinations, i.e. voices and written names, ring tones, and cell phones or brand names of these cell phones. After learning, participants were better at recognizing unimodal auditory voices that had been paired with faces than those paired with written names, and association of voices with faces resulted in an increased functional coupling between voice and face areas. No such effects were observed for ring tones that had been paired with cell phones or names. These findings demonstrate that brief exposure to ecologically valid and sensory redundant stimulus pairs, such as voices and faces, induces specific multisensory associations. Consistent with predictive coding theories, associative representations become thereafter available for unimodal perception and facilitate object recognition. These data suggest that for natural objects effective predictive signals can be generated across sensory systems and proceed by optimization of functional connectivity between specialized cortical sensory modules.
Implicit Multisensory Associations Influence Voice Recognition
Katharina von Kriegstein ,Anne-Lise Giraud
PLOS Biology , 2006, DOI: 10.1371/journal.pbio.0040326
Abstract: Natural objects provide partially redundant information to the brain through different sensory modalities. For example, voices and faces both give information about the speech content, age, and gender of a person. Thanks to this redundancy, multimodal recognition is fast, robust, and automatic. In unimodal perception, however, only part of the information about an object is available. Here, we addressed whether, even under conditions of unimodal sensory input, crossmodal neural circuits that have been shaped by previous associative learning become activated and underpin a performance benefit. We measured brain activity with functional magnetic resonance imaging before, while, and after participants learned to associate either sensory redundant stimuli, i.e. voices and faces, or arbitrary multimodal combinations, i.e. voices and written names, ring tones, and cell phones or brand names of these cell phones. After learning, participants were better at recognizing unimodal auditory voices that had been paired with faces than those paired with written names, and association of voices with faces resulted in an increased functional coupling between voice and face areas. No such effects were observed for ring tones that had been paired with cell phones or names. These findings demonstrate that brief exposure to ecologically valid and sensory redundant stimulus pairs, such as voices and faces, induces specific multisensory associations. Consistent with predictive coding theories, associative representations become thereafter available for unimodal perception and facilitate object recognition. These data suggest that for natural objects effective predictive signals can be generated across sensory systems and proceed by optimization of functional connectivity between specialized cortical sensory modules.
ocuk Edebiyat nda Ger ek E ilimler ve Geleneksel Modeller
Walter Scherf
Türk Kütüphanecili?i , 1978,
Abstract:
Fetal Calcium Regulates Branching Morphogenesis in the Developing Human and Mouse Lung: Involvement of Voltage-Gated Calcium Channels
Sarah C. Brennan, Brenda A. Finney, Maria Lazarou, Anne E. Rosser, Caroline Scherf, Dirk Adriaensen, Paul J. Kemp, Daniela Riccardi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080294
Abstract: Airway branching morphogenesis in utero is essential for optimal postnatal lung function. In the fetus, branching morphogenesis occurs during the pseudoglandular stage (weeks 9–17 of human gestation, embryonic days (E)11.5–16.5 in mouse) in a hypercalcaemic environment (~1.7 in the fetus vs. ~1.1–1.3 mM for an adult). Previously we have shown that fetal hypercalcemia exerts an inhibitory brake on branching morphogenesis via the calcium-sensing receptor. In addition, earlier studies have shown that nifedipine, a selective blocker of L-type voltage-gated Ca2+ channels (VGCC), inhibits fetal lung growth, suggesting a role for VGCC in lung development. The aim of this work was to investigate the expression of VGCC in the pseudoglandular human and mouse lung, and their role in branching morphogenesis. Expression of L-type (CaV1.2 and CaV1.3), P/Q type (CaV2.1), N-type (CaV2.2), R-type (CaV2.3), and T-type (CaV3.2 and CaV3.3) VGCC was investigated in paraffin sections from week 9 human fetal lungs and E12.5 mouse embryos. Here we show, for the first time, that Cav1.2 and Cav1.3 are expressed in both the smooth muscle and epithelium of the developing human and mouse lung. Additionally, Cav2.3 was expressed in the lung epithelium of both species. Incubating E12.5 mouse lung rudiments in the presence of nifedipine doubled the amount of branching, an effect which was partly mimicked by the Cav2.3 inhibitor, SNX-482. Direct measurements of changes in epithelial cell membrane potential, using the voltage-sensitive fluorescent dye DiSBAC2(3), demonstrated that cyclic depolarisations occur within the developing epithelium and coincide with rhythmic occlusions of the lumen, driven by the naturally occurring airway peristalsis. We conclude that VGCC are expressed and functional in the fetal human and mouse lung, where they play a role in branching morphogenesis. Furthermore, rhythmic epithelial depolarisations evoked by airway peristalsis would allow for branching to match growth and distension within the developing lung.
Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women
Anne Zimmermann, David Bernuit, Christoph Gerlinger, Matthias Schaefers, Katharina Geppert
BMC Women's Health , 2012, DOI: 10.1186/1472-6874-12-6
Abstract: 2,500 women (USA: 4,500 women) in each country (Brazil, Canada, France, Germany, Italy, South Korea, the UK, the USA) completed an online survey. Women included were in their reproductive age (age group 15-49 years; USA: 18-49 years) and had ever experienced menstrual bleedings. Quotas were applied for age, region, level of education and household income of respondents. Variables have been analyzed descriptively and exploratory statistical tests have been performed.The self-reported prevalence of uterine fibroids ranged from 4.5% (UK) to 9.8% (Italy), reaching 9.4% (UK) to 17.8% (Italy) in the age group of 40-49 years. Women with a diagnosis of uterine fibroids reported significantly more often about bleeding symptoms than women without a diagnosis: heavy bleedings (59.8% vs. 37.4%), prolonged bleedings (37.3% vs. 15.6%), bleeding between periods (33.3% vs. 13.5%), frequent periods (28.4% vs. 15.2%), irregular and predictable periods (36.3% vs. 23.9%). Furthermore women with diagnosed uterine fibroids reported significantly more often about the following pain symptoms: pressure on the bladder (32.6% vs. 15.0%), chronic pelvic pain (14.5% vs. 2.9%), painful sexual intercourse (23.5% vs. 9.1%) and pain occurring mid-cycle, after and during menstrual bleeding (31.3%, 16.7%, 59.7%, vs. 17.1%, 6.4%, 52.0%). 53.7% of women reported that their symptoms had a negative impact on their life in the last 12 month, influencing their sexual life (42.9%), performance at work (27.7%) and relationship & family (27.2%).Uterine fibroid is a common concern in women at fertile age causing multiple bleeding and pain symptoms which can have a negative impact on different aspects in women's life.Uterine fibroids (myomas or leiyomymas) are benign, monoclonal tumors of the smooth muscle cells found in the human uterus [1,2]. Despite the fact that their cause is still unknown, yet there is considerable evidence that estrogens and progestogens proliferate tumor growth [3,4], as the fibroids ra
Opinion Leaders and Lead Users in Marketing and Management Accounting and Impact on Small Business Performance  [PDF]
Katharina Simbeck
Social Networking (SN) , 2013, DOI: 10.4236/sn.2013.21002
Abstract: This paper empirically investigates into the business performance benefit that lead users or opinion leaders among small business owners draw from their higher involvement in management accounting or marketing topics. This work also contributes to a better identification of network members’ roles solely through their ties between each other. Indeed, lead users and opinion leaders can be differentiated by a higher degree centrality in comparison to their peers. However, being an opinion leader or a lead user does not yield a measurable business benefit to the small businesses studied in this sample.
The Pf332 gene codes for a megadalton protein of Plasmodium falciparum asexual blood stages
Mattei, Denise;Scherf, Artur;
Memórias do Instituto Oswaldo Cruz , 1992, DOI: 10.1590/S0074-02761992000700026
Abstract: we characterized the plasmodium falciparum antigen 332 (ag332) which is specifically expressed during the asexual intraerythrocytic cycle of the parasite. the corresponding pf332 gene has been located in the subtelomeric region of chromosome 11. furthermore, it is present in all strais so far analyzed and shows marked restriction length fragment polymorphism. partial sequence and restriction endonuclease digestion of cloned fragments revealed that the pf332 gene is composed of highly degenerated repeats rich is glutamic acid. mung been nuclease digestion and northern blot analysis suggested that pf332 gene codes for a protein of about 700 kda. these data were further confirmed by western blot and immunoprecipitation of parasites extracts with an antiserum raised against a recombinant clone expressing part of the ag332. confocal immunofluorescence showed that ag332 is translocated from the parasite to the surface of infected red blood cells within vesicle-like structures. in addition, ag332 was detected on the surface of monkey erythrocytes infected with plasmodium falciparum.
In kleinen Schritten und mit leisen T nen Quietly and With Small Steps
Ingrid Kurz-Scherf
querelles-net , 2006,
Abstract: Der von Annette Henninger und Helga Ostendorf herausgegebene Sammelband basiert auf einer Tagung des Arbeitskreises Politik und Geschlecht der Deutschen Vereinigung für Politische Wissenschaft im Mai 2001, die – so betonen Henninger und Ostendorf in ihrer Danksagung – als legend r“ (S. 7) in die Geschichte des Arbeitskreises eingegangen sei. Der Band enth lt 11 Beitr ge mit empirischen Befunden der feministisch-politikwissenschaftlichen Institutionenanalyse“ (S. 9). Vorangestellt haben die Herausgeberinnen den Einzelbeitr gen eine einleitende Abhandlung, in der sie deren Ertrag für die Weiterentwicklung der theoretischen Auseinandersetzung mit politischen Institutionen insbesondere im Hinblick auf ihre geschlechterpolitische Fundierung und Wirkungsweise reflektieren. Gleichzeitig werden Chancen und Barrieren institutionalisierter Frauen- und Geschlechterpolitik ausgelotet. The collected volume, edited by Annette Henninger and Helga Ostendorf, is based on a May 2001 conference of the working group for politics and gender of the German Union for Political Science, which—according to Henninger and Ostendorf’s dedication—has gone down in the history of the working group as legendary. The volume contains eleven contributions that hold empirical findings on “feminist institutional analysis.” The editors of the volume introduce the essays, individually as well as in an introductory chapter, by reflecting on their productivity with regard to further developing the theoretical dispute over political institutions, particularly with regard to their foundation in gender politics and their effectiveness. At the same time, the essays call forth the chances and barriers found in institutionalized politics on women and gender.
Weiterführung des ffentlichen Dialogs auf Grundlage des Kommentars von Univ.-Prof. Dr. Dieter Magometschnigg zum Artikel "Fehlgemessener oder realer Hypertoniker?" (Scherf HP et al. J Hyperton 2006; 10 (4): 6-11)
Hecht K,Scherf HP
Journal für Hypertonie , 2007,
Abstract:
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