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Search Results: 1 - 10 of 138584 matches for " K. Ghaffarzadegan "
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Expression of Membranous Epidermal Growth Factor Receptor in Colorectal Adenocarcinoma and It s Correlation with Clinicopathological Features
G. Mohammadi,K. Jamialahmadi,S. Lary,K. Ghaffarzadegan
Pakistan Journal of Biological Sciences , 2011,
Abstract: The aim of this study was to investigate the expression of membranous epidermal growth factor receptor in colorectal adenocarcinoma and its correlation with clinicopathological features. Fifty formalin-fixed, paraffin embedded archival specimens of colorectal cancer were included randomly as cases. Immunohistochemical staining was performed to assess EGFR expression. The results were correlated with the clinicopathological features of colorectal tumor tissues. More than 1% of membranous EGFR expression was found in 24 (48%) of cancer specimens. The immunoreactions intensity was classified as weak, moderate and strong representing 2, 22 and 24%, respectively. According to multivariate analysis, EGFR expression was not significantly associated with age, sex, tumor site, stage, grade and type of tumor in cases. These results suggest that the assessment of EGFR expression in colorectal cancer by conventional immunohistochemistry has not proven its predictive value and can not be useful to predict about outcome of patients.
Plasma Brain Natriuretic Peptide (BNP) as an Indicator of Left Ventricular Function, Early Outcome and Mechanical Complications after Acute Myocardial Infarction
A. Fazlinezhad,M. Khadem Rezaeian,H. Yousefzadeh,K. Ghaffarzadegan
Clinical Medicine Insights: Cardiology , 2011,
Abstract:
Plasma Brain Natriuretic Peptide (BNP) as an Indicator of Left Ventricular Function, Early Outcome and Mechanical Complications after Acute Myocardial Infarction
A. Fazlinezhad, M. Khadem Rezaeian, H. Yousefzadeh, K. Ghaffarzadegan and M. Khajedaluee
Clinical Medicine Insights: Cardiology , 2012, DOI: 10.4137/CMC.S7189
Abstract: Aims: This study investigated the prognostic value of B type natriuretic peptide (BNP) in acute myocardial infarction (AMI) patients and its relation with left ventricular function and post-myocardial infarction complications. Methods: In this cross-sectional study, plasma BNP level was measured for 42 consecutive patients (mean ± SD: 61.6 ± 10.85 years old) with acute ST elevation myocardial infarction (MI) and 42 healthy, age and gender matched subjects. Result: BNP level in AMI patients were significantly higher than control group (P < 0.001). Regarding to infarct location, the highest BNP level measured in inferoposterior MI (BNP = 4436.63 ± 6188.159 pg/ml) and the lowest one indicated in standalone inferior MI (BNP = 598.83 ± 309.867 pg/ml (P = 0.071). There was significant reverse relation between BNP and EF (P = 0.006, OR = -0.47) and a significant relationship between BNP and killip classification (P = 0.036). There was no significant relation between diastolic and right-ventricular function and BNP level (P = 0.61, P = 0.21). The highest BNP level was detected in LV septal rupture and false aneurysm (P = 0.02) and in ventricular tachycardia, but without significant relationship (P = 0.25). Conclusion: After the onset of AMI, BNP blood level can be used as an important predictor for left ventricular dysfunction, killip classification, early mechanical complications and cardiac death.
Evaluation of Angiogenesis in Colorectal Carcinoma by CD34 Immunohistochemistry Method and its Correlation with Clinicopathologic Parameters
Sharifi Nourieh,Ghaffarzadegan Kamran,Ayatollahi Hossein,Shakeri Mohammad Taghi
Acta Medica Iranica , 2009,
Abstract: The basic pathogenic step in the process of tumor growth, invasion and metastasis is tumor-induced angiogenesis. The aim of this study was to evaluate the angiogenesis in colorectal carcinoma by microvascular density (MVD) determination with IHC (immunohistochemistry) method and to determine if and how angiogenesis correlates with clinicopathologic parameters. Sixty two archival, paraffin embedded tissue samples of colorectal carcinoma from Omid Hospital (Mashhad, Islamic republic of Iran) were selected. Microvessels were identified immunohistochemically, using monoclonal CD34 antibody. Two investigators examined the microvessel density then the median value of MVD was determined and correlated with clinicopathologic parameters. Tumor-induced angiogenesis of colorectal carcinoma statistically correlated with histological tumor grade (P=0.000). There was no significant correlation between intratumoral microvessel density and sex and age of patients, localization, and stage and histologicalal tumor type (P > 0.1). Intratumoral microvessel density quantification in histologic specimens of colorectal carcinoma reflects the grade of tumors and may be a useful additional prognostic factor.
The Constrained Mean-Semivariance Portfolio Optimization Problem with the Support of a Novel Multiobjective Evolutionary Algorithm  [PDF]
K. Liagkouras, K. Metaxiotis
Journal of Software Engineering and Applications (JSEA) , 2013, DOI: 10.4236/jsea.2013.67B005
Abstract:

The paper addresses the constrained mean-semivariance portfolio optimization problem with the support of a novel multi-objective evolutionary algorithm (n-MOEA). The use of semivariance as the risk quantification measure and the real world constraints imposed to the model make the problem difficult to be solved with exact methods. Thanks to the exploratory mechanism, n-MOEA concentrates the search effort where is needed more and provides a well formed efficient frontier with the solutions spread across the whole frontier. We also provide evidence for the robustness of the produced non-dominated solutions by carrying out, out-of-sample testing during both bull and bear market conditions on FTSE-100.

