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Search Results: 1 - 10 of 141193 matches for " K. Watanabe "
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ACM bundles on K3 surfaces of genus 2
K. Watanabe
Mathematics , 2014,
Abstract: Let $\pi:X\rightarrow \mathbb{P}^2$ be a K3 surface of genus 2 and $L=\pi^{\ast}\mathcal{O}_{\mathbb{P}^2}(3)$, and assume that $\pi^{\ast}\mathcal{O}_{\mathbb{P}^2}(1)$ is ample as a line bundle on $X$. In this paper, we give a numerical characterization of initialized and ACM line bundles on $X$ with respect to $L$ and construct families of semistable indecomposable ACM bundles of higher rank, by using extensions of ACM line bundles.
Amplification of Quantum Meson Modes in the Late Time of the Chiral Phase Transition
Watanabe, K.;Tsue, Y.
High Energy Physics - Phenomenology , 2007, DOI: 10.1142/S0218301307007891
Abstract: We investigate the time evolution of the quantum meson modes in the late time of chiral phase transition. In particular, it is shown that there exists a possible solution to the equation of motion for the quantum meson modes, which reveals a parametric resonance and/or resonance through forced oscillation induced by the small oscillation of the chiral condensate. After that, we demonstrate the unstable regions for the quantum meson modes in both the cases of a uniform and spatially expanding system.
Amplification of Quantum Meson Modes in the Late Time of the Chiral Phase Transition
K. Watanabe,Y. Tsue
Physics , 2007, DOI: 10.1142/S0218301307007891
Abstract: We investigate the time evolution of the quantum meson modes in the late time of chiral phase transition. In particular, it is shown that there exists a possible solution to the equation of motion for the quantum meson modes, which reveals a parametric resonance and/or resonance through forced oscillation induced by the small oscillation of the chiral condensate. After that, we demonstrate the unstable regions for the quantum meson modes in both the cases of a uniform and spatially expanding system.
Potential inversion with subbarrier fusion data revisited
K. Hagino,Y. Watanabe
Physics , 2007, DOI: 10.1103/PhysRevC.76.021601
Abstract: We invert experimental data for heavy-ion fusion reactions at energies well below the Coulomb barrier in order to directly determine the internucleus potential between the colliding nuclei. In contrast to the previous applications of the inversion formula, we explicitly take into account the effect of channel couplings on fusion reactions, by assuming that fusion cross sections at deep subbarrier energies are governed by the lowest barrier in the barrier distribution. We apply this procedure to the $^{16}$O +$^{144}$Sm and $^{16}$O +$^{208}$Pb reactions, and find that the inverted internucleus potential are much thicker than phenomenological potentials. A relation to the steep fall-off phenomenon of fusion cross sections recently found at deep subbarrier energies is also discussed.
Goeritz Invariant of Torus Links
K. Ahara,S. Watanabe
Mathematics , 2013,
Abstract: We obtain the full list of Goeritz invariants of all torus knots and links.
Contributions of GRBs and Cen A-like Radio Galaxies to the Cosmic Gamma-ray Background
K. Watanabe,D. H. Hartmann
Physics , 2001, DOI: 10.1063/1.1419445
Abstract: The contribution to the cosmic diffuse gamma-ray background (CGB) from Gamma Ray Bursts (GRBs) is studied in the 40 keV - 2 MeV regime. We use High Energy Resolution (HER) data from the Burst And Transient Source Experiment (BATSE) aboard the Compton Gamma-Ray Observatory (CGRO) to generate a GRB template spectrum. Although the GRB contribution to the CGB is generally small, in comparison to the dominant flux from Type Ia supernovae, the integrated GRB flux is in fact comparable to that from SNIa in the narrow 10-40 keV range. GRBs contribute to the CGB at the same level as Type II supernovae do. Although BATSE data are not available below ~40 keV, extrapolation of the template spectrum suggests that bursts can fill a significant part of the existing gap between Seyfert galaxies (dominating the CGB below ~ 100 keV) and SNIa (dominating at ~1 MeV). We estimate contributions from Cen A-like (FR I) radio galaxies in this energy regime, where INTEGRAL data is expected to provide major advances.
Numerical evaluation of AC losses in an HTS insert coil for high field magnet during its energization
K. Kajikawa,S. Awaji,K. Watanabe
Physics , 2014,
Abstract: AC losses in a high temperature superconducting (HTS) insert coil for a 25-T cryogen-free superconducting magnet are numerically calculated during its energization, assuming slab approximation. The HTS insert coil consists of 68 single pancakes wound with coated conductors and generating a central magnetic field of 11.5 T, in addition to a contribution of 14.0 T from a set of low temperature superconducting (LTS) outsert coils. Both the HTS and LTS coils are cooled using cryocoolers, and energized simultaneously up to 25.5 T with a constant ramp rate for 60 min. The influences of the magnitudes and orientations of the locally applied magnetic fields, magnetic interactions between turns, and the transport currents flowing in the windings are taken into account in the AC loss calculations. The locally applied fields are separated into axial and radial components, and the individual contributions of these field components to the AC losses are summed simply to obtain the total losses. The contribution of the axial field component to the total AC loss is large at the early stages of the energization, whereas the total losses monotonically increase with time after the contribution of the radial field component becomes sufficiently large.
