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Search Results: 1 - 10 of 138905 matches for " K Gilani "
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Design and evaluation of a new dry powder inhaler
"Rouholamini Najafabadi AH,Gilani K,Hozan AA "
DARU : Journal of Pharmaceutical Sciences , 2001,
Abstract: Three versions of a new dry powder inhaler (DPI), RG-haler, were designed using two kinds of grid inserts. Salbutamol sulfate/lactose blend (Ventolin Rotacaps ) was selected as a model formulation to analyze the performance of all inhalers and compare their efficiency with three marketed devices (Rotahaler , Spinhaler and ISF inhalator ) using the twin impinger (TI). Deposition of the drug in device was significantly (P<0.05) lower for ISF inhalator and all kinds of RG-halers in comparison with those of Rotahaler and Spinhaler . The amount of drug deposited in the stage 2 and the respirable dose for RG-halers were similar to those of ISF inhalator and significantly (P<0.05) higher than those of Rotahaler and Spinhaler . The results suggest efficient aerosol generating capability of the RG-haler.
Weather Yield Model for the Semi Tropical Region (Pakistan)

Syed Faizan Haider,K H Asif,Amjad Hussain Gilani,

大气科学进展 , 1992,
Abstract: Weather models are essential tools for checking of the effect of the weather elements in terms of their effect on the production of the crop. This research is an attempt to see the effect of only two variables i.e., temperature and rainfall for the division Faisalabad (semitropical region of Pakistan).The model fitted is of the linear form:the values of a,b, c have been found. The expected yield has been calculated by using the aridity indices (X1 and X2 ) and the result in the form of coefficient of determination R2 has been found equal to 0.166. The significance of the regression coefficient has been tested, which shows that the contribution to the yield from aridity index at germination and that at ripening is significant.The wheat yields are the results of a wide variety of variables, most of which show varying degree of relationship with one another, some positive and some negative in terms of output. These variables may be technology, fertilizers, pesticides, epidemics, kinds of seeds used, market price of crop and the area under cultivation etc, which can be the source of variation in the wheat yield. Since rainfall during germination and temperature at the ripening periods are the necessary factors for the yield of wheat, for this purpose these parameters have been studied in order to their contribution.
Effects of treatment with radioiodine (131I) on the gonadal function of the hyperthyroid patients
Eftekhari M,Takavar A,Ansari Gilani K,Akhzari F
Iranian Journal of Nuclear Medicine , 2003,
Abstract: Introduction: Hyperthyroidism is a relatively common disorder caused by different etiologies. Graves’ disease, and toxic-nodular goiter (Plummer’s disease) are among the most common causes. Treatment with radioiodine is considered to be the treatment of choice in many of the patients. Higher biological half-life of 131I in hyperthyroid patients as compared with patients with differentiated thyroid carcinoma who have undergone thyroidectomy, may lead to a higher frequency of complications with radioiodine at similar dosage. Therefore gonadal dysfunction in hyperthyroid patients treated with radioactive iodine is not unlikely. Material and Methods: Hyperthyroid patients with the clinical diagnosis of Graves’ disease, toxic multinodular goiter and toxic adenoma were entered the study. Their age distribution was 16-40 years in women and 17-60 years in men (Reproductive years). Patients were euthyroid at the time of radioiodine treatment. FSH, LH, testosterone and semen analysis in men; and FSH, LH, estrogen and progesterone in women were measured before and 3 months after radioiodine therapy. All patients with previous history of radioiodine treatment, those with known sexual hormone abnormalities, women with a history of tube ligation and men with a history of vasectomy, as well as those women who were receiving OCP contraception were excluded from the study. Results: From 104 enrolled patients, 40 (38.5%) were men and 64 (61.5%) were women. The cause of hyperthyroidism was Graves’ disease in 66 cases (63.5%), toxic multinodular goiter in 28 cases (26.9%) and toxic adenoma in 10 others (9.6%). Hormonal status was normal in all patients before therapy while this became abnormal in 20 (19.2%) of patients after treatment. Semen analysis became abnormal in 8/20 (40%) of the patients after treatment. Conclusion: Among different variables which were analyzed during study, meaningful correlation was found in the following situations: FSH values in men and women were found to be increased after radioiodine treatment (P35) (P=0.003) and changes in hormonal status in women in two different age groups (=30) were found to be statistically significant (P=0.015).
