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Search Results: 1 - 10 of 3095 matches for " Junji Kobayashi "
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Oocyte quality improvement using a herbal medicine comprising 7 crude drugs  [PDF]
Taketo Inoue, Yoshiyuki Ono, Yukiko Yonezawa, Michinobu Oi, Naomi Kobayashi, Junji Kishi, Nobuyuki Emi
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.31A036

Maternal age is a significant factor in infertility treatment. Ovarian function and oocyte quality decrease with age, whereas the frequency of chromosomal abnormalities increases. In this study, improvement of oocyte quality and ovarian function were attempted using a herbal medicine comprising 7 crude drugs:Angelicae radix,Rehmanniae radix,Plantaginis semen,Lonicerae flos,Carthami flos,Ginseng radix, andCucurbita moschata Duch. Thirty-one women who repeatedly failed to conceive by intracytoplasmic sperm injection took the herbal medicine before breakfast and dinner from the start of menstrual cycle in the ovum pickup cycle. Average patient age was 38.5 ± 0.7 years, and the average ovum pickup frequency on the first dosage day was 7.9 ± 1.5. To analyze the effects of herbal medicine intake, the number of recovered and mature oocytes, their morphology and physical qualities, as well as the rates of fertilization, oocyte development, and pregnancy was compared before and after intake. The recovered and mature oocyte numbers, oocyte morphology and physical qualities, and fertilization rate were not significantly different before and after drug intake. However, the oocyte development rate was significantly higher(58.0%) after herbal medicine intake than before (32.5%; p = 0.0003). Moreover, the successful pregnancy rate was significantly higher after intake than before (6.9% versus 0%; p = 0.0111). Herbal medicine may constitute a useful adjunct to assisted reproductive technology in women.

Two-loop Renormalization Factors of Dimension-six Proton Decay Operators in the Supersymmetric Standard Models
Hisano, Junji;Kobayashi, Daiki;Muramatsu, Yu;Nagata, Natsumi
High Energy Physics - Phenomenology , 2013,
Abstract: The renormalization factors of the dimension-six effective operators for proton decay are evaluated at two-loop level in the supersymmetric grand unified theories. For this purpose, we use the previous results in which the quantum corrections to the effective Kahler potential are evaluated at two-loop level. Numerical values for the factors are presented in the case of the minimal supersymmetric SU(5) grand unified model. We also derive a simple formula for the one-loop renormalization factors for any higher-dimensional operators in the Kahler potential, assuming that they are induced by the gauge interactions.
Decoupling Can Revive Minimal Supersymmetric SU(5)
Hisano, Junji;Kobayashi, Daiki;Kuwahara, Takumi;Nagata, Natsumi
High Energy Physics - Phenomenology , 2013,
Abstract: We revisit proton decay via the color-triplet Higgs multiplets in the minimal supersymmetric grand unified model with heavy sfermions. Although the model has been believed to be excluded due to the too short lifetime of proton, we have found that it is possible to evade the experimental constraints on the proton decay rate if the supersymmetric particles have masses much heavier than the electroweak scale. With such heavy sfermions, the 126GeV Higgs boson is naturally explained, while they do not spoil the gauge coupling unification and the existence of dark matter candidates. Since the resultant proton lifetime lies in the regions which may be reached in the future experiments, proton decay searches may give us a chance to verify the scenario as well as the supersymmetric grand unified models.
Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus
Naoto Yamaaki,Kunimasa Yagi,Junji Kobayashi,Atsushi Nohara
Journal of Diabetes Research , 2013, DOI: 10.1155/2013/143515
Development of Pancreatic Ductal Adenocarcinoma Associated with Intraductal Papillary Mucinous Neoplasia
Kazuo Inui,Junji Yoshino,Hironao Miyoshi,Takashi Kobayashi
ISRN Gastroenterology , 2011, DOI: 10.5402/2011/940378
Short-Term Effect of Pitavastatin Treatment on Glucose and Lipid Metabolism and Oxidative Stress in Fasting and Postprandial State Using a Test Meal in Japanese Men
Hirokazu Kakuda,Junji Kobayashi,Mio Nakato,Noboru Takekoshi
Cholesterol , 2013, DOI: 10.1155/2013/314170
Abstract: Introduction. The objective of this study was to clarify how pitavastatin affects glucose and lipid metabolism, renal function, and oxidative stress. Methods. Ten Japanese men (average age of 33.9 years) were orally administered 2?mg of pitavastatin for 4 weeks. Postprandial glucose, lipoprotein metabolism, and oxidative stress markers were evaluated at 0 and 4 weeks of pitavastatin treatment (2?mg once daily) with a test meal consisting of total calories: 460?kcal, carbohydrates: 56.5?g (226?kcal), protein: 18?g (72?kcal), lipids: 18?g (162?kcal), and NaCl: 1.6?g. Metabolic parameters were measured at 0, 60, and 120 minutes after test meal ingestion. Results. After administration of pitavastatin, serum total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, arachidonic acid, insulin, and adjusted urinary excretion of uric acid decreased, whereas creatinine clearance ( ) and uric acid clearance ( ) increased. And postprandial versus fasting urine 8-hydroxydeoxyguanosine remained unchanged, while postprandial versus fasting isoprostane decreased after pitavastatin treatment. Next, we compared postprandial glucose and lipid metabolism after test meal ingestion before and after pitavastatin administration. Incremental areas under the curve significantly decreased for triglycerides ( ) and remnant-like particle cholesterol ( ), while those for apolipoprotein E (apoE), glucose, insulin, and high-sensitivity C-reactive protein remained unchanged. Conclusion. Pitavastatin improves postprandial oxidative stress along with hyperlipidemia. 1. Introduction It has been generally recognized that postprandial hyperglycemia and hyperlipidemia are highly related to the development of atherosclerosis [1–5]. Hyperglycemia is known to damage vascular endothelial cells, increase oxidative stress, promote the expression of adhesion molecules, and inhibit Nitric Oxide (NO) production [6]. Remnant lipoprotein, an important component of postprandial hyperlipidemia, promotes foam cell formation of macrophages and proliferation of smooth muscle cells [7]. A very recent study on a large number of subjects demonstrated that remnant cholesterol was a causal risk factor for ischemic heart disease [8]. Lipid-lowering drugs, such as statins, fibrates, and ezetimibe are considered to be useful for the treatment of postprandial hyperlipidemia [9–15]. Pitavastatin, a member of the medication class of statins, has been available in the market in Japan since 2003. It has been well recognized that this statin is markedly effective in reducing low-density lipoprotein
Why Are Children Impatient? Evolutionary Selection of Preferences  [PDF]
Junji Kageyama
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.35A3003

