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Search Results: 1 - 10 of 1704 matches for " Kamal Morshed "
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Usefulness and efficiency of formalin-fixed paraffin-embedded specimens from laryngeal squamous cell carcinoma in HPV detection by IHC and PCR/DEIA.
Kamal Morshed,Ma?gorzata Polz-Dacewicz,Marcin Szymański,Agata Smoleń
Folia Histochemica et Cytobiologica , 2010, DOI: 10.5603/4215
Abstract: The use of formalin-fixed paraffin-embedded (FFPE) tissues for HPV DNA detection by PCR from biopsy materials is not entirely clear in retrospective studies. The aim of our study was to evaluate the usefulness and efficiency of FFPE tissues from laryngeal cancer (LSCC) in HPV detection by immunohistochemistry reaction (IHC) and PCR-DNA enzyme immunoassay method (PCR/DEIA) and to compare with HPV detection from DFT. HPV-DNA was amplified from 54 FFPE tissues from LSCC specimens by the short PCR fragment (SPF10) primer set using PCR/DNA method and monoclonal anti Human Papillomavirus antibodies in IHC. In the same patients 54 specimens were collected and immediately deep-frozen and stored at (-70 °C) to (-80 °C). All the FFPE and deep-frozen tissue (DFT) specimens were positive for -globin amplification. HPV was detected by two methods (SPF10 PCR/DEIA and IHC) in 14 (25.92%) out of 54 specimens from FFPE. Significant differences were found between the HPV detection using PCR/DEIA method and IHC method in FFPE tissues. The comparative analysis of the 54 samples after assuming PCR method in FFPE tissues showed accuracy of 92.6%, sensitivity of 90.5% and specificity of 93.9%. The FFPE tissues method has high sensitivity, specificity and accuracy when used to detect HPV DNA by PCR reaction and it is comparable to DFT results. DNA quality of FFPE samples is adequate and it can be used in HPV-DNA detection and in retrospective studies on LSCC.
Y-Shaped Intra-Scleral Fixated Lens versus Retro-Pupillary Iris Claw Lens in the Treatment of Aphakia  [PDF]
Ahmed Mohamed Morshed, Mahmoud Nasr Aldeeb, Adel Kamal Abdeen, Salah Mohamed Almosalamy
Open Journal of Ophthalmology (OJOph) , 2019, DOI: 10.4236/ojoph.2019.92012
Abstract: Background: Many reasons can lead to an aphakia without adequate capsular support for implantation of a posterior chamber intraocular lens (IOL), such as intraoperative unintentional rupture of posterior capsule during phacoemulsification, planned intracapsular cataract extraction, ocular trauma and lens dislocation due to congenital and acquired causes. Purpose: To compare Y-shaped intra-scleral fixation of a posterior chamber IOL with retro pupillary fixation of an iris-claw intraocular lens (IOL) for Aphakic eyes without sufficient capsular support as respects safety, visual recovery and complications of both methods. Patients and Methods: One hundred Aphakic eyes were arbitrarily distributed between two groups. Group A included 50 eyes treated with retropupillary fixation of iris claw lens and group B included 50 eyes treated with Y-shaped intra-scleral fixation technique. Preoperative, intraoperative and postoperative data were analysed including best corrected visual acuity (BCVA), intraocular pressure (IOP), surgical time, intraoperative problems, IOL malposition and postoperative complications. Following up on patients was carried out for at least six months. Results: The mean duration of surgery was 21 ± 5.3 min in group A and was 53.4 ± 6.9 min in group B (p-value < 0.001). After 6 months, the mean BCVA was 0.34 ± 0.15 in group A and was 0.31 ± 0.16 in group B (p > 0.05). IOL tilt was found in 0 (0%) eyes in group A and in 5 (10%) eyes in group B (p < 0.05). IOL decentration was observed in 1 (2%) eye in group A and 7 (14%) eyes in group B, with statistically significant difference (p value = 0.03). Cystoid macular edema was found in 2 (4%) eyes in group A and in 5 (10%) eyes in group B (p > 0.05). Conclusion: The results of our study indicated that both methods are satisfactory in correcting aphakia without sufficient capsular support as regards postoperative best corrected visual acuity (BCVA); however the surgical technique of retropupillary iris claw lens is easier, shorter, with low intra- and postoperative complications and safer than those used for intra-scleral fixation of IOL. But for eyes which lack both iris and capsular support, a scleral fixation of a posterior chamber IOL remains the only option.
Automatic Simulation of the Chemical Langevin Equation  [PDF]
Silvana Ilie, Monjur Morshed
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.41A036
Abstract:

