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Search Results: 1 - 10 of 1027 matches for " Kanakavalli Murthy "
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Paternally derived translocation t(8;18)(q22.1;q22)pat associated in a patient with developmental delay: Case report and review
Rao Lakshmi,Kanakavalli Murthy,Padmalatha Venkata,Nallari Pratibha
Journal of Pediatric Neurosciences , 2010,
Abstract: The common cause of mental impairment and the wide range of physical abnormalities is balanced chromosome rearrangement. As such, it is difficult to interpret, posing as a diagnostic challenge in human development. We present a unique familial case report with the paternally inherited autosomal-balanced reciprocal translocation involving chromosomal regions 8q and 18q. The etiology of the translocation, i.e. 46,XX,t(8;18)(q22.1;q22) was detected by conventional high-resolution Giemsa-Trypsin-Giemsa-banding and fluorescence in situ hybridization techniques. The father was found to be the carrier of the chromosome defect and also the same was observed in the first female child referred with a history of delayed milestone development. However, the second female child showed normal 46, XX karyotype. This is the first report of reciprocal translocation involving 8q and 18q associated with the delayed milestone development. The reason likely may be due to the rearrangement of genetic material at these breakpoints having a crucial relationship and thus manifesting developmental delay in the progeny. Accordingly, this paper also shows genetic counseling discussion for the cause.
Unique Case Reports Associated with Ovarian Failure: Necessity of Two Intact X Chromosomes
Lakshmi Rao Kandukuri,Venkata Padmalatha,Murthy Kanakavalli,Raseswari Turlapati,Mangalipally Swapna,Metuku Vidyadhari,Govindaraghavan Saranaya,Kattera Himaja,Mamata Deenadayal,Bipin Kumar Sethi,Prasun Deb,Nalini Gupta,Baidyanath Chakraborthy,Pratibha Nallari,Lalji Singh
Case Reports in Genetics , 2012, DOI: 10.1155/2012/640563
Abstract: Premature ovarian failure is defined as the loss of functional follicles below the age of 40 years and the incidence of this abnormality is 0.1% among the 30–40 years age group. Unexplained POF is clinically recognized as amenorrhoea (>6 months) with low level of oestrogen and raised level of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH > 20 IU/l) occurring before the age of 40. It has been studied earlier that chromosomal defects can impair ovarian development and its function. Since there is paucity of data on chromosomal defects in Indian women, an attempt is made to carry out cytogenetic evaluation in patients with ovarian failure. Cytogenetic analysis of women with ovarian defects revealed the chromosome abnormalities to be associated with 14% of the cases analyzed. Interestingly, majority of the abnormalities involved the X-chromosome and we report two unique abnormalities, (46,XXdel(Xq21-22) and q28) and (mos,45XO/46,X
Unique Case Reports Associated with Ovarian Failure: Necessity of Two Intact X Chromosomes
Lakshmi Rao Kandukuri,Venkata Padmalatha,Murthy Kanakavalli,Raseswari Turlapati,Mangalipally Swapna,Metuku Vidyadhari,Govindaraghavan Saranaya,Kattera Himaja,Mamata Deenadayal,Bipin Kumar Sethi,Prasun Deb,Nalini Gupta,Baidyanath Chakraborthy,Pratibha Nallari,Lalji Singh
Case Reports in Genetics , 2012, DOI: 10.1155/2012/640563
Abstract: Premature ovarian failure is defined as the loss of functional follicles below the age of 40 years and the incidence of this abnormality is 0.1% among the 30–40 years age group. Unexplained POF is clinically recognized as amenorrhoea (>6 months) with low level of oestrogen and raised level of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH > 20?IU/l) occurring before the age of 40. It has been studied earlier that chromosomal defects can impair ovarian development and its function. Since there is paucity of data on chromosomal defects in Indian women, an attempt is made to carry out cytogenetic evaluation in patients with ovarian failure. Cytogenetic analysis of women with ovarian defects revealed the chromosome abnormalities to be associated with 14% of the cases analyzed. Interestingly, majority of the abnormalities involved the X-chromosome and we report two unique abnormalities, (46,XXdel(Xq21-22) and q28) and (mos,45XO/46,X+ringX) involving X chromosome in association with ovarian failure. This study revealed novel X chromosome abnormalities associated with ovarian defects and these observations would be helpful in genetic counseling and apart from, infertility clinics using the information to decide suitable strategies to help such patients. 