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Search Results: 1 - 10 of 209814 matches for " Kate L. Tomlinson "
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Neutralisation of Interleukin-13 in Mice Prevents Airway Pathology Caused by Chronic Exposure to House Dust Mite
Kate L. Tomlinson,Gareth C. G. Davies,Daniel J. Sutton,Roger T. Palframan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013136
Abstract: Repeated exposure to inhaled allergen can cause airway inflammation, remodeling and dysfunction that manifests as the symptoms of allergic asthma. We have investigated the role of the cytokine interleukin-13 (IL-13) in the generation and persistence of airway cellular inflammation, bronchial remodeling and deterioration in airway function in a model of allergic asthma caused by chronic exposure to the aeroallergen House Dust Mite (HDM).
An Evaluation of the Accessibility of E-resources from Theological Library Websites
Kate L. Ganski
Theological Librarianship , 2008,
Abstract: This study examines the accessibility of e-resources from the websites of theological libraries to discover if theological libraries are providing digital access to e-journals, recommended religious Internet resources, and digital libraries. Qualitative content analysis was used to evaluate the placement and terminology of e-resources on twenty-five theological library websites of faith-based institutions with primarily graduate/professional students. Findings revealed slightly more than half of these websites make e-resources available and are easily accessible through a quick navigational pathway. Terminology used was found to be diverse and varied. These findings suggest that theological library websites are attempting to meet the digital needs of their students. Further study is recommended to understand the impact, if any, these findings may have on the digital needs of theological students.
Marketing Today’s Academic Library: A Bold New Approach to Communicating with Students
Kate L. Ganski
Theological Librarianship , 2009,
The contribution of hypothalamic macroglia to the regulation of energy homeostasis
Kate L. J. Ellacott
Frontiers in Systems Neuroscience , 2014, DOI: 10.3389/fnsys.2014.00212
Abstract: The hypothalamus is critical for the regulation of energy homeostasis. Genetic and pharmacologic studies have identified a number of key hypothalamic neuronal circuits that integrate signals controlling food intake and energy expenditure. Recently, studies have begun to emerge demonstrating a role for non-neuronal cell types in the regulation of energy homeostasis. In particular the potential importance of different glial cell types is increasingly being recognized. A number of studies have described changes in the activity of hypothalamic macroglia (principally astrocytes and tanycytes) in response to states of positive and negative energy balance, such as obesity and fasting. This article will review these studies and discuss how these findings are changing our understanding of the cellular mechanisms by which energy homeostasis is regulated.
Transfer reaction experiments with radioactive beams: from halos to the r-process
Kate L. Jones
Physics , 2013, DOI: 10.1088/0031-8949/2013/T152/014020
Abstract: Transfer reactions are a powerful probe of the properties of atomic nuclei. When used in inverse kinematics with radioactive ion beams they can provide detailed information on the structure of exotic nuclei and can inform nucleosynthesis calculations. There are a number of groups around the world who use these reactions, usually with particle detection in large silicon arrays. Sometimes these arrays are coupled to gamma-ray detectors, and occasionally smaller arrays of silicon detectors are mounted within a solenoid magnet. Modern techniques using transfer reactions in inverse kinematics are covered, with specific examples, many from measurements made with beams from the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory.
A Synthesis of 6-(2,5-Dimethoxy-4-(2-aminopropyl)phenyl)-hexylthiol. A Ligand for Conjugation with Fluorescent Cadmium Selenide/Zinc Sulfide Core/Shell Nanocrystals and Biological Imaging
Ian D. Tomlinson,Jesse L. Grey,Sandra J. Rosenthal
Molecules , 2002, DOI: 10.3390/71100777
Abstract: The synthesis of 6-(2,5-dimethoxy-4-(2-aminopropyl)phenyl)hexylthiol, an agonist with a very high affinity for the 5HT2A serotonin receptor subtype is reported. This agonist was designed to be attached to highly fluorescent cadmium selenide/zinc sulfide core/shells via a thiol at the end of a linker arm. This conjugate has applications in biological assays and biological imaging.
