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Search Results: 1 - 10 of 464057 matches for " Julie A. Roden "
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Tomato TFT1 Is Required for PAMP-Triggered Immunity and Mutations that Prevent T3S Effector XopN from Binding to TFT1 Attenuate Xanthomonas Virulence
Kyle W. Taylor equal contributor,Jung-Gun Kim equal contributor,Xue B. Su,Chris D. Aakre,Julie A. Roden,Christopher M. Adams,Mary Beth Mudgett
PLOS Pathogens , 2012, DOI: 10.1371/journal.ppat.1002768
Abstract: XopN is a type III effector protein from Xanthomonas campestris pathovar vesicatoria that suppresses PAMP-triggered immunity (PTI) in tomato. Previous work reported that XopN interacts with the tomato 14-3-3 isoform TFT1; however, TFT1's role in PTI and/or XopN virulence was not determined. Here we show that TFT1 functions in PTI and is a XopN virulence target. Virus-induced gene silencing of TFT1 mRNA in tomato leaves resulted in increased growth of Xcv ΔxopN and Xcv ΔhrpF demonstrating that TFT1 is required to inhibit Xcv multiplication. TFT1 expression was required for Xcv-induced accumulation of PTI5, GRAS4, WRKY28, and LRR22 mRNAs, four PTI marker genes in tomato. Deletion analysis revealed that the XopN C-terminal domain (amino acids 344–733) is sufficient to bind TFT1. Removal of amino acids 605–733 disrupts XopN binding to TFT1 in plant extracts and inhibits XopN-dependent virulence in tomato, demonstrating that these residues are necessary for the XopN/TFT1 interaction. Phos-tag gel analysis and mass spectrometry showed that XopN is phosphorylated in plant extracts at serine 688 in a putative 14-3-3 recognition motif. Mutation of S688 reduced XopN's phosphorylation state but was not sufficient to inhibit binding to TFT1 or reduce XopN virulence. Mutation of S688 and two leucines (L64,L65) in XopN, however, eliminated XopN binding to TFT1 in plant extracts and XopN virulence. L64 and L65 are required for XopN to bind TARK1, a tomato atypical receptor kinase required for PTI. This suggested that TFT1 binding to XopN's C-terminal domain might be stabilized via TARK1/XopN interaction. Pull-down and BiFC analyses show that XopN promotes TARK1/TFT1 complex formation in vitro and in planta by functioning as a molecular scaffold. This is the first report showing that a type III effector targets a host 14-3-3 involved in PTI to promote bacterial pathogenesis.
10,12-Dimethylpteridino[6,7-f][1,10]phenanthroline-11,13(10H,12H)-dione–chloroform (1/1)
Waynie Olaprath,Jennifer Roden,Kraig A. Wheeler,Mark E. McGuire
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810031570
Abstract: In the title co-crystal, C18H12N6O2·CHCl3, intramolecular Cl3C—H...N hydrogen-bonding interactions occur between a single CHCl3 and both N atoms at the 1,10-positions on the phenanthroline portion of the molecule. The interplanar distance between inversion-related molecules is 3.241 (2) .
An efficient method to calculate excitation energy transfer in light harvesting systems. Application to the FMO complex
G. Ritschel,J. Roden,W. T. Strunz,A. Eisfeld
Physics , 2011, DOI: 10.1088/1367-2630/13/11/113034
Abstract: A master equation, derived from the non-Markovian quantum state diffusion (NMQSD), is used to calculate excitation energy transfer in the photosynthetic Fenna-Matthews-Olson (FMO) pigment-protein complex at various temperatures. This approach allows us to treat spectral densities that contain explicitly the coupling to internal vibrational modes of the chromophores. Moreover, the method is very efficient, with the result that the transfer dynamics can be calculated within about one minute on a standard PC, making systematic investigations w.r.t. parameter variations tractable. After demonstrating that our approach is able to reproduce the results of the numerically exact hierarchical equations of motion (HEOM) approach, we show how the inclusion of vibrational modes influences the transfer.