Biochemical systems have important practical applications, in particular to understanding critical intra-cellular processes. Often biochemical kinetic models represent cellular processes as systems of chemical reactions, traditionally modeled by the deterministic reaction rate equations. In the cellular environment, many biological processes are inherently stochastic. The stochastic fluctuations due to the presence of some low molecular populations may have a great impact on the biochemical system behavior. Then, stochastic models are required for an accurate description of the system dynamics. An important stochastic model of biochemical kinetics is the Chemical Langevin Equation. In this work, we provide a numerical method for approximating the solution of the Chemical Langevin Equation, namely the derivative-free Milstein scheme. The method is compared with the widely used strategy for this class of problems, the Milstein method. As opposed to the Milstein scheme, the proposed strategy has the advantage that it does not require the calculation of exact derivatives, while having the same strong order of accuracy as the Milstein scheme. Therefore it may be used for an automatic simulation of the numerical solution of the Chemical Langevin Equation. The tests on several models of practical interest show that our method performs very well.

Traumatic Intracerebral Hematoma
A. Morshed
Acta Medica Iranica , 1964,
Abstract:
Role of Vocabulary for Semantic Interoperability in Enabling the Linked Open Data Publishing
Ahsan Morshed
International Journal of Database Management Systems , 2012,
Abstract: In spite of the explosive growth of the Internet, information relevant to users often unavailable even when using the latest browsers. At the same time, there is an ever increasing number of documents that varywidely in content, format and quality. The documents often change in content and location because they do not belong to any kind of centralized control. On the other hand, there is a huge number of unknown users with extremely diverse needs, skills, education, and cultural and language backgrounds. One of the solutions to these problems might be to use standard terms with meaning, this can be termed as controlled vocabulary (CV). Though there is no specific notion of CV, we can define it as a set of concepts or preferred terms and existing relations among them. In this paper, we focus on the role of CV for publishing the web of Data on the web.
How To Prevent Foot Ulcers In Diabetic Patients
Ghada Morshed
European Journal of Cardiovascular Medicine , 2012,
Abstract: The prevalence of development of foot ulcers in diabetic patients is 4% to 10%, these ulcers may be infected, cause morbidity and may lead to lower extremity amputation.Objective: Prevention of diabetic foot ulcers in patients known to be diabetics by fasting blood sugar (FBS), HbA1C tests.Material and Methods: The study was done on 120 patients between March 2010 and July 2011 diagnosed as diabetics and they performed simple screening tests for peripheral neuropathy (Semmes-Weinstein monofilament examination (SWME), superficial pain, vibration testing by the on-off method, the timed method). Nerve conduction studies (NCS) were used as standard criterion for detection of neuropathy, they also underwent Doppler ultrasound and ankle-brachial pressure index (ABPI) measurement to assess the vascularity of their lower limbs. All patients were given proper education to prevent foot ulcers, including optimising glycemic control, cessation of smoking, debridement of calluses, appropriate foot wear and foot care with periodic foot examination.Results: In our study we succeeded in increasing the prevention of foot ulceration in our diabetic patients by 95%, compared to results achieved with the previous measures.Conclusion: Screening tests are effective for all diabetic patients to identify patients at risk of foot ulceration. They may benefit from prophylactic interventions including, optimising glycemic control, cessation of smoking, debridement of calluses, appropriate foot wear and intensive foot care.Also, we take care of patients with low risk of foot ulceration by adequate foot care and periodic foot examination to prevent foot ulceration.
Current Options for Determining Fracture Union
Saam Morshed
Advances in Medicine , 2014, DOI: 10.1155/2014/708574
Abstract: Determining whether a bone fracture is healed is one of the most important and fundamental clinical determinations made in orthopaedics. However, there are currently no standardized methods of assessing fracture union, which in turn has created significant disagreement among orthopaedic surgeons in both clinical and research settings. An extensive amount of research has been dedicated to finding novel and reliable ways of determining healing with some promising results. Recent advancements in imaging techniques and introduction of new radiographic scores have helped decrease the amount of disagreement on this topic among physicians. The knowledge gained from biomechanical studies of bone healing has helped us refine our tools and create more efficient and practical research instruments. Additionally, a deeper understanding of the molecular pathways involved in the bone healing process has led to emergence of serologic markers as possible candidates in assessment of fracture union. In addition to our current physician centered methods, patient-centered approaches assessing quality of life and function are gaining popularity in assessment of fracture union. Despite these advances, assessment of union remains an imperfect practice in the clinical setting. Therefore, clinicians need to draw on multiple modalities that directly and indirectly measure or correlate with bone healing when counseling patients. 1. Introduction There are about 6 million fractures in the United States annually and 5–10% of these fractures proceed to nonunion [1]. The risk of nonunion is increased based on certain patient factors such as smoking habit or diabetes and varies by location of fracture with those of the scaphoid waist, neck of femur, and open fractures of the tibia being especially susceptible [2–6]. Nonunions are associated with significantly higher rate of healthcare resource use, drastically higher per patient cost, and use of stronger opioid medications [7–10]. Infection can present as a delay or failure of fracture repair, and the clinician should always consider this in the differential diagnosis. Determining when a fracture is healed is a routine part of orthopaedic clinical care. It is crucial to making the right clinical decision for patients including determining their weight-bearing status, appropriate time for hardware removal, and diagnosis and treatment of nonunions. It is also tremendously important in interpreting research studies on treatment and therapeutics of fracture repair. Therefore, a valid and standard definition of fracture union should be an
Dressing after Dressing: Sadra’s Interpretation of Change  [PDF]
Muhammad Kamal
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.31009
Abstract:

