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ON g#p#-CONTINUOUS MAPS IN TOPOLOGICAL SPACES
S. PIOUS MISSIER,K. Alli
Journal of Global Research in Mathematical Archives , 2013,
Abstract: The aim of this paper is to introduce and study g#p#-continuous maps. Basic characterizations and several properties concerning them are obtained. Further, g#p#-irresolute map is also defined. Some of the properties are investigated. 1991 AMS Classification: 54A05, 54D10. Keywords: g#- closed set, g#p#-closed set, g#p#-continuous maps and g#p#-irresolute maps.
g#p#-closed sets in topological spaces
K. Alli,A. Subramanian,S. Pious Missier
International Journal of Mathematics and Soft Computing , 2013,
Abstract: In this paper, we introduce g#p#- closed sets of a topological space and study their properties.
Medullary carcinoma of the breast: Role of contrast-enhanced MRI in the diagnosis of multiple breast lesions
SN Abdul Rashid,K Rahmat,KJ Jayaprasagam,K Alli
Biomedical Imaging and Intervention Journal , 2009, DOI: 10.2349/biij.5.4.e27
Abstract:
Cotton-ball granuloma mimicking axillary lymphadenopathy in a breast cancer patient
H Hashim,K Alli,Y Faridah,K Rahmat
Biomedical Imaging and Intervention Journal , 2011, DOI: 10.2349/biij.7.3.e19
Abstract:
Preparation and characterization of a coacervate extended-release microparticulate delivery system for Lactobacillus rhamnosus
Alli SMA
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S19589
Abstract: eparation and characterization of a coacervate extended-release microparticulate delivery system for Lactobacillus rhamnosus Original Research (3257) Total Article Views Authors: Alli SMA Published Date August 2011 Volume 2011:6 Pages 1699 - 1707 DOI: http://dx.doi.org/10.2147/IJN.S19589 Sk Md Athar Alli Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India Background: The purpose of this study was to develop a mucoadhesive coacervate microparticulate system to deliver viable Lactobacillus rhamnosus cells into the gut for an extended period of time while maintaining high numbers of viable cells within the formulation throughout its shelf-life and during gastrointestinal transit. Methods: Core coacervate mucoadhesive microparticles of L. rhamnosus were developed using several grades of hypromellose and were subsequently enteric-coated with hypromellose phthalate. Microparticles were evaluated for percent yield, entrapment efficiency, surface morphology, particle size, size distribution, zeta potential, flow properties, in vitro swelling, mucoadhesion properties, in vitro release profile and release kinetics, in vivo probiotic activity, and stability. The values for the kinetic constant and release exponent of model-dependent approaches, the difference factor, similarity factor, and Rescigno indices of model-independent approaches were determined for analyzing in vitro dissolution profiles. Results: Experimental microparticles of formulation batches were of spherical shape with percent yields of 41.24%–58.18%, entrapment efficiency 45.18%–64.16%, mean particle size 33.10–49.62 μm, and zeta potential around -11.5 mV, confirming adequate stability of L. rhamnosus at room temperature. The in vitro L. rhamnosus release profile follows zero-order kinetics and depends on the grade of hypromellose and the L. rhamnosus to hypromellose ratio. Conclusion: Microparticles delivered L. rhamnosus in simulated intestinal conditions for an extended period, following zero-order kinetics, and exhibited appreciable mucoadhesion in simulated intestinal conditions.
Formulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres
Alli SMA
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S14621
Abstract: rmulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres Original Research (4228) Total Article Views Authors: Alli SMA Published Date March 2011 Volume 2011:6 Pages 619 - 629 DOI: http://dx.doi.org/10.2147/IJN.S14621 Sk Md Athar Alli Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India Abstract: Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose, a mucoadhesive polymer, following coacervation and phase separation technique and were subsequently enteric-coated with hypromellose phthalate. Microspheres were evaluated for percent yield; entrapment efficiency; in vitro swelling; surface morphology; particle size, size distribution, and zeta potential; flow property, mucoadhesion property by the ex vivo mucoadhesive strength test and the in vitro wash off test; in vitro release profile and release kinetic; in vivo probiotic activity; and stability. The values for the kinetic constant and regression coefficient of model-dependent approaches and the difference factor ( 1), the similarity factor ( 2), and the Rescigno index (ξ1 and ξ 2) of model independent approaches were determined for comparing in vitro dissolution profiles. Freeze dried B. coagulans cells were successfully formulated as enteric-coated mucoadhesive microspheres with satisfactory physical structure and yield. The viability of B. coagulans was maintained in the simulated gastric conditions and during processing; in simulated intestinal conditions exhibiting mucoadhesion, and controlling and extending the viable cell release following zero-order; and was satisfactorily stable at room temperature. Test results depict statistically significant effects of the hypromellose grade and their concentration on the performance and release profile of formulations.
Formulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres
Alli SMA
International Journal of Nanomedicine , 2011,
Abstract: Sk Md Athar AlliDepartment of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, IndiaAbstract: Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose, a mucoadhesive polymer, following coacervation and phase separation technique and were subsequently enteric-coated with hypromellose phthalate. Microspheres were evaluated for percent yield; entrapment efficiency; in vitro swelling; surface morphology; particle size, size distribution, and zeta potential; flow property, mucoadhesion property by the ex vivo mucoadhesive strength test and the in vitro wash off test; in vitro release profile and release kinetic; in vivo probiotic activity; and stability. The values for the kinetic constant and regression coefficient of model-dependent approaches and the difference factor ( 1), the similarity factor ( 2), and the Rescigno index (ξ1 and ξ 2) of model independent approaches were determined for comparing in vitro dissolution profiles. Freeze dried B. coagulans cells were successfully formulated as enteric-coated mucoadhesive microspheres with satisfactory physical structure and yield. The viability of B. coagulans was maintained in the simulated gastric conditions and during processing; in simulated intestinal conditions exhibiting mucoadhesion, and controlling and extending the viable cell release following zero-order; and was satisfactorily stable at room temperature. Test results depict statistically significant effects of the hypromellose grade and their concentration on the performance and release profile of formulations.Keywords: probiotics, B. coagulans, mucoadhesive, microspheres, extended-release
Preparation and characterization of a coacervate extended-release microparticulate delivery system for Lactobacillus rhamnosus
Alli SMA
International Journal of Nanomedicine , 2011,
Abstract: Sk Md Athar Alli Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, IndiaBackground: The purpose of this study was to develop a mucoadhesive coacervate microparticulate system to deliver viable Lactobacillus rhamnosus cells into the gut for an extended period of time while maintaining high numbers of viable cells within the formulation throughout its shelf-life and during gastrointestinal transit.Methods: Core coacervate mucoadhesive microparticles of L. rhamnosus were developed using several grades of hypromellose and were subsequently enteric-coated with hypromellose phthalate. Microparticles were evaluated for percent yield, entrapment efficiency, surface morphology, particle size, size distribution, zeta potential, flow properties, in vitro swelling, mucoadhesion properties, in vitro release profile and release kinetics, in vivo probiotic activity, and stability. The values for the kinetic constant and release exponent of model-dependent approaches, the difference factor, similarity factor, and Rescigno indices of model-independent approaches were determined for analyzing in vitro dissolution profiles.Results: Experimental microparticles of formulation batches were of spherical shape with percent yields of 41.24%–58.18%, entrapment efficiency 45.18%–64.16%, mean particle size 33.10–49.62 μm, and zeta potential around -11.5 mV, confirming adequate stability of L. rhamnosus at room temperature. The in vitro L. rhamnosus release profile follows zero-order kinetics and depends on the grade of hypromellose and the L. rhamnosus to hypromellose ratio.Conclusion: Microparticles delivered L. rhamnosus in simulated intestinal conditions for an extended period, following zero-order kinetics, and exhibited appreciable mucoadhesion in simulated intestinal conditions.Keywords: Lactobacillus rhamnosus, mucoadhesive, microparticles, extended-release, intestine
Evaluation of a Low-Threshold/High-Tolerance Methadone Maintenance Treatment Clinic in Saint John, New Brunswick, Canada: One Year Retention Rate and Illicit Drug Use
Timothy K. S. Christie,Alli Murugesan,Dana Manzer,Michael V. O'Shaughnessey,Duncan Webster
Journal of Addiction , 2013, DOI: 10.1155/2013/753409
Abstract: Objective. To report the one-year retention rate and the prevalence of illicit opioid use and cocaine use in the Low-Threshold/High-Tolerance (LTHT) methadone maintenance treatment (MMT) clinic located in Saint John, New Brunswick, Canada. Methods. A description of the LTHT MMT clinic is provided. The one-year retention rate was determined by collecting data on patients who enrolled in the LTHT MMT clinic between August 04, 2009 and August 04, 2010. The prevalence of illicit drug use was determined using a randomly selected retrospective cohort of 84 participants. For each participant the results of six consecutive urine tests for the most recent three months were compared to the results of the first six consecutive urine tests after program entry. Results. The one-year retention rate was 95%, 67% of the cohort achieved abstinence from illicit opioids and an additional 13% abstained from cocaine use. Conclusion. The novel feature of the LTHT MMT clinic is that patients are not denied methadone because of lack of ancillary services. Traditional comprehensive MMT programs invest the majority of financial resources in ancillary services that support the biopsychosocial model, whereas the LTHT approach utilizes a medical model and directs resources at medical management. 1. Introduction Most Canadian methadone maintenance treatment (MMT) programs have limited treatment capacity, hundreds of people on wait-lists and wait-times that exceed 6–12 months [1]. The result is that many people, who are motivated to seek treatment for their addiction, remain untreated. In Canada, the provision of MMT is regulated by Health Canada’s guidelines, with each province and/or territory having the option of developing their own [2]. A review of the Federal Guidelines and those of seven provinces demonstrate that each adheres to the biopsychosocial model of MMT and require, among other things, the provision of psychosocial counseling, random urine testing, and mechanisms for the involuntary discharge of patients [3–9]. This paper will report the evaluation results of the low-threshold/high-tolerance (LTHT) MMT clinic in Saint John, New Brunswick, Canada. The LTHT approach is novel because it utilizes a medical model rather than the traditional biopsychosocial model that predominates in Canada. This model incorporates recommendations of the Government of Canada “best practices” document with the foundational premise that the provision of MMT should not be contingent on the availability of resources for psychosocial treatment [10, 11]. The “low-threshold” aspect refers to the
Morality tales in comparative jurisprudence: what the law says about sex
Alli Leigh Jernow
Amsterdam Law Forum , 2011,
Abstract: This article examines the use of public morality justifications in constitutional challenges to laws that criminalize same-sex sexual relationships. The author summarizes the Hart-Devlin debate and then studies the use of privacy and equality as counter-arguments to morality in court cases from the United States, Zimbabwe, Botswana, South Africa, and India. Lastly the author posits that the use of equality to expose morality as animus has far-reaching implications in cases that beyond sexual conduct.
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