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Search Results: 1 - 10 of 481626 matches for " Julien Léopoldès "
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Slippery or sticky ! Control of wrinkling patterns by selective adhesion
Hugues Vandeparre,Julien Léopoldès,Christophe Poulard,Sylvain Desprez,Gwennaelle Derue,Cyprien Gay,Pascal Damman
Physics , 2007,
Abstract: Wrinkling patterns at the metallized surface of thin polymer films are shown to be sensitive to the sticky or slippery character of the polymer/substrate interface (titanium coating, polystyrene film and coated silicon substrate). Selective prefered wrinkle orientation and amplitude are achieved. Existing theoretical models are expanded to specific boundary conditions (adhesive vs slippery) and rationalize these observations.
Quality of Life of Chronic Haemodialytic Patients at Cotonou Teaching Hospital (BENIN)  [PDF]
Elhadji Fary Ka, Jacques Vigan, Ahmed Tall Lemrabott, Noriace Excelle Zohoun, Mohamedou Moustapha Cissé, Séraphin Ahoui, Maria Faye, Younoussa Keita, Khodia Fall, Bruno Léopold Agboton, Abdou Niang, Boucar Diouf
Open Journal of Nephrology (OJNeph) , 2014, DOI: 10.4236/ojneph.2014.44019
Abstract:
Introduction: The objectives of this work were to assess haemodialytic patients’ quality of life (QoL) and to identify factors affecting this QoL. Patients and Methods: It was a three (03) month monocentric and transversal study (from October 24, 2011 to January 27, 2012) conducted in the haemodialysis unit at Hubert Koutoukou Maga Teaching Hospital (CNHU-HKM) in Cotonou. Patients included were residents of Benin, aged 18 years and above, chronic haemodialysis in this unit for over 3 months, and willfully gave their consent. Quality of life was evaluated using questionnaire on Kidney Disease Quality of Life Short-Form French version 1.2 (KDQoL-SF 36). Epidemiological data, nephropathy etiologies and purification parametres were recorded in patients files. Data statistical analysis was performed using SPSS software 11.5. Results: In total 131 patients were involved in the study. The average age was 50.27 ± 12.17 years with a sex ratio of 1.69. Nephroangiosclerosis was the 1st cause. Most patients 128 (97.71 %) received two haemodialysis sessions on weekly basis. The Average Overall Score (AOS) based respectively on SF 36 and KDQoL was 48.55 and 58.55. The average of both SF 36 and KDQoL AOS was 53.55. Factors affecting hemodialytic patients quality of life were vitality, limitations related to mental health and physical condition, burden of kidney disease, effect of the disease on daily life and occupational status. The study revealed that: Patients education level was correlated with vitality (p < 0.017); The number of haemodialyses sessions was correlated with the consequences of kidney disease on daily life (p < 0.025). Conclusion: It is necessary to streng-then the staff by providing a psychologist and a dietician and also build new haemodialysis centres.
Triceps Brachii Tendon Reconstruction with V-Y Plasty: Indication and Functional Results of a Case at Bouaké Teaching Hospital  [PDF]
Krah Koffi Léopold, Sery Bada Léopold, Kone Samba, Digbeu Kévin, Assere Arnaud, Kouassi Aya Natacha, Kouassi Eric, M’Bra Innocent, Yao Loukou Blaise, Kodo Michel
Open Journal of Orthopedics (OJO) , 2017, DOI: 10.4236/ojo.2017.712041
Abstract: Repair of an old lesion of the triceps brachii tendon is infrequent. A V-Y plasty was performed 4 years after the injury in an adult. Post traumatic osteoarthritis limits functional outcomes. The patient is satisfied.
High Sugar-Induced Insulin Resistance in Drosophila Relies on the Lipocalin Neural Lazarillo
Matthieu Y. Pasco, Pierre Léopold
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036583
Abstract: In multicellular organisms, insulin/IGF signaling (IIS) plays a central role in matching energy needs with uptake and storage, participating in functions as diverse as metabolic homeostasis, growth, reproduction and ageing. In mammals, this pleiotropy of action relies in part on a dichotomy of action of insulin, IGF-I and their respective membrane-bound receptors. In organisms with simpler IIS, this functional separation is questionable. In Drosophila IIS consists of several insulin-like peptides called Dilps, activating a unique membrane receptor and its downstream signaling cascade. During larval development, IIS is involved in metabolic homeostasis and growth. We have used feeding conditions (high sugar diet, HSD) that induce an important change in metabolic homeostasis to monitor possible effects on growth. Unexpectedly we observed that HSD-fed animals exhibited severe growth inhibition as a consequence of peripheral Dilp resistance. Dilp-resistant animals present several metabolic disorders similar to those observed in type II diabetes (T2D) patients. By exploring the molecular mechanisms involved in Drosophila Dilp resistance, we found a major role for the lipocalin Neural Lazarillo (NLaz), a target of JNK signaling. NLaz expression is strongly increased upon HSD and animals heterozygous for an NLaz null mutation are fully protected from HSD-induced Dilp resistance. NLaz is a secreted protein homologous to the Retinol-Binding Protein 4 involved in the onset of T2D in human and mice. These results indicate that insulin resistance shares common molecular mechanisms in flies and human and that Drosophila could emerge as a powerful genetic system to study some aspects of this complex syndrome.
