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Search Results: 1 - 10 of 178478 matches for " K.Y. Musa "
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The Concentration of Cadmium in Borehole and Well Waters in Zaria, Nigeria
H. Musa,I.A Yakasai,H.H. Musa,K.Y Musa
Journal of Applied Sciences , 2007,
Abstract: The purpose of this study was to investigate whether the level of inorganic chemical cadmium (Cd) in wells and boreholes water in Zaria is sufficient to affect the health of the inhabitants of the area under study. Sixty open wells and 5 boreholes were randomly selected from Zaria and environs. Water samples were collected from the open wells and boreholes using standard techniques. In the study, Cd concentrations of the samples was determined using standard procedures. WHO acceptable limit for drinking water was used in the evaluation. Result obtained shows that Cd concentrations ranged from <0.001 to 0.28 mg L-1 with 68% of the samples above the WHO water guideline. Most of the open wells and boreholes water studied were contaminated with abnormal concentration of cadmium sufficient enough to affect the health of the inhabitants of the area.
Determination of Arsenic Concentration in Well and Borehole Waters in Zaria, Nigeria
H. Musa,I.A. Yakasai,K.Y. Musa,A.B. Isah
Journal of Applied Sciences , 2008,
Abstract: The objective of this research is to determine the concentration of arsenic in wells and boreholes water in Zaria, to see whether the concentration level is sufficient enough to affect the health of the people living in the area under study. In this study arsenic concentrations of sixty well and five bore hole water samples collected from Zaria and environs were determined using standard procedures. The results obtained shows that arsenic concentrations ranged from <0.002 to 0.51 mg L-1, with 75% of the samples above the World Health Organization drinking water guideline. Bore whole water samples were found to contain less arsenic compared with the shallow well water samples studied. Most wells and boreholes in Zaria were found to be contaminated with abnormal concentration of arsenic sufficient enough to cause serious health hazards to the users.
Evaluation of Effect of Ethanolic Leaf Extract of Mucuna pruriens on Blood Glucose Levels in Alloxan-Induced Diabetic Wistar Rats
E.D. Eze,A. Mohammed,K.Y. Musa,Y. Tanko
Asian Journal of Medical Sciences , 2012,
Abstract: Mucuna pruriens is used extensively for its medicinal value for the treatment of diabetes mellitus in Nigeria. This study investigated the anti-diabetic activity of Mucuna pruriens on the blood glucose levels and the histopathology of the pancreas. To achieve this, Acute toxicity studies of the plant extract was determined. Doses of 100, 200 and 400 mg/kg bw of the extract were administered orally daily for 21 days to alloxan-induced diabetic Wistar rats. Metformin was used as a standard anti-diabetic drug and given by gavage. The fasting blood glucose levels were determined at intervals of three days. Premininary phytochemical screening revealed the presence of flavonoids, saponin, tannins, cardiac glycosides, triterpenes and reducing sugars. The LD50 of the extract of Mucuna pruriens was found to be 2154 mg/kg. The study showed that there was a significant reduction (p<0.05) in the fasting blood sugar levels in alloxan-induced diabetic treated groups that received 100, 200 and 400 mg/kg of the extract orally, with a maximum reduction (p<0.01) of 161.83±18.2, 153.67±13.8 and 133.83±10.4 recorded in the groups treated with 100, 200 and 400 mg/kg. The histopathological studies of the pancreas of diabetic animals revealed the degeneration of pancreatic Islet cells, but with the restoration of pancreatic Islet cells in the pancreas of diabetic group treated with various doses of the plant extract. The implications of the results obtained in the present study provide the scientific rationale for the use of Mucuna pruriens as anidiabetic agent.
