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Search Results: 1 - 10 of 26035 matches for " Jungsik Kim;Won-Seok Choi;Jinho Jeong "
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Loop Switching Technique for Wireless Power Transfer Using Magnetic Resonance Coupling
Jungsik Kim;Won-Seok Choi;Jinho Jeong
PIER , 2013, DOI: 10.2528/PIER13012118
Abstract: We propose a loop switching technique to improve the efficiency of wireless power transfer (WPT) systems using magnetic resonance coupling. The proposed system employs several loops with different sizes, one of which is connected to the system with various distances between the transmitter and the receiver. It enables the coupling coefficient to be adjusted with the distance, which allows high efficiency over a wide range of distances. The proposed system is analyzed using an equivalent circuit model, and electromagnetic (EM) simulation is performed to predict the performance. It is shown from the experimental results at 13.56 MHz that the proposed loop switching technique can maintain high efficiency over a wide range. The efficiency is measured to be 50% at 100 cm, which corresponds to a 46% increase compared to a conventional WPT system without the loop switching technique.
Enhancement of Tumor Regression by Coulomb Nanoradiator Effect in Proton Treatment of Iron-Oxide Nanoparticle-Loaded Orthotopic Rat Glioma Model: Implication of Novel Particle Induced Radiation Therapy  [PDF]
Seung-Jun Seo, Jae-Kun Jeon, Eun-Ju Jeong, Won-Seok Chang, Gi-Hwan Choi, Jong-Ki Kim
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.411A004

Background: Proton-impact metallic nanoparticles, inducing low-energy electrons emission and characteristic X-rays termed as Coulomb nanoradiator effect (CNR), are known to produce therapeutic enhancement in proton treatment on experimental tumors. The purpose of this pilot study was to investigate the effect of CNR-based dose enhancement on tumor growth inhibition in an iron-oxide nanoparticle (FeONP)-loaded orthotopic rat glioma model. Methods: Proton-induced CNR was exploited to treat glioma-bearing SD rat loaded with FeONP by either fully-absorbed single pristine Bragg peak (APBP) or spread-out Bragg peak (SOBP) 45-MeV proton beam. A selected number of rats were examined by MRI before and after treatment to obtain the size and position information for adjusting irradiation field. Tumor regression assay was performed by histological analysis of residual tumor in the sacrificed rats 7 days after treatment. The results of CNR-treated groups were compared with the proton alone control. Results: Intravenous injection of FeONP (300 mg/kg) elevated the tumor concentration of iron up to 37 μg of Fe/g tissue, with a tumor-to-normal ratio of 5, 24 hours after injection. The group receiving FeONP and proton beam showed 65% - 79% smaller tumor volume dose-dependently compared with the proton alone group. The rats receiving FeONP and controlled irradiation field by MR imaging demonstrated more than 95% -

CRISPLD2 Is a Target of Progesterone Receptor and Its Expression Is Decreased in Women with Endometriosis
Jung-Yoon Yoo, Heesung Shin, Tae Hoon Kim, Won-Seok Choi, Susan D. Ferguson, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Un-Hwan Ha, Jae-Wook Jeong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100481
Abstract: Endometriosis, defined as the presence of endometrial cells outside of the uterine cavity, is a major cause of infertility and pelvic pain, afflicting more than 10% of reproductive age women. Endometriosis is a chronic inflammatory disease and lipopolysaccharide promotes the proliferation and invasion of endometriotic stromal cells. Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) has high affinity for lipopolysaccharide and plays a critical role in defense against endotoxin shock. However, the function of CRISPLD2 has not been studied in endometriosis and uterine biology. Herein, we examined the expression of CRISPLD2 in endometrium from patients with and without endometriosis using immunohistochemistry. The expression of CRISPLD2 was higher in the secretory phase in human menstrual cycle compared to proliferative phase. The expression of CRISPLD2 was significantly decreased in the endometrium of women with endometriosis in the early secretory phase compared to women without endometriosis. The increase of CRISPLD2 expression at the early secretory and dysregulation of its expression in endometriosis suggest progesterone (P4) regulation of CRISPLD2. To investigate whether CRISPLD2 is regulated by P4, we examined the expression of the CRISPLD2 in the uteri of wild-type and progesterone receptor knock out (PRKO) mice. The expression of CRISPLD2 was significantly increased after P4 treatment in the wild-type mice. However, CRISPLD2 expression was significantly decreased in the (PRKO) mice treated with P4. During early pregnancy, the expression of CRISPLD2 was increased in decidua of implantation and post-implantation stages. CRISPLD2 levels were also increased in cultured human endometrial stromal cells during in vitro decidualization. These results suggest that the CRISPLD2 is a target of the progesterone receptor and may play an important role in pathogenesis of endometriosis.
