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Search Results: 1 - 10 of 2663 matches for " Justin; "
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Stepsize Selection in Explicit Runge-Kutta Methods for Moderately Stiff Problems  [PDF]
Justin Steven Calder Prentice
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.26094
Abstract: We present an algorithm for determining the stepsize in an explicit Runge-Kutta method that is suitable when solving moderately stiff differential equations. The algorithm has a geometric character, and is based on a pair of semicircles that enclose the boundary of the stability region in the left half of the complex plane. The algorithm includes an error control device. We describe a vectorized form of the algorithm, and present a corresponding MATLAB code. Numerical examples for Runge-Kutta methods of third and fourth order demonstrate the properties and capabilities of the algorithm.
A Case Study of Gut Fermentation Syndrome (Auto-Brewery) with Saccharomyces cerevisiae as the Causative Organism  [PDF]
Barbara Cordell, Justin McCarthy
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.47054

Gut Fermentation Syndrome also known as Auto-Brewery Syndrome is a relatively unknown phenomenon in modern medicine. Very few articles have been written on the syndrome and most of them are anecdotal. This article presents a case study of a 61 years old male with a well documented case of Gut Fermentation Syndrome verified with glucose and carbohydrate challenges. Stool cultures demonstrated the causative organism as Saccharomyces cerevisiae. The patient was treated with antifungals and a low carbohydrate diet and the syndrome resolved. Helicobacter pylori was also found and could have been a possible confounding variable although the symptoms resolved post-treatment of the S. cerevisiae.

Strategizing the Development of Alzheimer’s Therapeutics  [PDF]
Justin Davis, Robin Couch
Advances in Alzheimer's Disease (AAD) , 2014, DOI: 10.4236/aad.2014.33011
Abstract: Alzheimer’s Disease is a complex, progressive condition with symptoms that do not reveal themselves until significant changes to neuronal morphology have already occurred. The delayed manifestation of cognitive decline makes determination of the true etiological origins difficult. As a result, identification of ideal drug targets becomes seemingly impossible. The existing treatments for Alzheimer’s Disease may temporarily suppress the rate of cognitive decline, but do little to slow or halt neuronal decay. While many believe that the current approaches to identifying a cure for the disease are too narrow-minded, focusing heavily on the physical manifestations of the diseased brain such as amyloid plaques and neurofibrillary tangles, this review asserts the status of Alzheimer’s research as rational and multi-faceted.
Cohesive Chains in the Transfiguration Narrative of Matthew 17:1-13  [PDF]
Justin R. Woods
Open Journal of Modern Linguistics (OJML) , 2015, DOI: 10.4236/ojml.2015.53027
Abstract: While much work in biblical studies has been offered in the form of theological exposition and historical critical speculation of literary origins of the gospels, few modern biblical studies scrutinize the language of these gospels from rigorous linguistic criteria. This paper takes a discourse analytic approach from the field of Systemic Functional Linguistics (SFL) founded by M. A. K. Halliday. The notion of cohesive chaining is taken in order to evaluate the level of literary unity in the original Greek of the episode of the transfiguration narrative found within the Gospel of Matthew. Cohesive chaining will be defined; its function within the greater sociolinguistic theory of SFL will be examined, and then the concept will be directly applied. The study concludes with a unique contribution demonstrating how these cohesive chains are then unified via choices in verbal aspect as the grammar that not only solidifies semantic continuity among those chains, but contours the discourse using a scheme of markedness that signals the prioritization of its message. The hope of this study is to reinforce the recent paradigm shift of biblical research utilizing modern linguistic paradigms as tools to transform biblical interpretation and exegesis into a rigorously discourse-centered linguistic methodology.
Beyond Values and Interests: The Anglo-America Special Relationship during the Syrian Conflict  [PDF]
Justin Gibbins, Shaghayegh Rostampour
Open Journal of Political Science (OJPS) , 2019, DOI: 10.4236/ojps.2019.91005
Abstract: This paper attempts to reveal how intervention in international conflicts (re) constructs the Anglo-American Special Relationship (AASR). To do this, this article uses Syria as a case study. Analyzing parliamentary debates, presidential/prime ministerial speeches and formal official addresses, it offers a discursive constructivist analysis of key British and US political spokespeople. We argue that historically embedded values and interests stemming from unity forged by World War Two have taken on new meanings: the AASR being constructed by both normative and strategic cultures. The former, we argue, continues to forge a common alliance between the US and Britain, while the latter produces notable tensions between the two states.
Generalisations of Rozansky-Witten invariants
Justin Roberts,Justin Sawon
Mathematics , 2001,
Abstract: We survey briefly the definition of the Rozansky-Witten invariants, and review their relevance to the study of compact hyperkahler manifolds. We consider how various generalisations of the invariants might prove useful for the study of non-compact hyperkahler manifolds, of quaternionic-Kahler manifolds, and of relations between hyperkahler manifolds and Lie algebras. The paper concludes with a list of additional problems.
Rad51 ATP binding but not hydrolysis is required to recruit Rad10 in synthesis-dependent strand annealing sites in S. cerevisiae  [PDF]
Justin Karlin, Paula L. Fischhaber
Advances in Biological Chemistry (ABC) , 2013, DOI: 10.4236/abc.2013.33033

Several modes of eukaryotic of DNA double strand break repair (DSBR) depend on synapsis of complementary DNA. The Rad51 ATPase, the S. cerevisiae homolog of E. coli RecA, plays a key role in this process by catalyzing homology searching and strand exchange between an invading DNA strand and a repair template (e.g. sister chromatid or homologous chromosome). Synthesis dependent strand annealing (SDSA), a mode of DSBR, requires Rad51. Another repair enzyme, the Rad1-Rad10 endonuclease, acts in the final stages of SDSA, hydrolyzing 3 overhanging single-stranded DNA. Here we show in vivo by fluo-rescence microscopy that the ATP binding function of yeast Rad51 is required to recruit Rad10 SDSA sites indicating that Rad51 pre-synaptic filament formation must occur prior to the recruitment of Rad1-Rad10. Our data also show that Rad51 ATPase activity, an important step in Rad51 filament disassembly, is not absolutely required in order to recruit Rad1- Rad10 to DSB sites.