The epidemiology of major depression in South Africa: Results from the South African Stress and Health study
M Tomlinson, AT Grimsrud, DJ Stein, DR Williams, L Myer
South African Medical Journal , 2009,
Abstract: Background. Mental disorders are a major contributor to the burden of disease in all regions of the world. There are limited data on the epidemiology of major depressive disorder in South Africa. Methods. A nationally representative household survey was conducted between 2002 and 2004 using the World Health Organization Composite International Diagnostic Interview (CIDI) to establish a diagnosis of depression. The dataset analysed included 4 351 adult South Africans of all racial groups. Results. The prevalence of major depression was 9.7% for lifetime and 4.9% for the 12 months prior to the interview. The prevalence of depression was significantly higher among females than among males. The prevalence was also higher among those with a low level of education. Over 90% of all respondents with depression reported global role impairment. Conclusion. In comparison with data from other countries, South Africa has lower rates of depression than the USA but higher rates than Nigeria. The findings are broadly consistent with previous findings in South Africa. These findings are the first step in documenting a level of need for care in a context of significant under-funding of mental health services and research in South Africa
A systematic review of symptom assessment scales in children with cancer
Dupuis L,Ethier Marie-Chantal,Tomlinson Deborah,Hesser Tanya
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-430
Abstract: Background The objective was to describe symptom assessment scales that have been used in children with cancer. Methods We conducted electronic searches of OVID Medline and EMBASE in order to identify all symptom assessment scales that have been used in pediatric cancer. Two reviewers abstracted information from each identified study. Data collected included study demographics and information related to the instrument and children enrolled. We also collected information about the purpose of instrument administration and whether treatment was altered as a result of this information. Results Fourteen studies were identified which evaluated eight different symptom assessment scales. Eight studies used child self-report and all studies included children on active treatment for cancer although 4 studies also included children following completion of treatment. The most common purpose of instrument administration was to measure the prevalence of symptom burden (n = 8). None of the 14 studies used the scale to screen for symptoms and none changed patient management on the basis of identified symptoms. Conclusions We failed to identify any symptom assessment scales that were used as a symptom screening tool. There is a need to develop such a tool for use in children with cancer.
Generalizability of guidelines and physicians' adherence. Case study on the Sixth Joint National Commitee's guidelines on hypertension
Claudio Pedone, Kate L Lapane
BMC Public Health , 2003, DOI: 10.1186/1471-2458-3-24
Abstract: We used the Sixth Joint National Committee's (JNC VI) guidelines on hypertension to evaluate our hypothesis. We evaluated the evidence from controlled clinical trials on which the JNC VI bases its recommendation, and compared the population enrolled in those trials with the American hypertensive population. Data on this population came from the National Health and Nutritional Examination Survey III.Twenty-three percent of the NHANES population had a diagnosis of hypertension, 11% had hypertension requiring drug treatment according to the JNC VI. Only half of the population requiring treatment would have been enrolled in at least two trials. Rate of adherence to CPG was 69%. We found a weak association between generalizability and physicians' adherence to guidelines. Baseline risk was the major determinant of the decision to treat.JNC VI guidelines may not be generalizable to their target population. We found a relatively poor adherence rate to these guidelines. Failing of completely taking into account the clinical characteristics of the patients may be partly responsible for this lack of adherence.Guidelines are "systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances".[1] Guidelines seem to be effective in improving the processes and outcomes of care, [2] and are being used to describe appropriate care based on scientific evidence.[3] Another proposed use of guidelines is for profiling and resource utilization reviews.[4]Despite evidence of effectiveness and widespread implementation efforts, adherence to guidelines is variable and generally poor.[5-7] The factors involved in a physician's adherence to guidelines have been extensively studied. Lack of familiarity and inertia to previous practice, characteristics of the health care professional and of the practice setting, physician perception of guidelines' usefulness, incentives, regulation and patient-related factors are c
Principles and Procedures for Self-Access Materials
Brian Tomlinson
Studies in Self-Access Learning Journal , 2010,
Abstract: Like all language learning materials, self-access materials need to be developed from principles driven by what is known about the needs and wants of the target users. In my view, there should be a specification of universal principles, delivery specific principles, and local principles before deciding what self-access materials to develop and how to develop them. Universal principles are principles of language acquisition and development (Tomlinson, 2007a) which are applicable to all learners everywhere regardless of their age, level, objectives, and context of learning. Delivery specific principles are those which are peculiar to the means of delivering the materials (i.e. through self-access). Local principles are those which are peculiar to the specified target learners.
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