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Search Results: 1 - 10 of 565 matches for " Kasper "
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Location of DNA damage by charge exchanging repair enzymes: effects of cooperativity on location time
Kasper Eriksen
Theoretical Biology and Medical Modelling , 2005, DOI: 10.1186/1742-4682-2-15
Abstract: Here the size of the speed-up gained from this charge exchange mechanism is calculated and the characteristic length and time scales are identified. In particular, for Escherichia coli, I estimate the speed-up is 50000/N, where N is the number of repair enzymes participating in the charge exchange mechanism. Even though N is not exactly known, a speed-up of order 10 is not entirely unreasonable. Furthermore, upon over expression of all the repair enzymes, the location time only varies as N-1/2 and not as 1/N.The revolutionary hypothesis that DNA repair enzymes use charge exchange along DNA to locate damaged sites more efficiently is actually sound from a purely theoretical point of view. Furthermore, the predicted collective behavior of the location time is important in assessing the impact of stress-ful and radioactive environments on individual cell mutation rates.Bases in DNA suffer damage both from normal cellular functions such as metabolism and from external oxidative stress and radiation. Naturally the cell has several lines of defense against direct lesions and ensuing mutagenic mispairings [1-3]. Oxidation of the base guanine (G) often results in the formation of 8-oxo-G (7,8-dihydro-8-oxo-2'-deoxyguanosine) [4]. During replication, 8-oxo-G can pair both with cytosine (C) and adenine (A) [5]. Following another round of replication, the 8-oxo-G:A pairs give rise to G:C to T:A mutations (if not corrected). In Escherichia coli, 8-oxo-G:C pairs are detected by the DNA glycosylase MutM (formamidopyrimidine glycosylase), which subsequently excises the 8-oxo-G from the DNA leaving an abasic site where the strand is nicked at both the 3' and 5' ends [6]. The abasic site is further processed by the base excision pathway (BER), eventually leading to the insertion of a G opposite the remaining C. The action of MutM brings the number of adenines A misincorporated opposite 8-oxo-G during replication down to around one per one million bases, even in cells challenged by H
Introducing Cadabra: a symbolic computer algebra system for field theory problems
Peeters, Kasper
High Energy Physics - Phenomenology , 2007,
Abstract: Cadabra is a new computer algebra system designed specifically for the solution of problems encountered in field theory. It has extensive functionality for tensor polynomial simplification taking care of Bianchi and Schouten identities, for fermions and anti-commuting variables, Clifford algebras and Fierz transformations, implicit coordinate dependence, multiple index types and many other field theory related concepts. The input format is a subset of TeX and thus easy to learn. Both a command-line and a graphical interface are available. The present paper is an introduction to the program using several concrete problems from gravity, supergravity and quantum field theory.
Man should not let death attain the dominion of his thoughts: An Essay on Subjectivity, Self-Preservation and Immortality
Kasper Lysemose
Meta : Research in Hermeneutics, Phenomenology and Practical Philosophy , 2010,
Abstract: Mortality seems to have no place in the theories on subjectivity in Kant and Husserl. It is suggested that this entente cordiale is an expression of the shared principle at the heart of their philosophy, i.e. the principle of selfpreservation. Self-preservation is a principle that in a certain sense excludes mortality. It is argued that the primary sense of this exclusion is not theoretical but practical. Kant and Husserl are both endorsing the imperative that man should not let death attain the dominion of his thoughts (cf. Mann 1976, 600). The positive correlate to this is to be found in the demand that man should think of himself as if he was immortal. With special regard to Husserl the predicament that accompanies his relentless attempt to fulfill this demand is described as a sluice through which anthropology threatens to flow into the phenomenological enterprise.
Robótica para la minería y su potencial como catalizador de la innovación tecnológica en Chile Mining robotics, a potential catalyzer for technological innovation in Chile
Kasper Stoy
Ingeniare : Revista Chilena de Ingeniería , 2013,
Abstract:
Trends und Perspektiven in der Psychiatrie: Psychiatrie, raus aus der Tabuzone!
Kasper S
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2012,
Abstract:
Trends und Perspektiven in der Psychiatrie: Begriffsverwirrung in der Psychopharmakologie
Kasper S
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2010,
Abstract:
Trends und Perspektiven: Wechselwirkungen zwischen seelischer Gesundheit und K rper meist untersch tzt
Kasper S
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2009,
Abstract:
Trends und Perspektiven in der Psychiatrie: Und sie wirken doch! Neuere Antidepressiva auf dem Prüfstand
Kasper S
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2009,
Abstract:
Trends und Perspektiven in der Psychiatrie: Die verschiedenen Facetten des Ansprechens auf eine antidepressive Therapie und deren praktische Bedeutung
Kasper S
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2011,
Abstract:
Trends und Perspektiven in der Psychiatrie: Bildgebung und Genetik in der Psychiatrie - quo vadis?
Kasper S
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2012,
Abstract:
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