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Search Results: 1 - 10 of 138694 matches for " K. Subathra "
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Coefficient Estimates for α-λ Sprial-Like Functions of Order β
S. Rajasekaran,K. Subathra
Journal of Modern Mathematics and Statistics , 2012,
Abstract: Let α≥ 0, 0 ≤β< 1, |λ| < π/2 and suppose that f(z) = z + is said to be α- λsprial-like of order β if it satisfies Re {(eiλ- α) zf (z)/f(z) + α(1+zf (z)/f (z)). In this study we determine sharp bounds for the moduli |an| of the coefficients.
Sphingomyelin Synthases Regulate Protein Trafficking and Secretion
Marimuthu Subathra,Asfia Qureshi,Chiara Luberto
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0023644
Abstract: Sphingomyelin synthases (SMS1 and 2) represent a class of enzymes that transfer a phosphocholine moiety from phosphatidylcholine onto ceramide thus producing sphingomyelin and diacylglycerol (DAG). SMS1 localizes at the Golgi while SMS2 localizes both at the Golgi and the plasma membrane. Previous studies from our laboratory showed that modulation of SMS1 and, to a lesser extent, of SMS2 affected the formation of DAG at the Golgi apparatus. As a consequence, down-regulation of SMS1 and SMS2 reduced the localization of the DAG-binding protein, protein kinase D (PKD), to the Golgi. Since PKD recruitment to the Golgi has been implicated in cellular secretion through the trans golgi network (TGN), the effect of down-regulation of SMSs on TGN-to-plasma membrane trafficking was studied. Down regulation of either SMS1 or SMS2 significantly retarded trafficking of the reporter protein vesicular stomatitis virus G protein tagged with GFP (VSVG-GFP) from the TGN to the cell surface. Inhibition of SMSs also induced tubular protrusions from the trans Golgi network reminiscent of inhibited TGN membrane fission. Since a recent study demonstrated the requirement of PKD activity for insulin secretion in beta cells, we tested the function of SMS in this model. Inhibition of SMS significantly reduced insulin secretion in rat INS-1 cells. Taken together these results provide the first direct evidence that both enzymes (SMS1 and 2) are capable of regulating TGN-mediated protein trafficking and secretion, functions that are compatible with PKD being a down-stream target for SMSs in the Golgi.
Studies on Various Atmospheric Microorganisms Affecting the Plant Tissue Culture Explants
C. Subathra Devi,V. Mohana Srinivasan
American Journal of Plant Physiology , 2006,
Abstract: Bacterial and fungal contaminants create a major problem in plant tissue culture laboratory. Once the explants have been established in vitro, it is essential that the culture to be indexed for the presence of microbial contaminants before being multiplied. Besides increased morality, the presence of latent infection can result in variable growth, tissue necrosis, reduced shoot proliferation and reduced rooting. The percentage occurrence of contaminants in initial and establishment stage of sugarcane tissue culture process was studied. Fungal and bacterial contaminants were isolated from different varieties sugarcane explants. Contaminants were more in the initial stage when compared to the establishment stage. The most predominantly occurring bacteria were Bacillus sp. Serratia sp. Pseudomonas sp. and Staphylococcus sp. and the most dominating fungal contaminants were Aspergillus, Candida, Cladosporium, Fusarium, Microsporum and Pencillum. Highest percentage occurrence was recorded for bacterial contaminants.