Effect of Pure Culture Fermentation on Biochemical Composition of Moringa oleifera Lam Leaves Powders  [PDF]
Noumo Ngangmou Thierry, Tatsadjieu Ngouné Léopold, Montet Didier, F. Mbofung Carl Moses
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.48111
Abstract:

This study was carried out to determine the effect of the age of the leaves and fermentation on in vitro protein digestibility and biochemical properties of leaves powder of Moringa oleifera. A 6 × 2 × 2 factorial design with two ages of the leaves (one and seven-month-old leaves), six times of fermentation and two fermentation temperatures was used for this purpose. One and seven-month-old fresh leaves were dried at 45 for 24 h, crushed to 1000 μm then fermented at 30 and 37 for 120 hours with Lactobacillus plantarum A6 at 108 CFU/g. Samples were withdrawn every 24 hours for physico-chemical analyses. Results showed that 7 month-old leaves were richer in iron, proteins, polyphenols and phytates than one month old leaves. The phytates content dropped from 66.92% and 61.95% in the seven and one month-old leaves powders respectively fermented at 37, and from 54.15% and 67.95% in the seven and one month-old leaves powders respectively fermented at 30. Protein content increased by 26.34% and 24.48% for the 1and 7-month-old leaves powders respectively fermented at 37, and by 13.06% and 13.97% for the 1and 7month-old leaves powders respectively, fermented at 30. Iron availability increased from 35.97% to 40.57% and 20.74% to 30.98% for the 1and 7-month-old leaves powders respectively, fermented at 37 and from 35.97% to 39.79% and 20.76% to 23.72% for the 1and 7-month-old leaves powders respectively, fermented at 30. There was a negative correlation between pH, total and reducing sugar contents, time as well as fermentation temperature, whereas there was a positive correlation between total protein content and pepsic digestibility of protein and fermentation time. From these results, fermentation of M. oleifera leaf powder by Lactobacillus plantarum A6 increases protein content, pepsic

Biology and Distribution of Mangrove Crabs in the Wouri River Estuary, Douala, Cameroon  [PDF]
Vanessa Maxemilie Ngo-Massou, Guillaume Léopold Essomè-Koum, Ernest Kottè-Mapoko, Ndongo Din
Journal of Water Resource and Protection (JWARP) , 2014, DOI: 10.4236/jwarp.2014.64029
Abstract:

Crabs appear as the most important group of mangrove epifauna. Their distribution seems influenced by some biotic and abiotic parameters. To verify the interactions between crab populations and relevant environmental components, six mangrove sites around the city of Douala (3°40' - 4°11'N and 9°16' - 9°52'E) were selected. During six months, four 25-min independent time-biased samples methods were conducted in the plot of 4 × 4 m2 delimited inside each zonation throughout transect. The distance from plot to water and its groundwater salinity, temperature, conductivity and pH were measured. The individual sex, fresh weight and carapace size were determined. 3016 individuals were harvested (57% of females). Perisesarma kamermani was the most abundant (29%) while Chiromates angolense was the most frequent (13.47%). Cardisoma armatum was only found in Pandanus zone. Crab species number was positively correlated with tree, suggesting that the mangrove vegetation is important to the crab fauna as a habitat and food supply. Sex ratio showed a significant difference for Chiromates buetikoferi 1:2.34 (χ2 = 33.21) and for Perisesarma huzardi 1.36:1 (χ2 = 39.98). Portunus

Prevalence of the Functional Dyspepsia and Associated Factors in the Chronic Hemodialysis Patients of the National Teaching Hospital “HKM” of Cotonou  [PDF]
Jean Jacques Sehonou, Jacques Vigan, Bruno Léopold Agboton, Gbètondji Michel Massi
Open Journal of Nephrology (OJNeph) , 2015, DOI: 10.4236/ojneph.2015.51002
Abstract:
Aim: To study the functional dyspepsia in chronic hemodialysis patients of CNHU-HKM of Cotonou. Methods: This descriptive, analytical and cross-sectional study ran from 1 September 2013 to 28 February 2014 in the University Clinic of Nephrology Dialysis of CNHU-HKM of Cotonou. It included all chronic renal failure patients on hemodialysis for at least 9 months prior to the survey. After identifying the patients with upper gastrointestinal disorders, we had submitted to clinical Rome III criteria for functional dyspepsia. Upper endoscopy was performed in patients with clinical criteria of functional dyspepsia. Clinical factors associated, paraclinical and therapeutic were sought by logistic regression in univariate analysis. Data were analyzed using EPI DATA version 3.1. Results: 1) One hundred and thirty-one haemodialysis patients had participated in the study (sex ratio: 1.5, average age 49.6 ± 12.4 years). 2) The prevalence was 71.8% for upper gastrointestinal disorders, 64.9% for dyspeptic syndrome and 1.5% for functional dyspepsia. 3) They were associated to clinical criteria of functional dyspepsia of Roma III, the presence of high blood pressure, hypocalcaemia, treatment with calcic inhibitors and iron supplementation. Conclusion: Functional dyspepsia is uncommon in hemodialysis. The search of an organic cause is imperative for every dyspepsia.
