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Search Results: 1 - 10 of 71715 matches for " KUTNER JOSé MAURO "
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STI571 (Glivecò), nova droga para o tratamento da leucemia mielóide cr nica
Revista da Associa??o Médica Brasileira , 2001,
Applications of blood group genotyping
Mariza A. Mota,Araci Sakashita,José Mauro Kutner,Lilian Castilho
Einstein (S?o Paulo) , 2006,
Abstract: Introduction: The determination of blood group polymorphism atthe genomic level facilitates the resolution of clinical problemsthat cannot be addressed by hemagglutination. They are useful to(a) determine antigen types for which currently available antibodiesare weakly reactive; (b) type patients who have been recentlytransfused; (c) identify fetuses at risk for hemolytic disease of thenewborn; and (d) to increase the reliability of repositories of antigennegative RBCs for transfusion. Objectives: This review assessedthe current applications of blood group genotyping in transfusionmedicine and hemolytic disease of the newborn. Search strategy:Blood group genotyping studies and reviews were searched ingeneral database (MEDLINE) and references were reviewed.Selection criteria: All published data and reviews were eligible forinclusion provided they reported results for molecular basis ofblood group antigens, DNA analysis for blood group polymorphisms,determination of fetal group status and applications of blood groupgenotyping in blood transfusion. Data collection: All data werecollected based on studies and reviews of blood grouppolymorphisms and their clinical applications.
Axoval neuropathy as initial manifestation of primary amyloidosis: report of a case submitted to bone marrow transplantation
Barsottini Orlando G. Povoas,Arantes Adriano,Sigulem Daniel,Kutner José Mauro
Arquivos de Neuro-Psiquiatria , 2004,
Abstract: Amyloidosis is a syndrome characterized by deposition of a highly insoluble protein material in the extracellular space that may affect several organs. It may be generalized and idiopathic (primary amyloidosis). We describe the case of a 48 years-old woman with axonal neuropathy associated with proteinuria, whose final investigation resulted in diagnosis of primary amyloidosis (AL). She was submitted to autologous bone marrow transplantation. We discuss some aspects related to diagnosis of neuropathy and current treatment of AL.
Autologous stem-cell transplantation for multiple myeloma: a Brazilian institution experience in 15 years of follow-up
Juliana Todaro,Ana Rita de Araújo Burgos Manhani,José Mauro Kutner,Andreza Alice Feitosa Ribeiro
Einstein (S?o Paulo) , 2011,
Abstract: Objective: To determine the 5-year post-transplant survival ofpatients with multiple myeloma. Methods: A retrospective study inpatients diagnosed with multiple myeloma submitted to autologousbone marrow transplantation at a Brazilian institution, during theperiod of 1993 to 2007. Results: Seventy-three patients wereevaluated with a median age of 55 years. Survival in 5 years was75% (2.4 to 60 months). Statistical analysis demonstrated statisticalsignificance for the applied grade of response prior to treatment withautologous bone marrow transplantation (p = 0.01). There was nostatistical significance for clinical staging or time of diagnosis (before or after the year 2000). Conclusion: Experience in autologous bone marrow transplantation for multiple myeloma at a Brazilian institution demonstrated an evolution consistent with that of medical literature and highlighted the importance of a response to treatment prior to transplantation in the survival of these patients.
Axoval neuropathy as initial manifestation of primary amyloidosis: report of a case submitted to bone marrow transplantation
Barsottini, Orlando G. Povoas;Arantes, Adriano;Sigulem, Daniel;Kutner, José Mauro;Ribeiro, Andreza Alice Feitosa;Moura, Luiz A.;Hamerschlak, Nelson;
Arquivos de Neuro-Psiquiatria , 2004, DOI: 10.1590/S0004-282X2004000400030
Abstract: amyloidosis is a syndrome characterized by deposition of a highly insoluble protein material in the extracellular space that may affect several organs. it may be generalized and idiopathic (primary amyloidosis). we describe the case of a 48 years-old woman with axonal neuropathy associated with proteinuria, whose final investigation resulted in diagnosis of primary amyloidosis (al). she was submitted to autologous bone marrow transplantation. we discuss some aspects related to diagnosis of neuropathy and current treatment of al.