Design of a Cantilever - Type Rotating Bending Fatigue Testing Machine  [PDF]
K. K. Alaneme
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.1011078
Abstract: This research is centered on the design of a low–cost cantilever loading rotating bending fatigue testing machine using locally sourced materials. The design principle was based on the adaptation of the technical theory of bending of elastic beams. Design drawings were produced and components/materials selections were based on functionality, durability, cost and local availability. The major parts of the machine: the machine main frame, the rotating shaft, the bearing and the bearing housing, the specimen clamping system, pulleys, speed counter, electric motor, and dead weights; were fabricated and then assembled following the design specifications. The machine performance was evaluated using test specimens which were machined in conformity with standard procedures. It was observed that the machine has the potentials of generating reliable bending stress – number of cycles data; and the cost of design (171,000 Naira) was lower in comparison to that of rotating bending machines from abroad. Also the machine has the advantages of ease of operation and maintenance, and is safe for use.
Wireless Sensor Network Lifetime Enhancement Using Modified Clustering and Scheduling Algorithm  [PDF]
K. Ramesh, K. Somasundaram
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.78154
Abstract: Random distribution of sensor nodes in large scale network leads redundant nodes in the application field. Sensor nodes are with irreplaceable battery in nature, which drains the energy due to?repeated collection of data and decreases network lifetime. Scheduling algorithms are the one way?of addressing this issue. In proposed method, an optimized sleep scheduling used to enhance the?network lifetime. While using the scheduling algorithm, the target coverage and data collection?must be maintained throughout the network. In-network, aggregation method also used to remove the unwanted information in the collected data in level. Modified clustering algorithm?highlights three cluster heads in each cluster which are separated by minimum distance between them.?The simulation results show the 20% improvement in network lifetime, 25% improvement in?throughput and 30% improvement in end to end delay.
FROM THE BOLOGNA DECLARATION IDEAS TO THE CREATION OF COL-LECTIVE INTELLIGENCE В Д ДЕЙ БОЛОНСЬКОЙ ДЕКЛАРАЦ ДО РЕАЛ Й СТВОРЕННЯ КОЛЕКТИВНОГО НТЕЛЕКТУ
K. Метешк?н,Х. Раковський
Information Technologies and Learning Tools , 2010,
Abstract: The results of Bologna process are investigated. It is underlined that theoretical – methodological bases of the Bologna process have been poorly developed. A scheme for master’s education both on requirements of separate states, and on requirements of EU is offered. Досл джуються п дсумки Болонського процесу. П дкреслю ться, що слабко розроблен теоретико-методолог чн основи Болонського процесу. Пропону ться схема навчання маг стр в, як для потреб окремих держав, так для потреб С.
THE FORMING OF NEW METHODOLOGICAL PARADIGM OF EDUCATION AND SCIENCE MANAGEMENT ФОРМУВАННЯ НОВО МЕТОДОЛОГ ЧНО ПАРАДИГМИ УПРАВЛ ННЯ ОСВ ТОЮ НАУКОЮ
Х.В. Раковський,Н.Х. Раковська,K.О. Метешк?н
Information Technologies and Learning Tools , 2010,
Abstract: The process and phenomena connected with the initiation of new methodological paradigm of the scientific and educational management in Ukraine has been investigated. The paradigm is conditioned by global tendencies of informatization, development of communicative means and integrative processes in education and science У статт досл джен процеси та явища, пов’язан з зародженням в Укра н ново методолог чно парадигми управл ння осв тою наукою, яка обумовлена глобальними тенденц ями нформатизац , розвитком комун кац йних засоб в, а також нтеграц йними процесами в осв т та науц .
ДОБ Р КОМП'ЮТЕРНОГО ПРОГРАМНОГО ЗАБЕЗПЕЧЕННЯ ДИСТАНЦ ЙНОГО НАВЧАННЯ ДЛЯ ОРГАН ЗАЦ П СЛЯДИПЛОМНО ОСВ ТИ ВЧИТЕЛ В НФОРМАТИКИ DISTANCE LEARNING COMPUTER SOFTWARE FOR THE ORGANIZATION OF THE POSTGRADUATE EDUCATION FOR INFORMATICS TEACHERS
K.Р. Ковальська
Information Technologies and Learning Tools , 2010,
Abstract: У статт визначено та охарактеризовано основн вимоги до дистанц йних систем, що використовуються для забезпечення потреб навчального процесу; наведено низку безкоштовних систем управл ння навчальними ресурсами; зроблено пор вняльний анал з основних систем для визначення оптимально дистанц йно платформи до розвитку предметно-ор нтовно компетентност вчител в у п слядипломн й педагог чн осв т . The main demands to the distance learning systems which are used for providing the needs of the studying process are defined and characterized in the article. There is also a list of free of charge systems for the management of the educational resources. A comparative analysis of the main systems has been done for determining the optimal distance learning platform for the development of the teachers’ subject-oriented competence in the postgraduate pedagogical education.
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