Effects of Fructooligofructoses Chain Length on the Bifidobacteria of the Human Colon: A Pilot Study  [PDF]
Krista Mendlik, Julie A. Albrecht, Marilynn Schnepf
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.312211
Abstract: Human gastrointestinal health may be improved by the consumption of prebiotic food ingredients such as fructooligo-fructoses. A study was initiated to determine the effect of fructooligofructoses of different chain lengths on gastrointes-tinal parameters. Nineteen healthy subjects aged 20 - 57 y took part in a 10-week cross-over designed study. Subjects consumed either inulin or oligofructose for 3 weeks followed by a 2-week washout period between treatments. Stool samples were collected five times (baseline, 2 treatments, 2 washout) and analyzed for bifidobacteria. Daily records were kept for stool frequency, stool consistency and flatulence frequency. Bifidobacteria counts (cfu/ml) were higher (trending toward significance) during inulin and oligofructose intakes (1.2 × 107 ± 4.8 × 107 and 2.0 × 108 ± 4.7 × 108) and washout periods (2.9 × 106 ± 6.5 × 106 and 1.1 × 107 ± 1.6 × 107) than baseline counts (2.2 × 105 ± 5.1 × 105 and 2.9 × 106 ± 6.5 × 106), respectively. Inulin and oligofructose treatment periods had a significant effect on stool consistency (watery/very hard) and flatulence frequency, but not stool frequency, when compared to baseline (P < 0.05). Further research is needed to confirm these results due to small sample size and the need for a longer washout period between treatments.
A Novel Combined Approach for Metastatic Breast Cancer with Dural and Leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study  [PDF]
Julie Taguchi, Christopher Duma, M. A. Nezami
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.93025
Abstract: Concurrent dural and leptomeningeal metastatic carcinomatosis are very rare and have a poor prognosis. Here we present a woman with advanced estrogen receptor (ER) positive and progesterone receptor (PR) positive breast cancer who presented with leptomeningeal disease. Patient underwent multi targeted epigenetic therapies applied in a protocol called MTET. She continued to respond to the interval treatment, which consisted only of the nutraceutical agents. Here we discuss her case in detail and we believe that such an example might be applied to other patients in this situation resulting clinical improvement and less toxicity.
Suppression of quantum oscillations and the dependence on site energies in electronic excitation transfer in the Fenna-Matthews-Olson trimer
G. Ritschel,J. Roden,W. T. Strunz,A. Aspuru-Guzik,A. Eisfeld
Physics , 2011, DOI: 10.1021/jz201119j
Abstract: Energy transfer in the photosynthetic complex of the Green Sulfur Bacteria known as the Fenna-Matthews-Olson (FMO) complex is studied theoretically taking all three subunits (monomers) of the FMO trimer and the recently found eighth bacteriochlorophyll (BChl) molecule into account. We find that in all considered cases there is very little transfer between the monomers. Since it is believed that the eighth BChl is located near the main light harvesting antenna we look at the differences in transfer between the situation when BChl 8 is initially excited and the usually considered case when BChl 1 or 6 is initially excited. We find strong differences in the transfer dynamics, both qualitatively and quantitatively. When the excited state dynamics is initialized at site eight of the FMO complex, we see a slow exponential-like decay of the excitation. This is in contrast to the oscillations and a relatively fast transfer that occurs when only seven sites or initialization at sites 1 and 6 is considered. Additionally we show that differences in the values of the electronic transition energies found in the literature lead to a large difference in the transfer dynamics.
