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Search Results: 1 - 10 of 3264 matches for " Julie Bergeron-Sawitzke "
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The ERCC6 Gene and Age-Related Macular Degeneration
Dominique C. Baas,Dominiek D. Despriet,Theo G. M. F. Gorgels,Julie Bergeron-Sawitzke,André G. Uitterlinden,Albert Hofman,Cornelia M. van Duijn,Joanna E. Merriam,R. Theodore Smith,Gaetano R. Barile,Jacoline B. ten Brink,Johannes R. Vingerling,Caroline C. W. Klaver,Rando Allikmets,Michael Dean,Arthur A. B. Bergen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013786
Abstract: Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the developed countries and is caused by both environmental and genetic factors. A recent study (Tuo et al., PNAS) reported an association between AMD and a single nucleotide polymorphism (SNP) (rs3793784) in the ERCC6 (NM_000124) gene. The risk allele also increased ERCC6 expression. ERCC6 is involved in DNA repair and mutations in ERCC6 cause Cockayne syndrome (CS). Amongst others, photosensitivity and pigmentary retinopathy are hallmarks of CS.
Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines
Karobi Moitra, Kate Im, Katy Limpert, Alexander Borsa, Julie Sawitzke, Rob Robey, Naoya Yuhki, Ram Savan, Da Wei Huang, Richard A. Lempicki, Susan Bates, Michael Dean
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045268
Abstract: In order to develop targeted strategies for combating drug resistance it is essential to understand it’s basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.
The 2001 Bethesda System
Bergeron,Christine;
Salud Pública de México , 2003, DOI: 10.1590/S0036-36342003000900007
Abstract: the bethesda system is a system of terminology for reporting the results of cervical cytology. it was developed in 1988, and is now widely used in the united states. this system was updated in april 2001. the most important modifications are the following: a) elimination of the category "satisfactory but limited by", b) the reintegration of benign modifications in the normal category, c) "atypical squamous cells of undetermined significance" is now named "atypical squamous cells" and subdivided into "atypical squamous cells of undetermined significance" and "cannot exclude high grade squamous intraepithelial lesion"; and d) endocervical adenocarcinoma in situ which is now a separate entity. low grade squamous intraepithelial lesions and high grade squamous intraepithelial cells remain unchanged. recommendations have been proposed concerning automated review and ancillary testing.
Dividend Policy and Consumption Risk
Claude Bergeron
International Journal of Economics and Finance , 2012, DOI: 10.5539/ijef.v4n8p1
Abstract: In this paper, we study the theoretical relationship between dividend policy and risk, in an intertemporal context. We use the fundamental framework of the consumption capital asset pricing model (CCAPM) to demonstrate that the dividend payout ratio of a stock (dividends divided by earnings) is negatively related to its covariance between dividends and consumption, cumulated over many periods. This result is consistent with the long-run definition of consumption risk, recently proposed in the literature. This result also suggests that long-run consumption risk influences dividend policy. In short, our model indicates that the target payout ratio of a firm can be estimated with a simple and easy-to-apply formula.
The 2001 Bethesda System
Bergeron Christine
Salud Pública de México , 2003,
Abstract: The Bethesda system is a system of terminology for reporting the results of cervical cytology. It was developed in 1988, and is now widely used in the United States. This system was updated in April 2001. The most important modifications are the following: a) elimination of the category "satisfactory but limited by", b) the reintegration of benign modifications in the normal category, c) "atypical squamous cells of undetermined significance" is now named "atypical squamous cells" and subdivided into "atypical squamous cells of undetermined significance" and "cannot exclude high grade squamous intraepithelial lesion"; and d) endocervical adenocarcinoma in situ which is now a separate entity. Low grade squamous intraepithelial lesions and high grade squamous intraepithelial cells remain unchanged. Recommendations have been proposed concerning automated review and ancillary testing.