An Evaluation of Location Privacy in Wireless Sensor Networks
International Journal of Computer Science and Mobile Computing , 2013,
Abstract: Due to the open nature of a sensor network, it is relatively easy for an adversary to eavesdrop andtrace packet movement in the network in order to capture the receiver physically. After studying theadversary’s behavior patterns, we present countermeasures to this problem. We propose a location-privacyrouting protocol (LPR) that is easy to implement and provides path diversity. Combining with fake packetinjection, LPR is able to minimize the traffic direction information that an adversary can retrieve fromeavesdropping. By making the directions of both incoming and outgoing traffic at a sensor node uniformlydistributed, the new defense system makes it very hard for an adversary to perform analysis on locallygathered information and infer the direction to which the receiver locates. We evaluate our defense systembased on three criteria: delivery time, privacy protection strength, and energy cost. The simulation resultsshow that LPR with fake packet injection is capable of providing strong protection for the receiver’s locationprivacy. Under similar energy cost, the safe time of the receiver provided by LPR is much longer than othermethods, including Phantom routing [1] and DEFP [2]. The performance of our system can be tunedthrough a couple of parameters that determine the tradeoff between energy cost and the strength of locationprivacyprotection.
In vitro Propagation of Gymnema sylvestre
C. Subathra Devi,V. Mohana Srinivasan
Asian Journal of Plant Sciences , 2008,
Abstract: The need of MS salts for shoot sprouting and proliferation shows the high salt requirement for the growth of Gymnema sylvestre. Influence of plant growth regulators, IAA, BA, 2,4-D and kinetin on shoot sprouting was investigated. Synergistic effect of Vitamin B2 was studied. To overcome phenolic exudation and the effects of antioxidants, the effect of activated charcoal, citric acid and ascorbic acid were investigated. Incorporation of citric acid (100 mg L-1) to the medium prevented phenolic exudation and increased the production of healthy normal shoots and shoot bud differentiation in Gymnema sylvestre. There was a considerable improvement in rooting as about 53% shoots could be induced to root on 1/2 MS medium within 45 days with a fairly good length and number of roots per shoot. MS medium containing 1 mg L-1 BA+0.5 mg L-1 IAA + 100 mg L-1 Vitamin B2+100 mg L-1 citric acid is best for shoot proliferation and 1/2 strength MS medium with IBA 3 mg L-1 is best for root induction.
Single Stage Switching Power Supply With Half
International Journal of Engineering and Advanced Technology , 2012,
Abstract: Single stage switching power supply with half bridgetopology simulation for LED lamp Driver is presented in thispaper.LED lamp driver needs only dc supply. In this paper dcsupply is obtained as output while giving ac input voltage of 110V.It is formed by combination of ac/dc converter and dc/dc postregulator. Compared to other switching power supply this reducescost ,size and simplifies circuit design. It increases efficiency andoutput voltage can be controlled. The simulation of single stageswitching power supply using half bridge topology using Psimsoftware is done and output voltage and power are verified .byusing this get an output voltage of 48 V dc output and power rangeup to 120 W ,and efficiency is above .89 . It is used in LED lampdrivers and piezoelectric element drivers.
Isolation and Identification of hydrocarbon degrading bacteria from Ennore creek
Mamitha Kumar Subathra,Grasian Immanuel,Albert Haridoss Sures
Bioinformation , 2013,
Abstract: The widespread problem caused due to petroleum products, is their discharge and accidental spillage in marine environment proving to be hazardous to the surroundings as well as life forms. Thus remediation of these hydrocarbons by natural decontamination process is of utmost importance. Bioremediation is a non-invasive and cost effective technique for the clean-up of these petroleum hydrocarbons. In this study we have investigated the ability of microorganisms present in the sediment sample to degrade these hydrocarbons, crude oil in particular, so that contaminated soils and water can be treated using microbes. Sediments samples were collected once in a month for a period of twelve months from area surrounding Ennore creek and screened for hydrocarbon degrading bacteria. Of the 113 crude oil degrading isolates 15 isolates were selected and cultivated in BH media with 1% crude oil as a sole carbon and energy source. 3 efficient crude oil bacterial isolates Bacillus subtilis I1, Pseudomonas aeruginosa I5 and Pseudomonas putida I8 were identified both biochemically and phylogenetically. The quantitative analysis of biodegradation is carried out gravimetrically and highest degradation rate, 55% was recorded by Pseudomonas aeruginosa I5 isolate.
