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Search Results: 1 - 10 of 42890 matches for " KONG Ling-yi "
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Two New Phragmalin-Type Limonoids from Chukrasia tabularis var. velutina
Yi Li,Jun Luo,Hui Li,Ling-Yi Kong
Molecules , 2013, DOI: 10.3390/molecules18010373
Abstract: Two new phragmalin-type limonoids with different structural skeletons, chuktabrin K ( 1) and tabulalin J ( 2), were isolated from the stem barks of Chukrasia tabularis var. velutina in the course of our ongoing research work in this area. Compound 1 was a 16-norphragmalin with an enolic alkyl appendage at C-15, and the carbonate moiety in 1 was also rare in natural organic molecules. The basic skeleton of compound 2 was a D-ring-opened phragmalin. Their structures were elucidated on HR-ESI-MS, 1H and 13C-NMR, HSQC, HMBC, and ROESY experiments.
The impact of urban planning on land use and land cover in Pudong of Shanghai, China
ZHAO Bin,Nobukazu Nakagoshi,CHEN Jia-Kuan,KONG Ling-yi,
ZHAO Bin
,Nobukazu Nakagoshi,CHEN Jia-kuan,KONG Ling-yi

环境科学学报(英文版) , 2003,
Abstract: Functional zones in cities constitute the most conspicuous components of newly developed urban area, and have been a hot spot for domestic and foreign investors in China, which not only show the expanse of urban space accompanied by the shifts both in landscape (from rural to urban) and land use (from less extensive to extensive), but also display the transformation of regional ecological functions. By using the theories and methods of landscape ecology, the structure of landscape and landscape ecological planning can be analyzed and evaluated for studying the urban functional zones' layout. In 1990, the Central Government of China declared to develop and open up Pudong New Area so as to promote economic development in Shanghai. Benefited from the advantages of Shanghai's location and economy, the government of Pudong New Area has successively built up 7 different functional zones over the past decade according to their functions and strategic goals. Based on the multi-spectral satellite imageries taken in 1990, 1997 and 2000, a landscape ecology analysis was carried out for Pudong New Area of Shanghai, supported by GIS technology. Green space (including croplands) and built-up area are the major factors considered in developing urban landscape. This paper was mainly concerned with the different spatial patterns and dynamic of green space, built-up areas and new buildings in different functional zones, influenced by different functional layouts and development strategies. The rapid urbanization in Pudong New Area resulted in a more homogeneous landscape. Agricultural landscape and suburban landscape were gradually replaced by urban landscape as the degree of urbanization increased. As consequence of urbanization in Pudong, not only built-up patches, but also newly-built patches and green patches merged into one large patch, which should be attributed to the construction policy of extensive green space as the urban development process in Pudong New Area. The shape of green area of 7 functional zones became more and more regular because of the horticultural needs in Shanghai urban planning. Some suggestions were finally made for the study of future urban planning and layout.
Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
Xiang Zhou,Miao Li,Xiao-Bing Wang,Tao Wang,Ling-Yi Kong
Molecules , 2010, DOI: 10.3390/molecules15128593
Abstract: During a synthesis of coumarins to obtain new candidates for treating Alzheimer’s Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives. The possible mechanism of the novel rearrangement was also discussed. All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil.