This paper deals with the doctrine of transubstantial change advocated by Mulla Sadra in which substances as well as accidents are thought to be in constant and gradual change. Against Aristotle’s doctrine of accidental change, Mulla Sadra argues that no stable ground can bring about change and since substance is renewable it cannot carry identity of a changing existent. Here we investigate whether identity is possible or not. If it is possible then what becomes a ground for establishing identity of changing substances.

Aliskiren Augments the Activities of Anti-Oxidant Enzymes in Liver Homogenates of DOCA Salt-Induced Hypertensive Rats  [PDF]
Sahar Kamal
Advances in Enzyme Research (AER) , 2014, DOI: 10.4236/aer.2014.22010
Abstract: Hypertension is a serious problem that is recently thought to be associated with damaging effects on target organs partially via oxidative stress. On the other hand, there is accumulating literature describing some sort of therapeutic interaction between antioxidant enzymes in vital organs and hypertension. Therefore, the aim of this study is to investigate the possible effect of a direct renin inhibitor, aliskiren, used in treatment of hypertension via renin-angiotensin-aldosterone system (RAAS), on selected anti-oxidant enzymes in hepatic homogenates in DOCA salt-induced hypertesnive albino rats. Thirty male wister albino rats were assigned randomly into 3 groups (n = 10/ group). Group 1 received no treatement and serves as control. Group 2 received 0.5% carboxymethylcellulose sodium ip as a solvent of aliskiren, as a direct renin inhibitor (DRI). Group 3 received aliskiren 100 mg/kg/day ip for 4 weeks through gastric tube. Systolic blood pressure (SBP) was measured every week and its mean was recorded at the end of the study. Superoxide dismutase (SOD) enzyme in RBCs lysates, activities of catalase (CAT) and glutathione peroxidase enzymes and thiobarbituric acid reactive substance (TBARS), as a marker of lipid peroxidation, in hepatic homogenates were measured at the end of the study. DRI produced a marked reduction in mean SBP of hypertensive rats. It also significantly (p < 0.05) increased the activities of measured anti-oxidant enzymes while it significantly (p < 0.05) reduced TBARS in liver homogenates. These results indicated that renin possesses an oxidative effect in the liver in hypertensive rats. Aliskiren, in addition to its powerful anti-hypertensive effect, it could induce a great anti-oxidant effect in liver homogenates of DOCA salt-hypertensive rats.
Individual Essences in Avicenna’s Metaphysics  [PDF]
Muhammad Kamal
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.41004
Abstract:

Central to Aristotle’s metaphysics is the question of individuality. The individuality of each substance is explained in relation to matter because the form is universal. Avicenna, as one of the Aristotelian Neoplatonist philosophers, is not content with this explanation and proposes to establish individuality on other grounds. In this paper, I argue that in his perspective it is not the matter which determines individuality but rather the principle of existence.

 

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