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Search Results: 1 - 10 of 150091 matches for " Kailash K. Singh "
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Profile of Cancer Cases at a Tertiary Care Level Teaching Hospital in Rural Western Maharashtra, India
Jayant D Deshpande , Kailash K Singh , Deepak B Phalke
National Journal of Community Medicine , 2012,
Abstract: Background: Cancer is one of the major public health problems worldwide. Prevalence and pattern of cancer is known to vary from region to region. Epidemiological information on cancer including the pattern is an important basis for determining the priorities for cancer control in any population group. Objective: Present work is an attempt to study magnitude, profile and some epidemiological aspects in relation to cancer cases at a tertiary care level teaching hospital in rural area. Method: All records were studied and analyzed. A total of 1106 patients were treated during the period studied. A proforma was used to collect data such as age, sex, place of residence, type of cancers and treatment given. The data collected were entered into MS-Excel sheets and analysis was carried out. The information obtained was tabulated analyzed using the software GraphPad Instat demo version. Results: A total of 1106 cancer patients were treated during the January 2010 to December 2010. Among these, 626(56.60) were females and 480(43.39) were females. In males, the common cancers were oral cavity cancers, lung cancers and GIT cancers. The most common cancers among females were the cervical carcinomas, which constituted 32.10% of the total number of cancers cases followed by cancers of breast. Almost 2/3rd of cases occurred in the age group of 41 to 70 years. Maximum frequency was observed in 51–60 year age group in both sexes. Maximum numbers (74.59%) of the cases were from rural area. The main methods of cancer treatment were surgery, chemotherapy and radiotherapy, used alone or in combination. Conclusion: Tobacco and alcohol related cancers predominated in males. In females, cervical cancer predominated over breast cancer. Human behavior is a major determinant in the successful control of cancer. Understanding cancer magnitude, risk and trends will be of help in cancer control.
Pattern of oral cancer registered at a tertiary care teaching hospital in rural Western Maharashtra
Purushottam A. Giri,Kailash K. Singh,Deepak B. Phalke
International Journal of Research in Medical Sciences , 2013, DOI: 10.5455/2320-6012.ijrms20130801
Abstract: Non-communicable diseases including cancer are emerging as major public health problems in India. Cancer usually means malignancy, has become one of the ten leading cause of death in India. The leading sites of cancer vary from country to country. Oral cancer ranks in the top three of all cancers in India, accounting for over 30% of all cancers reported in the country and its control is quickly becoming a global health priority. The present study was conducted to find out the contribution of different type of oral cancer in a tertiary care teaching hospital of western Maharashtra, India. A retrospective hospital record based study was carried out for the period of 2007-2011 in the department of Radiotherapy of Pravara Rural Hospital, Loni, Maharashtra, India. A total of 5879 patients who were diagnosed with cancer, of them 633 (10.76%) patients had oral cancer. Data was collected on the basis of the patient s record in the hospital and analyzed in the form of percentage and proportions whenever appropriate. A total of 633 oral cancer patients were screened, of which 411 (64.93%) were males and 222 (35.07%) were females. Among oral cancer, buccal mucosa was highest (37.12%); followed by tongue (36.80%), oropharynx (4.74%) and lip and palate (3.15%). Oral cancer is one of the common malignancies in developing countries like India. It is common in males compared to females and is usually seen after middle age. [Int J Res Med Sci 2013; 1(3.000): 233-236]
Radical radiotherapy treatment (EBRT + HDR-ICRT) of carcinoma of the uterine cervix: Outcome in patients treated at a rural center in India
Jain Vandana,Singh Kailash,Shrivastava Rajeev,Saumsundaram K
Journal of Cancer Research and Therapeutics , 2007,
Abstract: Aim: To report the outcome of carcinoma of the uterine cervix patients treated radically by external beam radiotherapy (EBRT) and high-dose-rate (HDR) intracavitary radiotherapy (ICRT). Materials and Methods: Between January 1997 to December 2001, a total of 550 newly diagnosed cases of carcinoma of the uterine cervix were reported in the department. All cases were staged according to the International Federation of Gynecologists and Oncologists (FIGO) staging system, but for analytical convenience, the staging was limited to stages I, II, III, and IV. Out of the 550 cases, 214 completed radical radiotherapy (EBRT + HDR-ICRT) and were retrospectively analyzed for presence of local residual disease, local recurrence, distant metastases, radiation reactions, and disease-free survival. Results: There were 7 (3.27%), 88 (41.1%), 101 (47.1%), and 18 (8.4%) patients in stage I, II, III, and IV, respectively. The median follow-up time for all patients was 43 months (range: 3-93 months) and for patients who were disease free till the last follow-up it was 59 months (range: 24-93 months). The overall treatment time (OTT) ranged from 52 to 73 days (median 61 days). The 5-year disease-free mean survival rate was 58%, 44%, 33%, and 15%, with 95% confidence interval of 48 to 68, 37 to 51, 24 to 35, and 6 to 24 for stages I, II, III, and IV, respectively. There were 62 (28.97%) cases with local residual disease, 35 (16.3%) developed local recurrence/distant metastases, 17 (7.9%) developed distant metastases, and 9 (4.2%) had local recurrence as well. Discussion and Conclusion: The overall outcome was poor in advanced stage disease, but might be improved by increasing the total dose, decreasing overall duration of treatment, and by adding chemotherapy in patients with disease limited to the pelvis.
