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Search Results: 1 - 10 of 6419 matches for " Karl-Philipp Puchner "
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Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries
Ariadne Malamitsi-Puchner,Nikolaos Vrachnis,Evi Samoli,Stavroula Baka,George Alexandrakis,Karl-Philipp Puchner,Zoe Iliodromiti,Demetrios Hassiakos
Mediators of Inflammation , 2006, DOI: 10.1155/mi/2006/94381
Abstract: Aims. Our aim is to investigate, in 13 cases (delivering preterm) and 21 matched (for age, parity, and gestational age) controls (delivering at term), whether midtrimester amniotic fluid concentrations of elastase, secretory leukocyte proteinase inhibitor (SLPI), soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule predict asymptomatic intra-amniotic inflammation/infection and preterm labor. Results. Concentrations of all substances were not statistically different among mothers, delivering preterm or at term. SLPI concentrations significantly increased in women, going into labor without ruptured membranes, irrespective of pre- or term delivery (P<.007, P<.001, resp) and correlated with elastase (r=0.508, P<.002). Conclusions. Midtrimester amniotic fluid SLPI concentrations significantly decrease when membrane rupture precedes pre- or full-term labor. However, none of the investigated substances predict preterm delivery.
Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant Pairs
Ariadne Malamitsi-Puchner,Despina D. Briana,Dimitrios Gourgiotis,Maria Boutsikou,Karl-Philipp Puchner,Stavroula Baka,Antonios Marmarinos,Dimitrios Hassiakos
Mediators of Inflammation , 2007, DOI: 10.1155/2007/42646
Abstract: Insulin-like growth factor (IGF)-I and insulin are essential for fetal growth. We investigated perinatal changes of both factors in 40 mothers and their 20 appropriate-for-gestational-age (AGA) and 20 intrauterine-growth-restricted (IUGR) fetuses and neonates on day 1 (N1) and day 4 (N4) postpartum. Fetal and N1, but not N4, IGF-I levels were increased in AGA (P<.001 and P=.037, resp.). N1 insulin levels were lower in IUGR (P=.048). Maternal, fetal, and N1 IGF-I, and fetal insulin levels positively correlated with customized centiles (r=.374, P=.035, r=.608, P<.001, r=.485, P=.006, and r=.654, P=.021, resp.). Female infants presented elevated fetal and N4 IGF-I levels (P=.023 and P=.016, resp.). Positive correlations of maternal, fetal, and neonatal IGF-I levels, and fetal insulin levels with customized centiles underline implication of both hormones in fetal growth. IUGR infants present gradually increasing IGF-I levels. Higher IGF-I levels are documented in females.
Evaluation of radial distribution of cartilage degeneration and necessity of pre-contrast measurements using radial dGEMRIC in adults with acetabular dysplasia
Xu Li,Su Yongbin,Kienle Karl-Philipp,Hayashi Daichi
BMC Musculoskeletal Disorders , 2012, DOI: 10.1186/1471-2474-13-212
Abstract: Background The purpose of the present study was to investigate the radial distribution patterns of cartilage degeneration in dysplastic hips at different stages of secondary osteoarthritis (OA) by using radial delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), and to assess whether pre-contrast measurements are necessary. Methods Thirty-five hips in 21 subjects (mean age ± SD, 27.6 ± 10.8 years) with acetabular dysplasia (lateral CE angle < 25°) were studied. Severity of OA was assessed on radiographs using T nnis grading. Pre- (T1pre) and post-contrast T1 (T1Gd) values were measured at 7 sub-regions on radial reformatted slices acquired from a 3-dimensional (3D) T1 mapping sequence using a 1.5 T MR scanner. Values of radial T1pre, T1Gd and ΔR1 (1/T1Gd - 1/T1pre) of subgroups with different severity of OA were compared to those of the subgroup without OA using nonparametric tests, and bivariate linear Pearson correlations between radial T1Gd and ΔR1 were analyzed for each subgroup. Results Compared to the subgroup without OA, the subgroup with mild OA was observed with a significant decrease in T1Gd in the anterosuperior to superior sub-regions (mean, 476 ~ 507 ms, p = 0.026 ~ 0.042) and a significant increase in ΔR1 in the anterosuperior to superoposterior and posterior sub-regions (mean, 0.93 ~ 1.37 s-1, p = 0.012 ~ 0.042). The subgroup with moderate to severe OA was observed with a significant overall decrease in T1Gd (mean, 404 ~ 452 ms, p = 0.001 ~ 0.020) and an increase in ΔR1 (mean, 1.17 ~1.69 s-1, p = 0.001 ~ 0.020). High correlations were observed between radial T1Gd and ΔR1 for all subgroups (r = 0.869 ~ 0.944, p < 0.001). Conclusions Radial dGEMRIC without pre-contrast measurements is useful for evaluating different patterns of cartilage degeneration in the entire hip joint of patients with hip dysplasia, particularly for those in early stages of secondary OA.