Menthol Prevents Liver Damage Induced by Paracetamol and CCl4
K.H. Janbaz,A.H. Gilani
Pakistan Journal of Biological Sciences , 2002,
Abstract: Menthol, a terpenoid from Mentha piperita was investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. Paracetamol produced 100% mortality at the dose of 1 g kg -1 in mice while pre-treatment of animals with menthol (50 mg kg -1) reduced the death rate to 40%. Oral administration of paracetamol (640 mg kg -1) produced liver damage in rats as manifested by the rise in serum enzyme levels of alkaline phosphatase (ALP) and transaminase (AST and ALT). Pre-treatment of rats with menthol prevented the paracetamol-induced rise in serum enzymes. The hepatotoxic dose of CCl4 (1.5 ml kg -1; orally) also raised the serum ALP, AST and ALT levels. The same dose of menthol was able to prevent the CCl4-induced rise in serum enzymes and prolongation in pentobarbital sleeping time. In conclusion menthol possesses hepatoprotective activity, demanding further scientific evaluations to validate its future role in hepato-biliary complications.
Nanosilver in the treatment of localized cutaneous leishmaniasis caused by Leishmania major (MRHO/IR/75/ER): an in vitro and in vivo study
M Mohebali,M.M Rezayat,K Gilani,S Sarkar
DARU : Journal of Pharmaceutical Sciences , 2009,
Abstract: "n "n "n "n "nBackground and the purpose of the study: "n This study was designed to evaluate the effectiveness of different concentrations of Nanosilver solution against Iranian strain of Leishmania major (MRHO/IR/75/ER) both in vitro and in vivo "n "non BALB/c mice model for the first time. "nMethods: "n this is an interventional study which was conducted on the infected macrophages by L. major amastigotes in vitro. In order to confirm the in vitro results, various concentration of Nanosilver solution were administered topically on skin lesions caused by L.major "n "nin 78 inbred BALB/c mice as test or interventional and 52 mice as control groups once or twice daily for 14 days. Results and major conclusion : Results of this study showed that different concentration of Nanosilver reduced proliferation of L. major amastigotes compared with the control wells but the differences were not statistically significant. Also, different concentrations of Nanosilver did not decrease the lesion sizes and amastigote counts in the BALB/c mice significantly. Secondary infection was significantly decreased in Nanosilver- treated groups compared with control groups (p<0.01). In conclusion, Nanosilver seems to be effective for control of secondary infection of localized cutaneous leishmaniasis.
Precipitation of fluticasone propionate microparticles using supercritical antisolvent
A Vatanara,A Rouholamini Najafabadi,K Gilani,R Asgharian
DARU : Journal of Pharmaceutical Sciences , 2009,
Abstract: ABSTRACT Background: The ability of supercritical fluids (SCFs), such as carbon dioxide, to dissolve and expand or extract organic solvents and as result lower their solvation power, makes it possible the use of SCFs for the precipitation of solids from organic solutions. The process could be the injection of a solution of the substrate in an organic solvent into a vessel which is swept by a supercritical fluid. The aim of this study was to ascertain the feasibility of supercritical processing to prepare different particulate forms of fluticasone propionate (FP), and to evaluate the influence of different liquid solvents and precipitation temperatures on the morphology, size and crystal habit of particles. Method: The solution of FP in organic solvents, was precipitated by supercritical carbon dioxide (SCCO2) at two pressure and temperature levels. Effects of process parameters on the physicochemical characteristics of harvested microparticles were evaluated. Results: Particle formation was observed only at the lower selected pressure, whilst at the higher pressure, no precipitation of particles was occurred due to dissolution of FP in supercritical antisolvent. The micrographs of the produced particles showed different morphologies for FP obtained from different conditions. The results of thermal analysis of the resulted particles showed that changes in the processing conditions didn't influence thermal behavior of the precipitated particles. Evaluation of the effect of temperature on the size distribution of particles showed that increase in the temperature from 40 oC to 50 oC, resulted in reduction of the mean particle size from about 30 μm to about 12 μm. Conclusion: From the results of this study it may be concluded that, processing of FP by supercritical antisolvent could be an approach for production of diverse forms of the drug and drastic changes in the physical characteristics of microparticles could be achieved by changing the type of solvent and temperature of operation.
Influence of mechanical milling time on physicochemical properties and stability of cefotaxime sodium
Rouholamini Najafabadi A.,Asgharian R.,Tajerzadeh H.,Gilani K.
DARU : Journal of Pharmaceutical Sciences , 2007,
Abstract: The aim of this study was to examine the effect of mechanical milling time on physicochemical properties and stability of Cefotaxime sodium (CS). CS was micronized by ball milling in five period of time: 30, 60, 120, 240, and 360 min. The powder properties of the samples were examined by HPLC assay, laser diffraction, helium densitometery, IR spectrophotometery, X-ray diffraction (XRD), scaning electron microscopy (SEM), differential scanning calorimetery (DSC), thermogravimetric analysis (TGA) and Karl-Fisher titrimetery. The results showed that ball milling was not an appropriate method for particle size reduction to make solid dosage form such as dry powder inhaler formulation (DPI) of CS and by increase in milling time, degradation of CS increased.