Response shift and glycemic control in children with diabetes
Julie A Wagner
Health and Quality of Life Outcomes , 2005, DOI: 10.1186/1477-7525-3-38
Abstract: At year 1, thirty-eight children with type 1 diabetes attending a diabetes summer camp participated. At baseline and post-camp they completed the Problem Areas in Diabetes (PAID) questionnaire. Post-camp, the PAID was also completed using the 'thentest' method, which requires a retrospective judgment about their baseline functioning. At year 2, fifteen of the original participants reported their HbA1c.PAID scores significantly decreased from baseline to post-camp. An even larger difference was found between thentest and post-camp scores, suggesting scale recalibration. There was a significant positive correlation between year 1 HbA1c and thentest scores. Partial correlation analysis between PAID thentest scores and year 2 HbA1c, controlling for year 1 HbA1c, showed that higher PAID thentest scores were associated with higher year 2 HbA1c.Results from this small sample suggest that children with diabetes do show scale recalibration, and that it may be related to glycemic control.Diabetes is one of the most common chronic diseases of childhood. Adjustment to the disease and the demands of its complex regimen are formidable tasks even for adults. Children face these demands in the context of already challenging normative developmental tasks. Understanding children's diabetes-related problems can inform intervention designed to improve medical outcomes and quality of life for this population.Response shift is a theoretical construct that provides a framework for this investigation. In essence, it posits that people can adjust how they think about their quality of life when they encounter relevant new information. In this model, antecedents (e.g., demographics, personality), interact with a catalyst (intervention or change in health status) to elicit psychological mechanisms (e.g., social comparison) in order to accommodate the catalyst. Response shift then influences one's quality of life evaluation (see figure 1). According to Schwartz & Sprangers [1], response shift p
L'Américanisme fran?ais au début du XXème siècle: projets politiques, muséologie et terrains brésiliens
Cavignac, Julie A.;
Vibrant: Virtual Brazilian Anthropology , 2012, DOI: 10.1590/S1809-43412012000100002
Abstract: this article aims to evaluate the importance of americanist studies and the place of french researchers in the constitution of an international research network in the early 20th century. we try to understand how this disciplinary field emerged centered on the native american people, especially their cultural and social specificities. an analysis of the methodological underpinnings of the first collections reveals that special attention was given to the collection and the study of material culture since it bore witness to the diversity of human societies. young collaborators were hired to be in charge of and to analyze the collection of objects for the musée de l'homme in order to fill the lacuna of knowledge of the "native americans cultures". lévi-strauss' two missions (1935 and 1938) to make the inventory of the material culture that were part of this project inaugurated a new phase of americanist studies, focussed on the study of social structure. we evaluate the importance of this change for americanist research in the amazon and the consolidation of an international research network that came into being prior to the second world war. such a documental review, which questions the 'museologized' ethnographic object, is important because it allows us to reread the history of the discipline, in the light of the importance of the historical contexts, political debates and the place of americanist studies in brazil and in france. it is also possible to define the limits of an anthropology which becomes autonomous and takes a critical position in relation to colonial states and welfare services provided to native americans.
Spoke Top Antenna for Transient Radiation
Julie A. LaComb
PIER Letters , 2009, DOI: 10.2528/PIERL09080602
Abstract: When an antenna transmits a short pulse of energy such as used for ultra-wide band applications, the pulse gets distorted upon transmission. To examine the properties of pulse transmission it is helpful to analyze the system in the time domain versus the frequency domain. Presented is a spoke top antenna for transient radiation. The spokes reduce the reflection from the open end of the antenna significantly reducing the trailing pulses commonly seen in the time domain. Comparisons are made with a dipole antenna. Both analytical, modeled and experimental results are presented.
The Situated Nature of Virtual Teamwork: Understanding the Constitutive Role of
Julie A. Rennecker
Sprouts : Working Papers on Information Systems , 2002,
Abstract: The time-space configurations of place and space are used to ground an analysis and discussion of the constitutive role of place, or virtual team members' respective local contexts, in the conduct of virtual teamwork. In contrast to the majority of current virtual teams research, which emphasizes the "spatial," or virtual aspect of virtual teamwork, this study uses an extended example, the establishment of a computer-conferencing infrastructure, to show the constitutive role played by local institutionalized rhythms, relationships, rules, politics, and resources in the enactment of virtual team tasks. Implications for studying, designing, and managing virtual teams are discussed.
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