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Free radicals, oxidative stress and importance of antioxidants in human health
Amit Kunwar,K.I. Priyadarsini
Journal of Medical and Allied Sciences , 2011,
Abstract: Reactive oxygen species (ROS) is a collective term used for oxygen containing free radicals, depending on their reactivity and oxidizing ability. ROS participate in a variety of chemical reactions with biomolecules leading to a pathological condition known as oxidative stress. Antioxidants are employed to protect biomolecules from the damaging effects of such ROS. In the beginning, antioxidant research was mainly aimed at understanding free radical reactions of ROS with antioxidants employing biochemical assays and kinetic methods. Later on, studies began to be directed to monitor the ability of anti-oxidants to modulate cellular signaling proteins like receptors, secondary messengers, transcription factors, etc. Of late several studies have indicated that antioxidants can also have deleterious effects on human health depending on dosage and bio-availability. It is therefore, necessary to validate the utility of antioxidants in improvement of human health in order to take full advantage of their therapeutic potential.
Normal and anomaly development of embryonic heart outflow tract and outflow tract defects. Participation of neural crest cells
Shapoval K.I.
Морфолог?я , 2008,
Abstract: This work analyzes the basic stages of development of the important transient structure in the cardiogenesis - outflow tract (OT). It is the predecessor of aorta and pulmonary trunk, which determines and controls many events of embryonic hearts development: the closure of secundary interventricular foramen, valves formation, aortic vestibule and pulmonary infundibulum development. The basic stages of normal OT development are reorganization of the aortopulmonary septation complex, rotation, formation of conotrunk transition, aortic vestibule and pulmonary infundibulum formation, the closure of interventricular foramen. The abnormalities of these processes cause the birth heart defects. The late closure interventricular septum results in abnormal establishment of aorta and alignment of ventricles with large vessels. The disputable questions concerning terminology, spatial representation and hypothetical models of OT, sources of an origin continue to remain. The future researches will be connected to neural crest cells contribution to OT transformation, namely their influence on processes of cell apoptosis and proliferation.
Effect of antihypertensive therapy based on new method of individual choice of drugs on left ventricular hypertrophy in elderly patients
K.I. Pshenichkin
Rational Pharmacotherapy in Cardiology , 2007,
Abstract: Aim. To study the effects of antihypertensive therapy based on consideration of individual heart rhythm variability (HRV) on left ventricular hypertrophy (LVH) in hypertensive elderly patients.Material and methods. 60 hypertensive elderly patients with LVH were included in the study. They were split in two groups (30 people in each one).Patients of the group-I had common antihypertensive therapy. Patients of group-II received medications prescribed with consideration of individual heart rate variability. Holter monitoring with analysis of HRV, 24-hour blood pressure monitoring and ultra sonography were conducted initially and 18 months after treatment beginning.Results. BP control was reached in the majority of patients of both groups. The patients of group-II in comparison with patients of group-I had reduction of low- high frequency power ratio (LF/HF) and higher rate of LVH reduction. Relationship between LVH dynamics and ratio LF/HF was found.Conclusion. Arterial hypertension therapy considering individual HRV contributes in LVH reduction in elderly patients.
Qualitative and quantitative characteristic ofthe population of mesenchymal cells in structural components from conotruncal region of the embryo heart on its early hystogenesis
Dyagovets K.I.
Морфолог?я , 2012,
Abstract: Character of the distribution of the mesenchymal’s cellspopulation was analysed during the early hystogenesis of the conotruncal region of the mouse embr yo heart. Conotruncalregion is the predecessor of the proximal part of the aorta and pulmonary trunk, of the aortic ruff and conus arteriosus and semilunar valves. Violation of its transformations leading to the formation of congenital heart disease,which named conotruncal defects . The material was used embryos mice by the C57BL / 6 line, which covers the period of from 10 to 12.5th day, which corresponded to a 16-21 Teilor stages. Quantify the planar and volumetric distribution of a population of mesenchymal stem cells conotruncus’s pillows and ridges by the original method; on the basis of serial pictures of embryo heart with the use of the computer providing Photoshop Cs5, Amira of for microscopy 5.0, 3ds max 8.0, we created the three-dimensional models of structural components of the conotruncus embryonic mouse heart. During this research noted the phased settlement condensed esenchymal stem fraction first and then tapered sections, given the qualitative and quantitative assessment of the distribution of the conotruncus’s mesenchyme embryonic mouse heart.