Effect of Ethanolic Leaf Extract of Mucunapruriens (fabaceae) on Lipid Profile inAlloxan-Induced Diabetic Wistar rats
E.D. Eze,A. Mohammed,K.Y. Musa,Y. Tanko
British Journal of Pharmacology and Toxicology , 2012,
Abstract: Diabetes mellitus is a global health burden leading to an increase in the search for herbal hypoglycemic agents as alternative to synthetic ones. The effect of diabetes on lipid metabolism is well established. This study was aimed at evaluating the effects of ethanolic leaf extract of M. pruriens on lipid profile levels in alloxan-induced diabetic Wistarrats. Diabetes was induced by injection of Alloxan monohydrate (150 mg/kg b w) intraperitoneally to rats. Diabetic rats were randomly divided into the following groups (n = 6). Group I (normal control) received distilled water, Group II (diabetic control) received distilled water, group III, IV and V received 100, 200 and 400 mg/kg b w of the extract, respectively, while group VI received 250 mg/kg b w Metformin orally once daily for 21 days. At the end of the treatment period, blood samples were collected from the animals and assayed spectrophotometrically for serum concentration of TC, TG, HDL-C and LDL-C. The study showed that there was a significant reduction (p<0.05) in the serum levels TC, TG, LDL-C and increased HDL-C in alloxan-induced diabetic treated groups.However, there was a marked reduction (p<0.01) of 96.86±10.6, 106.31±7.5, 48.09±11.0 observed in the groups treated with 400 mg/kg for TC, TG, LDL-C. While a maximum increase (p<0.01) of 23.01±1.8 and 28.52±0.90 recorded in the group treated with 200 and 400 mg/kg for HDL-C. The result shows that the plant may be useful in the management of secondary complications of diabetes (dyslipidemia) associated with diabetes mellitus.
Effect of Aqueous-Methanolic Stem Bark Extract of Acacia polyacantha on Blood Glucose Levels on Normoglycemic Wistar Rats
A.O. Okpanachi,A.D.T. Goji,I. Ezekiel,K.Y. Musa
International Journal of Animal and Veterinary Advances , 2012,
Abstract: This study was carried out to investigate the blood glucose reducing effect (hypoglycemic effect) of stem bark extract of Acacia polyacantha on normal wistar rats over a 24 h period. Three groups of previously fasted wistar rats, with each group made up of 5 rats each were administered with 100, 200 and 400 mg/kg p.o of aqueous methanolic stem bark extract of A. polyacantha. The hypoglycemic effect of A . polyacantha stem bark aqueous methanolic extract was compared with that of Metformin (250 mg/kg) in fasted normal rats. Following treatment, relatively moderate to high doses of A. polyacantha (100, 200 and 400 mg/kg p.o.) produced a dose-dependent, significant reduction (p<0.05) in blood glucose levels of fasted normal rats. The three doses of the extract did not significantly alter the blood glucose levels after 2 h of extract administration. After 8 and 16 h of extract administration at a dose of 200 mg/kg significantly (p<0.05) decreased the blood glucose levels when compared to control, while the dose of 400 mg/kg significantly decreased the blood glucose levels after 4, 8 and 16 h of extract administration when compared with the control group. The Preliminary phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, triterpenoids, anthraquinones, steroids and saponins. The median lethal dose (LD50) in rats was calculated to be 3807.9 mg/kg body weight. In conclusion the aqueous methanolic extract of Acacia polyacantha possesses hypoglycemic activity in normoglycemic rats.
Effect of Ethanolic Leaf Extract of Mucuna pruriens on Blood Glucose Levels on Normoglycemic Wistar Rats
E.D. Eze,A. Mohammed,K.Y. Musa,I.S. Malgwi
International Journal of Animal and Veterinary Advances , 2012,
Abstract: The present study was undertaken to evaluate the effect of Ethanolic leaf extract of Mucuna pruriens on blood glucose levels on normoglycemic Wistar rats. The acute toxicity study of the plant extract was investigated. Different doses of 100, 200 and 400 mg/kg b w of extract were administered orally by gavage to three groups of normal fasted rats and metformin 250 mg/kg was given to a group and served as positive control while a group was given normal saline for a period of 21day and also served as the negative control. A significant decrease (p<0.05) in the blood glucose levels was observed after 6 day with 100 and 400 mg/kg b w when compared to control. However, there was a significant change (p<0.05) in the blood glucose levels with all does of the plant extract after 9 and 21 day. The preliminary phytochemical screening of the extract showed the presence of flavonoids, saponins, tannins, cardiac glycosides, steroids, cyanogenetic glycosides and alkaloids. The median lethal dose (LD50) in rats was found to be 2154.0 mg.kg body weight. In conclusion,the findings of the study showed that the Ethanolic leaf extract of Mucuna pruriens possess hypoglycemic properties on normoglycemic rats.
