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Search Results: 1 - 10 of 20455 matches for " Jungmin Kim "
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Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats
Kim Jungmin,Park Yongsoon
Nutrition & Metabolism , 2012, DOI: 10.1186/1743-7075-9-106
Abstract: Background It has been suggested that Sorghum, a rich source of phytochemicals, has a hypoglycemic effect, but the mechanism is unknown. We investigated the effects of oral administration of sorghum extract (SE) on hepatic gluconeogenesis and the glucose uptake of muscle in streptozotocin-induced diabetic rats for six weeks. Methods Male Wistar rats were divided in five groups (n=5 per group): normal control (NC), rats with STZ-induced diabetic mellitus (DM), diabetic rats administrated 0.4 g/kg body weight of SE (DM-SE 0.4) and 0.6 g/kg body weight of SE (DM-SE 0.6), and diabetic rats administrated 0.7 mg/kg body weight of glibenclamide (DM-G). Results Administration of SE and G reduced the concentration of triglycerides, total and LDL-cholesterol and glucose, and the area under the curve of glucose during intraperitoneal glucose tolerance tests down to the levels observed in non-diabetic rats. In addition, administration of 0.4 and 0.6 g/kg SE and 0.7 mg/kg glibenclamide (G) significantly reduced the expression of phosphoenolpyruvate carboxykinase and the phosphor-p38/p38 ratio, while increased phosphor adenosine monophosphate activated protein kinase (AMPK)/AMPK ratio, but the glucose transporter 4 translocation and the phosphor-Akt/Akt ratio was significantly increased only by administration of G. Conclusions These results indicate that the hypoglycemic effect of SE was related to hepatic gluconeogenesis but not the glucose uptake of skeletal muscle, and the effect was similar to that of anti-diabetic medication.
The derivatives of Asian call option prices
Jungmin Choi,Kyounghee Kim
Mathematics , 2007,
Abstract: The distribution of a time integral of geometric Brownian motion is not well understood. To price an Asian option and to obtain measures of its dependence on the parameters of time, strike price, and underlying market price, it is essential to have the distribution of time integral of geometric Brownian motion and it is also required to have a way to manipulate its distribution. We present integral forms for key quantities in the price of Asian option and its derivatives ({\it{delta, gamma,theta, and vega}}). For example for any $a>0$ $\mathbb{E} [ (A_t -a)^+] = t -a + a^{2} \mathbb{E} [ (a+A_t)^{-1} \exp (\frac{2M_t}{a+ A_t} - \frac{2}{a}) ]$, where $A_t = \int^t_0 \exp (B_s -s/2) ds$ and $M_t =\exp (B_t -t/2).$
Thickness of Rectus Abdominis Muscle and Abdominal Subcutaneous Fat Tissue in Adult Women: Correlation with Age, Pregnancy, Laparotomy, and Body Mass Index
Jungmin Kim,Hyoseob Lim,Se Il Lee,Yu Jin Kim
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.5.528
Abstract: Background Rectus abdominis muscle and abdominal subcutaneous fat tissue are usefulfor reconstruction of the chest wall, and abdominal, vaginal, and perianal defects. Thus,preoperative evaluation of rectus abdominis muscle and abdominal subcutaneous fat tissue isimportant. This is a retrospective study that measured the thickness of rectus abdominis muscleand abdominal subcutaneous fat tissue using computed tomography (CT) and analyzed thecorrelation with the patients’ age, gestational history, history of laparotomy, and body massindex (BMI).Methods A total of 545 adult women were studied. Rectus abdominis muscle and abdominalsubcutaneous fat thicknesses were measured with abdominopelvic CT. The results were analyzedto determine if the thickness of the rectus abdominis muscle or subcutaneous fat tissue wassignificantly correlated with age, number of pregnancies, history of laparotomy, and BMI.Results Rectus abdominis muscle thicknesses were 9.58 mm (right) and 9.73 mm (left) at thexiphoid level and 10.26 mm (right) and 10.26 mm (left) at the umbilicus level. Subcutaneousfat thicknesses were 24.31 mm (right) and 23.39 mm (left). Rectus abdominismuscle thicknessdecreased with age and pregnancy. History of laparotomy had a significant negative correlationwith rectus abdominis muscle thickness at the xiphoid level. Abdominal subcutaneous fatthickness had no correlation with age, number of pregnancies, or history of laparotomy.Conclusions Age, gestational history, and history of laparotomy influenced rectus abdominismuscle thickness but did not influence abdominal subcutaneous fat thickness. These results areclinically valuable for planning a rectus abdominis muscle flap and safe elevation of muscle flap.
