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Search Results: 1 - 10 of 325450 matches for " Jyotsna S. Meshram "
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Synthesis and Biological Activities of 4-Aminoantipyrine Derivatives Derived from Betti-Type Reaction
Ipsita Mohanram,Jyotsna Meshram
ISRN Organic Chemistry , 2014, DOI: 10.1155/2014/639392
Abstract: The present work deals with the synthesis and evaluation of biological activities of 4-aminoantipyrine derivatives derived from a three-component Betti reaction. The synthesis was initiated by the condensation of aromatic aldehyde, 4-aminoantipyrine, and 8-hydroxyquinoline in presence of fluorite as catalyst in a simple one-step protocol. The reactions were stirred at room temperature for 10–15?min achieving 92–95% yield. The structures of synthesized derivatives were established on the basis of spectroscopic and elemental analysis. All derivatives 4(a–h) were screened in vivo and in vitro for anti-inflammatory and anthelmintic activity against a reference drug, Diclofenac and Albendazole, respectively. The screening results show that compounds 4c, 4d, 4f, and 4h were found to possess potential anti-inflammatory activity while compounds 4a, 4b, 4e, and 4g are potent anthelmintic agents when compared with reference drugs, respectively. The bioactivity of these derivatives has also been evaluated with respect to Lipinski’s rule of five using molinspiration cheminformatics software. 1. Introduction Multicomponent reactions (MCRs) have appeared as an imperative means for the construction of diverse and complex organic molecules [1]. They have intrinsic advantages over two component reactions in several aspects including the simplicity of a one-pot procedures and possible structural variation. The synthetic competence comes from several tandem bond formation reactions in MCRs, which save time, energy, and raw material. Betti reaction is a modified type of Mannich reaction [2] which has subsequently become vital in synthetic chemistry because of C–C bond formation under mild experimental conditions. Interest in the chemistry of Betti reaction derivatives was also strengthened as it was found to possess various catalytic and biological applications [3–5]. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most clinically important medicine used for the treatment of inflammation-related diseases like arthritis, asthma, and cardiovascular diseases [6]. However, the long-term administration of NSAID may induce gastrointestinal ulcers, bleeding, and renal disorders due to their nonselective inhibition of both constitutive (COX-1) and inducible (COX-2) isoforms of the cyclooxygenase enzymes [7–9]. Therefore, new anti-inflammatory drugs lacking those effects are being searched all over the world as alternatives to NSAIDs [10]. Due to the emerging need of improved and highly selective inhibitors of COX-2, various heterocyclic compounds are synthesized amongst
Photocatalytic Degradation of Phenolics by N-Doped Mesoporous Titania under Solar Radiation
Priti A. Mangrulkar,Sanjay P. Kamble,Meenal M. Joshi,Jyotsna S. Meshram,Nitin K. Labhsetwar,Sadhana S. Rayalu
International Journal of Photoenergy , 2012, DOI: 10.1155/2012/780562
Abstract: In this study, nitrogen-doped mesoporous titania was synthesized by templating method using chitosan. This biopolymer chitosan plays the dual role of acting as a template (which imparts mesoporosity) and precursor for nitrogen. BET-SA, XRD, UV-DRS, SEM, and FTIR were used to characterize the photocatalyst. The doping of nitrogen into TiO2 lattice and its state was substantiated and measured by XPS. The photocatalytic activity of the prepared N-doped mesoporous titania for phenol and o-chlorophenol degradation was investigated under solar and artificial radiation. The rate of photocatalytic degradation was observed to be higher for o-chlorophenol than that of phenol. The photodegradation of o-chlorophenol was 98.62% and 72.2%, while in case of phenol, degradation to the tune of 69.25% and 30.58% was achieved in solar and artificial radiation. The effect of various operating parameters, namely, catalyst loading, pH, initial concentration and the effect of coexisting ions on the rate of photocatalytic degradation were studied in detail.
Synthesis of 2-[4-(10H-Substituted Phenothiazine-3-yl)-6-Pyrimidin-2-Phenylthiol/ol/amine/thiol] Pyrroles
Meghasham Narule,Jyotsna Meshram,B. Santhakumari,A. Shanware
Journal of Chemistry , 2007, DOI: 10.1155/2007/572543
Some Modification in ID-Based Public key Cryptosystem using IFP and DDLP
Chandrashekhar Meshram,S.A. Meshram
International Journal of Advanced Computer Sciences and Applications , 2011,
Abstract: In 1984, Shamir [1] introduced the concept of an identity-based cryptosystem. In this system, each user needs to visit a key authentication center (KAC) and identify him self before joining a communication network. Once a user is accepted, the KAC will provide him with a secret key. In this way, if a user wants to communicate with others, he only needs to know the “identity” of his communication partner and the public key of the KAC. There is no public file required in this system. However, Shamir did not succeed in constructing an identity based cryptosystem, but only in constructing an identity-based signature scheme. Meshram and Agrawal [5] have proposed an id - based cryptosystem based on integer factoring and double discrete logarithm problem which uses the public key cryptosystem based on integer factoring and double discrete logarithm problem. In this paper, we propose the modification in an id based cryptosystem based on the integer factoring and double discrete logarithm problem and we consider the security against a conspiracy of some entities in the proposed system and show the possibility of establishing a more secure system.
