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Preparation, physicochemical characterization, dissolution and formulation studies of telmisartan cyclodextrin inclusion complexes
Kane Rajesh,Kuchekar Bhanudas
Asian Journal of Pharmaceutics , 2010,
Abstract: The objective of this research was to prepare, characterize, and to study dissolution properties of inclusion complexes of telmisartan (TLM), with β-cyclodextrin and hydroxypropyl-β-cyclodextrin and to study effect of complexation on aqueous solubility and rate of dissolution in dissolution media. The phase solubility curve was classified as an A P type for both the CDs, which indicated formation of the inclusion complex of TLM in 1:2 stoichiometries with β-CD and HP-β-CD. The inclusion complexes in molar ratio of 1:2 were prepared by various methods. The molecular behavior of TLM in all samples were characterized by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and powder X-ray diffraction studies. The result of studies showed inclusion of TLM molecule into cyclodextrin cavities. The highest improvement in in-vitro dissolution of TLM was observed in a complex prepared with HPβ-CD using the kneading method. Mean dissolution time (MDT) and similarity factor (f2) indicated a significant difference between the release profile of TLM from complexes, physical mixture, and pure TLM. The highest improvement in solubility and in-vitro drug release were observed in inclusion complex prepared with HP-β-CD by kneading method. Improvement in solubility and in-vitro drug release of telmisartan was more with HP-β-CD as compared to β-CD
Medicated Chewing Gum: New Reformulation Technique
Bumrela Shrinivas B.,Kane Rajesh N.,Dhat Shalaka P.
Pharmaceutical Reviews , 2005,
Abstract: Medicated Chewing Gum (MCG) is a novel drug delivery system containing masticatory gum base with pharmacologically active ingredient and intended to use for local treatment of mouth diseases or systemic absorption through oral mucosa. MCG is considered as vehicle or a drug delivery system to administer active principles that can improve health and nutrition. The present article reviews MCG Drug Delivery System concepts including its merits and demerits.INTRODUCTION:Pharmacological Active Agents or Drugs are formulated into variety ofdosage forms like Tablets, Capsules, Injectables, Inhalers, Ointments etc consideringPhysicochemical properties, Pharmacokinetic & Pharmacodynamic parametersand Biopharmaceutical aspects of Drugs. In addition to its confectionary role,Chewing Gum (CG) also has proven value as a delivery vehicle for pharmaceuticaland nutraceutical ingredients1. Today CG is convenient drug deliverysystem which is appropriate for a wide range of active substances2.Many therapeutic agents are absorbed in the oral cavity. For the drugs havingsignificant buccal absorption, dosage forms such as Lozenges, Chewable tabletsand Chewing Gum permits more rapid therapeutic action compared to per-oral dosageforms3. Chewable tablets and chewing gum have been very well receivedby the parents for use in children with full dentition. Children in particularmay consider chewing gum as a more preferred method of drug administration comparedwith oral liquids and tablets. The use of MCG is feasible in local treatmentof diseases of oral cavity as well as treatment of systemic conditions.
Existence of Black Neutron Star  [PDF]
Trivedi Rajesh
International Journal of Astronomy and Astrophysics (IJAA) , 2015, DOI: 10.4236/ijaa.2015.51002
Abstract: A sufficiently large star will collapse to form a Black Hole Singularity due to Gravitational Pressure beyond Neutron Degeneracy. A Black Hole exhibits extremely strong Gravitational attraction that no particle or electromagnetic radiation can escape from it. The boundary of the region from which no escape is possible is called Event Horizon. In this work it is proposed that there exists a Neutron star smaller than Event Horizon, which is termed as Black Neutron Star. Furthermore an alternative method is proposed to ascertain the maximum permissible mass limit of the Neutron Star and the minimum mass limit of the naturally occurring gravitationally collapsed Black hole.
Free Will And The Dialectic Of Selfhood: Can One Make Sense Of A Traditional Free Will Requiring Ultimate Responsibility?
KANE,ROBERT;
Ideas y Valores , 2009,
Abstract: for four decades, i have been developing a distinctive view of free will according to which agents are required to be ultimately responsible for the creation or formation of their own wills (characters and purposes). the aim of this paper is to explain how a free will of this traditional kind -which i argue is incompatible with determinism- can be reconciled with modern developments in the sciences and philosophy. i address criticisms that a nondeterminist free will of this kind does not allow sufficient agent control, reduces to mere chance or randomness, fails to account of moral responsibility, and cannot be reconciled with modern science; and i relate such a free will to the nature of the self or person by developing what i call a "dialectic of selfhood."
Islamism: What is New, What is Not? Lessons from West Africa
O Kane
African Journal of International Affairs , 2008,
Abstract: In the aftermath of the Islamic Revolution in Iran of 1979, a marked scholarly interest in Islam driven by policy concerns developed in Western countries. Hitherto the monopoly of a few Orientalists, Islamic studies soon became a multidisciplinary field, attracting experts across the spectrum of the social sciences and the humanities, and indeed beyond academia, and many studies were carried out on Islamism. This article, which focuses on West Africa, questions some of the widely held assumptions on Islamism. The author’s main argument is that Islamism is not a new phenomenon. A second point made here is that ‘Islamist’ movements are not primarily Salafi. A third point is that ‘Islamists’ are not inherently violent. What is new, according to the author, is the perception of Islamism as a threat in the West.