The Halo White Dwarf WD 0346+246 Revisited
P. Bergeron
Physics , 2001, DOI: 10.1086/322316
Abstract: The extreme helium-rich atmospheric composition determined for the halo white dwarf WD 0346+246 is reexamined. This solution is shown to be improbable from an astrophysical point of view when accretion of hydrogen and metals from the interstellar medium is taken into account. An alternate solution is proposed where hydrogen and helium are present in the atmospheric regions in equal amounts. The best fit at Teff=3780 K, log g=8.34, and N(He)/N(H)=1.3 is achieved by including in the model calculations a bound-free opacity from the Lyman edge associated with the so-called dissolved atomic levels of the hydrogen atom, or pseudo-continuum opacity.
A Critical Examination of Halo White Dwarf Candidates
P. Bergeron
Physics , 2002, DOI: 10.1086/367618
Abstract: A detailed analysis of halo white dwarf candidates is presented, which is based on model atmosphere fits to observed energy distributions built from photoelectric or photographic magnitudes. Most of the candidates identified in reduced proper motion diagrams are shown to be too warm (Teff > 5000 K) and most likely too young to be members of the galactic halo, while the tangential velocities of the cooler and thus older white dwarfs are shown to be entirely consistent with the disk population. The results suggest that some white dwarf stars born in the young disk may have high velocities with respect to the local standard of rest. Such objects could represent the remnants of donor stars from close mass-transfer binaries that produced type Ia supernovae via the single degenerate channel, or other scenarios suggested in the literature. Ongoing surveys that rely solely on reduced proper motion diagrams are likely to identify more of these high velocity young degenerates, rather than to unveil the old white dwarf population of the galactic halo. The importance of infrared photometry for studying extremely cool white dwarfs is also emphasized.
About Statistical Questions Involved in the Data Analysis of the OPERA Experiment
H. Bergeron
Physics , 2011,
Abstract: The authors of the OPERA experiment [arXiv:1109.4897] claim that "the measurement indicates an early arrival time of CNGS muon neutrinos with respect to the one computed assuming the speed of light in vacuum". In this note we analyze the statistical aspects of the experimental results presented in [arXiv:1109.4897], assuming that no hidden experimental bias exists. Due to statistical constraints, we show (through two different methods) that the experimental data presented in [arXiv:1109.4897] do not permit to conclude unambiguously with the existence of a superluminal behavior of neutrinos. The problem lies essentially in the interpretation of the data and not in their veracity.
From Classical to Quantum Mechanics: "How to translate physical ideas into mathematical language"
H. Bergeron
Physics , 2001, DOI: 10.1063/1.1386410
Abstract: In this paper, we investigate the connection between Classical and Quantum Mechanics by dividing Quantum Theory in two parts: - General Quantum Axiomatics (a system is described by a state in a Hilbert space, observables are self-adjoint operators and so on) - Quantum Mechanics properly that specifies the Hilbert space, the Heisenberg rule, the free Hamiltonian... We show that General Quantum Axiomatics (up to a supplementary "axiom of classicity") can be used as a non-standard mathematical ground to formulate all the ideas and equations of ordinary Classical Statistical Mechanics. So the question of a "true quantization" with "h" must be seen as an independent problem not directly related with quantum formalism. Moreover, this non-standard formulation of Classical Mechanics exhibits a new kind of operation with no classical counterpart: this operation is related to the "quantization process", and we show why quantization physically depends on group theory (Galileo group). This analytical procedure of quantization replaces the "correspondence principle" (or canonical quantization) and allows to map Classical Mechanics into Quantum Mechanics, giving all operators of Quantum Mechanics and Schrodinger equation. Moreover spins for particles are naturally generated, including an approximation of their interaction with magnetic fields. We find also that this approach gives a natural semi-classical formalism: some exact quantum results are obtained only using classical-like formula. So this procedure has the nice property of enlightening in a more comprehensible way both logical and analytical connection between classical and quantum pictures.
Représentations cohomologiques isolées, applications cohomologiques
N. Bergeron
Mathematics , 2005,
Abstract: We give a new proof of a Theorem of Vogan which classify the cohomological representations of a real semisimple Lie group $G$ which are isolated in the unitary dual of $G$. We investigate the same question in the automorphic dual, and obtain partial results. We derive applications of all this results (or conjectures) to the study of the cohomology of arithmetic locally symmetric spaces.
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