Physical and Metals Impact of Traditional Gold Mining on Soils in Kombo-Laka Area (Meiganga, Cameroon)  [PDF]
Ekengele Nga Léopold, Danala Danga Sabine, Zo’o Zame Philémon, Myung Chae Jung
International Journal of Geosciences (IJG) , 2016, DOI: 10.4236/ijg.2016.79084
Abstract: Concentrations of metals (As, Cr, Cd, Fe, Ni, Pb, Sb, and Zn) in soil samples from Kombo-Laka were investigated. The area under study is subjected to traditional gold mining and receives various wastes from miners and mining activities. Direct observations on the field displayed the destruction of soils by this activity. An assessment of pollution was performed using an Enrichment Factor (EF) and geoaccumulation index (Igeo). Levels of As, Cr, Cd, Cu, Pb and Sb in soil samples were above average in the Upper Continental Crust (UCC). EF revealed anthropogenic sources for Cd, As and Sb in these soils. Igeo indicates that Kombo-Laka soils are moderately to extremely polluted with As and Sb. There are high to very high positive correlations among the metals suggesting their possible common sources. This study reveals that traditional gold mining activities in the area are harmful to the environment.
Intravenous Neuromyelitis Optica Autoantibody in Mice Targets Aquaporin-4 in Peripheral Organs and Area Postrema
Julien Ratelade, Jeffrey L. Bennett, A. S. Verkman
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027412
Abstract: The pathogenesis of neuromyelitis optica (NMO) involves binding of IgG autoantibodies (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system (CNS). We studied the in vivo processing in mice of a recombinant monoclonal human NMO-IgG that binds strongly to mouse AQP4. Following intravenous administration, serum [NMO-IgG] decreased with t1/2 ~18 hours in wildtype mice and ~41 hours in AQP4 knockout mice. NMO-IgG was localized to AQP4-expressing cell membranes in kidney (collecting duct), skeletal muscle, trachea (epithelial cells) and stomach (parietal cells). NMO-IgG was seen on astrocytes in the area postrema in brain, but not elsewhere in brain, spinal cord, optic nerve or retina. Intravenously administered NMO-IgG was also seen in brain following mechanical disruption of the blood-brain barrier. Selective cellular localization was not found for control (non-NMO) IgG, or for NMO-IgG in AQP4 knockout mice. NMO-IgG injected directly into brain parenchyma diffused over an area of ~5 mm2 over 24 hours and targeted astrocyte foot-processes. Our data establish NMO-IgG pharmacokinetics and tissue distribution in mice. The rapid access of serum NMO-IgG to AQP4 in peripheral organs but not the CNS indicates that restricted antibody access cannot account for the absence of NMO pathology in peripheral organs.
Vibrated polar disks: spontaneous motion, binary collisions, and collective dynamics
Julien Deseigne,Sébastien Léonard,Olivier Dauchot,Hugues Chaté
Physics , 2012,
Abstract: We study the spontaneous motion, binary collisions, and collective dynamics of "polar disks", i.e. purpose-built particles which, when vibrated between two horizontal plates, move coherently along a direction strongly correlated to their intrinsic polarity. The motion of our particles, although nominally three-dimensional and complicated, is well accounted for by a two-dimensional persistent random walk. Their binary collisions are spatiotemporally extended events during which multiple actual collisions happen, yielding a weak average effective alignment. We show that this well-controlled, "dry active matter" system can display collective motion with orientationally-ordered regions of the order of the system size. We provide evidence of strong number density in the most ordered regimes observed. These results are discussed in the light of the limitations of our system, notably those due to the inevitable presence of walls.
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