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Search Results: 1 - 10 of 2797 matches for " Junji Yoshida "
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IF1, a natural inhibitor of mitochondrial ATP synthase, is not essential for the normal growth and breeding of mice
Junji Nakamura,Makoto Fujikawa,Masasuke Yoshida
Bioscience Reports , 2013, DOI: 10.1042/bsr20130078
Abstract: IF1 is an endogenous inhibitor protein of mitochondrial ATP synthase. It is evolutionarily conserved throughout all eukaryotes and it has been proposed to play crucial roles in prevention of the wasteful reverse reaction of ATP synthase, in the metabolic shift from oxidative phosphorylation to glycolysis, in the suppression of ROS (reactive oxygen species) generation, in mitochondria morphology and in haem biosynthesis in mitochondria, which leads to anaemia. Here, we report the phenotype of a mouse strain in which IF1 gene was destroyed. Unexpectedly, individuals of this IF1-KO (knockout) mouse strain grew and bred without defect. The general behaviours, blood test results and responses to starvation of the IF1-KO mice were apparently normal. There were no abnormalities in the tissue anatomy or the autophagy. Mitochondria of the IF1-KO mice were normal in morphology, in the content of ATP synthase molecules and in ATP synthesis activity. Thus, IF1 is not an essential protein for mice despite its ubiquitous presence in eukaryotes.
Improvement of die life in high speed injection die casting
Yasuhiro Arisuda,Akihito Hasuno,Junji Yoshida
China Foundry , 2008,
Abstract: High-speed injection die casting is an effi cient manufacturing technology for upgrading aluminum die-cast products. However, defi ciencies (such as die damage in early period) due to larger load on the molding die compared with conventional technology have brought new challenges. In this study, the cause of damage generated in super high-speed injection was investigated by the combination of experimental observation of the dies and CAE simulation (e.g. die emperature analysis, fl ow analysis and thermal stress analysis). The potential countermeasures to solve the above problems were also proposed.
Transport in two dimensional periodic magnetic fields
Junji Yoshida,Tomi Ohtsuki,Yoshiyuki Ono
Physics , 1998, DOI: 10.1143/JPSJ.67.3886
Abstract: Ballistic transport properties in a two dimensional electron gas are studied numerically, where magnetic fields are perpendicular to the plane of two dimensional electron systemsand periodically modulated both in $x$ and $y$ directions. We show that there are three types of trajectories of classical electron motions in this system; chaotic, pinned and runaway trajectories. It is found that the runaway trajectories can explain the peaks of magnetoresistance as a function of external magnetic fields, which is believed to be related to the commensurability effect between the classical cyclotron diameter and the period of magnetic modulation. The similarity with and difference from the results in the antidot lattice are discussed.
Surgical resection of a solitary para-aortic lymph node metastasis from hepatocellular carcinoma
Junji Ueda,Hiroshi Yoshida,Yasuhiro Mamada,Nobuhiko Taniai
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i23.3027
Abstract: Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor. He had already undergone radiofrequency ablation, transcatheter arterial chemoembolization, and percutaneous ethanol injection therapy for HCC. Despite treatment, viable regions remained in segments 4 and 8. We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver. Six months later, serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased. Enhanced computed tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta. Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value. There was no evidence of recurrence in other regions. Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract. Para-aortic LN metastasis from HCC was thus diagnosed. We performed lymphadenectomy. Histopathological examination revealed that the tumor was largely necrotic, with poorly differentiated HCC on its surface, which confirmed the suspected diagnosis. After 6 mo tumor marker levels were normal, with no evidence of recurrence. Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically.
Surgical Resection of a Leiomyosarcoma of the Inferior Vena Cava Mimicking Hepatic Tumor
Junji Ueda,Hiroshi Yoshida,Yasuhiro Mamada,Nobuhiko Taniai
Case Reports in Medicine , 2013, DOI: 10.1155/2013/235698
Abstract:
Why Are Children Impatient? Evolutionary Selection of Preferences  [PDF]
Junji Kageyama
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.35A3003
Abstract:

This study aims to explain why children are impatient. Using a biological framework called the life history theory, the study investigates the evolutionary root of time preference, paying particular attention to childhood. The results show that the biologically endowed rate of time preference is equal to the mortality rate not only in adulthood but also in childhood, reflecting the change in the biological value of survival. Mortality is the baseline for time preference through the entire course of life. These results are consistent with the findings in previous empirical and experimental studies that the discount rate is U-shaped in age, and account for why young children, in particular, are impatient. In addition, the difference in time preference between adults and children provides a biological explanation for the parent-offspring conflict, in which the higher discount rate among children causes parents and their children to disagree over intertemporal allocation of resources in collective decision-making particularly within the household.