1. Introduction Ovarian failure reflects spectrum of symptoms, which include amenorrhea, gonadal dysgenesis, and premature ovarian failure (POF). Amenorrhea can be primary or secondary. POF is defined as the loss of functional follicles below the age of 40 years. The incidence of this abnormality is 0.1% among the 30–40 years age group. It keeps increasing and reaches up to 1% among the 40 years age group [1]. The diagnosis of unexplained POF is clinically recognized as amenorrhoea (>6 months) occurring before the age of 40 with low level of oestrogen and raised level of luteinizing hormone (LH) and follicle-stimulating hormone (FSH > 20?IU/l) [2]. Different rationales based on immunological abnormalities [3], viral infections [4], cytotoxic drugs [5], physical stress, nutrient deficiency, chemotherapy, and radiation effects [6] have been advanced to explain POF. The crucial factor also includes the important role of chromosomes in maintaining the normal ovarian development and function. It has been studied earlier that chromosomal defects can impair ovarian development and its function [7]. The most frequent phenotype associated with sex chromosomal defects is Turner’s syndrome in which there is only one X chromosome instead of two. Most of the women with primary amenorrhea possess Turner’s or
Privacy Policies Considerations in Socio-Technical Systems  [PDF]
Murthy Rallapalli
Technology and Investment (TI) , 2012, DOI: 10.4236/ti.2012.32009
Abstract: The idea of a socio-technical system (STS) is an intellectual tool to help recognize patterns in the way technology is used and produced. Identification of these patterns will help in analyzing the ethical issues associated with the technology-and-its-social-system [1]. By way of example, consider a relatively simple technology: a set of twenty laptops connected by a local area network. The social and ethical issues associated with these networked devices will change dramatically depending upon the socio-technical system in which they are embedded. Few technologies have ever had the capability of gathering information (with or without the user’s knowledge) as effectively as the World Wide Web. Internet has the greatest potential of targeting precise marketing demographics. Internet is also capable of disseminating information widely and quickly. This paper will study the role of privacy policies in web based socio-technical systems. This paper will research the role played by privacy policies in web user adaptation in the context of web based sociotechnical systems.
Privacy Negotiation in Socio-Technical Systems  [PDF]
Murthy Rallapalli, Dinesh Verma
Technology and Investment (TI) , 2012, DOI: 10.4236/ti.2012.31003
Abstract: A socio-technical system (STS) is an approach to complex organizational work design that recognizes the interaction between people and technology in workplaces. The term also refers to the interaction between society’s complex infra-structures and human behavior. In this sense, society itself, and most of its substructures, are complex socio-technical systems. This paper addresses a class of socio-technical systems, represented by web services in a number of domains and attempts to understand the possibility of empowering the web users and consumers to have a say in the develop-ment of privacy agreements. This paper examines the likelihood of the web users and consumers leveraging such a capability, should it exist. This should improve the way privacy agreements are handled that benefits both the service providers and the web users.
Palynomorphs and Oribatid Mites—From the Denwa Formation, Satpura Basin, Madhya Pradesh, India  [PDF]
Vijaya Vijaya, Srikanta Murthy
International Journal of Geosciences (IJG) , 2012, DOI: 10.4236/ijg.2012.31022
Abstract: Palynological investigation of the Denwa Formation exposed along Denwa river succession at Saptadara picnic point near village Jhirpa, Satpura Basin, Madhya Pradesh, has revealed the presence of spore-pollen, fungal remains and Oribatid mites. Here, the mites are on record for the first time. Presence of fungal remains strongly depicts the prevalence of a very humid climate with high temperature and rainfall in the region. Poor occurrence of spore-pollen restricts the age determination of the studied section; hence, its age assessment is relative. Thus, an over-view of spore-pollen along with dinocysts and insects reported earlier from the subsurface strata comprising Denwa Formation, from other two localities in the nearby area of village Anhoni, is dealt herein, and that had inferred an age—range from Carnian to Rhaetic for the palynoflora and fauna.
Orbital Spin: A New Hypothesis to Explain Precession of Equinox—The Third Motion of Earth  [PDF]
Rama Chandra Murthy Mothe
International Journal of Astronomy and Astrophysics (IJAA) , 2014, DOI: 10.4236/ijaa.2014.41004
Abstract:

