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Search Results: 1 - 10 of 2951 matches for " Julie Groleau "
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Accelerated Vascular Aging in CuZnSOD-Deficient Mice: Impact on EPC Function and Reparative Neovascularization
Jessika Groleau, Sylvie Dussault, Julie Turgeon, Paola Haddad, Alain Rivard
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023308
Abstract: Objective Aging is associated with increased oxidative stress levels and impaired neovascularization following ischemia. CuZnSOD has an important role to limit oxidative stress in the vasculature. Here we investigated the role of CuZnSOD for the modulation of ischemia-induced neovascularisation during aging. Methods and Results Hindlimb ischemia was surgically induced in young (2- month-old) or older (8-month-old) wild type (WT) and CuZnSOD?/? mice. We found that blood flow recovery after ischemia and vascular density in ischemic muscles were significantly reduced in older compared to young WT mice. Both in young and older mice, CuZnSOD deficiency led to a further reduction of neovascularization. Accordingly, the resulting neovascularisation potential in a young CuZnSOD?/? mouse was similar to that of an older WT mouse. Oxidative stress levels were also increased to similar levels in the ischemic muscles of young CuZnSOD?/? and older WT mice. To identify potential mechanisms involved, we investigated the effect of aging and CuZnSOD deficiency on the number and the function of endothelial progenitor cells (EPCs). Both aging and CuZnSOD deficiency were associated with reduced number of bone marrow and peripheral EPCs. The effect of moderate aging alone on specific functional activities of EPCs (migration, integration into tubules) was modest. However, CuZnSOD deficiency was associated with severe age-dependent defects in EPC functional activities. Conclusions CuZnSOD deficiency is associated with accelerated vascular aging and impaired ischemia-induced neovascularization. Our results suggest that in the context of aging, CuZnSOD has an essential role to protect against excessive oxidative stress in ischemic tissues and preserve the function of EPCs.
A biomechanical model of the face including muscles for the prediction of deformations during speech production
Julie Groleau,Matthieu Chabanas,Christophe Marecaux,Natacha Payrard,Brice Segaud,Michel Rochette,Pascal Perrier,Yohan Payan
Physics , 2008,
Abstract: A 3D biomechanical finite element model of the face is presented. Muscles are represented by piece-wise uniaxial tension cable elements linking the insertion points. Such insertion points are specific entities differing from nodes of the finite element mesh, which makes possible to change either the mesh or the muscle implementation totally independently of each other. Lip/teeth and upper lip/lower lip contacts are also modeled. Simulations of smiling and of an Orbicularis Oris activation are presented and interpreted. The importance of a proper account of contacts and of an accurate anatomical description is shown
Embodying 'health citizenship' in health knowledge to fight health inequalities
Groleau, Danielle;
Revista Brasileira de Enfermagem , 2011, DOI: 10.1590/S0034-71672011000500002
Abstract: this paper wishes to contribute to the debate around citizen participation in health system decision-making that has been present internationally for the last 30 years. i argue that if we aim to change health inequalities, health professionals and planners need to understand the illness and health service experience of citizens. the concept of 'health citizenship' introduced here refers to health knowledge that integrates the lay knowledge of patients and that this integration is translated into health actions such as clinical communication and the planning of health care, programs, and policy. we illustrate our argument with the two cases: health literacy and the promotion of breastfeeding in a canadian population living in context of poverty. this paper then concludes by addressing the leadership role, brazilian graduate nursing schools can play in promoting 'health citizenship' and by doing so, contribute to fight health inequalities.
La vérité affective chez Michel Henry
étienne Groleau
Phares : Revue Philosophique étudiante de l’Université Laval , 2011,
Breastfeeding practices after Kangaroo Mother Method in Rio de Janeiro: the necessity for he alth education and nursing intervention at homea
Cabral, Ivone Evangelista;Groleau, Danielle;
Escola Anna Nery , 2009, DOI: 10.1590/S1414-81452009000400011
Abstract: ithe "teaching-leaning" is part of the brazilian kangaroo mother method with the objective of increasing skills of mother's breastfeeding infants with special health needs. nevertheless, we do not know if this knowledge was embodied in the family inner circle, so we aimed at identifying and analyzing how this medical knowledge was incorporated in the context of infants' homes. participatory research was developed at home with eleven groups of mother, family members and neighbors. local knowledge of neighbors' and family members' replaced the medical knowledge and changed infant feeding practices. health education should be implemented beyond hospital and include family members.