Amoebal Endosymbiont Protochlamydia Induces Apoptosis to Human Immortal HEp-2 Cells
Atsushi Ito,Junji Matsuo,Shinji Nakamura,Asahi Yoshida,Miho Okude,Yasuhiro Hayashi,Haruna Sakai,Mitsutaka Yoshida,Kaori Takahashi,Hiroyuki Yamaguchi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030270
Abstract: Protochlamydia, an environmental chlamydia and obligate amoebal endosymbiotic bacterium, evolved to survive within protist hosts, such as Acanthamobae, 700 million years ago. However, these bacteria do not live in vertebrates, including humans. This raises the possibility that interactions between Protochlamydia and human cells could induce a novel cytopathic effect, leading to new insights into host-parasite relationships. Therefore, we studied the effect of Protochlamydia on the survival of human immortal cell line, HEp-2 cells and primary peripheral blood mononuclear cells (PBMC). Using mainly 4′,6-diamidino-2-phenylindole staining, fluorescent in situ hybridization, transmission electron microscopy, and also TUNEL and Transwell assays, we demonstrated that the Protochlamydia induced apoptosis in HEp-2 cells. The attachment of viable bacterial cells, but not an increase of bacterial infectious progenies within the cells, was required for the apoptosis. Other chlamydiae [Parachlamydia acanthamoebae and Chlamydia trachomatis (serovars D and L2)] did not induce the same phenomena, indicating that the observed apoptosis may be specific to the Protochlamydia. Furthermore, the bacteria had no effect on the survival of primary PBMCs collected from five volunteers, regardless of activation. We concluded that Protochlamydia induces apoptosis in human-immortal HEp-2 cells and that this endosymbiont could potentially be used as a biological tool for the elucidation of novel host-parasite relationships.
Measurement of Surface SH-Wave Velocities Generated on the Surface of Japanese Cypress Column  [PDF]
Masumi Hasegawa, Junji Matsumura
Open Journal of Acoustics (OJA) , 2014, DOI: 10.4236/oja.2014.44018
Abstract: Polyetherimide resin wedge transducers were used to generate a shear wave that was obliquely incident relative to the surface of a Japanese cypress column for measuring the surface SH-wave velocity. As the inter-transducer distance increased, the propagation time increased and the am-plitude became smaller. The propagation time and the amplitude were significantly correlated with the inter-transducer distance. The SH-wave velocity ranged from 1270 m/s to 1496 m/s. Surface SH-wave velocity was lower in the central part of the column and higher in the outer part. Velocity was negatively correlated with moisture content at 1% of significance level. These results suggest the accomplishment of the first target for applying the surface SH-wave acoustoelastic technique to nondestructive evaluation of drying stress in wood.
New spherically symmetric solutions in Einstein-Yang-Mills-Higgs model
Jia, Junji
High Energy Physics - Phenomenology , 2008,
Abstract: We study classical solutions in the SU(2) Einstein-Yang-Mills-Higgs theory. The spherically symmetric ans\"atze for all fields are given and the equations of motion are derived as a system of ordinary differential equations. The asymptotics and the boundary conditions at space origin for regular solutions and at event horizon for black hole solutions are studied. Using the shooting method, we found numerical solutions to the theory. For regular solutions, we find two new sets of asymptotically flat solutions. Each of these sets contains continua of solutions in the parameter space spanned by the shooting parameters. The solutions bifurcate along these parameter curves and the bifurcation are argued to be due to the internal structure of the model. Both sets of the solutions are asymptotically flat but one is exponentially so and the other is so with oscillations. For black holes, a new set of boundary conditions is studied and it is found that there also exists a continuum of black hole solutions in parameter space and similar bifurcation behavior is also present to these solutions. The SU(2) charges of these solutions are found zero and these solutions are proven to be unstable.
Charged Lepton-Flavor Violation in Beyond-Standard Models
Hisano, Junji
High Energy Physics - Phenomenology , 2008,
Abstract: I discuss charged lepton-flavor violation in physics beyond the standard model and review topics related to it.
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