Platelet aggregation and lipoprotein levels in a patient with familial hypercholescholesterolemia after selective LDL-apheresis
Pares, Madalena Nunes da Silva;D'Amico, Elbio Antonio;Kutner, José Mauro;Chamone, Dalton de Alencar Fischer;Bydlowski, Sergio Paulo;
Sao Paulo Medical Journal , 1997, DOI: 10.1590/S1516-31801997000300009
Abstract: platelet aggregation was studied in a patient with familial hypercholesterolemia immediately after aphereis selective for low-density lipoprotein (ldl), a lipid-lowering procedure.this treatment reduced plasmatic levels of total and ldl-cholesterol, apo b, and triglyceride. increased platelet aggregation was reduced immediately after the apheresis in whole blood as well as in platelet-rich plasma. however, aggregation in washed platelets remained unchanged after ldl-apheresis. in conclusion, in this patient reduction of ldl-cholesterol improved platelet function in the very short term.
Evaluation of three methods for hemoglobin measurement in a blood donor setting
Rosenblit, Jacob;Abreu, Cláudia Regina;Szterling, Leonel Nulman;Kutner, José Mauro;Hamerschlak, Nelson;Frutuoso, Paula;Paiva, Thelma Regina Silva Stracieri de;Ferreira Júnior, Orlando da Costa;
Sao Paulo Medical Journal , 1999, DOI: 10.1590/S1516-31801999000300003
Abstract: context: the hemoglobin (hb) level is the most-used parameter for screening blood donors for the presence of anemia, one of the most-used methods for measuring hb levels is based on photometric detection of cyanmetahemoglobin, as an alternative to this technology, hemocue has developed a photometric method based on the determination of azide metahemoglobin. objective: to evaluate the performance of three methods for hemoglobin (hb) determination in a blood bank setting. design: prospective study utilizing blood samples to compare methods for hb determination. setting: hemotherapy service of the hospital israelita albert einstein, a private institution in the tertiary health care system. sample: serial blood samples were collected from 259 individuals during the period from march to june 1996. main measurements: test performances and their comparisons were assessed by the analysis of coefficients of variation (cv), linear regression and mean differences. results: the cv for the three methods were: coulter 0.68%, cobas 0.82% and hemocue 0.69%. there was no difference between the mean hb determination for the three methods (p>0.05). the coulter and cobas methods showed the best agreement and the hemocue method gave a lower hb determination when compared to both the coulter and cobas methods. however, pairs of methods involving the hemocue seem to have narrower limits of agreement (± 0.78 and ± 1.02) than the coulter and cobas combination (± 1.13). conclusion: the three methods provide good agreement for hemoglobin determination.
Allogeneic hematopoietic stem cell transplantation in children with primary immunodeficiencies: Hospital Israelita Albert Einstein experience
Juliana Folloni Fernandes,Fabio Rodrigues Kerbauy,Andreza Alice Feitosa Ribeiro,Jose Mauro Kutner
Einstein (S?o Paulo) , 2011,
Abstract: Objective: To report the experience of a tertiary care hospital withallogeneic hematopoietic stem cell transplantation in children withprimary immunodeficiencies. Methods: Seven patients with primaryimmunodeficiencies (severe combined immunodeficiency: n = 2;combined immunodeficiency: n = 1; chronic granulomatous disease:n = 1; hyper-IgM syndrome: n = 2; and IPEX syndrome: n = 1)who underwent eight hematopoietic stem cell transplants (HSCT)in a single center, from 2007 to 2010, were studied. Results: Twopatients received transplants from HLA-identical siblings; the othersix transplants were done with unrelated donors (bone marrow: n= 1; cord blood: n = 5). All patients had pre-existing infectionsbefore hematopoietic stem cell transplants. One patient receivedonly anti-thymocyte globulin prior to transplant, three transplantswere done with reduced intensity conditioning regimens and fourtransplants were done after myeloablative therapy. Two patientswere not evaluable for engraftment due to early death. Three patientsengrafted, two had primary graft failure and one received a secondtransplant with posterior engraftment. Two patients died of regimenrelated toxicity (hepatic sinusoidal obstruction syndrome); one patient died of progressive respiratory failure due to Parainfluenza infection diagnosed prior to transplant. Four patients are alive and well from 60 days to 14 months after transplant. Conclusion: Patients’ status prior to transplant is the most important risk factor on the outcome of hematopoietic stem cell transplants in the treatment of these diseases. Early diagnosis and the possibility of a faster referral of these patients for treatment in reference centers may substantially improve their survival and quality of life.
