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Search Results: 1 - 10 of 138763 matches for " K. Haliloglu "
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Distribution of PLRV, PVS, PVX and PVY (PVYN, PVYo and PVYc) in the Seed Potato Tubers in Turkey
H. Bostan,K. Haliloglu
Pakistan Journal of Biological Sciences , 2004,
Abstract: This study was conducted in order to determine the distribution ratio of PLRV, PVS and PVY (PVYN, PVYo and PVYc) in the seed potato tubers used for planting material in the important potato production regions of Turkey and observe the symptoms caused by single or mixed infection of these viruses under field condition. Firstly, over 880 leaf samples were tested by using virus-specific polyclonal antibodies. Secondly, 83 samples found to be infected with PVY in the result of first ELISA were retested by using PVYo, PVYN and PVYc-specific monoclonal antibodies. The ELISA results showed that seed potato tubers used for planting material was infected with at the rate of PLRV (14.2%), PVX (11.8%), PVS (4.6%) and PVY (17.7%). On the other hand, the result of monoclonal antibody for PVY-strains showed that the frequency of PVYN and PVYo were (13.4%, 4.3%) but PVYc was not found. Under field condition, plants infected with PLRV exhibited the rolling of young leaves, upright growth and pinky color but PVS did not cause any distinct symptoms. PVX alone or the combination of PVX with PLRV, PVS and PVY caused mild or severe mosaic symptoms on all cultivars. PVY induced yellowing of leaves, leaf drop streak, veinal necrosis on some plants from all cultivars, however, some plants did not develop any distinct symptoms in case of infected with PVY. The combination of PVY and PVX caused more severe mosaic, rugosity and reduced of leaf size. When plants infected with PVY and PLRV exhibited yellowing of leaves, leaf drop, dwarfing, rolling of leaves and rogositiy. However, some plants from Morfona and Granola cultivars died. On the other hand, the symptoms on plants infected with PVS and PLRV or PVS and PVY were similar to single infection of PLRV and PVY.
Evaluation of Side Effects of Monotherapy and Combined Drug Therapies on Gastrointestinal System in Patients with Juvenile Idiopathic Arthritis
Erguven M,,Sahin K,,Yilmaz O,,Haliloglu B
Calicut Medical Journal , 2007,
Abstract: Aim: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatologic disease of childhood. The aim of treatment in children with JIA is to suppress chronic inflammation and chronic joint pain and to provide a normal growth and development. In our study, we aimed to determine the gastrointestinal side effects of mono-therapy and combined therapy of Disease Modifying Anti-rheumatic Drugs (DMARDs) (methotrexate, sulfasalazine) and corticosteroids.Patients and Methods: Fifty out of 119 patients with JIA, followed-up in our Rheumatology out-patient clinic between the years 1996-2006 were enrolled in the study. The patients were grouped according to duration of drug intake and number of drugs used as; patients receiving therapy ≤ 3 years and patients receiving therapy > 3 years; patients treated with one drug and patients treated with multiple drugs. Features of gastrointestinal side effects are evaluated with laboratory and radiological work-up and the difference of side effects between single and combined drug therapies is investigated.Results: Twenty-four (48%) of the cases were female and 26 were male (52%). The average age of the patients was 11.82 ± 4.53 years. There was statistically no significant difference in terms of aminotransferase levels between the patients receiving mono-therapy and combined therapy and also between the patients that received ≤ 3 years and > 3 years therapy. Prevalence of nausea and vomiting was statistically higher in patients being treated >3 years, in patients receiving ≥2 drugs and with corticosteroids and methotrexate (p=0.0001). There was no significant relation between the type of the drug used and gastrointestinal system bleeding.Conclusion: Combined therapies can be safely used in terms of gastrointestinal side effects under regular follow-up.
Wheat Immature Embryo Culture for Embryogenic Callus Induction
Kamil Haliloglu
Journal of Biological Sciences , 2002,
Abstract: Four 2,4-D concentrations along with three embryo developmental stages were tested to determine the optimum morphogenesis of wheat immature embryo culture. Concentration of 2 mg L -1 2,4-D was found to be optimum level for morphogenesis which was a good indicator of embryogenesis. Compact and nodular calli were observed in first and second developmental stages of 2 mg L 1 2,4-D concentration. In addition, five callus initiation media were tested to determine effects of medium constituents on somatic embryogenesis of wheat (Triticum aestivum L.). The highest embryogenic callus formation was observed on MS+B5 medium (98.3%). Therefore, first and second developmental stages of 2 mg L -1 2,4-D concentration along with MS+B5 medium is suitable for embryogenic callus production in wheat.
Ullrich Congenital Muscular Dystrophy
Goknur Haliloglu,Haluk Topaloglu
Iranian Journal of Child Neurology , 2011,
Abstract: ObjectiveUllrich congenital muscular dystrophy is a rather severe type of congenital muscular dystrophy with early onset features related to motor development.In general it is inherited in autosomal recessive principles, however in the Western world mostly seen with de novo dominant mutations in the collagen VI genes. Milder form of the condition is the Bethlem myopathy. There may be overlap forms in the clinic resembling the Ehler-Danlos syndrome. There has been some radical efforts for cure especially through the apoptosis cascades.
