oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 68 )

2018 ( 469 )

2017 ( 463 )

2016 ( 437 )

Custom range...

Search Results: 1 - 10 of 33042 matches for " Junwei Guo "
All listed articles are free for downloading (OA Articles)
Page 1 /33042
Display every page Item
Edible Peanut Worm(Sipunculus nudus) in the Beibu Gulf: Resource, Aquaculture, Ecological Impact and Counterplan Edible Peanut Worm(Sipunculus nudus) in the Beibu Gulf: Resource, Aquaculture, Ecological Impact and Counterplan
LI Junwei,XIE Xiaoyong,ZHU Changbo,GUO Yongjian,CHEN Suwen
- , 2017,
Abstract: Sipunculus nudus is an important economic species because of its high nutritional and medicinal values. The exploitation and utilization of S. nudus primarily occur in the coastal regions of the Beibu Gulf. However, wild resource of S. nudus is rapidly decreasing because of the overexploitation, which has led to considerable developments of artificial breeding techniques. The cultivation scale of S. nudus has increased in response to successful artificial breeding; however, methods for culturing S. nudus in tidal flats or ponds require further study. Most studies have focused on the breeding, nutrition, medical value and ecological impact of these worms. Studies on the distribution, sediment requirements, nutrition characteristics, breeding techniques and aquaculture ecology of this species are summarized in this paper to promote the development of the aquaculture industry for S. nudus. The high biomass of S. nudus in the Beibu Gulf is positively correlated with the sediment characteristics and water quality of the region. The production of peanut worm has improved to some extent through culturing; however, the nutrient value and ecological environment problems have been observed, which reflect the over exploitation of trace elements and the sediment. These problems will worsen unless they are resolved, and the release of organic materials, nitrogen and phosphorus during harvesting impacts the coastal environment. Moreover, genetic erosion is a potential risk for larvae in artificial breeding programs in tidal flats. Therefore, culturing and collecting methods should be improved and the wild resource conservation should be implemented to promote the sustainable development of the peanut worm
Research on the Interference Trend of National Taxation with Price and Inflation  [PDF]
Shufeng Wang, Junwei Han
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.63011
Abstract:
In view of the objective reality that the market prices stay high in recent years, inflation which continues to rise is not effectively inhibited, combined with the previous economic circles who attributed the reasons to inflation for commodity supply and demand, the issuance of money and neglect the role of tax factors led to national governance inflation decision-making that is limited by the phenomenon. By means of comparative analysis, Granger causality analysis and Augmented Dickey-Fuller test, we dissect the external disturbance and endogenous factors of influencing inflation, select the 2001-2016 tax index and CPI index and make an empirical research of the interference from government taxation to price and inflation trends and strength. It is approved there is single causal relationship between tax and price rising, and sums up that government taxation can promote inflation, but inflation can’t lead to tax rising. Of course, this conclusion can also provide theoretical support for national governance of inflation.
Polymorphisms in CTLA4 Influence Incidence of Drug-Induced Liver Injury after Renal Transplantation in Chinese Recipients
Yifeng Guo, Yu Fan, Jianxin Qiu, Yong Liu, Junwei Gao, Fang Guo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051723
Abstract: Genetic polymorphisms in cytotoxic T lymphocyte-associated antigen 4 (CTLA4) play an influential role in graft rejection and the long-term clinical outcome of organ transplantation. We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients. Each recipient underwent a 24-month follow-up observation for drug-induced liver damage. The CTLA4 SNPs were genotyped in 864 renal transplantation recipients. A significant association was found between the rs231775 genotype and an early onset of DILI in the recipients. Multivariate analyses revealed that a risk factor, recipient rs231775 genotype (p = 0.040), was associated with DILI. Five haplotypes were estimated for 4 SNPs (excluding rs733618); the frequency of haplotype ACGG was significantly higher in the DILI group (68.9%) than in the non-DILI group (61.1%) (p = 0.041). In conclusion, CTLA4 haplotype ACGG was partially associated with the development of DILI in Chinese kidney transplant recipients. The rs231775 GG genotype may be a risk factor for immunosuppressive drug-induced liver damage.
CTLA4 Gene Polymorphisms Influence the Incidence of Infection after Renal Transplantation in Chinese Recipients
Yifeng Guo, Fang Guo, Chongyang Wei, Jianxin Qiu, Yong Liu, Yu Fang, Junwei Gao
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070824
Abstract: Background Immunosuppressive therapy is usually administered following renal transplantation to protect the graft from rejection. However, this often causes complications such as infections to occur. Single nucleotide polymorphisms (SNPs) within the CTLA4 gene, such as ?1772T/C (rs733618), +49A/G (rs231775) and +6230 G/A (rs3087243), can affect graft rejection and the long-term clinical outcome of organ transplantation. The role of CTLA4 SNPs in T cell-mediated immunity in renal transplantation and association with infection after transplantation is unknown. Methods In this study, the risk of infection according to CTLA4 SNPs was investigated in 304 patients who received kidney graft transplants between 2008 and 2012. Results The frequency of the rs4553808 GG genotype was significantly higher in recipients with viral infection (14.89%) than in those without infections (3.50%) (Bonferroni-adjusted p = 0.005). A significant difference (p = 0.001) in patients with the rs4553808 GG genotype from those with the AA+AG genotypes was found in the viral cohort using the log-rank test. A significant association was found between the rs4553808 genotype and onset of viral infection in transplant recipients (p = 0.001). The frequencies of the CGTAG and CGCAG haplotypes were significantly higher in the viral infection group (9.6% and 5.3%) than in the non-viral infection group (3.8% and 1.4%) (p = 0.0149 and p = 0.0111). No association between any CTLA4 SNP and bacterial infection was found. Multivariate analyses revealed that one risk factor, the use of antibody induction therapy (p = 0.007), was associated with bacterial infection, and two risk factors, antibody use (p = 0.015) and recipient rs4553808 genotype (p = 0.001), were associated with viral infection. Conclusions The rs4553808 GG genotype may be a risk factor for viral infection in kidney transplantation. The CTLA4 haplotypes CGTAG and CGCAG were partially associated with the development of viral infection in Chinese kidney transplant recipients.
The presence of phosphorylation form of D1 protein in its cross-linked aggregates in high light treated spinach leaves in vivo
Huimin Wei,Junwei Guo,Shuang Zhang,Bo Huang,Yinqiu Liu,Linfang Du,
WEI
,Huimin,GUO,Junwei,ZHANG,Shuang,HUANG,Bo,LIU,Yinqiu,DU,Linfang

