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Search Results: 1 - 10 of 3266 matches for " Julie Taguchi "
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A Novel Combined Approach for Metastatic Breast Cancer with Dural and Leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study  [PDF]
Julie Taguchi, Christopher Duma, M. A. Nezami
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.93025
Abstract: Concurrent dural and leptomeningeal metastatic carcinomatosis are very rare and have a poor prognosis. Here we present a woman with advanced estrogen receptor (ER) positive and progesterone receptor (PR) positive breast cancer who presented with leptomeningeal disease. Patient underwent multi targeted epigenetic therapies applied in a protocol called MTET. She continued to respond to the interval treatment, which consisted only of the nutraceutical agents. Here we discuss her case in detail and we believe that such an example might be applied to other patients in this situation resulting clinical improvement and less toxicity.
Biological Modulation of Parp Inhibition in Triple Negative Breast Cancer, a Combinational Approach Implementing Multitargeted Epigenetic Therapy (Mtet) with Parp Inhibition, in Advanced Breast Cancer: A Case Study  [PDF]
M. Nezami, Steve Hager, Julie Taguchi
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.99060
Abstract: The introduction of PARP inhibitors as active agents to inhibit the DNA repair was a revolution in the cancer therapeutics, however, such approach only has shown promising results for a short time in majority of cases due to secondary mutations and promoter gene methylation, and most of patients with triple negative breast cancer when treated with such agents only benefit for a short time, until the tumor shows resistance and further the therapy fails [1]. Considering this category of drugs and their mechanism of action in DNA repair [2] [3], several recent studies have focused on combination of PARP inhibitors with chemotherapy, immune therapy and interestingly relevant to this article, epigenetic therapies [4]. That said, to our knowledge the human data in this regard is missing. Here we discuss a case report of a patient with stage four refractory and resistant BRCA1 mutated triple negative breast cancer who responded in matter of two weeks to a combinational therapy, consisting of PARP inhibitor and epigenetic therapies. As the patient already had exhausted the PARP inhibitor by excessive presence of BRCA positive altered circulatory DNA, the response merely reflects the epigenetic therapy as back bone of treatment. The liquid biopsy repeated after two weeks of combination therapy showed complete disappearance (resolution of positive BRCA gene/c DNA), reflecting a synergism by proposed modulation of resistance as mechanism of action. (The initial c DNA showed 93 percent mutation allele fraction of BRCA gene.) To our knowledge, this is the first study on combinational therapy in human. The finding in this case
Dual Band MIMO Antenna Composed of Two Low Profile Unbalanced Fed Inverted L Antennas for Wireless Communications  [PDF]
Erfan Rohadi, Mitsuo Taguchi
Wireless Engineering and Technology (WET) , 2014, DOI: 10.4236/wet.2014.53007
A low profile dual-band multiple-input-multiple-output (MIMO) antenna system is proposed. The proposed MIMO antenna consists of two low profile unbalanced fed inverted L antennas with parasitic elements to resonate at 2.45 GHz and 5 GHz. The structure is uncomplicated by locating two ultra low profile inverted L antennas on the finite conducting plane. The proposed MIMO antenna is numerically and experimentally analyzed. When the size of conducting plane is 55 mm by 55 mm and the height of antenna is 9 mm, the directive gain of 4.11 dBi and the S11 bandwidth of 5.71% are achieved for lower frequency of 2.45 GHz. At the upper frequency of 5 GHz, the directive gain of 8.22 dBi and the S11 bandwidth of 6% are obtained. The proposed antenna has good diversity gain, shown by the correlation coefficient becomes less than 0.005 at the frequency of 2.45 GHz and 5 GHz band when the distance between inverted L elements is 41 mm. A good agreement between calculated and measured results is obtained. The results show that the weak mutual coupling of the proposed antenna and this feature enables it to cover the required bandwidths for WLAN operation at the 2.4 GHz band and 5 GHz band.
Two Low Profile Unbalanced Fed Inverted L Elements on Square Conducting Plane for MIMO Applications  [PDF]
E. Rohadi, M. Taguchi
Wireless Engineering and Technology (WET) , 2014, DOI: 10.4236/wet.2014.52005

Two ultra low profile inverted L antennas located on the square conducting plane are numerically and experimentally analyzed as the multiple input multiple output (MIMO) antenna system. When the size of conducting plane is 0.45 λ by 0.45 λ and the height of antenna is 0.03 λ, the directive gain of 4.12 dBi and the return loss bandwidth of 3.67% are achieved. The proposed antenna has good diversity gain shown by the correlation coefficient, and becomes less than 0.02 at the frequency of 2.45 GHz band when the distance between inverted L elements is 0.33 λ. The results show the weak mutual coupling of the proposed antenna and its performances are promising as MIMO antenna applications.

Acupuncture Anesthesia and Analgesia for Clinical Acute Pain in Japan
Reina Taguchi
Evidence-Based Complementary and Alternative Medicine , 2008, DOI: 10.1093/ecam/nem056
Abstract: Acupuncture anesthesia has been practiced in China since about 1960. In Japan, Hyodo reported 30 cases of acupuncture anesthesia in 1972. However, from around 1980, the direction of acupuncture investigations turned from anesthesia to analgesia. Acupuncture analgesia is presently considered a way to activate the body's endogenous analgesic system. Recently, with the rise of acupuncture as one of the most well known CAM therapies, acupuncture or moxibustion treatment has been reported for both acute and chronic pain. Even so, few clinical reports and original articles have been reported in Japan. This review illustrates how acupuncture is being used in Japan for acute pain such as surgical operations, post- operative pain (POP), neuropathic pain, pain associated with teeth extractions and after the extraction of impacted wisdom teeth.
