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Search Results: 1 - 10 of 4830 matches for " Juliana Magdalon "
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A proteomic analysis of the functional effects of fatty acids in NIH 3T3 fibroblasts
Juliana Magdalon, Elaine Hatanaka, Talita Romanatto, Hosana G Rodrigues, Wilson MT Kuwabara, Caitriona Scaife, Philip Newsholme, Rui Curi
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-218
Abstract: Found in the majority of tissues of the body, fibroblasts are responsible for the synthesis and secretion of most extracellular matrix (ECM) components, such as proteoglycans, collagens, laminin and fibronectin, which bind to proteins expressed on cell surfaces thus modulating physiologic responses. Fibroblasts can also secrete proteinases, including matrix metalloproteinases and plasminogen, hence playing an important role in ECM degradation and tissue remodeling [1-3].The dysregulation of fibroblast biology is associated with several diseases and pathological states, including deficient wound healing [4-6], pulmonary diseases [7,8], cardiovascular diseases [9,10] and cancer [11]. Therefore, the discovery of new therapies modulating fibroblast biology could be a powerful target to develop treatment against such diseases. Oleic (18:1n-9), linoleic (18:2n-6) and palmitic (16:0) acids are the most abundant fatty acids in the western diets [12]. The latter is a saturated fatty acid found in palm oil, butter, milk, cheese and meats, whereas oleic acid is a monounsaturated fatty acid found in olive oil, meat, eggs and milk and linoleic acid is a polyunsaturated fatty acid found in soybean, sunflower, safflower and corn oils. The effects of prostaglandin derived from n-3 and n-6 fatty acids on specific protein expression (e.g. COX-2 and IL-6) in NIH 3T3 fibroblasts [13] and some aspects of the impact of fatty acids on process involving fibroblast function [14-16] have been reported. However, no systematic study has assessed the pleiotropic effects of fatty acids on fibroblast protein expression. Therefore, the aim of this study was to assess the effects of oleic (OLA), linoleic (LNA) or palmitic acids (PAM) on protein expression of NIH 3T3 fibroblasts, as determined by 2D-DIGE, i.e., separation of proteins by isoelectric focusing in the first dimension followed by SDS-PAGE in the second. This approach has been successful in elucidating the actions of palmitic acid on prot
Effects of neuromuscular electrical stimulation on tibialis anterior muscle of spastic hemiparetic children
Nunes, LCBG;Quevedo, AAF;Magdalon, EC;
Brazilian Journal of Physical Therapy , 2008, DOI: 10.1590/S1413-35552008000400011
Abstract: objective: this study evaluated the effects of neuromuscular electrical stimulation (nmes) on muscle strength, range of motion (rom) and gross motor function, among spastic hemiparetic children while standing, walking, running and jumping. methods: ten children were divided into two groups of five. the children who were normally receiving physical therapy sessions twice a week had two 30-minute nmes sessions per week (group 1), while those who were having one physical therapy session per week had one 30-minute nmes session per week (group 2), for seven weeks in both groups. the children were evaluated three times: before beginning the nmes protocol (initial), right after the end of the protocol (final) and eight weeks after the final evaluation (follow-up). the evaluations included manual goniometry on ankle dorsiflexion, manual muscle strength of the tibialis anterior and gross motor function (measurements while standing, walking, running and jumping). the statistical analysis was performed using the wilcoxon and mann-whitney tests, considering a p level of 0.05. results: there were significant increases in muscle strength, gross motor function and passive rom of ankle dorsiflexion, in both groups, and in active dorsiflexion in the first group. no significant differences were found between the groups. conclusions: the improvements in rom, muscle strength and gross motor function demonstrated that the use of nmes was effective in both groups, since no significant differences were found between the groups. this study suggests that nmes may be a useful therapeutic tool, even when applied once a week. further studies are needed to confirm these findings.
Diagnostics, rehabilitation and models of Parkinson’s disease  [PDF]
Juliana Dushanova
Health (Health) , 2012, DOI: 10.4236/health.2012.431178
Abstract: Diagnostics and rehabilitation of Parkinson’s disease (PD) presents the current information pertaining to etiology, early biomarkers for diagnostics, novel methods to evaluate symptoms, multidisciplinary rehabilitation, new applications of brain imaging and invasive methods to the study of PD. Researchers have only recently begun to focus on the non-motor symptoms of PD, which are poorly recognized and inadequately treated by clinicians. The non-motor symptoms of PD have a significant impact on patient quality of life and mortality, and include cognitive impairments, autonomic, gastrointestinal, and sensory symptoms. Indepth discussion of the use of imaging tools to study disease mechanisms is also provided, with emphasis on the abnormal network organization in parkinsonism. Deep brain stimulation management is a paradigm-shifting therapy for PD, essential tremor and dystonia. In the recent years, new approaches of early diagnostics, training programmes and treatments have vastly improved the lives of people with PD, substantially reducing symptoms and significantly delaying disability. PD results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction and oxidative stress, may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cas-cade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
When a Glue Sniffer Turns Weak  [PDF]
Poh Juliana, Puneet Seth
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.37A135

Toluene inhalation can result in electrolyte and acid-base derangements and should be considered in the differential diagnosis of young patients with unexplained hypokalaemia and normal anion gap metabolic acidosis. This case serves to illustrate the abnormalities and heighten awareness among emergency physicians who may not have laboratory results on hand when evaluating causes of limb weakness.