SSR and AFLP based genetic diversity of soybean germplasm differing in photoperiod sensitivity
Singh, Ram K.;Bhatia, Virendra S.;Bhat, K.V.;Mohapatra, Trilochan;Singh, Nagendra K.;Bansal, Kailash C.;Koundal, K.R.;
Genetics and Molecular Biology , 2010, DOI: 10.1590/S1415-47572010005000024
Abstract: forty-four soybean genotypes with different photoperiod response were selected after screening of 1000 soybean accessions under artificial condition and were profiled using 40 ssr and 5 aflp primer pairs. the average polymorphism information content (pic) for ssr and aflp marker systems was 0.507 and 0.120, respectively. clustering of genotypes was done using upgma method for ssr and aflp and correlation was 0.337 and 0.504, respectively. mantel's correlation coefficients between jaccard's similarity coefficient and the cophenetic values were fairly high in both the marker systems (ssr = 0.924; aflp = 0.958) indicating very good fit for the clustering pattern. upgma based cluster analysis classified soybean genotypes into four major groups with fairly moderate bootstrap support. these major clusters corresponded with the photoperiod response and place of origin. the results indicate that the photoperiod insensitive genotypes, 11/2/1939 (ec 325097) and macs 330 would be better choice for broadening the genetic base of soybean for this trait.
Quadratic Dynamic Matrix Control of Isopropyl Acetate Reactive Distillation Column
Neha Sharma,Kailash Singh
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
The Ionic and Hydrophobic Interactions Are Required for the Auto Activation of Cysteine Proteases of Plasmodium falciparum
Srinivasan Sundararaj, Deepak Singh, Ajay K. Saxena, Kapil Vashisht, Puran S. Sijwali, Rajnikant Dixit, Kailash C. Pandey
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047227
Abstract: The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 are major hemoglobinases and potential antimalarial drug targets. Our previous studies demonstrated that these enzymes are equipped with specific domains for specific functions. Structural and functional analysis of falcipains showed that they have unique domains including a refolding domain and a hemoglobin binding domain. As with many proteases, falcipain-2 and falcipain-3 are synthesized as inactive zymogens. However, it is not known how these enzymes get activated for hemoglobin hydrolysis. In this study, we are presenting the first evidence that salt bridges and hydrophobic interactions are required for the auto activation of cysteine proteases of P.falciparum. To investigate the mechanism of activation of these enzymes, we expressed the wild type protein as well as different mutants in E.coli. Refolding was assessed by circular dichroism. Both CD and trans activation data showed that the wild type enzymes and mutants are rich in secondary structures with similar folds. Our study revealed that prodomain-mature domain of falcipain-2 and falcipain-3 interacts via salt bridges and hydrophobic interactions. We mutated specific residues of falcipain-2 and falcipain-3, and evaluated their ability to undergo auto processing. Mutagenesis result showed that two salt bridges (Arg 185 - Glu 221, Glu 210 - Lys 403) in falcipain-2, and one salt bridge (Arg 202-Glu 238) in falcipain-3, play crucial roles in the activation of these enzymes. Further study revealed that hydrophobic interactions present both in falcipain-2 (Phe214, Trp449 Trp 453) and falcipain-3 (Phe 231 Trp 457 Trp 461) also play important roles in the activation of these enzymes. Our results revealed the interactions involved in auto processing of two major hemoglobinases of malaria parasite.