This study aims to explain why children are impatient. Using a biological framework called the life history theory, the study investigates the evolutionary root of time preference, paying particular attention to childhood. The results show that the biologically endowed rate of time preference is equal to the mortality rate not only in adulthood but also in childhood, reflecting the change in the biological value of survival. Mortality is the baseline for time preference through the entire course of life. These results are consistent with the findings in previous empirical and experimental studies that the discount rate is U-shaped in age, and account for why young children, in particular, are impatient. In addition, the difference in time preference between adults and children provides a biological explanation for the parent-offspring conflict, in which the higher discount rate among children causes parents and their children to disagree over intertemporal allocation of resources in collective decision-making particularly within the household.

Measurement of Surface SH-Wave Velocities Generated on the Surface of Japanese Cypress Column  [PDF]
Masumi Hasegawa, Junji Matsumura
Open Journal of Acoustics (OJA) , 2014, DOI: 10.4236/oja.2014.44018
Abstract: Polyetherimide resin wedge transducers were used to generate a shear wave that was obliquely incident relative to the surface of a Japanese cypress column for measuring the surface SH-wave velocity. As the inter-transducer distance increased, the propagation time increased and the am-plitude became smaller. The propagation time and the amplitude were significantly correlated with the inter-transducer distance. The SH-wave velocity ranged from 1270 m/s to 1496 m/s. Surface SH-wave velocity was lower in the central part of the column and higher in the outer part. Velocity was negatively correlated with moisture content at 1% of significance level. These results suggest the accomplishment of the first target for applying the surface SH-wave acoustoelastic technique to nondestructive evaluation of drying stress in wood.
Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Hepatic Ischemia Reperfusion Injury in a Rat Model
Hiroyuki Kanazawa,Yasuhiro Fujimoto,Takumi Teratani,Junji Iwasaki,Naoya Kasahara,Kouji Negishi,Tatsuaki Tsuruyama,Shinji Uemoto,Eiji Kobayashi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019195
Abstract: Ischemia-reperfusion (I/R) injury associated with living donor liver transplantation impairs liver graft regeneration. Mesenchymal stem cells (MSCs) are potential cell therapeutic targets for liver disease. In this study, we demonstrate the impact of MSCs against hepatic I/R injury and hepatectomy.
New spherically symmetric solutions in Einstein-Yang-Mills-Higgs model
Jia, Junji
High Energy Physics - Phenomenology , 2008,
Abstract: We study classical solutions in the SU(2) Einstein-Yang-Mills-Higgs theory. The spherically symmetric ans\"atze for all fields are given and the equations of motion are derived as a system of ordinary differential equations. The asymptotics and the boundary conditions at space origin for regular solutions and at event horizon for black hole solutions are studied. Using the shooting method, we found numerical solutions to the theory. For regular solutions, we find two new sets of asymptotically flat solutions. Each of these sets contains continua of solutions in the parameter space spanned by the shooting parameters. The solutions bifurcate along these parameter curves and the bifurcation are argued to be due to the internal structure of the model. Both sets of the solutions are asymptotically flat but one is exponentially so and the other is so with oscillations. For black holes, a new set of boundary conditions is studied and it is found that there also exists a continuum of black hole solutions in parameter space and similar bifurcation behavior is also present to these solutions. The SU(2) charges of these solutions are found zero and these solutions are proven to be unstable.
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