Changes in Lipid Profile of Rats Administered with Ethanolic Leaf Extract of Mucuna pruriens (Fabaceae)
E.D. Eze,A. Mohammed,K.Y. Musa,I.S. Malgwi
Current Research Journal of Biological Sciences , 2012,
Abstract: The study evaluated the effect of ethanolic leaf extract of Mucuna pruriens on some lipid profile parameters of normoglycemic Wistar rats. The acute oral toxicity studies were conducted. The animals were administered with the plant extract at graded doses of 100, 200 and 400 mg/kg b w and metformin 250 mg/kg bw orally for 21 days. Blood samples were collected from the animals at the end of the treatment period and assayed for the serum concentration of total cholesterol, triglyceride, low-density lipoprotein and high-density lipoprotein cholesterol. The results showed the extract significantly reduced (p<0.05) the levels of serum total cholesterol, triglyceride, low-density lipoprotein and elevated high-density lipoprotein in the groups treated with 100 and 200 mg/kg b w. There was no significant changes (p>0.05) in the lipid profile in the group treated with 400 and 250 mg/kg b w of metformin. In conclusion, the results of the present findings may be beneficial and of clinical importance to individuals at risks of cardiovascular problems.
Toxicity Studies on the Methanolic Extract of Portulaca oleracea L. (Fam. Portulacaceae)
K.Y. Musa,A. Ahmed,G. Ibrahim,O.E. Ojonugwa
Journal of Biological Sciences , 2007,
Abstract: Toxicity studies on the methanolic extract of Portulaca oleracea L. were carried out on mice intraperitoneally. The LD50 was calculated using the methods of Miller and Tainter (LD50, 1853.5 mg kg-1), Reed and Muench (LD50, 1871 mg kg-1) and Karber method (LD50, 1875 mg kg-1) these values placed the plant to be moderately toxic. Histopathological findings revealed that the extract has effect on the kidney, lung and liver in a dose dependent manner.
Effects of Wood Dust on Cardiopulmonary Functions and Anthropometric Parameters of Carpenters and Non-Carpenters in Sabon Gari Local Government Area, Kaduna State, Nigeria
Y. Tanko,Y. Olakunle, A. Jimoh, A. Mohammed, A.D.T. Goji and K.Y. Musa
Asian Journal of Medical Sciences , 2011,
Abstract: The aim of the study is to assess the blood pressure, pulse rate, peak expiratory flow rate, Forced Expiratory Volume in 1 sec (FEV1), and Forced Vital Capacity (FVC) of carpenters and non-carpenters in Sabon- Gari local government area, Zaria. Their Body Mass Index (BMI) and other anthropometric data were also obtained. 200 males between the ages of 18 and 35 were used for this research. 100 were carpenters and 100 were non carpenters. As regard to the pulse rate there was no significant change in the carpenters when compared with the non-carpenters. In relation to the systolic, diastolic and mean arterial blood pressure, there was a significant increase (p<0.05) in the carpenters when compared with the non-carpenters. Regarding the Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 sec (FEVI), (FEV1%), and peak expiratory flow rate, there was a significant decrease (p<0.05) in the carpenters when compared with the non-carpenters. Also, in the anthropometric parameters measured (height, weight, and BMI) there was no significant change in the carpenters when compared with the non-carpenters. In conclusion, the effect of wood dust on carpenters increases the arterial blood pressure, decreases the forced vital capacity, forced expiratory volume in 1 sec and peak expiratory flow rate.
Supernumerary Bones in the Walls of the Bony Orbit
K.Y. Manjunath
People's Journal of Scientific Research , 2013,
Abstract: Occurrence of supernumerary bones in the walls of the orbit especially in the medial wall and the roof has beendescribed in the literature. Studies of the prevalence of supernumerary bones in the bony wall of the orbit are scarce in theliterature. Present study was undertaken to find the prevalence of supernumerary bones in the walls of the orbit in acollection of adult Indian skulls.In the present study three hundred and twenty six orbital walls from one hundred and sixty three skulls wereexamined for the presence of the sutural bones. Their location with reference to the sutures in the walls of the orbit andtheir size was noted. The supernumerary bones were found in 25 skulls (15.34 %) mainly in the lateral wall (11.04 %) and theroof of the orbit (4.29 %). Prevalence of such supernumerary bones in the walls of the bony orbit is of anthropologicalinterest. Many of the bony ossicles were of sufficiently large size, enough to be visualized on lateral skull X-ray and couldeasily be mistaken for fracture of the bony wall of the orbit.
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