Correlates of degree of nerve involvement in early Bell's palsy
Ru-Lan Hsieh, Chia-Wei Wu, Ling-Yi Wang, Wen-Chung Lee
BMC Neurology , 2009, DOI: 10.1186/1471-2377-9-22
Abstract: This retrospective chart review study of newly diagnosed cases of Bell's palsy was conducted over a three-year period. Information on age, sex, day of onset, comorbidities, corticosteroid use, and electroneurographic test results were collected. The electroneurographic quotient (amplitude of compound muscle action potential on the affected side divided by that on the healthy side and expressed in percent) was used as an index of nerve involvement, with lower quotient indicating more severe disease.Data were collected on 563 patients. The mean electroneurographic quotient varied inversely with age (p < 0.001) and was higher in patients who used corticosteroids than those who did not (47.1% vs. 40.3%; p = 0.002). There was no correlation between the degree of nerve involvement and sex, season of onset, hypertension, or diabetes.The degree of nerve involvement in early Bell's palsy correlates positively with age and negatively with corticosteroid use.A concern of both patients with Bell's palsy and their physicians is when and how facial paralysis will be completely resolved [1]. Many previous studies have focused on the long-term prognosis of Bell's palsy [1-8]. Systems for clinically assessing prognosis include the House-Brackmann facial nerve grading system, Yanagihara scoring system, nerve excitability test, electroneurography, electromyography, blink reflex, stapedial muscle reflex, prediction equations using combinations of these, brain magnetic resonance imaging, and even a novel 3-dimensional real-time video acquisition system [1-3,7-12]. Of these, electroneurography is the most frequently used because it provides objective, quantitative, and accurate data for assessing facial nerve function [1,6]. It measures and records the amplitudes of muscle summation potentials resulting from the synchronous firing of motor units [6]. A percent of nerve fibers that are neuropraxic is obtained by comparing the amplitude of the compound muscle action potentials on the affec
Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring
Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao, Eagle Huang
Journal of Biomedical Science , 2009, DOI: 10.1186/1423-0127-16-106
Abstract: Growth retardation, delayed motor development and behavior abnormalities have been proposed in offspring of heroin-addicted mothers [1]. Infants passively exposed to morphine through their addicted mothers easily developed morphine withdrawal syndrome after birth, whom even needed intensive care [2-4]. In our previous studies, we observed that many adverse effects caused by prenatal exposure of morphine could be prevented by the co-administration of dextromethorphan (DM) in morphine-dependent rat dams [5,6]. However, the possible impacts of prenatal exposure of morphine on the vulnerability to drug addiction have seldom been examined. In humans, the liability to opioid dependence can be affected by acquired physical conditions and social factors in offspring from morphine-addicted mother. Thus, we attempted to investigate the possible effects of prenatal exposure to morphine on the vulnerability to morphine-induced reward in an animal model of rats. In addition, the possible protective effect of the co-administered DM was also tested.Being a non-competitive antagonist at the glutamatergic N-methyl-D-aspartate (NMDA) receptors, DM was thought to exert many of its pharmacological actions through the blockade of NMDA receptor [7], although DM was reported to act at the other targets (e.g. nicotinic α3β4 receptors and sigma receptors) as well [8,9]. Activation of the NMDA receptors has been implicated in the regulation of reward-related mesolimbic pathway in many reports [10-12]. Therefore, we speculated that the prenatal administration of morphine and DM to the dams may affect the development of the neural systems which will be functionally correlated with opioid-induced reward in the offspring. In order to investigate the liability to morphine-induced reward, we used conditioned place preference (CPP) test to perform quantitative verification of morphine-induced reward. The CPP tests were carried out on the rats which were the offspring from the morphine-dependent dam
Inverse Association of N-Terminal Pro-B-Type Natriuretic Peptide with Metabolic Syndrome in Patients with Congestive Heart Failure
Huai-Ren Chang, Jen-Che Hsieh, Bang-Gee Hsu, Ling-Yi Wang, Michael Yu-Chih Chen, Ji-Hung Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079096
Abstract: Background Metabolic syndrome has been shown to be associated with lower levels of plasma N-terminal pro-B-type natriuretic peptide (Nt-proBNP) in the general population. We sought to elucidate the relationship between Nt-proBNP and components of metabolic syndrome in patients with congestive heart failure (CHF). Methods Fasting blood samples were obtained from 93 patients in our institution. Plasma levels of Nt-proBNP and other biochemical data were measured. The New York Heart Association (NYHA) classification system (I-IV) was used to define the functional capacity of CHF. Metabolic syndrome and its components were defined using diagnostic criteria from the International Diabetes Federation. Results Forty-nine patients (52.7%) had CHF. There was a positive correlation between plasma Nt-proBNP levels and NYHA functional capacity in CHF patients. Plasma Nt-proBNP levels increased significantly with each increasing NYHA class of the disease. The prevalence of metabolic syndrome in CHF patients was higher than that in patients without CHF. Most importantly, we found that plasma Nt-proBNP levels were lower in CHF patients with metabolic syndrome attributable to inverse relationships between plasma Nt-proBNP and body mass index (β = ?0.297), plasma triglyceride (β = ?0.286) and homeostasis model assessment of insulin resistance (HOMA-IR; β = ?0.346). Fasting glucose to insulin ratio (FGIR, an insulin sensitivity index) was positively associated with plasma Nt-proBNP levels (β = 0.491), and was the independent predictor of plasma Nt-proBNP levels in CHF patients. Conclusions Plasma Nt-proBNP levels are inversely associated with metabolic syndrome in CHF patients. Reduced plasma Nt-proBNP levels in CHF patients may lead to impaired lipolysis and metabolic function, and may contribute to the development of metabolic syndrome in CHF patients.
