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Search Results: 1 - 10 of 44612 matches for " Jyh-Horng Wu "
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Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells
Yun-Ju Chen,Chieh-Shan Wu,Jeng-Jer Shieh,Jyh-Horng Wu
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/124747
Steroidal Carboxylic Acids from Soft Coral Paraminabea acronocephala
Chih-Hua Chao,Yang-Chang Wu,Zhi-Hong Wen,Jyh-Horng Sheu
Marine Drugs , 2013, DOI: 10.3390/md11010136
Abstract: Three new steroidal carboxylic acids, paraminabic acids A–C ( 1– 3) were isolated from a Formosan soft coral Paraminabea acronocephala. The structures of these compounds were established by extensive spectroscopic analysis and chemical methods. Application of the PGME method allowed the establishment of the absolute configurations at C-25 and C-24 for 1 and 2, respectively. Compound 3 showed potent cytotoxicity toward Hep3B, MDA-MB-231, MCF-7, and A-549 cancer cell lines, with IC 50 values ranging from 2.05 to 2.83 μg/mL. Compounds 2 and 3 were found to inhibit the accumulation of the pro-inflammatory iNOS protein.
Purification and Functionalization of Single-Walled Carbon Nanotubes through Different Treatment Procedures
Peir-An Tsai,Hsuan-Yuan Kuo,Wei-Ming Chiu,Jyh-Horng Wu
Journal of Nanomaterials , 2013, DOI: 10.1155/2013/937697
Reinforcement of dynamically vulcanized EPDM/PP elastomers using organoclay fillers
Yuhsin Tsai, Jyh-Horng Wu, Yao-Tsu Wu, Chia-Hao Li and Ming-Tsong Leu
Science and Technology of Advanced Materials , 2008,
Abstract: Dynamically vulcanized EPDM/PP (ethylene-propylene-diene/polypropylene) elastomers reinforced with various amounts of organoclay were prepared using octylphenol-formaldehyde resin and stannous chloride dehydrate as vulcanizing agents. The effects of organoclay on vulcanization characteristics, rheological behavior, morphology, thermal stability and thermomechanical properties were studied. Experimental results showed that organoclay affected neither the vulcanization process nor the degree of vulcanization chemically. X-ray analysis revealed that these organoclay-filled thermoplastic vulcanizates (TPVs) were intercalated. With respect to the mechanical properties, organoclay increased both the strength and degree of elongation of TPVs. The morphological observation of fractured surfaces suggested that organoclay acted as a nucleating agent in TPVs, improving their mechanical properties. However, adding organoclay reduced the thermal stability of TPVs by decomposing the swelling agents in the organoclay.
Different Brain Network Activations Induced by Modulation and Nonmodulation Laser Acupuncture
Chang-Wei Hsieh,Jih-Huah Wu,Chao-Hsien Hsieh,Qwa-Fun Wang,Jyh-Horng Chen
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/951258
Abstract: The aim of this study is to compare the distinct cerebral activation with continued wave (CW) and 10 Hz-modulated wave (MW) stimulation during low-level laser acupuncture. Functional magnetic resonance imaging (fMRI) studies were performed to investigate the possible mechanism during laser acupuncture stimulation at the left foot's yongquan (K1) acupoint. There are 12 healthy right-handed volunteers for each type of laser stimulation (10-Hz-Modulated wave: 8 males and 4 females; continued wave: 9 males and 3 females). The analysis of multisubjects in this experiment was applied by random-effect (RFX) analysis. In CW groups, significant activations were found within the inferior parietal lobule, the primary somatosensory cortex, and the precuneus of left parietal lobe. Medial and superior frontal gyrus of left frontal lobe were also aroused. In MW groups, significant activations were found within the primary motor cortex and middle temporal gyrus of left hemisphere and bilateral cuneus. Placebo stimulation did not show any activation. Most activation areas were involved in the functions of memory, attention, and self-consciousness. The results showed the cerebral hemodynamic responses of two laser acupuncture stimulation modes and implied that its mechanism was not only based upon afferent sensory information processing, but that it also had the hemodynamic property altered during external stimulation.
Leaf Extracts of Calocedrus formosana (Florin) Induce G2/M Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells
Sheau-Yun Yuan,Chi-Chen Lin,Shih-Lan Hsu,Ya-Wen Cheng,Jyh-Horng Wu,Chen-Li Cheng,Chi-Rei Yang
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/380923
Abstract: Calocedrus formosana (Florin) bark acetone/ethylacetate extracts are known to exert an antitumor effect on some human cancer cell lines, but the mechanism is yet to be defined. The aim of this study was to determine the effects of Florin leaf methanol extracts on the growth and apoptosis of human bladder cancer cell lines. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay showed that the growth of these bladder cancer cells was potently inhibited by the Florin leaf extracts. The cell cycle of these extract-treated cells (TCCSUP cells) was arrested at the G2/M phase as determined by flow cytometry. Western blot analysis revealed the increases of cyclin B1 and Cdc2 kinase levels, alone with the decrease of phosphorylated Cdc2 kinase, after treating these cells with the extracts. An immunofluorescence assessment of β-tubulin showed decreased levels of polymerized tubulin in treated cells. However, the proteolytic cleavage of poly ADP-ribose polymerase and the activation of caspase-3/-8/-9 were all increased upon treatments of extracts. The concurrent increase of Bax and decrease of Bcl-2 levels indicated that the extracts could induce apoptosis in these treated cells. Taken together, these results suggest that the Florin leaf extracts may be an effective antibladder cancer agent.