Ultrasonic Attenuation in Calcium Oxide  [PDF]
Jitendra Kumar, Kailash R., Sanjeev Kumar Shrivastava, Devraj Singh, Virendra Kumar
Advances in Materials Physics and Chemistry (AMPC) , 2011, DOI: 10.4236/ampc.2011.12008
Abstract: Ultrasonic attenuation studies can be used to characterize material not only after production but during processing as well. The most important causes of ultrasonic attenuation in solids are electron-phonon, phonon-phonon interaction and that due to thermo elastic relaxation. The two dominant processes that will give rise to appreciable ultrasonic attenuation at higher temperature are the phonon-phonon interaction also known as Akhiezer loss and that due to thermo elastic relaxation are observed in calcium oxide crystal. At frequencies of ultrasonic range and at higher temperatures in solids, phonon-phonon interaction mechanism is dominating cause for attenuation. Ultrasonic attenuation due to phonon-phonon interaction (α/f2)p-p and thermo elastic relaxation (α/f2)th are evaluated in Calcium Oxide crystal up to an elevated temperature from 100 K - 1500 K along <100>, <110> and <111> crystallographic directions. Temperature dependence of ultrasonic attenuation along different crystallographic direction reveals some typical characteristic features.
Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: A case report and review of the literature
Singh Abhishek,Pandey Kailash,Pant Nirdosh
Journal of Cancer Research and Therapeutics , 2010,
Abstract: Mucoepidermoid carcinomas (MECs) of lung are rare neoplasms originating in bronchial submucosal glands and comprising 0.1-0.2% of primary lung cancers. MECs, the most common malignancy in salivary glands, were earlier thought to occur only in salivary glands. Later studies showed that they can arise as a primary in bronchus, esophagus, lacrimal glands, pancreas, thymus and thyroid gland. Initially described as a benign adenoma, it is now considered to be a malignant epithelial tumor. There have been reports of metastases to regional lymph nodes, other parts of the lung and distant organs. Cavitary lesion in MEC of lung is rare. Here, we report a case of MEC of lung with metastases to skeletal muscles of thigh and arm. To the best of our knowledge, this is the only case of MEC of lung presenting with such unusual pattern of metastasis as presenting feature with almost no symptoms of primary lesion.
Surgery for gastric cancer: An evidence-based perspective
D'souza Melroy,Singh Kailash,Shrikhande Shailesh
Journal of Cancer Research and Therapeutics , 2009,
Abstract: Despite a decreasing incidence, stomach cancer is the second leading cause of cancer mortality worldwide. Surgical resection offers the only chance for cure in this aggressive cancer. The surgical management of gastric cancer has witnessed numerous debates in the past decades. These include the extent of lymphadenectomy, extent of surgery, role of laparoscopic gastrectomy, and the impact of high volume of centers, on the outcome of surgery. This review attempts to address these controversies with an evidence-based perspective. A literature search in MEDLINE (www.pubmed.org) has been performed with the relevant key words and corresponding MeSH terms. The search has been limited to English publications on human subjects. A manual search of the bibliographies has also been carried out, to identify the relevant publications for possible inclusion.
Application of Alvarado Scoring System in Diagnosis of Acute Appendicitis
Kailash Singh, Shyam Gupta, Pinki Pargal
JK Science : Journal of Medical Education & Research , 2008,
Abstract: This is a prospective study to assess the accuracy of the Alvarado Scoring System in predicting acuteappendicitis in our set up.100 consecutive patients with suspected acute appendicitis were included inthe study. They were given specific scores according to variables of Alvarado scoring system and thendivided into 3 groups. Group A included patients with score of 7 or more and they underwent surgery,Group B included patients with score of 5-6 and they were admitted for observation and Group Cincluded patients with score of 4 or less and they were discharged after symptomatic treatment. Patientsfrom group B with increased symptom intensity (score 7 or more) in re-evaluation underwent surgery.Diagnosis was confirmed by histopathological examination. Reliability of scoring system was assessedby calculating negative appendectomy rate and positive predictive value .Out of a total of 100 patients74 underwent surgery and appendicitis was confirmed by histopathological examination in 62 patients,thus giving negative appendectomy rate of 16.21% and positive predictive value of 83.79%.AlvaradoScoring System is a simple, easy and reliable tool in the diagnosis of acute appendicitis
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