The Role of Interferon-γ Inducible Protein-10 in a Mouse Model of Acute Liver Injury Post Induced Pluripotent Stem Cells Transplantation
Che-Chang Chan, Ling-Yi Cheng, Jean Lu, Yi-Hsiang Huang, Shih-Hwa Chiou, Ping-Hsing Tsai, Teh-Ia Huo, Han-Chieh Lin, Fa-Yauh Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050577
Abstract: Background Liver injuries are important medical problems that require effective therapy. Stem cell or hepatocyte transplantation has the potential to restore function of the damaged liver and ameliorate injury. However, the regulatory factors crucial for the repair and regeneration after cell transplantation have not been fully characterized. Our study investigated the effects and the expression of the regulatory factors in mouse models of acute liver injury either transplanted with the induced pluripotent stem cells (iPS) or the hepatocytes that differentiated from iPS cells (iHL). Methods/Principal Findings Mice received CCl4 injection and were randomized to receive vehicle, iPS, or iHL transfusions vial tail veins and were observed for 24, 48 or 72 hours. The group of mice with iPS transplantation performed better than the group of mice receiving iHL in reducing the serum alanine aminotransferase, aspartate aminotransferase, and liver necrosis areas at 24 hours after CCl4 injury. Moreover, iPS significantly increased the numbers of proliferating hepatocytes at 48 hours. Cytokine array identified that chemokine IP-10 could be the potential regulatory factor that ameliorates liver injury. Further studies revealed that iPS secreted IP-10 in vitro and transfusion of iPS increased IP-10 protein and mRNA expressions in the injured livers in vivo. The primary hepatocytes and non-parenchyma cells were isolated from normal and injured livers. Hepatocytes from injured livers that received iPS treatment expressed more IP-10 mRNA than their non-hepatocyte counter-parts. In addition, animal studies revealed that administration of recombinant IP-10 (rIP-10) effectively reduced liver injuries while IP-10-neutralizing antibody attenuated the protective effects of iPS and decreased hepatocyte proliferation. Both iPS and rIP-10 significantly reduced the 72-hour mortality rate in mice that received multiple CCl4-injuries. Conclusions/Significance These findings suggested that IP-10 may have an important regulatory role in facilitating the repair and regeneration of injured liver after iPS transplantation.
男生首次遗精年龄与体力活动和睡眠时间的关系研究
Association between age of first spermatorrhea and physical activity or sleeping time in boys

彭林丽,王宏,何芳,程绪婷,王翎懿,蒋佳佳
PENG Lin-li
, WANG Hong, HE Fang, CHENG Xu-ting, WANG ling-yi, JIANG Jia-jia

- , 2017, DOI: 10.3969/j.issn.1674-8115.2017.03.023
Abstract: 目的 ·通过了解重庆市主城区中小学男生首次遗精发生情况,探讨首次遗精发生年龄与体力活动和睡眠时间的关系。方法 ·采用分层随机整群抽样抽取重庆市主城区男生3 403人(10~18岁),进行体格检查和问卷调查,选择其中经历首次遗精的1 282人作为研究对象。根据首次遗精发生年龄,分为适时组(964人)和较晚组(318人)。结果 · 2组在平均每周进行高等(χ2=11.488,P=0.009)、中等(χ2=7.829,P=0.050)强度体力活动,平均每天睡眠时间(χ2=17.803,P=0.000)构成上均存在差异。控制年龄、身高、体质量等协变量,与适时组相比,较晚组的男生更少进行每周5~7 d(OR=0.596,95% CI:0.367~0.967)和3~4 d(OR=0.590,95% CI:0.370~0.941)高等强度体力活动,也更少有平均每天9~11 h (OR=0.207,95% CI:0.088~0.489)睡眠时间。结论 ·男生首次遗精发生年龄可能与其每周进行体力活动的强度和每天睡眠时间有关。
: Objective · To understand boys’ pubertal timing in school in two urban districts of Chongqing and explore the relationship between pubertal timing and physical activity or sleeping time. Methods · Using a stratified random cluster sampling, 3 403 boy students (10-18 year-old) were selected and completed the physical examination and questionnaire survey. 1 282 participants experiencing first spermatorrhea were chosen as research objects. According to age of first spermatorrhea, the objects were divided into on-time group (964 cases) and later group (318 cases). Results · The composition of weekly high (χ2=11.488, P=0.009), medium (χ2=7.829, P=0.050) physical activity and daily sleeping time (χ2=17.803, P=0.000) in two groups were significantly different. Controlling covariates (age, height and weight), compared with boys in on-time group, later group boys were less likely to engage in 5-7 days (OR=0.596, 95% CI 0.367-0.967) and 3-4 days (OR=0.590, 95% CI: 0.370-0.941) high physical activity every week, and 9-11h (OR=0.207, 95% CI: 0.088-0.489) sleep every day. Conclusion · The age of first spermatorrhea in boys might be associated with the intensity of weekly physical activity and daily sleeping time