Pb concentrations and isotopic compositions in the soil and sediments around the abandoned mine in southwest of Korea  [PDF]
Jong-Woo Choi, Eun-Jin Yoo, Jee-young Kim, Jong-Yeon Hwang, Khanghyun Lee, Won-Seok Lee, Jin-Seok Han, Kyu-Seung Lee
Journal of Agricultural Chemistry and Environment (JACEN) , 2013, DOI: 10.4236/jacen.2013.24015
Abstract: This study was undertaken to investigate the influence of Pb contaminant dispersal from an abandoned mine. For the study, 23 samples of sediment and soil were collected around the abandoned mine located in southwest of Korea. Pb concentrations and isotope ratios of sediment samples were analyzed through ICP-OES (Optima 5300 DV, Perkin Elmer) and MC-ICP-MS (Plasma II, Nu), respectively. The sediment samples collected in the main stream from the mine entrance showed high Pb concentrations of 139 - 1079 mg/kg, while Pb concentrations of the other sites were 19 - 29 mg/kg. Pb isotope ratios of the main stream sediments were 2.4854 - 2.4883 for 208Pb/207Pb and 1.1693 - 1.1740 for 206Pb/207Pb. On the other hand, the Pb isotopic compositions of sediments collected from the other sites were clearly different from those of ore deposits. The Pb isotope ratios versus inverse concentrations plot showed high linear correlation between the main stream, the tributary stream and one of the downstream sites representing the two end member mixing system between these sites. According to the binary mixing equation, the relative contribution of Pb pollutants from the abandoned mine to the downstream area were approximately 33% - 36%.
Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells
Soung-Hoon Lee, Juyong Yoon, Seung Ho Shin, Muhamad Zahoor, Hyoung Jun Kim, Phil June Park, Won-Seok Park, Do Sik Min, Hyun-Yi Kim, Kang-Yell Choi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034152
Abstract: Background Alopecia is the common hair loss problem that can affect many people. However, current therapies for treatment of alopecia are limited by low efficacy and potentially undesirable side effects. We have identified a new function for valproic acid (VPA), a GSK3β inhibitor that activates the Wnt/β-catenin pathway, to promote hair re-growth in vitro and in vivo. Methodology/ Principal Findings Topical application of VPA to male C3H mice critically stimulated hair re-growth and induced terminally differentiated epidermal markers such as filaggrin and loricrin, and the dermal papilla marker alkaline phosphatase (ALP). VPA induced ALP in human dermal papilla cells by up-regulating the Wnt/β-catenin pathway, whereas minoxidil (MNX), a drug commonly used to treat alopecia, did not significantly affect the Wnt/β-catenin pathway. VPA analogs and other GSK3β inhibitors that activate the Wnt/β-catenin pathway such as 4-phenyl butyric acid, LiCl, and BeCl2 also exhibited hair growth-promoting activities in vivo. Importantly, VPA, but not MNX, successfully stimulate hair growth in the wounds of C3H mice. Conclusions/ Significance Our findings indicate that small molecules that activate the Wnt/β-catenin pathway, such as VPA, can potentially be developed as drugs to stimulate hair re-growth.