Phonological and Spelling Mistakes among Dyslexic and Non-Dyslexic Children Learning Two Different Languages: Greek vs English  [PDF]
Georgia Andreou, Julie Baseki
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.38089
Abstract: The aim of our study was to examine the phonological and spelling errors made by dyslexic and non-dyslexic children in two different languages, one (Greek, L1) much more transparent than the other (English, L2). For these purposes, our subjects (poor spellers officially diagnosed as dyslexics) composed two picture elicited narratives, one in Greek and one in English with the aid of Script Log, an online recording tool for experimental research on the process of writing. Our results showed that dyslexics generally made statistically significant (p < 0.05) more mistakes in both languages in comparison to non-dyslexics and statistically significant more phonological mistakes in English than in Greek. In addition, dyslexics made a great number of spelling mistakes in both languages, though of different nature depending on the language in which they occurred. Thus, the dyslexics in our study presented different error profiles in English and in Greek and implications are made that instruction methods should be language specific.
Exploring Second Life as a Learning Environment for Computer Programming  [PDF]
Atul Sajjanhar, Julie Faulkner
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.51010

Computer programming can be challenging for beginners because of the need to understand abstract programming concepts. In this paper, we study the use of the Second Life (SL) virtual world for learning computer programming concepts. We conduct an empirical study for learning computer programming in SL by addressing affordances of SL for experiential problem-based learning pedagogies. We present preliminary findings, the promises and the limitations of Second Life as an environment for learning computer programming.

An Exploratory Analysis of the Relationships between Personality Characteristics and the Perceptions of Virtual Merchandising  [PDF]
Al Bellamy, Julie Becker
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.33019
Abstract: This study explored the relationship between individual’s perception of presence within a virtual merchandising environment and their attitudes toward virtual shopping. Symbolic interactionism was used as the theoretical framework. Utilizing four of the Big Five personality framework, it also examined if individual’s personality affected their attitude toward virtual shopping as well as the relationship between presence and attitudes toward online shopping. The study was conducted among 81 students enrolled in an undergraduate Apparel Textiles and Merchandising Program at a university located in Southeastern Michigan. Results indicate a positive correlation between perceptions of presence and individual willingness to make purchases within an online shopping environment as well as their overall satisfaction with shopping in such an environment. Two of the personality factors from the Big Five personality framework, neuroticism and extroversion, were shown to moderate these relationships. Overall, the study confirmed the idea that individual personality traits affect one’s disposition towards shopping within a virtual environment.
Technical Adequacy of the Student Protective Factors Screening Scale (SPF-7) as a Universal Screening Tool  [PDF]
Julie Q. Morrison
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.67081
Abstract: Universal screening is a critical foundation for school-based prevention and early intervention. This study examined the technical adequacy of the SPF-7, an instrument designed to assist school personnel in the early identification of students at-risk for emotional and behavioral concerns. The SPF-7 differs from other measures used in identifying emotionally and behaviorally at-risk students, as the SPF-7 focuses on protective factors rather than risk factors. The results of this study suggest that the SPF-7 has adequate test-retest reliability and criterion validity, but limited inter-rater agreement. The SPF-7 is a potentially promising tool for identifying students in need of support within a multi-tiered system of increasingly intensive interventions.
Production of functionalized polyhydroxyalkanoates by genetically modified Methylobacterium extorquens strains
Philipp H?fer, Young J Choi, Michael J Osborne, Carlos B Miguez, Patrick Vermette, Denis Groleau
Microbial Cell Factories , 2010, DOI: 10.1186/1475-2859-9-70
Abstract: Our proprietary M. extorquens ATCC 55366 was found unable to yield functionalized PHAs when fed methanol and selected unsaturated carboxylic acids as secondary substrates. However, cloning of either the phaC1 or the phaC2 gene from P. fluorescens GK13, using an inducible and regulated expression system based on cumate as inducer (the cumate switch), yielded recombinant M. extorquens strains capable of incorporating modest quantities of C-C double bonds into PHA, starting from either C6= and/or C8=. The two recombinant strains gave poor results with C11=. The strain containing the phaC2 gene was better at using C8= and at incorporating C-C double bonds into PHA. Solvent fractioning indicated that the produced polymers were PHA blends that consequently originated from independent actions of the native and the recombinant PHA synthases.This work constitutes an example of metabolic engineering applied to the construction of a methanol-utilizing bacterium capable of producing functionalized PHAs containing C-C double bonds. In this regard, the PhaC2 synthase appeared superior to the PhaC1 synthase at utilizing C8= as source of C-C double bonds and at incorporating C-C double bonds into PHA from either C6= or C8=. The M. ex-phaC2 strain is, therefore, a promising biocatalyst for generating advanced (functionalized) PHAs for future high value applications in various fields.Polyhydroxyalkanoates with functional groups (functionalized PHAs) have attracted increasing attention in the last ten years or so [1-9]. It has been generally recognized that important needs and markets exist for various types of functionalized PHAs as advanced materials in areas, such as tissue engineering [2,10,11], biocomposites [12], various medical applications [5,13], and polymers with tunable properties [6], only to name a few.Although many types of functionalized PHAs have been described in the literature, generally speaking, the quantities produced have been very modest and barely sufficient to
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