科学通报(英文版) , 2006,
Abstract: In the present study, using specific antibody against D1 protein, we detected four aggregates of D1 protein in thylakoid membranes from spinach leaves illuminated at high light (800–2500 μmol photons·m 2·s 1) for 3 h. Their accumulations were dependent on the light intensity to which the leaves had been subjected. Further immunoblot analysis indicated that 70 kD aggregate was a product of D1 protein cross-linked with CP43, 65 and 60 kD aggregate were two cross-linked products between D1 and D2 proteins, and 41 kD aggregate was one cross-linked D1 with α-subunit of cytochrome b 559 (Cyt b 559). This result provided the evidence for the existence of the aggregation of the D1 protein in vivo. The maximal level of D1/Cyt b 559 aggregate occurred at 1000 μmol photons·m 2·s 1 but drastically decreased with further increasing light intensity. Immunoblot analysis with phosphothreonine (Thr (P)) antibody indicated that D1/CP43 and D1/Cyt b 559 aggregates contained the phosphorylated protein(s). In vitro dephosphorylation experiment also showed that D1/Cyt b 559 and D1/CP43 aggregates lost the immunoreactivity with Thr (P) antibody after the phosphatase treatment of the membranes from high-light-illuminated leaves. Our results demonstrated that strong illumination of spinach leaves induced cross-linked products of D1 protein with its nearby polypeptides of PS, some of which co.n-tained the phosphorylated D1 protein.
Decrease of Plasma Platelet-Activating Factor Acetylhydrolase Activity in Lipopolysaccharide Induced Mongolian Gerbil Sepsis Model
Junwei Yang,Jing Xu,Xiaoying Chen,Yixuan Zhang,Xucheng Jiang,Xiaokui Guo,Guoping Zhao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009190
Abstract: Platelet-activating factor (PAF) plays an important role in the pathogenesis of sepsis, and the level of plasma PAF acetylhydrolase (pPAF-AH), which inactivates PAF, decreases in sepsis patients except for the sepsis caused by severe leptospirosis. Usually, increase of pPAF-AH activity was observed in lipopolysaccharide (LPS)-induced Syrian hamster and rat sepsis models, while contradictory effects were reported for mouse model in different studies. Here, we demonstrated the in vivo effects of LPS upon the change of pPAF-AH activity in C57BL/6 mice and Mongolian gerbils. After LPS-treatment, the clinical manifestations of Mongolian gerbil model were apparently similar to that of C57BL/6 mouse sepsis model. The pPAF-AH activity increased in C57BL/6 mice after LPS induction, but decreased in Mongolian gerbils, which was similar to that of the human sepsis. It thus suggests that among the LPS-induced rodent sepsis models, only Mongolian gerbil could be used for the study of pPAF-AH related to the pathogenesis of human sepsis. Proper application of this model might enable people to clarify the underline mechanism accounted for the contradictory results between the phase II and phase III clinical trials for the administration of recombinant human pPAF-AH in the sepsis therapy.
The presence of phosphorylation form of D1 protein in its cross-linked aggregates in high light treated spinach leaves in vivo
Huimin Wei,Junwei Guo,Shuang Zhang,Bo Huang,Yinqiu Liu,Linfang Du
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-005-1529-3
Abstract: In the present study, using specific antibody against D1 protein, we detected four aggregates of D1 protein in thylakoid membranes from spinach leaves illuminated at high light (800–2500 μmol photons·m 2·s 1) for 3 h. Their accumulations were dependent on the light intensity to which the leaves had been subjected. Further immunoblot analysis indicated that 70 kD aggregate was a product of D1 protein cross-linked with CP43, 65 and 60 kD aggregate were two cross-linked products between D1 and D2 proteins, and 41 kD aggregate was one cross-linked D1 with α-subunit of cytochrome b 559 (Cyt b 559). This result provided the evidence for the existence of the aggregation of the D1 protein in vivo. The maximal level of D1/Cyt b 559 aggregate occurred at 1000 μmol photons·m 2·s 1 but drastically decreased with further increasing light intensity. Immunoblot analysis with phosphothreonine (Thr (P)) antibody indicated that D1/CP43 and D1/Cyt b 559 aggregates contained the phosphorylated protein(s). In vitro dephosphorylation experiment also showed that D1/Cyt b 559 and D1/CP43 aggregates lost the immunoreactivity with Thr (P) antibody after the phosphatase treatment of the membranes from high-light-illuminated leaves. Our results demonstrated that strong illumination of spinach leaves induced cross-linked products of D1 protein with its nearby polypeptides of PS, some of which co.n-tained the phosphorylated D1 protein.
Novel Single Nucleotide Polymorphisms in Interleukin 6 Affect Tacrolimus Metabolism in Liver Transplant Patients
Dawei Chen, Junwei Fan, Feng Guo, Shengying Qin, Zhaowen Wang, Zhihai Peng
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073405