Acute and subchronic dermal toxicity of nanosilver in guinea pig
Korani M, Rezayat SM, Gilani K, Arbabi Bidgoli S, Adeli S
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S17065
Abstract: cute and subchronic dermal toxicity of nanosilver in guinea pig Original Research (6705) Total Article Views Authors: Korani M, Rezayat SM, Gilani K, Arbabi Bidgoli S, Adeli S Published Date April 2011 Volume 2011:6 Pages 855 - 862 DOI: http://dx.doi.org/10.2147/IJN.S17065 M Korani1, SM Rezayat1,2,4, K Gilani3, S Arbabi Bidgoli4, S Adeli1 1Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences; 2Department of Nanotechnology, Faculty of Advanced Sciences and Technology in Medicine, Tehran University of Medical Sciences; 3Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences; 4Department of Toxicology & Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran Abstract: Silver has been used as an antimicrobial agent for a long time in different forms, but silver nanoparticles (nanosilver) have recently been recognized as potent antimicrobial agents. Although nanosilver is finding diverse medical applications such as silver-based dressings and silver-coated medical devices, its dermal and systemic toxicity via dermal use has not yet been identified. In this study, we analyzed the potential toxicity of colloidal nanosilver in acute and subchronic guinea pigs. Before toxicity assessments, the size of colloidal nanosilver was recorded in sizes <100 nm by X-ray diffraction and transmission electron microscopy. For toxicological assessments, male guinea pigs weighing 350 to 400 g were exposed to two different concentrations of nanosilver (1000 and 10,000 μg/mL) in an acute study and three concentrations of nanosilver (100, 1000, and 10,000 μg/mL) in a subchronic study. Toxic responses were assessed by clinical and histopathologic parameters. In all experimental animals the sites of exposure were scored for any type of dermal toxicity and compared with negative control and positive control groups. In autopsy studies during the acute test, no significant changes in organ weight or major macroscopic changes were detected, but dose-dependent histopathologic abnormalities were seen in skin, liver, and spleen of all test groups. In addition, experimental animals subjected to subchronic tests showed greater tissue abnormalities than the subjects of acute tests. It seems that colloidal nanosilver has the potential to provide target organ toxicities in a dose- and time-dependent manner.
Effects of depression on myocardial perfusion scintigraphy
K. Ansari-Gilani,J. Modaresi Esfeh,B. Fallahi,M. Shahidzadeh Mahani
Iranian Journal of Nuclear Medicine , 2006,
Abstract: Objectives: The relationship between depression and coronary artery disease is well established; however assessment of this relationship using functional and semi-quantitative imaging (myocardial perfusion scintigraphy) was lacking. The aim of this study was to assess the relationship between the severity of depression and the severity of myocardial perfusion abnormality. Methods: Patients were assessed with rest/stress 99mTc-MIBI myocardial perfusion scintigraphy using Single Photon Emission Computed Tomography (SPECT) and Beck Depression Inventory (BDI-II). Visual and semi-quantitative assessment of myocardial perfusion score (MPS) in a five-scale measurement for standard 20-segment-model were used. Results: when all patients (n=167) were evaluated, no correlation was found between MPS and BDI-score. Considering only those with significant perfusion abnormality (MPS95) (p=0.097), but other myocardial walls failed to show such association. Conclusions: In patients with significant perfusion abnormality, the greater is this abnormality the more severe is the depression. Also patients with inferior wall infarction, have a higher BDI-score as compared with normal subjects.
Effects of Depression on Myocardial Perfusion Scintigraphy1
K. Ansari Gilani,J. Modaresi Esfeh,B. Fallahi,M. Shahidzadeh Mahani
Iranian Journal of Nuclear Medicine , 2006,
Abstract: Introduction: The relationship between depression and coronary artery disease is well established; however assessment of this relationship using functional and semi-quantitative imaging (myocardial perfusion scintigraphy) was lacking. The aim of this study was to assess the relationship between the severity of depression and the severity of myocardial perfusion abnormality. Methods: Patients were assessed with rest/stress 99mTc-MIBI myocardial perfusion scintigraphy using Single Photon Emission Computed Tomography (SPECT) and Beck Depression Inventory (BDI-II). Visual and semi-quantitative assessment of myocardial perfusion score (MPS) in a five-scale measurement for standard 20-segment-model were used. Results: When all patients (n=167) were evaluated, no correlation was found between MPS and BDI-score. Considering only those with significant perfusion abnormality (MPS<90, n=38), negative correlation was found between MPS and BDI score (r= -0.641, p=0.017). Also higher BDI scores were recorded for patients with inferior wall infarction when compared with those with normal or near-normal MPS (MPS>95) (p=0.097), but other myocardial walls failed to show such association. Conclusion: In patients with significant perfusion abnormality, the greater is this abnormality the more severe is the depression. Also patients with inferior wall infarction, have a higher BDI-score as compared with normal subjects.
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