Bilateral Circular Xanthelasma Palpebrarum
Jungmin Kim,Yu Jin Kim,Hyoseob Lim,Se Il Lee
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.4.435
Chicoric acid: chemistry, distribution, and production
Jungmin Lee
Frontiers in Chemistry , 2013, DOI: 10.3389/fchem.2013.00040
Abstract: Though chicoric acid was first identified in 1958, it was largely ignored until recent popular media coverage cited potential health beneficial properties from consuming food and dietary supplements containing this compound. To date, plants from at least 63 genera and species have been found to contain chicoric acid, and while the compound is used as a processing quality indicator, it may also have useful health benefits. This review of chicoric acid summarizes research findings and highlights gaps in research knowledge for investigators, industry stakeholders, and consumers alike. Additionally, chicoric acid identification, and quantification methods, biosynthesis, processing improvements to increase chicoric acid retention, and potential areas for future research are discussed.
Genetic and Metabolic Characterization of Insomnia
Hyo-Jeong Ban,Sang Cheol Kim,Jungmin Seo,Ho-Bum Kang,Jung Kyoon Choi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018455
Abstract: Insomnia is reported to chronically affect 10~15% of the adult population. However, very little is known about the genetics and metabolism of insomnia. Here we surveyed 10,038 Korean subjects whose genotypes have been previously profiled on a genome-wide scale. About 16.5% reported insomnia and displayed distinct metabolic changes reflecting an increase in insulin secretion, a higher risk of diabetes, and disrupted calcium signaling. Insomnia-associated genotypic differences were highly concentrated within genes involved in neural function. The most significant SNPs resided in ROR1 and PLCB1, genes known to be involved in bipolar disorder and schizophrenia, respectively. Putative enhancers, as indicated by the histone mark H3K4me1, were discovered within both genes near the significant SNPs. In neuronal cells, the enhancers were bound by PAX6, a neural transcription factor that is essential for central nervous system development. Open chromatin signatures were found on the enhancers in human pancreas, a tissue where PAX6 is known to play a role in insulin secretion. In PLCB1, CTCF was found to bind downstream of the enhancer and interact with PAX6, suggesting that it can probably inhibit gene activation by PAX6. PLCB4, a circadian gene that is closely located downstream of PLCB1, was identified as a candidate target gene. Hence, dysregulation of ROR1, PLCB1, or PLCB4 by PAX6 and CTCF may be one mechanism that links neural and pancreatic dysfunction not only in insomnia but also in the relevant psychiatric disorders that are accompanied with circadian rhythm disruption and metabolic syndrome.
Identification of the minimal region in lipase ABC transporter recognition domain of Pseudomonas fluorescens for secretion and fluorescence of green fluorescent protein
Yeonwoo Park, Yuseok Moon, Jungmin Ryoo, Nayeon Kim, Hyounghoon Cho, Jung Hoon Ahn
Microbial Cell Factories , 2012, DOI: 10.1186/1475-2859-11-60
Abstract: Among the fusion proteins, GFP or EGF with 105-residue LARD3 was most efficiently secreted. In addition, GFP-LARD3 emitted wild type GFP fluorescence. Structurally, LARD3 had the 4 RTX repeats exposed at the N-terminus, while other LARDs had additional residues prior to them or missed some of the RTX repeats. LARD3 was both necessary and sufficient for efficient secretion and maintenance of GFP fluorescence in E. coli, which was also confirmed in P. fluorescens and P. fluorescens ?tliA, a knock-out mutant of tliA.LARD3 was a potent secretion signal in T1SS for its fusion flanking RTX motif, which enhanced secretion and preserved the fluorescence of GFP. LARD3-mediated secretion in E. coli or P. fluorescens will enable the development of enhanced protein manufacturing factory and recombinant microbe secreting protein of interest in situ.