Museu de ciência, divulga??o científica e hegemonia
Loureiro, José Mauro Matheus;
Ciência da Informa??o , 2003, DOI: 10.1590/S0100-19652003000100009
Abstract: this is an analysis of public scientific museum as informational field, taking into consideration the conditions of production and dissemination of information/museum object. it investigates the articulation of hegemony action, as developed by gramsci, in the representations of science presented on the scientific museum exhibition.
Luiz Felipe: o Médico de Família que fez a diferen a Luiz Felipe: the Family Doctor who made the difference Luiz Felipe: el Médico de Familia que hizo la diferencia
José Mauro Ceratti Lopes
Revista Brasileira de Medicina de Família e Comunidade , 2012, DOI: 10.5712/rbmfc7(25)680
Abstract: Luiz Felipe Cunha Mattos (21/02/1956 – 04/12/2012) “Se antes ajudava a construir a história da Medicina de Família, hoje é parte fundamental desta história.” Luiz Felipe formou-se em Medicina pela Universidade de Passo Fundo (UPF-RS), desde este período apresentava interesse pela saúde pública. Nas apresenta es e atividades, quando perguntado sobre qual o professor que marcara sua forma o, sempre se referia ao seu professor de saúde coletiva da UPF. Formado em 1981, e contrariando a “moda” da época, realizou sua Residência em Medicina Geral e Comunitária na Unidade Sanitária S o José do Murialdo (Porto Alegre, 1982-1983), sendo colega de Airton Stein, Elizabeth Wartchow, Magda Costa, Maria Teresa Pinho e Cristina Lemos, os quais - juntamente com ele e Wanda Loguércio, José Mauro C. Lopes e Hermes Cattani - em 1984 iriam compor o grupo dos primeiros médicos contratados da Unidade de Medicina de Família do Hospital Nossa Senhora da Concei o (HNSC). Este fato teve dois aspectos inovadores: foi, talvez, a primeira contrata o de médicos de família como tais, e realizada através de concurso que envolveu um processo seletivo rigoroso (prova da Associa o Médica do Rio Grande do Sul (AMRIGS), entrevista e prova oral). Desde 26 de abril de 1984, Luiz Felipe atuou como médico da Unidade Concei o, “na ponta”, sem interrup es na atividade clínica, sendo um dos médicos de maior longitudinalidade no Brasil. Desde o início envolveu-se ativamente na constru o do Servi o de Saúde Comunitária, participando de sua expans o. Ocupou cargos como Chefe de Unidade, Preceptor e Supervisor da Residência em MFC e Coordenador da COREME do HNSC. Alguns destes cargos foram ocupados por vários mandatos. Uma de suas preocupa es constantes era com a qualifica o clínica do MFC, participando ativamente das discuss es e debates dos anos 80 e 90 sobre qual o perfil do MFC necessário para o Sistema de Saúde do Brasil. Um aspecto talvez desconhecido seja sua atua o - durante a fase da Reforma Sanitária – no Conselho Municipal de Saúde de Porto Alegre, como representante do HNSC, tendo feito parte de sua Camara Técnica. Fez especializa o em Saúde Pública pela Escola de Saúde Pública do RS, no final dos anos 80, tendo como tema de seu trabalho de conclus o “O paciente frequente”. Desde o início desempenhou importante papel nas atividades associativas, fazendo parte do grupo de MFCs que assumiu pela primeira vez o Departamento de Saúde Coletiva da Associa o Médica do Rio Grande do Sul (anos 80). Outra atividade pouco conhecida do Luiz Felipe foi participar nos anos 90, juntamente c
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