Tannin–Phenol Formaldehyde Resins As Binders for Cellulosic Fibers: Mechanical Properties  [PDF]
A.S. Hussein, K.I. Ibrahim, K. M. Abdulla
Natural Resources (NR) , 2011, DOI: 10.4236/nr.2011.22013
Abstract: In this study Eucalyptus tannin (T) was isolated from outer bark of Eucalyptus trees; as sodium phenoxide salt and used as extender or copolymer into phenol formaldehyde (PF) resin at five percent (10, 20, 30, 40 and 50)% W/W. Tan-nin-phenol formaldehyde (TPF) and tannin formaldehyde-phenol formaldehyde (TFPF) resins that synthesized in this study were evaluated as adhesive material for cellulosic fibers by study the mechanical properties of the composite sheets .The results show that the substituting of (PF) with tannin at (10 –50)% W/W give resins with mechanical properties comparable or near to those of pure (PF) , where the tensile strength at break (Tb) ranging from 15.15 Mpa to 22.27 Mpa as compared with 17.6 Mpa for pure (PF); while the impact strength properties (Im) of composites sheets increased with increased the (T) percents which were about 5.16 KJ/m2 for (TPF – 10%) and 7.21 KJ/m2 for (TPF - 50%) .On the other hand modification of (T) to tannin formaldehyde resin (TF) appear less performance at the results of this study , this effect probably to low penetration of (TFPF) resins between the small voids of cellulose fibers when soaked it in resin solutions. In general the results of this study indicate that the Eucalyptus tannin can be used for par-tial substitution of (PF) to produce resins with feasible mechanical properties and can be used in some applications of (PF) resins.
Repositioning the Power Industry in Nigeria to Guarantee Reliability in Operations and Services
K.I. Idigbe,S.O. Onohaebi
Journal of Engineering and Applied Sciences , 2012,
Abstract: Nigeria is endowed with reserves of natural gas in excess of 200 Trillion cubic feet (Tcf), to thermally generate enough power for all sectors-home, commercial and industries. While, there is no doubt about the high demand for electricity in Nigeria, the power industry has being marginally functional. This study reviewed the present state of the power industry in Nigeria and investigated the modalities of re-positioning power to guarantee reliability in operations and services. The findings showed that a collaborative and mutually beneficial business initiative with the petroleum industry is desired and should be encouraged and sustained. Power should be classified and traded as a commodity through a private value market, with greater emphasis on best practices in operations and asset management, a free market oriented supply side management structure should be put in place and service contract financing with Construct, Commission, Operate to recover costs and Lease (CCOL) scheme option is desired for all projects in the power sector.
Profitability of Catfish Production in JOS Metropolis of Plateau State, Nigeria: A Profit Function Approach
K.I. Okeke-Agulu,N.A. Chukwuone
Agricultural Journal , 2013, DOI: 10.3923/aj.2012.226.229
Abstract: The study examined the profitability of catfish production in JOS metropolis of Plateau state, Nigeria. Primary data were obtained from 60 respondents drawn from the list of members of catfish farmers association using simple random sampling technique. Data were analysed using net farm income and profit function models. Results showed that the average returns per farm of 1000 fish capacity was 246,343 per production cycle while the returns per naira invested was 2.3 times. The profit function analysis revealed that 83% of the variation in maximum variable profit was explained by the combined effects of the variable costs in the function. The t-statistics indicated that with the exception of labour, all other variable costs were positively significant in influencing profit, although the cost of drugs and veterinary care showed a negative significant relationship. The study recommends the investigation of the alleged detrimental effect of cold weather on fish growth and development in the study area by the National Institute for Fresh Water fisheries research with a view to advising the farmers appropriately.
