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Search Results: 1 - 10 of 14206 matches for " KK Singh "
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Possible impact of increase in female medical student admissions in Nepal: Findings from a qualitative study among medical undergraduates
PR Shankar,KK Singh,S Singh
Australasian Medical Journal , 2012,
Abstract: BackgroundIn Nepal, a developing country in South Asia, the number of female medical students has increased significantly.AimsThe present study was carried out to explore perceived perceptions for this increase, study the perceived impact on teaching-learning activities, medical school infrastructure and possible perceived changes in the doctor-patient relationship.MethodFirst, second and third year students were invited to participate in focus group discussions (FGDs). Fifty-four students were willing to participate. Twenty-five were from the first year, 20 from the second and 9 from the third year. The FGDs conducted over a 90 minute period were voice and video recorded. The groups consisted of both males and females from a particular intake. The findings were transcribed verbatim.ResultsParticipants felt more female students were taking up medicine in the country because of more colleges opening in the cities and towns making it easier for female students to enrol in the course. Also parents consider medicine as a safe, noble and dignified profession for their daughters. Participants suggested women are more empathetic doctors and the doctor-patient relationship might become more patient-focused. Women doctors can serve as a source of inspiration and the overall impact on Nepal would be positive.ConclusionParticipating students perceived the increasing number of female medical students may be due to changes in Nepalese society. This study was carried out only among three batches of students in a single medical school. Further studies among different batches of students and among interns in other medical schools are required. Studies among postgraduate students and doctors are also needed.
Investigation on the sorption of aluminium in drinking water by low-cost adsorbents
TS Singh, B Parikh, KK Pant
Water SA , 2005,
Abstract: Aluminium is one of the trace inorganic metals present in drinking water. High aluminium concentrations (3.6 to 6 mg/ ) may precipitate as aluminium hydroxide affecting aquatic life. Aluminium is also a suspected agent of neurological disorders such as Alzheimer\'s disease and senile dementia. The present investigation aims at the sorption of aluminium from drinking water using a low-cost adsorbent. Rice husk char and activated rice husk char were prepared and characterised for various physicochemical properties. The performance of rice husk char (RHC) was compared with other low-cost adsorbents for their aluminium removal capacity. The effect of pH, initial concentration, contact time and temperature was studied for adsorption of aluminium from water under batch conditions. The maximum adsorption capacity was observed with rice husk char at an optimal pH of 4.2. The adsorption of aluminium follows the Freundlich adsorption isotherm. The rate of aluminium adsorption was successfully described by a first-order kinetic model. The thermodynamic study revealed that aluminium adsorption is an exothermic process and the adsorption decreases with an increase in temperature. Water SA Vol 32(1)pp:49-54
Application of BPNN in the analysis of SBI’s Credit Capacity
Roli Pradhan,KK Pathak,VP Singh
International Journal of Soft Computing & Engineering , 2011,
Abstract: During the existing business scenario much need exists for a system that can predict the failure of any firm with accuracy much before the bankruptcy actually occurs. Credit decisions by commercial banks are based to a large extent on the financial statements provided by corporate borrowers as monitored using financial ratios suggesting their financial position. This paper uses the tailored back-propagation neural network endeavors to predict the financial ratios expressing the position of a firm to regulate the bankruptcy and assess the credit risks. It first estimates the financial ratio for a firm from 2001-2008 to the train the BPNN and uses the estimates of the year 2009 and 2010 values for the validation process. Finally it dwells to draw predictions for the period 2011-2015 and emphasizes the growing role of BPNN application based prediction models for banking sector with a case study of State Bank of India. We conclude with practical suggestions on how best to integrate models and research into policy making decisions. Along with establishing the ratios, analysis regarding the bankruptcy status of the firm is also analysed. The basic Z Score value of the firm from 2001-2008 has been used to predict the Z Score values upto 2015.
Erythromycin Induced Carbamazepine Toxicity- A Preventable Drug Interaction
Devendra Shrestha,AK Dhakal,KK Singh
Journal of Chitwan Medical College , 2013, DOI: 10.3126/jcmc.v3i4.9556
Abstract: A drug interaction between Erythromycin and Carbamazepine is well established and harmful effects of Carbamazepine toxicity can be avoided. We report a patient who developed features of Carbamazepine toxicity namely ataxia, vomiting and nystagmus within 24 hours of oral Erythromycin with high serum Carbamazepine level and improved after discontinuation of Erythromycin with returning of serum Carbamazepine level to therapeutic range. Awareness among health professionals, patient education, proper record keeping and strengthening pharmacy services are essential to prevent such drug interactions. Journal of Chitwan Medical College 2013; 3(4); 52-53 DOI: http://dx.doi.org/10.3126/jcmc.v3i4.9556
Gemcitabine concurrent with radiation therapy for locally advanced head and neck carcinomas
A Chauhan, H Singh, T Sharma, KK Manocha
African Health Sciences , 2008,