Assembly of cells and vesicles for organ engineering
Tetsushi Taguchi
Science and Technology of Advanced Materials , 2011,
Abstract: The development of materials and technologies for the assembly of cells and/or vesicles is a key for the next generation of tissue engineering. Since the introduction of the tissue engineering concept in 1993, various types of scaffolds have been developed for the regeneration of connective tissues in vitro and in vivo. Cartilage, bone and skin have been successfully regenerated in vitro, and these regenerated tissues have been applied clinically. However, organs such as the liver and pancreas constitute numerous cell types, contain small amounts of extracellular matrix, and are highly vascularized. Therefore, organ engineering will require the assembly of cells and/or vesicles. In particular, adhesion between cells/vesicles will be required for regeneration of organs in vitro. This review introduces and discusses the key technologies and materials for the assembly of cells/vesicles for organ regeneration.
Capital Inflows and Asset Prices: The Recent Evidence of Selected East Asian Economies
Hiroyuki Taguchi
Asian Economic and Financial Review , 2012,
Abstract: This paper aims at providing empirical evidence on the relationship between capital inflows and asset prices, focusing on China, Hong Kong, Indonesia, Korea and Thailand. Main findings are: the positive responses of share prices to portfolio inflows shocks were verified in all the estimated economies, which implies the function of the direct channel into stock market; the indirect channel through domestic money supply appeared to work in the economies with peg regime like Hong Kong, whereas it did not in those with floating regime like Indonesia, Korea and Thailand, due to the sterilization of intervention in foreign exchange markets.
Bright light treatment for prevention of perioperative delirium in elderly patients
Toyoe Taguchi
Journal of Nursing Education and Practice , 2013, DOI: 10.5430/jnep.v3n10p10
Abstract: Background: Bright light treatment aims to improve circadian rhythms in patients living indoors with poor light-dark transitions by complementing insufficient natural light and highlighting the difference between their day- and night-time activities. In addition to bright light treatment, it is called “phototherapy” or “high-intensity light therapy”, and has been reported to be effective to prevent delirium and sleep disorders in the elderly. Under such circumstances, this study examined the validity of bright light treatment as a perioperative care approach for the elderly who are regarded as vulnerable to delirium due to hospitalization or therapeutic intervention. Methods: The study was conducted in the mixed surgical ward of approximately 200 beds, located in Kyoto Prefecture. Subjects were elderly male and female patients who underwent surgery for lower limbs, mainly the femur, and were randomly divided into intervention and control groups. The intervention group received bright light treatment with approximately 2,500 lx of bright light from the day after admission; on the day of surgery and at postoperative week 1, while the control group was treated with normal light during this period. The evaluation of delirium was conducted based on the results of nurses’ observation and the Japanese-Version NEECHAM Confusion Scale (NEECHAM scale). In addition to this, information regarding the patients’ activities of daily living was also collected. As physiological indices, light-exposure-dependent changes in blood serotonin levels and stress-dependent changes in blood cortisol levels were also evaluated. The period of the study was between 2008 and 2010; data were collected from November to February in each year, when the number of target patients increased. Results: As a result, data regarding 24 patients were obtained within this 2-year period. Excluding those with severe dementia, a total of 16 (intervention: 6; and control: 10) were studied. As a result, delirium occurred in the patients who underwent surgery of the lower limbs, mainly the femur, within the period between the day of surgery and postoperative day 3. The type of delirium was hyperactive in all cases, and its symptoms persisted for 3 to 4 days. Conclusion: The incidence of delirium was generally lower in the intervention than in the control group, suggesting the validity of bright light treatment.
Mouse Hepatitis Virus Receptor as a Determinant of the Mouse Susceptibility to MHV Infection
Fumihiro Taguchi
Frontiers in Microbiology , 2012, DOI: 10.3389/fmicb.2012.00068
Abstract: In this review, we report that the receptor of mouse hepatitis virus (MHV), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), is an important determinant of mouse susceptibility to MHV infection. This finding was revealed by using mouse strains with two different allelic forms of the MHV receptor, Ceacam1a and Ceacam1b. Although previous studies indicated that susceptibility is determined by a single gene, Ceacam1, our recent work in gene-replaced mice with chimeric Ceacam1 pointed toward the involvement of other host factors (genes) in the susceptibility. Studies on mouse susceptibility to MHV, as well as the factors involved in their susceptibility, are overviewed.
$L^p(Ω)$-Difference of One-Dimensional Stochastic Differential Equations with Discontinuous Drift
Dai Taguchi
Mathematics , 2014,
Abstract: We consider a one-dimensional stochastic differential equations (SDE) with irregular coefficients. The purpose of this paper is to estimate the $L^p(\Omega)$-difference of SDEs using the norm of the difference of coefficients, where the discontinuous drift coefficient satisfies a one-sided Lipschitz condition and the diffusion coefficient is bounded, uniformly elliptic and H\"older continuous. As an application, we consider the stability problem.
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