Efficacy of Diminazene Aceturate with and without Levamisole or Dimethyl Sulfoxide in Reducing Organ Weight and Parasitemia in T. congolense Infected Rats
Eghianruwa, K.I.,Anika, S.M.
International Journal of Animal and Veterinary Advances , 2012,
Abstract: The efficacies of diminazene aceturate alone and in separate combinations with levamisole and Dimethyl Sulfoxide (DMSO) in the treatment of T. congolense infection in rats were assessed on day 7 post infection and days 7 and 14 post treatment using changes in the weights and histology of the liver, spleen, heart and brain as well as parasitemia as parameters. Infected rats were treated with 7.0 mg/kg diminazene aceturate on day 7 post infection following which DMSO (0.5, 1.0 and 2.0 g/kg, respectively) and levamisole (10, 20 and 40 mg/kg, respectively) were administered as daily supplements to different groups of rats. Trypanosoma congolense only caused significant increase in spleen weight. There were no histopathological lesions in any organ. Infection had no effect on heart weight. Liver and spleen weights were lower in the diminazene group by day 7 Post Treatment (PT), but this situation was reversed by day 14 PT. Increase in the dose of DMSO caused increased liver weight. Diminazene/DMSO combination was more effective at 14 days PT in reducing spleen weight than treatment with diminazene alone. On the contrary, diminazene/levamisole combination was less effective than diminazene alone in reducing spleen weight. Parasites disappeared after diminazene treatment but reappeared only in the diminazene and levamisole groups by day 14 PT. Early relapse and high virulence of the Basa strainof T. congolense used may be responsible for the ineffectiveness of the three treatment protocols.
Effects of DMSO on Diminazene Efficacy in Experimental Murine T. brucei Infection
K.I. Eghianruwa,S.M. Anika
International Journal of Animal and Veterinary Advances , 2012,
Abstract: This study evaluated the influence of dimethyl sulfoxide (DMSO) daily supplementation on diminazene treatment of trypanosomosis. Four groups of Trypanosoma brucei brucei infected rats received 7.0 mg/kg diminazene aceturate on day 7 post infection. Three of the four groups received different doses of DMSO (0.5, 1.0 and 2.0 g/kg, respectively) in addition to diminazene treatment. The changes in hematological parameters and the weights of liver, spleen and heart caused by T. brucei infection were monitored and used to assess the efficacy of treatment. The prepatent period of infection was four days. Infection caused significant increases in WBC count, spleen and liver weights but it caused decreases in PCV, HB and RBC by day 7 post infection (PI7). By PI14, spleen weight and WBC counts were reduced from the PI7 level without treatment. Diminazene/DMSO combination did not reduce liver weight or increased hematological parameters more significantly than diminazene treatment alone. Increase in the dose of DMSO caused increases in liver weight. Diminazene/DMSO combination reduced spleen weight more significantly than diminazene treatment alone. Diminazene/DMSO combination delayed re-emergence of parasites beyond PT21 at which time parasites were detected in the blood of rats treated only with diminazene. The limited advantages of diminazene/DMSO combination over diminazene alone as well as the possible liver toxicity of DMSO at high doses would not make DMSO supplementation a viable addition to trypanosomosis chemotherapy.
Studies on the Anti–Inflammatory and Analgesic Properties of Chenopodium Ambrosioides Leaf Extract in Rats
G.F. Ibironke,K.I. Ajiboye
International Journal of Pharmacology , 2007,
Abstract: A methanol extract of the dried leaves of Chenopodium ambrosioides was investigated for anti-inflammatory and analgesic activities. The extract (300-700 mg kg-1, p.o.) produced a dose related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with the hotplate device maintained at 55°C as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of Chenopodium ambrosioides traditionally for the treatment of painful inflammatory conditions.
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