Abstract: Background: Management of advanced head and neck carcinoma is a challenging proposition. Presently concomitant chemoirradiation has become the standard of care in such patients. Many chemotherapeutic drugs have shown radio-sensitising effects when used concomitantly along with radiation. The present study was carried out with the objective of assessing the feasibility and efficacy of low dose gemcitabine as radiosensitizer when used during radical radiotherapeutic management of patients with locally advanced head and neck carcinomas. Patients and methods: From November 2000 to March 2003, Eighty histopathologically proven cases of squamous cell head and neck carcinoma were included in this trial, 40 patients were randomly assigned to receive radiotherapy alone and 40 patients to receive gemcitabine along with radiotherapy. Results: All patients were assessable for toxicity and response. Severe mucositis (WHO level 5 reactions were observed in 67% patients in the CT/RT group vs 16% patients in the RT only group. No severe hematological toxicity was seen. The rates of complete and partial responses were 42.5% & 57.5% respectively for RT only and 62.5% &37.5%, respectively for CT/RT group. There was no significant difference in the response rates at the end of treatment but disease free survival at three years was better in the CT/RT group (63.3% vs 20%). Nine of the 17 patients with complete response in the radiation only group developed relapse while no relapses were seen in CT/RT group. Conclusion: In the present study the combination of gemcitabine and radiotherapy has not shown any statistical difference in locoregional control but survival advantage was seen as compared to radiotherapy alone. At the same time more mucosal and skin toxicity was encountered when Gemcitabine is given concurrently with radiation. African Health Sciences Vol. 8 (3) 2008: pp. 149-155
Expression of mannose binding lectin in HIV-1-infected brain: implications for HIV-related neuronal damage and neuroAIDS
Singh KK,Nathamu S,Adame A,Alire TU
Neurobehavioral HIV Medicine , 2011,
Abstract: Kumud K Singh1, Satyanarayana Nathamu1, Anthony Adame2, Tara U Alire1, Wilmar Dumaop2, Ben Gouaux3, David J Moore3, Eliezer Masliah2, and HIV Neurobehavioral Research Center Group1Department of Pediatrics, 2Department of Neurosciences, 3Department of Psychiatry, University of California San Diego, La Jolla, CA, USAAbstract: Mannose binding lectin (MBL) activates complement pathway that leads to pathogen opsonization and phagocytosis. MBL deficiency is linked to HIV transmission and disease progression. We sought to determine the role of MBL in HIV encephalitis (HIVE) by evaluating its presence and distribution in the HIV-1-infected brain and by assessing its association with monocyte chemoattractant protein-1 (MCP-1) expression. This retrospective study utilized archived post-mortem brain tissues obtained from 35 individuals enrolled in a longitudinal study as part of the California NeuroAIDS Tissue Network. MBL, MCP-1 and brain cell markers in post-mortem brain tissues with or without HIVE were evaluated using immunocytochemistry, immunofluorescence, confocal microscopy, and western blots. MBL was expressed in neurons, astrocytes, microglia, and oligodendrocytes of the frontal cortex of the HIV-1-infected brain. Overall, there were 30% to 40% more MBL-positive brain cells in HIVE vs non-HIVE cases (P = 0.01, paired t-test). Specifically, there was an increased MBL expression in the neuronal axons of HIVE cases. Also, western blots showed 3- to 4-fold higher levels of 78 kD MBL trimers in HIVE vs non-HIVE cases. This MBL-HIVE link was further confirmed by MBL associated higher MCP-1 expression in HIVE vs non-HIVE cases. HIV negative healthy individuals and normal or the gp120 transgenic mice did not show any differential MBL expression. Increased MBL expression in the major brain cell types, specifically in the neuronal axons of HIVE brain, and MBL associated higher MCP-1 expression in HIVE suggest that MBL could cause neuroinflammation and neuronal injury through MBL complement activation pathway.Keywords: mannose binding lectin, HIV encephalitis, complement activation, neuroinflammation, neuroAIDS, MCP-1
The impact of DNA chip technology on molecular medicine
KK Wilgenbus
Arthritis Research & Therapy , 2001, DOI: 10.1186/ar151
Advances in the field of nanooncology
KK Jain
BMC Medicine , 2010, DOI: 10.1186/1741-7015-8-83
Abstract: Nanotechnology is the creation and utilization of materials, devices and systems through the control of matter on the nanometer-length scale, that is, at the level of atoms, molecules and supramolecular structures. Given the inherent nanoscale functional components of living cells, it was inevitable that nanotechnology would be applied in biotechnology settings, giving rise to the term nanobiotechnology, that is, the application of nanotechnology in the life sciences. Nanobiotechnology is already starting to show the promise of an impact on health care. Nanomedicine is defined as the application of nanobiotechnology to medicine and is based on the use of nanoscale materials and devices for diagnosis and drug delivery as well as for the development of advanced pharmaceuticals referred to as nanopharmaceuticals [1]. Nanobiotechnology is also being applied to refine surgery from microsurgery to nanosurgery. Examples include the construction of nanoscale robots, nanobots, for navigating the human body to detect as well as treat various diseases, and cell surgery using nanodevices and nanolasers. During the past few years, considerable progress has been made in the application of nanobiotechnology in cancer, that is, nanooncology, which is currently the most important chapter of nanomedicine.Nanobiotechnology plays an important role in the discovery of biomarkers of cancer. Several drugs in development for cancer are based on nanobiotechnology, and a few of these are already approved. Nanobiotechnology-based devices are in development as aids to cancer surgery. Finally, nanobiotechnology is playing an important role in personalized therapy for cancer. The impact of nanobiotechnology on oncology is shown schematically in Figure 1.Nanobiotechnologies have extended the limits of and refined molecular diagnostics [2]. Nanobiotechnology offers a novel set of tools for the detection of cancer and contributes to early detection of cancer as follows:1. It can complement existing
The Legislative and Institutional Framework of Environmental Protection in the Oil and Gas Sector in Nigeria – A Review
KK Ezeibe
Nnamdi Azikiwe University Journal of International Law and Jurisprudence , 2011,
Abstract: This article shall present a detailed and critical review of the legislative and institutional framework of environmental protection and pollution control in the oil and gas sector in Nigeria; it shall conclude with some recommendations for a better, more efficient and effective environmental protection and pollution control regime in the sector.
The analysis and teaching of gender in Greek nouns
KK Vancouver
Tydskrif vir letterkunde , 2001,
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