Wide Integral-Field Infrared Spectroscopy of the Bright [Fe II] Shell in the Young Supernova Remnant G11.2-0.3
Ho-Gyu Lee,Dae-Sik Moon,Bon-Chul Koo,Mubdi Rahman,Stephen S. Eikenberry,Nicolas Gruel,Takashi Onaka,Hyun-Jeong Kim,Won-Seok Chun,J. C. Raymond,S. Nicholas Raines,Rafael Guzman
Physics , 2013, DOI: 10.1088/0004-637X/770/2/143
Abstract: We present the results of wide integral-field near-infrared (1.0-1.8 um) spectroscopic observations of the southeastern shell of the young core-collapse supernova remnant (SNR) G11.2-0.3. We first construct [Fe II] 1.644 um line images of three bright clumps from the obtained spectral image cubes and compare them with those of other transitions such as [Fe II] 1.257, [Fe II] 1.534 and He I 1.083 um line images. This allows us to estimate the electron density (~ 4,700-9,400 cm^-3) and extinction (Av ~ 16-20 mag) of the shell, including detailed two-dimensional distribution of the properties in the brightest clump, as well as the discovery of a faint high-velocity (~ -440 km/s) component in the clump. Our SNR shock model calculations estimate the preshock number density of ~ 250-500 cm^-3 and shock speed of ~ 80-250 km/s in the [Fe II]-emitting region of the SNR. The comparison between the observed and modelled radial profiles of the line intensities and their ratios reveals that the shell is composed of multiple thin filaments which have been likely formed in episodic mass loss processes of a progenitor star. The discovery of the faint high-velocity component supports the interpretation that the southeastern shell of G11.2-0.3 is mainly composed of circumstellar material with contamination by supernova ejecta and also that its ejected material was expelled primarily in the southeast-northwest direction.
Association of interleukin-18 gene polymorphism with body mass index in women
Hye-Lin Kim, Sung One Cho, Seon-Young Kim, Sung-Hoon Kim, Won-Seok Chung, Seok-Hee Chung, Sung-Soo Kim, Seong-Gyu Ko, Chang-Hyun Jeong, Su-Jin kim, Seung-Heon Hong, Jae-Young Um
Reproductive Biology and Endocrinology , 2012, DOI: 10.1186/1477-7827-10-31
Abstract: All 680 subjects were genotyped for the polymorphisms of IL-18 gene promoters (at positions ?137?G/C and ?607?C/A) using a polymerase chain reaction (271 cases with BMI ≥25?kg/m2 and 409 controls with BMI <25?kg/m2). A chi-square test was used to compare the genotype and allele frequencies between the cases and control populations.Analyses of the genotype distributions revealed that IL-18 –607?C/A polymorphism was associated with an increase in body mass index in obese women in the Korean population (chi(2)?=?12.301, df?=?2, p?=?0.015).Carriage of the A allele at position ?607 in the promoter of the IL-18 gene may have a role in the development of obesity.
Gardenia jasminoides protects against cerulein-induced acute pancreatitis
Won-Seok Jung, Young-Seok Chae, Do-Yun Kim, Sang-Wan Seo, Hee-Je Park, Gi-Sang Bae, Tae-Hyeon Kim, Hyo-Jeong Oh, Ki-Jung Yun, Rae-Kil Park, Jong-Suk Kim, Eun-Cheol Kim, Sung-Yeon Hwang, Sung-Joo Park, Ho-Joon Song
World Journal of Gastroenterology , 2008,
Abstract: AIM: To investigate the effect of Gardenia jasminoides (GJ) on cerulein-induced acute pancreatitis (AP) in mice.METHODS: C57BL/6 mice weighing 18-20 g were divided into three groups. (1) Normal saline-treated group, (2) treatment with GJ at a dose of 0.1 g/kg, (3) treatment with GJ at a dose of 1 g/kg. GJ was administered orally (n = 6 per group) for 1 wk. Three hours later, the mice were given an intraperitoneal injection of cerulein (50 μg/kg), a stable cholecystokinin (CCK) analogue, every hour for a total of 6 h as described previously. The mice were sacrificed at 6 h after completion of cerulein injections. Blood samples were obtained to determine serum amylase, lipase and cytokine levels. The pancreas was rapidly removed for morphologic examination and scoring. A portion of pancreas was stored at -70°C and prepared for the measurement of tissue myeloperoxidase (MPO) activity, an indicator of neutrophil sequestration, and for reverse-transcriptase PCR (RT-PCR) and real-time PCR measurements.RESULTS: Treatment with GJ decreased significantly the severity of pancreatitis and pancreatitis-associated lung injury. Treatment with GJ attenuated the severity of AP compared with saline-treated mice, as shown by reduction in pancreatic edema, neutrophil infiltration, serum amylase and lipase levels, serum cytokine levels, and mRNA expression of multiple inflammatory mediators.CONCLUSION: These results suggest that GJ attenuated the severity of AP as well as pancreatitis-associated lung injury.
