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Search Results: 1 - 10 of 680 matches for " Karigar Asif "
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REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE ANALYSIS OF GLIPIZIDE IN PHARMACEUTICAL DOSAGE FORMS
Sheikh Rahila,Karigar Asif
International Journal of Research in Ayurveda and Pharmacy , 2010,
Abstract: A rapid and sensitive reverse phase high performance liquid chromatographic methods depicted for the qualitative and quantitative assay of glipizide in pharmaceutical dosage forms. Glipizide was chromatographed on reverse phase C18 column with mobile phase consisting of 0.05 M Potassium Dihydrogen Orthophosphate: Methanol [15: 85 %v/v, pH 7.0 ± 0.05, adjusted with 1% Triethylamine]. The mobile phase was pumped at a flow rate 1 mL/min. Quantification was achieved by monitoring the ultraviolet absorbance at 225 ηm. The average retention time for Glipizide was found to be 3.21 ± 0.07. With this method, linearity was observed in the range of 10 – 2000 ηg/ml. The LOD and LOQ were found to be 5 ηg/ml and 15 ηg/ml respectively. The method was applicable for the analysis of drug in tablet formulation. The results of analysis were validated statistically.
FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF SERTACONAZOLE NITRATE
Kansagra Hemang,Mallick Subrata,Karigar Asif
International Research Journal of Pharmacy , 2012,
Abstract: The present work was designed to develop suitable transdermal matrix patch of sertaconazole nitrate, which is of the imidazole class used for antifungal medication, using Ethyl cellulose (EC), Polyvinyl pyrrolidone (PVPK-30) and Dibutyl phthalate. The aqueous insolubility of the drug inspires for the formulation of controlled release transdermal patches. Different batches developed using Ethyl cellulose and Polyvinyl pyrrolidone in different ratios by solvent evaporation technique. Drug excipient interaction study was further carried out using Fourier Transform Infrared (FTIR) spectroscopic technique. Physical evaluation performed such as moisture content, moisture uptake, thickness and folding endurance. In vitro diffusion studies were performed using cellulose nitrate membrane (pore size 0.45μ) in modified Franz’s diffusion cells in buffer of pH 7.4. Permeation studies illustrated that the ratio of polyvinyl pyrrolidone and ethyl cellulose 1:5 shows good controlled release. Higuchi and Korsmeyer-Peppas models were used for optimizing the formulation.
GREEN TECHNIQUE-SOLVENT FREE SYNTHESIS AND ITS ADVANTAGES
M.Himaja,Das Poppy,Karigar Asif
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Green Chemistry, the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances is an overarching approach that is applicable to all aspects of chemistry. All synthetic processes involve the use of different solvents. Unfortunately many of the solvents are used in industry and retail are volatile organic compounds (VOCs) which lead to environmental damage, through pollution, risks to human health and to resource depletion, we need to develop and apply more environmentally friendly approaches. So, all traditional and old synthetic routes obviously give adverse effects to the mankind and all living beings. Green chemistry provides “Green” paths for different synthetic routes using non-hazardous solvents and environmental- friendly chemicals. Solvent free synthesis has several advantages over the classical method of synthesis. Due to enormous advantages of solvent free reactions, new solvent-free approaches are being discovered for eco-friendly synthesis of many compounds.
BUCCAL DRUG DELIVERY SYSTEM: THE CURRENT INTEREST
Patel Mitul,Karigar Asif,Savaliya Pratik,Ramana MV
International Research Journal of Pharmacy , 2011,
Abstract: This review highlights the several advantages of buccal drug delivery system (BDDS) over the conventional and systemic formulation majorly. It helps to enhance bioavailability through bypassing the first pass metabolism. On this drug delivery system the formulation keeps in contact with the mucosal surface resulting in better absorption and prolonged resident time. Though all drugs are not suitable for this drug delivery system yet is useful for most of the drugs. Bioadhesive polymers roles a major part in this drug delivery system because the extent of Mucoadhesion is a very important phenomena for the buccal drug delivery system. This review covers merits and demerits of buccal drug delivery system, anatomy of oral mucosa, mechanism of drug permeation, polymers and permeation enhancer used in buccal drug delivery system. This review also covers available marketed product as buccal drug delivery system and future aspects of buccal drug delivery system.
SYNTHESIS, DOCKING STUDIES AND ANTIOXIDANT ACTIVITY OF LINEAR TETRAPEPTIDE FAYV
Sreekanth K.,Himaja M.,Anand Ranjitha,Karigar Asif
International Research Journal of Pharmacy , 2011,
Abstract: The linear tetrapeptide Phe-Ala-Tyr-Val (FAYV) was designed based on docking results using Schrodinger Software tool. The tetrapeptide was conveniently synthesized by solution phase peptide synthesis using Dicyclohexylcarbidomide (DCC) as coupling agent and triethyl amine as the base. Qikprop (a tool to predict drug like properties) results showed that the ligands mostly show antihypertensive and antidiabetic properties. The compounds were evaluated for antioxidant property by using 1,1-diphenyl-2-picryl-hydrazil (DPPH.) method and were found to possess significant antioxidant activity.