Managerial Skills, Financial Capability and Strategic Planning in Organizations  [PDF]
Vincent Bagire, Juliana Namada
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.35055

This study sought to establish the relationship between managerial skills, financial capability and the level of strategic planning. The study was premised on the increasing focus on strategic planning in Ugandan organizations. There was however, a lack of local empirical studies on the factors driving this trend. Data were obtained from organizations in various sectors that included government institutions, private and family business organizations. The findings confirmed that organizations were involved in significant level of strategic planning. There was a positive and significant relationship with managerial skills. However, there was a very weak relationship with the financial capability. The implication of the findings for management was to give more attention to managerial skills to ensure congruence of operations.

Discourse Analysis: Ronald Reagan’s Evil Empire Speech  [PDF]
Juliana Vianna da Nobrega
Open Journal of Modern Linguistics (OJML) , 2014, DOI: 10.4236/ojml.2014.41014

Language can be a powerful tool to convince others and make them cooperative. Cialdini (2007) has worked out several principles along which it is possible to analyze discourses in terms of their persuasiveness. Others also have contributed with tools to analyzing discourses such as Fairclough (2003). These tools are used to analyze the “Evil Empire Speech” of the US President Ronald Reagan that he held at the National Association of Evangelicals, 1983, in Orlando Florida. His historical speech was aimed at convincing the nation about the righteousness of his nuclear policy. He partly rewrote the already prepared script and included the “evil empire” part. The analysis supports that his speech was an exceptionally effective one. Reagan made his speech an example of the following principles of persuasiveness such as reciprocity, authority, commitment, liking, scarcity and social proof. He wanted support for belligerent intentions from a faithful community, which was already problematic, but he got the audience on his side through emphasizing his similarities with them, his own faithfulness, the presentation of strong examples and balancing humor and seriousness. Additionally, he introduced the striking metaphor “evil empire”, which stuck to the peoples’ minds and had an impact on them. He also appealed to the people through implicitly distinguishing the evil from the ones who were not evil—the US citizens. Thus, he made the American people feel better, to ensure them that they do the right thing when following him. He ranked religious people above him when he was joking about clergy men and politicians. To reinforce his authority, he borrowed the authority of various respected men through citing them. He improved his position and the power of his arguments using the philosophical wisdom of others.

Forasteiros na floresta subtropical: notas para uma história ambiental da coloniza??o alem? no Rio Grande do Sul
Bublitz, Juliana;
Ambiente & Sociedade , 2008, DOI: 10.1590/S1414-753X2008000200008
Abstract: the topic of this article is the german colonization in the brazilian state of rio grande do sul in the 19th century from the perspective of environmental history and with special attention to what the settlers felt when they first got into touch with subtropical forest. the reader finds a discussion about the deforestation on behalf of civilization and the environmental impact of this process.
Leyendo en el espacio local: La experiencia de las mujeres de una biblioteca popular en Neuquén
La aljaba , 2010,
Abstract: in this paper i present the collective experience of a group of women that runs a community library in the neighborhood of la sirena in the city of neuquén. i set the framework of this experience in two contexts: globalization and the particular stage in the life of each of the women involved. the first one allows to see how the local area, the neighborhood, is resignified as a microworld as well as the role that women play in it; the second allows to look into how each one builds her identity as a woman in relation to volunteer and free work and how they deal with the changes imposed both by today's world and by the "second life of women." from the dialogue between these two contexts there arises a tension between what is public and what is private, between the local and the global, between paid time and donated time, between the social and the particular, between the inside and the outside. when each pair is analyzed from a gender perspective, this tension is reconceputalized and makes visible the way in which the unequal relations between men and women is expressed and reproduced in the organization of the territory.
Igualdad de oportunidades y autonomía familiar
An??lisis filos?3fico , 2007,
Abstract: this essay analyzes the problem of the normative incompatibility between two principles which are widely accepted by liberals -the principle of equality of opportunities and that of family autonomy- and this within the framework of rawls′s theory of justice. after specifying different ways in which the autonomy of the family necessarily leads to inequality of opportunities between individuals, i examine two different solutions suggested by rawls in a theory of justice and i intend to demonstrate why they are wrong.
Atua??o da OTAN no pós-Guerra Fria: implica??es para a seguran?a internacional e para a ONU
Bertazzo, Juliana;
Contexto Internacional , 2010, DOI: 10.1590/S0102-85292010000100003
Abstract: after the end of the cold war, the north atlantic treaty organization (nato) used its military capabilities for the first time in actual conflict. since then, it has been acting regularly, either under a united nations' mandate or not. this work presents the debate in the literature on the permanence of nato after the end of the cold war and analyzes its transformation and new role in a distinct world context. alliance theory does not explain the persistence of such an arrangement. regime theory, on the other hand, allows for nato persistence in a changed context, provided that it is able to transform itself and adapt to new conditions. the data obtained are used to test the hypothesis that there is a recent decline in un humanitarian activism, which would make room for new actors to work on the field of global security. the conclusion is that although there is a decrease in un activity, it is not significant compared to the cold war period. thus, instead of a possible omission on the part of the un, it is the need to justify the permanence of the transatlantic link in a new strategic scenario that rises as a key factor in explaining why nato takes on this interventionist and expeditionary character, quite distinct from its original one. the legitimacy nato could have or lack for this type of missions is also part of the discussion. finally, it is stressed here that legal problems of nato action vis-à-vis the un are included in an overarching question: the need for review of global collective security arrangements and of the security council, particularly.
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