Free Will and the Dialectic of Selfhood: Can One Make Sense of a Traditional Free Will Requiring Ultimate Responsibility?
Robert Kane
Ideas y Valores , 2009,
Abstract: For four decades, I have been developing a distinctive view of free will according to which agents are required to be ultimately responsible for the creation or formation of their own wills (characters and purposes).The aim of this paper is to explain how a free will of this traditional kind —which I argue is incompatible with determinism— can be reconciled with modern developments in the sciences and philosophy. I address criticisms that a nondeterminist free will of this kind does not allow sufficient agent control, reduces to mere chance or randomness, fails to account of moral responsibility, and cannot be reconciled with modern science; and I relate such a free will to the nature of the self or person by developing what I call a ‘‘dialectic of selfhood.”
Family communication: A catalyst for socially desired behaviours
Kane Hopkins
PRism Online PR Journal , 2005,
Abstract: This study examines how mass-communicated messages from two pro-environmental public information communication campaigns, the Big Clean Up and Clean Up New Zealand, affect interpersonal communication in families. It also considers how interpersonal communication flows on to affect family behaviour. The findings from these two campaigns indicate that while parents tended not to pass on information they obtained from campaign messages, children were more enthusiastic about sharing messages with other family members. Parents, it was found, had their current beliefs and behaviour patterns endorsed as a result of the messages. There were no notable behaviour changes in families where the parent was the initial message receiver. However, where children provided initial intervention behaviour, changes ranged from minor to remarkable. These findings have implications for public information campaign designers, where behaviour change is a campaign objective, and indicate an area where further research is required.
DETERMINING THE NUMBER OF CLUSTERS FOR A K-MEANS CLUSTERING ALGORTIHM
Abhijit Kane
Indian Journal of Computer Science and Engineering , 2012,
Abstract: Clustering is a process used to divide data into a number of groups. All data points have some mathematical parameter according to which grouping can be done. For instance, if we have a number of points on a twodimensional grid, the x and y coordinates of the points are the parameters according to which clustering is done. If the k-means algorithm is run with k=3, the data points will be split into 3 groups such that the sum of the variance for each group is minimized. The problem here, of course, is the choice of the parameter k. We mayget a much better modeling of the data if we split the data points into 2 or 4 groups. Determining the ‘best’ value of k is a broad problem – there is no obvious parameter according to which this can be done. This paper looks at a new, efficient approach to determine the number of clusters.
AN EFFICIENT GESTURE RECOGNITION TOOLKIT
Abhijit Kane
Indian Journal of Computer Science and Engineering , 2012,
Abstract: The rapid growth of computing has made effective human-computer interaction essential. It is important for the growing number of computer users whose schedules will not allow the elaborate training and experience that was once necessary to take advantage of computing. As computing affects more aspects of our lives, the needfor usable systems becomes even more important. An attempt has been made to develop a few basic tools for Human-Computer Interaction (HCI), and show how these can be used a basis for developing more advanced applications. The major component used in the project is OpenCV, which is an open-source image processing library developed by Intel. Basic interaction with the computer has been achieved using hand-held aids like colored thimbles. The ability to recognize the position of the fingers without these aids has also been explored.These simple techniques illustrate the steps required to achieve primitive interaction. These can be extended to achieve better interaction, both in terms of accuracy and scope.
Stress causing psychosomatic illness among nurses
Kane Pratibha
Indian Journal of Occupational and Environmental Medicine , 2009,
Abstract: Stress in nurses is an endemic problem. It contributes to health problems in nurses and decreases their efficiency. Documenting the causes and extent of stress in any healthcare unit is essential for successful interventions . Aim : Establishing the existence and extent of work stress in nurses in a hospital setting, identifying the major sources of stress, and finding the incidence of psychosomatic illness related to stress. Materials and Methods: This study used a questionnaire relating to stressors and a list of psychosomatic ailments. One hundred and six nurses responded and they were all included in the study. Stressors were based on four main factors: work related, work interactions, job satisfaction, and home stress. The factors relating to stress were given weights according to the severity. The total score of 50 was divided into mild, moderate, severe, and burnout. Results: Most important causes of stress were jobs not finishing in time because of shortage of staff, conflict with patient relatives, overtime, and insufficient pay. Psychosomatic disorders like acidity, back pain, stiffness in neck and shoulders, forgetfulness, anger, and worry significantly increased in nurses having higher stress scores. Increase in age or seniority did not significantly decrease stress. Conclusion: Moderate levels of stress are seen in a majority of the nurses. Incidence of psychosomatic illness increases with the level of stress. Healthcare organizations need to urgently take preemptive steps to counter this problem.
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