Abstract: Background Tacrolimus is the first-line immunosuppressant after organ transplantation. It is mainly metabolized by cytochrome P450, family 3, subfamily A (CYP3A) enzymes, but there are large individual differences in metabolism. Interleukin 6 (IL6) has been shown to cause a pan-suppression of mRNA levels of ten major CYP enzymes in human hepatocyte cultures. IL6 has been shown to provide hepatoprotection in various models of liver injury. Rs1800796 is a locus in the IL6 gene promoter region which regulates cytokine production. We speculated that IL6 rs1800796 polymorphisms may lead to individual differences in tacrolimus metabolism by affecting CYP3A enzymes levels and liver function after liver transplantation. Methodology/Principal Findings Ninety-six liver transplant patients receiving tacrolimus were enrolled in the study. Two single nucleotide polymorphisms (SNP), CYP3A5 rs776746 and IL6 rs1800796, were genotyped in both donors and recipients. The effects of SNPs on tacrolimus concentration/dose (C/D ratio) at four weeks after transplantation were studied, as well as the effects of donor IL6 rs1800796 polymorphisms on liver function. Both donor and recipient CYP3A5 rs776746 allele A showed association with lower C/D ratios, while donor IL6 rs1800796 allele G showed an association with higher C/D ratios. Donor CYP3A5 rs776746 allele A, IL6 rs1800796 allele C, and recipient CYP3A5 rs776746 allele A were associated with fast tacrolimus metabolism. With increasing numbers of these alleles, patients were found to have increasingly lower tacrolimus C/D ratios at time points after transplantation. Donor IL6 rs1800796 allele G carriers showed an association with higher glutamic-pyruvic transaminase (GPT) levels. Conclusions Combined analysis of donor CYP3A5 rs776746, IL6 rs1800796, and recipient CYP3A5 rs776746 polymorphisms may distinguish tacrolimus metabolism better than CYP3A5 rs776746 alone. IL6 may lead to individual differences in tacrolimus metabolism mainly by affecting liver function.
A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human Brain
Xiaojin Li,Xintao Hu,Changfeng Jin,Junwei Han,Tianming Liu,Lei Guo,Wei Hao,Lingjiang Li
International Journal of Biomedical Imaging , 2013, DOI: 10.1155/2013/201735
Abstract: Previous studies have investigated both structural and functional brain networks via graph-theoretical methods. However, there is an important issue that has not been adequately discussed before: what is the optimal theoretical graph model for describing the structural networks of human brain? In this paper, we perform a comparative study to address this problem. Firstly, large-scale cortical regions of interest (ROIs) are localized by recently developed and validated brain reference system named Dense Individualized Common Connectivity-based Cortical Landmarks (DICCCOL) to address the limitations in the identification of the brain network ROIs in previous studies. Then, we construct structural brain networks based on diffusion tensor imaging (DTI) data. Afterwards, the global and local graph properties of the constructed structural brain networks are measured using the state-of-the-art graph analysis algorithms and tools and are further compared with seven popular theoretical graph models. In addition, we compare the topological properties between two graph models, namely, stickiness-index-based model (STICKY) and scale-free gene duplication model (SF-GD), that have higher similarity with the real structural brain networks in terms of global and local graph properties. Our experimental results suggest that among the seven theoretical graph models compared in this study, STICKY and SF-GD models have better performances in characterizing the structural human brain network. 1. Introduction The human brain is intrinsically organized into distinct large-scale functional networks, and cognitive functions arise from the dynamic interactions of distributed brain areas operating in these networks [1]. New advances in neuroimaging techniques have shown the possibility of systematic exploring the human brain formal complex network perspective. Graph theory provides a theoretical framework in which the topological properties of the brain networks can be examined such as centrality, clustering, efficiency, hierarchy, modularity, robustness, small-worldness, and synchronizability [2], and it can reveal important information about both the global and local organizations of the human brain networks. The improved characterization of brain networks achieved via graph-theoretical methods provides not only parsimonious accounts of normal cognitive processes [3], but also novel insights into psychiatric and neurological disorders such as Alzheimer’s disease [4, 5], multiple sclerosis [6], and attention-deficit disorder [7]. Many complex systems show remarkably similar
用地下水潮汐效应确定潜水含水层水文地质参数
Estimating Unconfined Aquifer Parameters Based on Groundwater Tidal Effect