Appraising Spatio-Temporal Shifting of Urban Growth Center of Pimpri-Chinchwad Industrialized City, India Using Shannon Entropy Method  [PDF]
R. S. Ranpise, A. K. Kadam, S. W. Gaikwad, D. C. Meshram
Current Urban Studies (CUS) , 2016, DOI: 10.4236/cus.2016.43023
Abstract: Uncontrolled urban development of Pimpri Chinchwad area was assessed to understand shifting of urban growth center and its controlling factors during last forty years. Out of forty, initial 20 years span (1973 to 1993) is compared to subsequent 20 years (1993 to 2013). The secondary data i.e. topographic maps (year 1970 and 2009) and satellite image MSS, LISS III (year 1973 and 1993) and LISS IV image (year 2013) were used for preparation of land use land cover maps. Furthermore, Shannon entropy computed by built-up land class, was showing the entropy 0.81, 0.92 and 0.97 for year 1973, 1993 and 2013 respectively, hence the steady growth during past forty years. However, growth centers of urban development shifts from automobile industries at Pimpri (central part) to information technology (IT) industries towards Hinjewadi (western part) area. This shift was determined from the demographic alteration in study area. To understand demographic alteration, the spatial results were verified through ground truth survey reveals population growth is in the form of vertical growth such as increase in multi storey buildings instead of single storey housing. This study highlights the shifting of urban growth centers in developing countries such as India from automobile to IT industries. The shifting of growth center was resulted into impact on existing public services (drinking water, sanitation, waste management, roads, hospitals etc.). In conclusion, present study warrants the attentions towards shifting of urban growth center from such rapidly growing industrial city of the developing countries while deciding future urban planning.
Design Approach for Fault Tolerance in FPGA Architecture
Ms. Shweta S. Meshram,Ujwala A. Belorkar
International Journal of VLSI Design & Communication Systems , 2011,
Abstract: Failures of nano-metric technologies owing to defects and shrinking process tolerances give rise tosignificant challenges for IC testing. In recent years the application space of reconfigurable devices hasgrown to include many platforms with a strong need for fault tolerance. While these systems frequentlycontain hardware redundancy to allow for continued operation in the presence of operational faults, theneed to recover faulty hardware and return it to full functionality quickly and efficiently is great. Inaddition to providing functional density, FPGAs provide a level of fault tolerance generally not found inmask-programmable devices by including the capability to reconfigure around operational faults in thefield. Reliability and process variability are serious issues for FPGAs in the future. With advancement inprocess technology, the feature size is decreasing which leads to higher defect densities, moresophisticated techniques at increased costs are required to avoid defects. If nano-technology fabricationare applied the yield may go down to zero as avoiding defect during fabrication will not be a feasibleoption Hence, feature architecture have to be defect tolerant. In regular structure like FPGA, redundancyis commonly used for fault tolerance. In this work we present a solution in which configuration bit-streamof FPGA is modified by a hardware controller that is present on the chip itself. The technique usesredundant device for replacing faulty device and increases the yield.
Phosphor Converted White Led with Improved CRI  [PDF]
P. J. Yadav, N. D. Meshram, C. P. Joshi, S. V. Moharil
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.64058
Most of the commercial white LED lamps use blue chip coated with yellow emitting phosphor. YAG:Ce3+ phosphor is coated on blue chip to obtain white light. Though this is commercially successful, there are several drawbacks such as “halo effect”, poor colour rendition, etc. In recent years several efforts have been made to improve LED lamp performance. In this paper modifica-tion of YAG:Ce phosphor for improving CRI, by introducing Gd3+, Pr3+ or Tb3+ at Ce3+ site is reported.