Perinatal Plasma Monocyte Chemotactic Protein-1 Concentrations in Intrauterine Growth Restriction
Despina D. Briana,Maria Boutsikou,Stavroula Baka,George Papadopoulos,Dimitrios Gourgiotis,Karl Philipp Puchner,Dimitrios Hassiakos,Ariadne Malamitsi-Puchner
Mediators of Inflammation , 2007, DOI: 10.1155/2007/65032
Abstract: Monocyte chemotactic protein-1 (MCP-1) plays vital roles in immune response, angiogenesis, and pregnancy outcome. We investigated plasma MCP-1 concentrations in 40 mothers and their 20 intrauterine-growth-restricted (IUGR) and 20 appropriate-for-gestational-age (AGA) fetuses and neonates on postnatal days 1 (N1) and 4 (N4). Maternal and fetal MCP-1 concentrations were decreased (P<001 and P = .018, resp.), whereas N1 MCP-1 concentrations were elevated in IUGR group (P = .012). In both groups, fetal MCP-1 concentrations were lower compared to N1 and N4 ones (P = .045, P = .012, resp., for AGA, P< .001 in each case for IUGR). Reduced maternal and fetal MCP-1 concentrations in IUGR may reflect failure of trophoblast invasion, suggesting that down-regulation of MCP-1 may be involved in the pathogenesis of IUGR. Increased MCP-1 concentrations in IUGR neonates and higher postnatal ones in all infants may be attributed to gradual initiation of ex utero angiogenesis, which is possibly enhanced in IUGR.
The phase structure of a chirally invariant lattice Higgs-Yukawa model
Philipp Gerhold,Karl Jansen
Physics , 2007,
Abstract: We consider a chirally invariant lattice Higgs-Yukawa model based on the Neuberger overlap operator. As a first step towards the eventual determination of Higgs mass bounds we present the phase structure of the model analytically in the large Nf-limit in the physically interesting region of the Yukawa coupling constant. We confront the analytically obtained phase diagram with corresponding HMC-simulations and find an excellent agreement at large values of Nf. In the opposite case the large Nf computation still gives a good qualitative description of the phase diagram. We also present first and very preliminary results on the Higgs upper bound at one selected cut-off of the theory.
Bell's theorem: Critique of proofs with and without inequalities
Karl Hess,Walter Philipp
Physics , 2004, DOI: 10.1063/1.1874568
Abstract: Most of the standard proofs of the Bell theorem are based on the Kolmogorov axioms of probability theory. We show that these proofs contain mathematical steps that cannot be reconciled with the Kolmogorov axioms. Specifically we demonstrate that these proofs ignore the conclusion of a theorem of Vorob'ev on the consistency of joint distributions. As a consequence Bell's theorem stated in its full generality remains unproven, in particular, for extended parameter spaces that are still objective local and that include instrument parameters that are correlated by both time and instrument settings. Although the Bell theorem correctly rules out certain small classes of hidden variables, for these extended parameter spaces the standard proofs come to a halt. The Greenberger-Horne-Zeilinger (GHZ) approach is based on similar fallacious arguments. For this case we are able to present an objective local computer experiment that simulates the experimental test of GHZ performed by Pan, Bouwmeester, Daniell, Weinfurter and Zeilinger and that directly contradicts their claim that Einstein-local elements of reality can neither explain the results of quantum mechanical theory nor their experimental results.
Comment on Mermin's Recent Proof of the Theorem of Bell
Karl Hess,Walter Philipp
Physics , 2002,
Abstract: Mermin states in a recent paper that his nontechnical version of Bell's theorem stands and is not invalidated by time and setting dependent instrument parameters as claimed in one of our previous papers. We identify a number of misinterpretations (of our definitions) and mathematical inconsistencies in Mermin's paper and show that Mermin's conclusions are therefore not valid: his proof does not go forward if certain possible time dependencies are taken into account.
Logical Inconsistencies in Proofs of the Theorem of Bell
Karl Hess,Walter Philipp
Physics , 2002,
Abstract: We discuss a class of proofs of Bell-type inequalities that are based on tables of potential outcomes. These proofs state in essence: if one can only imagine (or write down in a table) the potential outcome of a hidden parameter model for EPR experiments then a contradiction to experiment and quantum mechanics follows. We show that these proofs do not contain hidden variables that relate to time or, if they do, lead to logical contradictions that render them invalid.
Einstein-separability, time related hidden parameters for correlated spins, and the theorem of Bell
Karl Hess,Walter Philipp
Physics , 2001,
Abstract: We analyze the assumptions that are made in the proofs of Bell-type inequalities for the results of Einstein-Podolsky-Rosen type of experiments. We find that the introduction of time-like random variables permits the construction of a broader mathematical model which accounts for all correlations of variables that are contained in the time dependent parameter set of the backward light cone. It also permits to obtain the quantum result for the spin pair correlation, a result that contradicts Bell's inequality. Two key features of our mathematical model are (i) the introduction of time operators that are indexed by the measurement settings and appear in addition to Bell's source parameters and (ii) the related introduction of a probability measure for all parameters that does depend on the analyzer settings. Using the theory of B-splines, we then show that this probability measure can be constructed as a linear combination of setting dependent subspace product measures and that the construction guarantees Einstein-separability.
Classical information and Mermin's non-technical proof of the theorem of Bell
Karl Hess,Walter Philipp
Physics , 2002,
Abstract: We show that Mermin's reasoning against our refutation of his non-technical proof for Bell-type inequalities is of limited significance or contains mathematical inconsistencies that, when taken into account, do not permit his proof to go forward. Our refutation therefore stands.
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