In this paper, the phenomena of Earth’s motion about its own axis, the ecliptic plane of the Earth’s orbit around the Sun, the definitions of equinoxes, the precession of equinoxes, Earth’s wobble and other astronomical terminology are briefly described. Some of the existing theories explaining the precession of equinox and their inadequacies are brought out. New Hypothesis is that precession of equinoxes is a direct result of Orbital spin of Earth in a retrograde direction—a celestial phenomenon similar to that of Moon’s Orbital spin around the Earth. The study of Moon’s orbit round the Earth reveals the exact movement of Earth’s orbit, which causes precession of equinoxes without any ambiguity. The analogy presented herein demonstrates the plausible hypothesis.

Cardiac Sarcolemmal Defects in Acute Myocarditis Due to Scorpion Envenoming Syndrome  [PDF]
K. Radha Krishna Murthy
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.49054
Abstract:

Death due to scorpion envenoming syndrome is a common event in tropical and subtropical countries. Severe scorpion envenoming causes autonomic storm, massive release of catecholamines, counter-regulatory hormones, suppressed insulin/hyperinsulinemia, acute myocarditis, hyperglycemia, increased free fatty Acid levels, acute pancreatitis, disseminated intra-vascular coagulation, acute pulmonary oedema and death. Severe scorpion envenoming causes cardiac sarcolemmal defects displayed by alterations in Na+ - K+ ATPase, Mg++ ATPase and Ca2+ ATPase activities, inhibition of erythrocyte Na+ - K+ ATPase activities, hyperkalemia and may result in death. Based on our animal experiments in which insulin administration reversed the metabolic and ECG changes induced by scorpion envenoming and treating the poisonous scorpion sting victims with insulin, we consider that insulin has a primary metabolic role in preventing and reversing acute myocarditis, the cardiovascular, haemodynamic, and neurological manifestations and pulmonary oedema induced by scorpion envenoming. Administration of insulin-glucose infusion to scorpion sting victims appears to be the physiological basis for the control of the metabolic response when that has become a determinant to survival. Continuous infusion of regular crystalline insulin should be given at the rate of 0.3 U/g glucose and glucose at the rate of 0.1 g/kg body weight/hour, for 48 - 72 hours, with supplementation of potassium as needed and maintenance of fluid, electrolytes and acid-base balance. The observation of cardiac sarcolemmal defects and physiological basis of various patho-physiological mechanisms involved in the genesis of scorpion envenoming syndrome and its reversal (in the experimental animals and scorpion sting victims) by administration of insulin are reviewed.

Hypertension, Autonomic Storm, Increased Counter Regulatory Hormones and Suppressed Insulin in Acute Myocarditis in Scorpion Envenoming Syndrome  [PDF]
Kari Radha Krishna Murthy
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.44027
Abstract: Death due to scorpion envenoming syndrome is a common event in many of the tropical and non-tropical counties. Initial transient hypertension is commonly observed in scorpion sting victims. Scorpion envenoming causes autonomic storm resulting in initial transient hypertension followed by hypotension, cold clammy skin, hypothermia, cardiovascular disturbances, acute myocarditis, sarcolemmal defects, pulmonary oedema, acute pancreatitis, disseminated intravascular coagulation (DIC), Adult respiratory distress syndrome (ARDS), and many other clinical manifestations. All these manifestations could be due to sudden increase in catecholamines, angiotensin II, glucagon, Cortisol and either due to suppressed insulin secretion or insulin resistance and death. The sudden increase of metabolic A in counter-regulatory hormones along with either suppressed insulin secretion/or insulin resistance results in glycogenolysis in liver, cardiac and skeletal muscles causing hyperglycemia and a sudden increase in free fatty acid levels. Free Fatty Acids increase the susceptibility of the ventricles to the disorganized electrical behavior, inhibit cardiac sarcolemmal Na+-K+ ATPase activity, increase the tendency to intravascular thrombus, increase myocardial oxygen consumption, interfere with tropomyosin-troponin activation of Actin-Myosin coupling, show detergent effects on cell membranes and they could alter the stabilization of lysosomal membranes and probably become toxic to the myocardium. Based on our animal experiments in which insulin administration reversed the metabolic and ECG changes induced by scorpion envenoming and treating the poisonous scorpion sting victims with insulin, we consider that insulin has a primary metabolic role in preventing, counter-acting and reversing all the deleterious effects of FFA by inhibiting the catecholamine induced by lipolysis, and increasing intra-cellular K+, facilitating glucose transport to the myocardium and glucose metabolism through different pathways. Administration of insulin-glucose infusion to scorpion sting victims appears to be the physiological basis for the control of the metabolic response when that has become a determinant to survival. Treatment using continuous infusion of regular crystalline insulin should be given at the rate of 0.3 U/g glucose and glucose at the rate of 0.1 g/kg body weight/hour, for 48 - 72 hours, with supplementation of potassium as needed and maintenance of fluid, electrolytes and acid-base balance.
Innovative Structured Matrices  [PDF]
Rahul Gupta, Garimella Rama Murthy
Advances in Linear Algebra & Matrix Theory (ALAMT) , 2013, DOI: 10.4236/alamt.2013.33004
Abstract:

Various directions of obtaining novel structured matrices are discussed. A new class of matrices, called “the L-family” matrices are introduced and their properties are studied.

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