Molecular Pathology of Hereditary Diffuse Gastric Cancer  [PDF]
Justin I. Odegaard, Iris Schrijver
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.42070

Hereditary diffuse gastric cancer is a rare, autosomal dominant hereditary cancer syndrome associated with germline mutations in CDH1 in which 60% - 80% of affected individuals develop advanced diffuse gastric cancer, many as young adults. At clinical presentation, ~90% of these malignancies represent advanced, surgically incurable disease. As such, presymptomatic identification of germline CDH1 mutation carriers followed by early prophylactic total gastrictomy is the sole effective management strategy available. DNA sequence analysis of the CDH1 gene to identify the affected germline allele is the diagnostic standard of care; however, CDH1s relatively high frequency of polymorphisms and the limited amount of experience available regarding them dictate that many identified variants are, as yet, of unknown clinical significance. Given the dramatic consequences of inappropriately offered or withheld treatment, careful clinical selection of at-risk individuals is critical. To facilitate this, multiple groups have published screening criteria recommendations, and while there is disagreement regarding the optimal diagnostic approach, the most widely-used overlap to a considerable degree.

Flowering Ecology of the Species of the Genus Hypoxidia (Hypoxidaceae: Asparagales)
Justin Gerlach
Journal of Botany , 2011, DOI: 10.1155/2011/104736
Abstract: Hypoxidia (Hypoxidaceae) is endemic to the Seychelles islands. The two species H. rhizophylla and H. maheensis have rarely been studied. The first studies of floral ecology are described based on 19 years of observations of cultivated (1992–1994) and wild (1998–2011) plants of H. rhizophylla and a single flowering event of cultivated H. maheensis. In H. rhizophylla, heavy rainfall acts as a trigger to flowering, with flowers opening 14 days after heavy rain. This can occur in any month and local rainfall can act as a trigger even in generally dry conditions. Flowers are only open for a few hours, usually in the morning. Pollinators have not been identified but only one specie has been seen visiting flowers regularly; the fly Dichaetomyia fasciculifera (Muscidae) is common on Silhouette island where 12% of flowers are pollinated but very scarce on Mahé where fruiting of H. rhizophylla is rarely recorded. Low rates of pollination and limited dispersal is thought to result in effective isolation of most populations which probably mainly reproduce clonally. Clarification of this requires further research into genetic structuring of the populations. 1. Introduction Hypoxidia is an isolated genus of the family Hypoxidaceae. It comprises two species, restricted to the Seychelles islands and forms a monophyletic Seychelles clade with the species “Curucligo” seychellensis [1]. The Hypoxidaceae have largely been overlooked in ecological studies due to the relatively small size and inconspicuous nature of most of the species. The Seychelles Hypoxidaceae are unusual in that they can be argued to form a major part of the forest ecosystems, being among the few herbaceous plants to be found in the closed woodlands of the larger Seychelles islands. Hypoxidia rhizophylla (Baker) F. Friedmann is the most widespread of the Seychelles Hypoxidaceae, being recorded from Mahé, Silhouette, Praslin, La Digue, Curieuse, and Felicite [2, 3]. On these islands it is rarely found below 150?m?a.s.l. but can be found from sea level to 900?m?a.s.l. (personal observation). In contrast, H. maheensis F. Friedmann is known only from most forests above 300?m on Mahé island. The two species differ in floral morphology and in some vegetative characters. H. rhizophylla is highly variable in leaf shape and size but always shows the ability to reproduce with epiphyllous buds. As a result it frequently forms what are probably clonal clumps. H. maheensis does not appear to form epiphyllous buds and has lower density populations. A high degree of geographical variation in floral characters has been
Reproductive Declines in an Endangered Seabird: Cause for Concern or Signs of Conservation Success?
Justin Schuetz
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019489
Abstract: Collection and analysis of demographic data play a critical role in monitoring and management of endangered taxa. I analyzed long-term clutch size and fledgling productivity data for California least tern (Sternula antillarum browni), a federally endangered subspecies that has recently become a candidate for down-listing. While the breeding population grew from approximately 1,253 to 7,241 pairs (578%) during the study period (1988–2009) both clutch size and fledgling productivity declined. Clutch size decreased by approximately 0.27 eggs (14%) from 1990–2004 then showed a moderate increase of 0.11 eggs from 2004–2009. Estimates of fledgling productivity showed a similar pattern of decline and moderate increase even after controlling for clutch size. Sea surface temperature anomalies, an index of El Ni?o-Southern Oscillation activity, did not influence clutch size but were associated with fledgling productivity through a non-linear relationship. Both clutch size and fledgling productivity increased with latitude, potentially indicating a gradient of life-history trade-offs. Random site effects explained little of the overall variation in clutch size (3%) or fledgling productivity (<1%) suggesting that site characteristics beyond those associated with latitude had little bearing on either measure of reproduction. Despite intensive monitoring and management, causes of variation in key demographic parameters remain poorly understood. Long-term declines in clutch size and fledgling productivity may reflect: 1) reduced food availability, 2) increased density-dependent competition, and/or 3) age-dependent reproduction coupled with a shifting population age-structure. Until the mechanisms shaping demographic parameters and population change are better understood, the success of past management and the probability of ongoing recovery will remain difficult to characterize.
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