FACILE SYNTHESIS, DOCKING STUDIES AND ANTIOXIDANT ACTIVITY OF FGVR
Himaja M,Abdulla M,Karigar Asif,Ramana M.V
International Research Journal of Pharmacy , 2011,
Abstract: A rational designing of linear Tetrapeptide FGVR was done and was synthesized by solution phase peptide synthesis. The docking studies of designed linear tetrapeptide FGVR was carried out by using Schrodinger Software Solutions, USA. Qikprop results show the ligand FGVR mostly act as antihypertensive and anti coagulant properties. The solution phase synthesis of FGVR is carried out by using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) as coupling agents and N-Methyl morpholine (NMM) as base. Structure of synthesized FGVR was confirmed by FTIR, 1H NMR and Mass spectral data, and evaluated for antioxidant property by using 1,1-diphenyl-2-picryl-hydrazil (DPPH.) method and the synthesized peptides FGVR possess moderate antioxidant activity.
CHEWING GUM: A MODERN ERA OF DRUG DELIVERY
Savaliya Pratik,Karigar Asif,Ramana MV,Patel Mitul
International Research Journal of Pharmacy , 2011,
Abstract: Chewing gum as a drug delivery system has many advantages over other oral dosage forms and oral route is the most preferred route amongst the patient and clinicians because the first pass metabolism can be avoided by the absorption of drug through buccal mucosa in the systemic circulation. It can be applied to cure and prevent the dental caries, pain, smoking cessation, obesity, xerostomia, motion sickness, acidity and specially diabetes. It has many advantages like fast onset of action, no first pass metabolism, patient compliance, taste masking, reduced risk of erosion of gastric mucosa, overdose and some marketing advantages. This review indicates that further study on medicated chewing gum can be used to improve it as a modern drug delivery.
SYNTHESIS OF GLABRIN A AND ITS N-METHYLATED ANALOG AS POTENT INSECTICIDAL AGENTS
M. Himaja,G. Vani,Ramana M.V,Karigar Asif
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: Two new cyclohexapeptides, Glabrin A and Glabrin B were isolated from the seeds of Annona glabra. The cyclohexapeptides show simple architectures with highly repeated residue units, which showed moderate antifungal and weak antitumor activities in vitro. The Glabrin A and its N-Methylated analogs were synthesized and were evaluated for their biological activity. The N-methylated peptide antibiotics are found to possess enhanced activity as compared to the unmethylated forms. The structure of the new compounds was confirmed by IR, 1HNMR and Mass spectroscopy. The synthesized compounds were tested for their anthelmintic activity and insecticidal activity.
CHRONOTHERAPY: A NOVEL DRUG DELIVERY SYSTEM
Dubal Ashwini,Karigar Asif,Ramana MV,Patel Mitul
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Recent advances in chronopharmacology and requirement of an appropriate technology to deliver the drug at specific time and site led to the development of novel type of drug delivery systems as “chronotropic or Pulsatile drug delivery systems”. Rationale behind designing these drug delivery systems is to release the drug at desired time (pathophysiological need of disease), which results into improved therapeutic efficacy and patient-compliance. These systems are meant for treatment of those diseases that are caused due to circadian changes in body like asthma, peptic ulcer, cardiovascular diseases, arthritis and when zero order drug release is not desired. These drug delivery systems are designed to release the drug within a short period of time, immediately after a predetermined lag time. The current article focuses on diseases requiring chronotropic systems and their chronological behavior, various approaches like time controlled chronotropic systems, stimuli induced pulsatile drug delivery systems, externally regulated pulsatile drug delivery systems to design them, recent technologies for chronotherapy and currently available marketed formulations.
SYNTHESIS AND EVALUATION OF ANTITUBERCULAR ACTIVITY OF SOME LAMIVUDINE BASED HYBRID DRUGS
M. Himaja,M. Vijaya Simha,D. Munirajasekhar,Karigar Asif
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: A series of Lamivudine based hybrid drugs (1-4) were synthesized by solution phase peptide synthesis. The docking studies of the designed compounds were carried out against tuberculosis target protein 3OEI using Hex software resulting in a good dock score. Synthesis of these compounds is carried out by using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and Dicyclohexyl carbodiimide (DCC) as coupling agents. Structure of synthesized compounds was confirmed by spectroscopic techniques and the compounds were evaluated for antitubercular property by Micro Plate Alamar Blue (MABA) assay method. The synthesized compounds possesed moderate antitubercular activity.
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