Nucleotide Sequence Analysis for Assessment of Variability of Potato Leafroll Virus and Phylogenetic Comparisons
Kamil Haliloglu,Hidayet Bostan
Journal of Biological Sciences , 2002,
Abstract: Relationships were investigated by comparing the nucleotide sequences from 17 PLRV coat protein genes submitted in GenBank. The alignment of 479 positions required few gaps and these positions showed consensus among the sequences. Overall identity was 45.17%. A phylogenetic tree based on the nucleotide sequences was established. There are two major clusters originated from a common branch in the phylogram, but are distinct from each other. Australian isolate was found to be very distinct compared to other isolates in the phylogenetic relationship. In this study nine conserved region and their length ranging from 18 to 58 bp were found. Sequences of conserved regions are prerequisite to design PCR primers for group or isolate based diagnosis of viruses. This study provides preliminary information about relationships of CP genes of PLRV isolates to develop strategy in designing as well as engineering of CP based transgenic resistancy in plants.
Predicting Important Residues and Interaction Pathways in Proteins Using Gaussian Network Model: Binding and Stability of HLA Proteins
Turkan Haliloglu ,Ahmet Gul,Burak Erman
PLOS Computational Biology , 2010, DOI: 10.1371/journal.pcbi.1000845
Abstract: A statistical thermodynamics approach is proposed to determine structurally and functionally important residues in native proteins that are involved in energy exchange with a ligand and other residues along an interaction pathway. The structure-function relationships, ligand binding and allosteric activities of ten structures of HLA Class I proteins of the immune system are studied by the Gaussian Network Model. Five of these models are associated with inflammatory rheumatic disease and the remaining five are properly functioning. In the Gaussian Network Model, the protein structures are modeled as an elastic network where the inter-residue interactions are harmonic. Important residues and the interaction pathways in the proteins are identified by focusing on the largest eigenvalue of the residue interaction matrix. Predicted important residues match those known from previous experimental and clinical work. Graph perturbation is used to determine the response of the important residues along the interaction pathway. Differences in response patterns of the two sets of proteins are identified and their relations to disease are discussed.
Cooperative Transition between Open and Closed Conformations in Potassium Channels
Turkan Haliloglu ,Nir Ben-Tal
PLOS Computational Biology , 2008, DOI: 10.1371/journal.pcbi.1000164
Abstract: Potassium (K+) ion channels switch between open and closed conformations. The nature of this important transition was revealed by comparing the X-ray crystal structures of the MthK channel from Methanobacterium thermoautotrophicum, obtained in its open conformation, and the KcsA channel from Streptomyces lividans, obtained in its closed conformation. We analyzed the dynamic characteristics and energetics of these homotetrameric structures in order to study the role of the intersubunit cooperativity in this transition. For this, elastic models and in silico alanine-scanning mutagenesis were used, respectively. Reassuringly, the calculations manifested motion from the open (closed) towards the closed (open) conformation. The calculations also revealed a network of dynamically and energetically coupled residues. Interestingly, the network suggests coupling between the selectivity filter and the gate, which are located at the two ends of the channel pore. Coupling between these two regions was not observed in calculations that were conducted with the monomer, which emphasizes the importance of the intersubunit interactions within the tetrameric structure for the cooperative gating behavior of the channel.
Hot Spots in a Network of Functional Sites
Pemra Ozbek, Seren Soner, Turkan Haliloglu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074320
Abstract: It is of significant interest to understand how proteins interact, which holds the key phenomenon in biological functions. Using dynamic fluctuations in high frequency modes, we show that the Gaussian Network Model (GNM) predicts hot spot residues with success rates ranging between S 8–58%, C 84–95%, P 5–19% and A 81–92% on unbound structures and S 8–51%, C 97–99%, P 14–50%, A 94–97% on complex structures for sensitivity, specificity, precision and accuracy, respectively. High specificity and accuracy rates with a single property on unbound protein structures suggest that hot spots are predefined in the dynamics of unbound structures and forming the binding core of interfaces, whereas the prediction of other functional residues with similar dynamic behavior explains the lower precision values. The latter is demonstrated with the case studies; ubiquitin, hen egg-white lysozyme and M2 proton channel. The dynamic fluctuations suggest a pseudo network of residues with high frequency fluctuations, which could be plausible for the mechanism of biological interactions and allosteric regulation.
The Effects of Dietary Protein Level on Serum Growth Hormone, Insulin-Like Growth Factors and Performance in Kivircik Lambs
T. Bilal,O. Keser,B. Serpek,S. Haliloglu
Journal of Animal and Veterinary Advances , 2012,
Abstract: Due to studies on the effect of dietary protein on serum Growth Hormone (GH) and insulin-like growth factor-1 (IGF-1) concentrations in lambs fed at different levels of dietary protein are limited, this study was conducted to determine the effect of dietary protein level on GH and IGF-1 concentrations and performance in lambs. A total of 50 Kivircik male lambs were randomly selected for this experiment. Lambs were randomly assigned ten lambs to each of the five treatment diets containing 10, 12, 14, 16 and 18% CP to determine the effects of dietary CP level on performance, serum GH and IGF-1 concentrations. The initial body weight was similar for all lambs and averaged 26.20 1.10 kg. Final body weight of lambs were 37.31 1.46, 39.60 1.18, 39.85 1.24, 42.04 1.25 and 41.44 1.13 kg for groups fed 10, 12, 14, 16 and 18% CP, respectively and lambs fed 16 and 18% CP diet had significantly higher body weight than those of 10% CP (p<0.05). Mean concentrations of GH and IGF-1 in blood serum of lambs were not different significantly between groups.
Right ventricular lipoma
Ilkay Erdogan,Dursun Alehan,Tuncay Hazirolan,Mithat Haliloglu
Anadolu Kardiyoloji Dergisi , 2008,
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