Arriving at a correlation between the flagellar arrangement and multicellularity  [PDF]
Suruchi Jamkhedkar, Jyotsna Dongerdive, Kavita Jain, Siby Abraham, Jacinta S. D’Souza
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.41014
Abstract: Cilia and flagella are organelles of motility that enable cells to swim or move liquid over its surface. An exhaustive literature survey for the presence of the organelle in organisms across phyla showed that most animal cells harbor cilia in contrast to very few fungal cells. While this was not unexpected, it was the position and arrangement of this organelle in each cell that intrigued our attention. Natural selection might have favored motility over chemotaxis; and it would have done so to evolve a stable structure that could have undergone an optimization process requiring a precise geometry in the shape of cells and the structure that would help cells to move. The positioning of such a structure would play a pre-dominant role in optimal motility. It is now known that the flagellar position of a cell is a genetically distinct trait, occasionally used in phylogeny of bacteria, distributed in distinguishing patterns over cellular surface, but basically are of two types, either polar (one flagellum arising from one pole per cell) or peritrichous (lateral flagella distributed over the entire cell surface). Irrespective of the cellular habitat, flagella origin, ultrastructure and proteome, the present investigation surveyed 26 sub-types of flagellar arrangements from as many species as possible. A peculiar pattern ensued-Prokaryotes harbored predominantly polar and peritrichous types; eukaryotes showed a mere change of the peritrichous one. These numbers when used to create a Similarity tree depicted a similarity distance of 14 between the Eubacteria and Archaebacteria forming the first neighborhood; Protozoans, Algae, Fungi, Plantae and Animalia formed a second neighborhood. We offer a working hypothesis for this pattern and the gradual shift in the flagellar arrangement from polar, peritrichous, sub-apical, and apical to lateral throughout evolution.
Corrosion and Inhibition Effects of Mild Steel in Hydrochloric Acid Solutions Containing Organophosphonic Acid
Manish Gupta,Jyotsna Mishra,K. S. Pitre
International Journal of Corrosion , 2013, DOI: 10.1155/2013/582982
Abstract: A study has been made on the mechanism of corrosion of mild steel and the effect of nitrilo trimethylene phosphonic (NTMP) acid as a corrosion inhibitor in acidic medium, that is, 10% HC1 using the weight loss method and electrochemical techniques, that is, potentiodynamic and galvanostatic polarization measurements. Although corrosion is a long-time process, but it takes place at a faster rate in the beginning which goes on decreasing with due course of time. The above-mentioned methods of corrosion rate determination furnish an average value for a long-time interval. Looking at the versatility and minimum detection limit of the voltammetric method, the authors have developed a new voltammetric method for the determination of corrosion rate at short-time intervals. The results of corrosion of mild steel in 10% HC1 solution with and without NTMP inhibitor at short-time intervals have been reported. The corrosion inhibition efficiency of NTMP is 93% after 24?h. 1. Introduction Mild steel is a major material of construction. It is extensively used in chemical and allied industries for handling alkalis, acids, and salt solutions [1]. Hydrochloric (HC1) acid is the solvent most often employed for chemical cleaning. It attacks a wide range of scales [2]. Nitrogen compounds constitute the largest class of inhibitors for hydrochloric acid [3] solution. During the past decade a number of polymers and phosphonates have been used in different inhibitor compositions in aqueous and acid solutions [4]. They form stable complexes and some times act as detergent also. The role of inhibitor is the prevention of the adsorption of aggressive anions and reduction of the dissolution rate of the passivating oxide. In the present paper we have studied the action and effectiveness of nitrilo trimethylene phosphonic acid (NTMP) as inhibitor for corrosion of carbon steel in (10% HCl) acid solution. Most of the methods are proposed in the field of corrosion rate determination, but they furnish an average value for a long-time interval [5]. Looking at the sensitivity and minimum detection limits [6, 7] of polarographic techniques, that is, direct current polarography (DCP), differential pulse polarography (DPP), and voltammetric, that is, differential pulse anodic stripping voltammetric (DPASV) method has been used to determine the corrosion rates and inhibition efficiency of NTMP of mild steel in 10% HC1 solution at short time intervals. Significantly it has also been possible to determine the corrosion rates simultaneously with respect to Fe(II) and Fe(III) which is not
Treatment of Clinical Cases of Bacterial Enteritis in Goat with New Polyherbal  Antidiarrhoeal formulation
Meshram D.,Ravikanth K.,Maini S.,and Rekhe D.S.
Veterinary World , 2009,
Abstract: A study was conducted in fifty non-descript goats of 1-2 years of age, presented in Veterinary clinics of Shirval Veterinary College Maharashtra, India. Faecal and blood samples were collected from all the goats suffering from enteritis. Confirmative diagnosis of bacterial enteritis was done on the basis of bacteriological and haemato-biochemical tests. Animals were randomly divided into four (Group II to V) groups. Group I constituted of healthy animals (n= 10) (negative control), group II constituted diarrhoeic untreated animals (n=10) and Group III, IV and V (n=10) were the treatment groups. Group III animals were treated with polyherbal antidiarrhoeal formulation AV/ADC/16 @10gm BID for 4 days (coded formulation supplied by Ayurvet ltd. Baddi India), group IV treated with AV/ADC/16@15gms BID for 4 days and group V was treated with combination of AV/ADC/16 @ 10 gm and Ofloxacin @100mg BID for 4 days. In addition to clinical observations, haemato-biochemical parameters were recorded before and after treatment. The polyherbal antidiarrhoeal formulation AV/ADC/16 alone and in combination with antibiotics was found to be effective to treat diarrhoea, regain appetite and improved overall general body condition. [Vet. World 2009; 2(4.000): 143-145]
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