C. Senthilkumar,G. Rameshkumar,S. Subathra,T. Suresh Kumar
International Research Journal of Pharmacy , 2012,
Abstract: The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Aqueous solubility of any therapeutically active substance is a key property, as it governs dissolution, absorption and thus the in vivo efficacy. The solubility behavior of drug remains one of the most challenging aspects in formulation development. Once if we are able to increase the aqueous solubility of a drug, the disintegration and dissolution properties can be easily altered, as a result, an increase in bioavailability can be easily achieved. This study deals with enhancing the dissolution of poorly soluble Class IV drug Cefpodoxime Proxetil, using different excipients. In order to achieve maximum dissolution, eight different formulations were developed. Optimization has proven as an effective tool in product development. The formulation ARL 8 was found to be optimized product. The different physical properties and in vitro release profile showed better and stable results when compared with marketed product.
Color Doppler evaluation of left gastric vein hemodynamics in cirrhosis with portal hypertension and its correlation with esophageal varices and variceal bleed
Adithan Subathra,Venkatesan Bhuvaneswari,Sundarajan Elangovan,Kate Vikram
Indian Journal of Radiology and Imaging , 2010,
Abstract: Aim: The purpose of this study was to assess the value of Doppler evaluation of left gastric vein hemodynamics when monitoring portal hypertension patients, by correlating Doppler ultrasonography (USG) parameters with the severity of esophageal varices and occurrence of variceal bleeding. Methods: This study was carried out on 100 patients using Doppler USG and endoscopy. Forty-seven of these were patients with cirrhosis with portal hypertension, who had not had a recent variceal bleed (group 1) and 26 were patients with cirrhosis with portal hypertension, with a recent history of bleeding (group 2). The control group comprised of 27 subjects who did not have liver disease or varices on endoscopy (group 3). The hemodynamic parameters, namely the diameter of the left gastric vein and the direction and flow velocity in the vessel, were compared in these groups, with the grade of esophageal varices. Results: Hepatofugal flow velocity in the left gastric vein was higher in patients with large-sized varices compared to those patients with small-sized varices (P < 0.001). The left gastric vein hepatofugal flow velocity was higher in patients with a recent variceal bleed than in those patients without a history of a recent variceal bleed (P < 0.0149). Large-sized varices were more commonly found in patients with a history of a recent variceal bleed (P < 0.0124). Conclusion: Left gastric vein hemodynamics were found to correlate with the severity of the varices and the occurrence of recent variceal bleed in patients with cirrhosis with portal hypertension. Evaluation of the left gastric vein portal dynamics could be helpful in monitoring the progress of the disease in these patients.
Rapid serodiagnosis of leptospirosis by latex agglutination test and flow-through assay
Senthilkumar TMA,Subathra M,Phil M,Ramadass P
Indian Journal of Medical Microbiology , 2008,
Abstract: Purpose: Diagnosis of leptospirosis facilitates patient management and initiation of therapy. The microscopic agglutination test (MAT) is the serological test used in reference laboratories because of its high degree of sensitivity and specificity. But the results are not available quickly for patient management. In the present study, in order to develop a simple, rapid immunodiagnostic assay, one of the outer membrane proteins (OMPs), recombinant LipL41 (rLipL41) has been utilised in latex agglutination test (LAT) and flow-through assay. Methods: Part of LipL41 gene was expressed in Escherichia coli system and purified. The rLipL41 antigen of pathogenic Leptospira interrogans serovar Icterohaemorrhagiae, which is conserved in all pathogenic Leptospira spp. was used as capture antigen in the LAT and flow-through test. Both tests are very rapid and could be completed within 5 minutes. The sensitivity and specificity of rLipL41 was assessed and evaluated in LAT and flow-through assay in comparison with standard MAT. Results: The sensitivity and specificity of the LAT were 89.70 and 90.45% and flow-through assay were 89.09 and 77.70%, respectively. Conclusions: The developed LAT and flow-through assays were simple, rapid and economical for the detection of leptospira infection and suitable for large-scale screening of samples in endemic areas without any sophisticated equipment.
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