Antioxidant Activities and Phytochemical Study of Leaf Extracts from 18 Indigenous Tree Species in Taiwan
Shang-Tse Ho,Yu-Tang Tung,Yong-Long Chen,Ying-Ying Zhao,Min-Jay Chung,Jyh-Horng Wu
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/215959
Abstract: The objective of this study is to assess antioxidant activities of methanolic extracts from the leaves of 18 indigenous tree species in Taiwan. Results revealed that, among 18 species, Acer oliverianum exhibited the best free radical scavenging activities. The IC50 values were 5.8 and 11.8 μg/mL on DPPH radical and superoxide radical scavenging activities, respectively. In addition, A. oliverianum also exhibited the strongest ferrous ion chelating activity. Based on a bioactivity-guided isolation principle, the resulting methanolic crude extracts of A. oliverianum leaves were fractionated to yield soluble fractions of hexane, EtOAc, BuOH, and water. Of these, the EtOAc fraction had the best antioxidant activity. Furthermore, 8 specific phytochemicals were isolated and identified from the EtOAc fraction. Among them, 1,2,3,4,6-O-penta-galloyl-β-D-glucopyranose had the best free radical scavenging activity. These results demonstrate that methanolic extracts and their derived phytochemicals of A. oliverianum leaves have excellent antioxidant activities and thus they have great potential as sources for natural health products.
The Hypouricemic Effect of Balanophora laxiflora Extracts and Derived Phytochemicals in Hyperuricemic Mice
Shang-Tse Ho,Yu-Tang Tung,Chi-Chang Huang,Chao-Lin Kuo,Chi-Chen Lin,Suh-Ching Yang,Jyh-Horng Wu
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/910152
Abstract: The objective of this study is to evaluate the lowering of uric acid using Balanophora laxiflora extracts and derived phytochemicals on potassium-oxonate-(PO-) induced hyperuricemia in mice. The results revealed that ethyl acetate (EtOAc) fraction of B. laxiflora extracts exhibited strong xanthine-oxidase-(XOD-) inhibitory activity. In addition, among the 10 subfractions (EA1–10) derived from EtOAc fraction, subfraction 8 (EA8) exhibited the best XOD-inhibitory activity. Four specific phytochemicals, 1-O-(E)-caffeoyl-β-D-glucopyranose (1), 1-O-(E)-p-coumaroyl-β-D-glucopyranose (2), 1,3-di-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-β-D-glucopyranose (3), and 1-O-(E)-caffeoyl-4,6-(S)-hexahydroxydiphenoyl-β-D-glucopyranose (4), were further isolated and identified from this subfraction. Compounds 3 and 4 exhibited the strongest XOD-inhibitory activity compared with other compounds, and both hydrolyzable tannins were determined to be noncompetitive inhibitors according to the Lineweaver-Burk plot. On the other hand, the in vivo hypouricemic effect in hyperuricemic mice was consistent with XOD-inhibitory activity, indicating that B. laxiflora extracts and derived phytochemicals could be potential candidates as new hypouricemic agents.
Aciculatin Inhibits Granulocyte Colony-Stimulating Factor Production by Human Interleukin 1β-Stimulated Fibroblast-Like Synoviocytes
Kao-Shang Shih, Jyh-Horng Wang, Yi-Wen Wu, Che-Ming Teng, Chien-Chih Chen, Chia-Ron Yang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042389
Abstract: The expression of granulocyte colony-stimulating factor (G-CSF), the major regulator of neutrophil maturation, by human fibroblast-like synoviocytes (FLS) can be stimulated by the inflammatory cytokine interleukin-1β (IL-1β). G-CSF is known to contribute to the pathologic processes of destructive arthritis, but the induction mechanism remains unknown. The aims of this study were to identify the signaling pathways involved in IL-1β-stimulated G-CSF production and to determine whether this process was inhibited by aciculatin (8-((2R,4S,5S,6R)-tetrahydro-4,5-dihydroxy-6-methyl-2H-pyran-2-yl)-5-hydroxy-2-(4-hydroxypheny?l)-7-methoxy-4H-chromen-4-one), the major bioactive component of Chrysopogon aciculatus. IL-1β-induced cytokine expression was evaluated by measuring mRNA and protein levels by RT-PCR, ELISA, and Milliplex? assay. Whether aciculatin inhibited IL-1β-stimulated G-CSF expression, and if so, how, were evaluated using western blot assay, an electrophoretic mobility shift assay, and a reporter gene assay. Neutrophil differentiation was determined by Wright-Giemsa staining and flow cytometry. Aciculatin markedly inhibited G-CSF expression induced by IL-1β (10 ng/mL) in a concentration-dependent manner (1–10 μM). In clarifying the mechanisms involved, aciculatin was found to inhibit the IL-1β-induced activation of the IκB kinase (IKK)/IκB/nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways by suppressing the DNA binding activity of the transcription factors NF-κB and activator protein (AP)-1. Furthermore, aciculatin significantly inhibited the G-CSF-mediated phosphorylation of Janus kinase-signal transducer and activator of transcription (JAK-STAT) and Akt and neutrophil differentiation from precursor cells. Our results show that aciculatin inhibits IL-1β-stimulated G-CSF expression and the subsequent neutrophil differentiation, suggesting that it might have therapeutic potential for inflammatory arthritis.
Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
Shwu-Li Wu,Jui-Hsin Su,Chiung-Yao Huang,Chi-Jen Tai,Ping-Jyun Sung,Chih-Chung Liaw,Jyh-Horng Sheu
Marine Drugs , 2012, DOI: 10.3390/md10061203
Abstract: Four new eunicellin-based diterpenes, simplexins P–S ( 1– 4), and the known compound simplexin A ( 5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3– 5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
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