The Earth effects on the supernova neutrino spectra
K. Takahashi,M. Watanabe,K. Sato
Physics , 2000, DOI: 10.1016/S0370-2693(01)00610-4
Abstract: The Earth effects on the energy spectra of supernova neutrinos are studied. We analyze numerically the time-integrated energy spectra of neutrino in a mantle-core-mantle step function model of the Earth's matter density profile. We consider a realistic frame-work in which there are three active neutrinos whose mass squared differences and mixings are constrained by the present understanding of solar and atmospheric neutrinos. We find that the energy spectra change for some allowed mixing parameters. Especially, the expected number of events at SNO shows characteristic behavior with respect to energy, i.e. a great dip and peak. We show that observations of the Earth effect allow us to identify the solar neutrino solution and to probe the mixing angle $\theta_{2}$.
Pharmacogenetics of Anti-Diabetes Drugs
Johanna K. DiStefano,Richard M. Watanabe
Pharmaceuticals , 2010, DOI: 10.3390/ph3082610
Abstract: A variety of treatment modalities exist for individuals with type 2 diabetes mellitus (T2D). In addition to dietary and physical activity interventions, T2D is also treated pharmacologically with nine major classes of approved drugs. These medications include insulin and its analogues, sulfonylureas, biguanides, thiazolidinediones (TZDs), meglitinides, α-glucosidase inhibitors, amylin analogues, incretin hormone mimetics, and dipeptidyl peptidase 4 (DPP4) inhibitors. Pharmacological treatment strategies for T2D are typically based on efficacy, yet favorable responses to such therapeutics are oftentimes variable and difficult to predict. Characterization of drug response is expected to substantially enhance our ability to provide patients with the most effective treatment strategy given their individual backgrounds, yet pharmacogenetic study of diabetes medications is still in its infancy. To date, major pharmacogenetic studies have focused on response to sulfonylureas, biguanides, and TZDs. Here, we provide a comprehensive review of pharmacogenetics investigations of these specific anti-diabetes medications. We focus not only on the results of these studies, but also on how experimental design, study sample issues, and definition of ‘response’ can significantly impact our interpretation of findings. Understanding the pharmacogenetics of anti-diabetes medications will provide critical baseline information for the development and implementation of genetic screening into therapeutic decision making, and lay the foundation for “individualized medicine” for patients with T2D.
Functional coating of liposomes using a folate–polymer conjugate to target folate receptors
Watanabe K, Kaneko M, Maitani Y
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S32853
Abstract: nctional coating of liposomes using a folate–polymer conjugate to target folate receptors Original Research (2483) Total Article Views Authors: Watanabe K, Kaneko M, Maitani Y Published Date July 2012 Volume 2012:7 Pages 3679 - 3688 DOI: http://dx.doi.org/10.2147/IJN.S32853 Received: 11 April 2012 Accepted: 14 May 2012 Published: 13 July 2012 Kazuo Watanabe, Makoto Kaneko, Yoshie Maitani Institute of Medical Chemistry, Hoshi University, Tokyo, Japan Abstract: Folate-polymer-coated liposomes were developed for targeted chemotherapy using doxorubicin (DXR) as a model drug. Folate-poly(L-lysine) (F–PLL) conjugates with a folate modification degree of 16.7 mol% on epsilon amino groups of PLL were synthesized. DXR-loaded anionic liposomes were coated with F–PLL, and the cellular association of F–PLL-coated liposomes was evaluated by flow cytometry, and confocal microscopy in human nasopharyngeal carcinoma KB cells overexpressing folate receptors (FRs), and human lung adenocarcinoma A549 cells [FR (-)]. The existence of a polymer layer on the surface of F–PLL-coated liposomes was confirmed by zeta potential analysis. The KB cellular association of F–PLL-coated liposomal DXR was increased compared with that of PLL-coated liposomes and was inhibited in the presence of free folic acid. Twofold higher cytotoxicity of F–PLL-coated liposomal DXR was observed compared with that of the PLL-coated liposomal DXR in KB cells, but not in A549 cells, suggesting the presence of FR-mediated endocytosis. These results indicated that folate-targeted liposomes were prepared successfully by coating the folate–polymer conjugate F–PLL. This novel preparation method of folate-targeted liposomes is expected to provide a powerful tool for the development of a folate-targeting drug nanodevice as coating with ligand–polymer conjugates can be applicable to many kinds of particles, as well as to lipid-based particles.
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