1H NMR-Based Metabolite Profiling of Planktonic and Biofilm Cells in Acinetobacter baumannii 1656-2
Jinki Yeom, Ji-Hyun Shin, Ji-Young Yang, Jungmin Kim, Geum-Sook Hwang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057730
Abstract: Acinetobacter baumannii is an aerobic and gram-negative pathogenic bacterium that is resistant to most antibiotics. Recently, A. baumannii 1656-2 exhibited the ability to form biofilms under clinical conditions. In this study, global metabolite profiling of both planktonic and biofilm forms of A. baumannii 1656-2 was performed using high-resolution nuclear magnetic resonance (NMR) spectroscopy and multivariate statistical analysis to investigate the metabolic patterns leading to biofilm formation. Principal components analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) score plots showed a distinct separation between planktonic and biofilm cells. Metabolites including acetates, pyruvate, succinate, UDP-glucose, AMP, glutamate, and lysine were increasingly involved in the energy metabolism of biofilm formation. In particular, the ratio of N-acetyl-D-glucosamine (GlcNAc) to D-glucosamine (GlcNH2) was significantly higher during biofilm formation than under the planktonic condition. This study demonstrates that NMR-based global metabolite profiling of bacterial cells can provide valuable insight into the metabolic changes in multidrug resistant and biofilm-forming bacteria such as A. baumannii 1656-2.
Monitoring of multi-frequency polarization of gamma-ray bright AGNs
Sang-Sung Lee,Myounghee Han,Sincheol Kang,Jungmin Seen,Do-Young Byun,Jun-Hyun Baek,Soon-Wook Kim,Jeong-Sook Kim
Physics , 2013, DOI: 10.1051/epjconf/20136107007
Abstract: We started two observing programs with the Korean VLBI Network (KVN) monitoring changes in the flux density and polarization of relativistic jets in gamma-ray bright AGNs simultaneously at 22, 43, 86, 129 GHz. One is a single-dish weekly-observing program in dual polarization with KVN 21-m diameter radio telescopes beginning in 2011 May. The other is a VLBI monthly-observing program with the three-element VLBI network at an angular resolution range of 1.0--9.2 mas beginning in 2012 December. The monitoring observations aim to study correlation of variability in gamma-ray with that in radio flux density and polarization of relativistic jets when they flare up. These observations enable us to study the origin of the gamma-ray flares of AGNs.
Genetic Landscape of Open Chromatin in Yeast
Kibaick Lee equal contributor,Sang Cheol Kim equal contributor,Inkyung Jung equal contributor,Kwoneel Kim,Jungmin Seo,Heun-Sik Lee,Gireesh K. Bogu,Dongsup Kim,Sanghyuk Lee,Byungwook Lee ,Jung Kyoon Choi
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003229
Abstract: Chromatin regulation underlies a variety of DNA metabolism processes, including transcription, recombination, repair, and replication. To perform a quantitative genetic analysis of chromatin accessibility, we obtained open chromatin profiles across 96 genetically different yeast strains by FAIRE (formaldehyde-assisted isolation of regulatory elements) assay followed by sequencing. While 5~10% of open chromatin region (OCRs) were significantly affected by variations in their underlying DNA sequences, subtelomeric areas as well as gene-rich and gene-poor regions displayed high levels of sequence-independent variation. We performed quantitative trait loci (QTL) mapping using the FAIRE signal for each OCR as a quantitative trait. While individual OCRs were associated with a handful of specific genetic markers, gene expression levels were associated with many regulatory loci. We found multi-target trans-loci responsible for a very large number of OCRs, which seemed to reflect the widespread influence of certain chromatin regulators. Such regulatory hotspots were enriched for known regulatory functions, such as recombinational DNA repair, telomere replication, and general transcription control. The OCRs associated with these multi-target trans-loci coincided with recombination hotspots, telomeres, and gene-rich regions according to the function of the associated regulators. Our findings provide a global quantitative picture of the genetic architecture of chromatin regulation.
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