Should anticoagulants be administered for portal vein thrombosis associated with acute pancreatitis?
Won-Seok Park,Hyeong-Il Kim,Byung-Jun Jeon,Seong-Hun Kim
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i42.6168
Abstract: Venous complications in patients with acute pancreatitis typically occur as a form of splenic, portal, or superior mesenteric vein thrombosis and have been detected more frequently in recent reports. Although a well-organized protocol for the treatment of venous thrombosis has not been established, anticoagulation therapy is commonly recommended. A 73-year-old man was diagnosed with acute progressive portal vein thrombosis associated with acute pancreatitis. After one month of anticoagulation therapy, the patient developed severe hematemesis. With endoscopy and an abdominal computed tomography scan, hemorrhages in the pancreatic pseudocyst, which was ruptured into the duodenal bulb, were confirmed. After conservative treatment, the patient was stabilized. While the rupture of a pseudocyst into the surrounding viscera is a well-known phenomenon, spontaneous rupture into the duodenum is rare. Moreover, no reports of upper gastrointestinal bleeding caused by pseudocyst rupture in patients under anticoagulation therapy for venous thrombosis associated with acute pancreatitis have been published. Herein, we report a unique case of massive upper gastrointestinal bleeding due to pancreatic pseudocyst rupture into the duodenum, which developed during anticoagulation therapy for portal vein thrombosis associated with acute pancreatitis.
Effect of Korean Herbal Medicine Combined with a Probiotic Mixture on Diarrhea-Dominant Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo-Controlled Trial
Seok-Jae Ko,Gajin Han,Seul-Ki Kim,Jae-Gu Seo,Won-Seok Chung,Bongha Ryu,Jinsung Kim,Inkwon Yeo,Beom-Joon Lee,Jin-Moo Lee,Jae-Woo Park
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/824605
Abstract: Introduction. Although combination therapy with herbal medicine and probiotics is gaining popularity for controlling diarrhea-dominant irritable bowel syndrome (D-IBS) symptoms, few studies have investigated its clinical effects. Materials and Methods. Fifty-three patients with D-IBS were randomly allocated into 1 of the following 4 groups: herbal medicine (Gwakhyangjeonggisan; GJS) plus probiotics (Duolac7S; DUO), GJS plus placebo DUO, placebo GJS plus DUO, and placebo GJS plus placebo DUO. The study period consisted of a 2-week run-in, 8 weeks of administration, and 2 weeks of follow-up. The primary outcomes were weekly adequate relief (AR) of overall IBS symptoms and the proportion of responders (PR) during the administration period. The secondary outcomes included individual IBS symptoms, stool assessment, and quality of life. Changes of intestinal microbiota and intestinal permeability were also analyzed. Results and Discussion. Weekly AR was not different among the 4 groups throughout the treatment period. However, the 3 treatment groups exhibited significant improvements in PR compared to the findings in the placebo group. In the intestinal microbiota assessment, herbal medicine and probiotics synergistically increased beneficial bacteria counts. Conclusion. Combination therapy with herbal medicine and probiotics appears to relieve overall IBS symptoms by synergistically increasing beneficial intestinal microbe counts. 1. Introduction Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain, discomfort, and bowel disturbances without any structural abnormality [1]. IBS may cause significant inconvenience to patients, impair their social functioning, and deteriorate their quality of life [2]. The involvement of various factors in the pathophysiology of IBS makes treatment more difficult [3]. Factors such as imbalances of intestinal microbiota and increased intestinal permeability have been identified as important elements in the pathophysiology of IBS [4, 5]. Therefore, therapeutic approaches aimed at resolving disturbances in the intestinal microbiota and maintaining mucosal barrier homeostasis can be helpful in the treatment of IBS. However, due to dissatisfying results with conventional IBS treatments, complementary therapies including herbal medicine and probiotics are becoming attractive options for many patients [6]. Herbal medicines have long been used in Asian countries due to their safety and having only a few side effects. Gwakhyangjeonggisan (GJS; Kkako-shoki-san in Kampo Medicine;
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