Relationship between psychosomatic health and both maladjustment and job burnout in military personnel
Ling-ming KONG,Wei GUO,Li-yi ZHANG,Gao-feng YAO
Medical Journal of Chinese People's Liberation Army , 2012,
Abstract: Objective To explore the influence of mental maladjustment and job burnout on the psychosomatic health of military personnel and their relationship and build a path mode. Methods A total of 358 military personnel were selected by random cluster sampling. Military Mental Maladjustment Scale (MMMS), Military Job Burnout Scale (MJBS), and Chinese Psychosomatic Health Scale (CPSHS) were applied to collect data. SPSS (version 17.0) and Amos (version 7.0) were used for data analysis by correlative analysis, multiple-regression analysis, and path analysis. Results All single factors of job burnout were significantly positively related to interpersonal relationship and emotional disorder due to mental maladjustment (P < 0.05 or P < 0.01). All single factors of mental maladjustment and job burnout were significantly positively related to the psychosomatic health of military personnel (P < 0.01). Multiple regression analysis showed that somatization, negative cacanny, emotional disorder, and interpersonal relationship entered into the regression equation of total psychosomatic health score as dependent variable, and could serve as predictors for military personnel's psychosomatic health (P < 0.01), the four independent variables accounted for 45% of the total variance of psychosomatic health. The influence of mental maladjustment on psychosomatic health was enhanced by intervention of job burnout into the path model, the fit indexes of which were as follows: χ2/df=35.248 (P=0.000), GFI=0.963, AGFI=0.875, CFI=0.902, RMSEA=0.003. Conclusions Emotional disorder, poor interpersonal relationship, somatization, and negative cacanny exert significant effects on military personnel's psychosomatic health. Job burnout mediates the relationship between mental maladjustment and psychosomatic health.
Time feature of Chinese military personnel’s suicide ideation and its relationship with psychosomatic health
Li-yi ZHANG,Ling-ming KONG,Gui-sen MEI,Zhong-wen REN
Medical Journal of Chinese People's Liberation Army , 2012,
Abstract: Objective To investigate the time feature of Chinese military personnel's suicide ideation and its relationship with psychosomatic health to provide scientific basis for formulation of mental health policy and intervention of related psychological crisis. Methods By random cluster sampling, a total of 11 362 military personnel including army, navy and air-force (1100 in 1980s, 8000 in 1990s, 2262 in year 2000) were tested by Chinese Psychosomatic Health Scale (CPSHS). SPSS statistic 17.0 program was used for data analysis, i.e., χ2-test, T-test and stepwise regression analysis. Results The incidence rate of military personnel's suicide ideation in the three decades from 1980 to 2000 was 10.27%, 7.09% and 2.83% respectively, which revealed a decreasing trend (P < 0.01). The scores of cardiovascular symptom, alimentary system, skin, reproductive-endocrine system, nervous system, depression, psychotic symptom and family history of recruited military personnel who had suicide ideation were significantly higher than those of control population (P < 0.05-0.01); The other factor scores showed no significant difference between the two groups (military personnel with vswithout suicide ideation, P>0.05). Suicide ideation was selected into the regression equation of mental health, physical health, and total psychosomatic health scores, which could positively predict the level of military personnel's psychosomatic health (P=0.05 or 0.01). Conclusions Military personnel's suicide ideation presents a decreasing trend; the psychosomatic health of military personnel who have suicide ideation is worse than that of personnel without suicide ideation.
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