郭敏,万军伟,江峰,黄琨
Guo Min
, Wan Junwei, Jiang Feng, Huang Kun

地球科学(中国地质大学学报) , 2017, DOI: 10.3799/dqkx.2017.012
Abstract: 目前对潜水含水层地下水潮汐效应和水文地质参数求解方法的研究相对较少.通过对福建古雷半岛滨海潜水含水层地下水潮汐效应和海水潮汐动态的观测,运用Fourier频谱分析方法确定了研究区海水潮汐波动方程(波动特征参数),并以此作为地下水的边界条件,推导了潜水含水层地下水潮汐效应的波动方程,利用最小二乘法以地下水水位波动观测值为目标函数对潜水含水层的渗透系数与重力给水度的比值进行了反演识别,为类似地区水文地质参数的确定提供了借鉴,也为该区后续地下水中溶质迁移规律的研究奠定了基础.
Studies on the groundwater tidal effect in unconfined aquifer and the method of calculating unconfined aquifer hydrogeological parameters are relatively inefficient. In this study, spectral analysis is used to obtain an analytical formula for tidal level description by firstly observing groundwater table in a well of a coastal unconfined aquifer and tidal level in Gulei peninsula. Then the formula is used as the boundary condition of groundwater flow to deduce the solution of groundwater table in the unconfined aquifer. At last the least square method is used to calculate the hydrogeological parameters in the unconfined aquifer, which provides a reference to similar areas and gives basic information for the study on the groundwater solute transport in this area
Page 1 /33042
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.