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Search Results: 1 - 10 of 17830 matches for " Jui-Hsin Su "
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Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum
Nai-Lun Lee,Jui-Hsin Su
Marine Drugs , 2011, DOI: 10.3390/md9122526
Abstract: Three new cembranoids, culobophylins A–C ( 1– 3), along with two known compounds ( 4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines.
Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular
Jui-Hsin Su,Zhi-Hong Wen
Marine Drugs , 2011, DOI: 10.3390/md9060944
Abstract: Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1– 5, including two new metabolites, triangulenes A ( 1) and B ( 2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR ( 1H– 1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 3 and 5 exhibited moderate cytotoxicity to human tumor cell lines CCRF-CEM and DLD-1. Furthermore, 3– 5 displayed significant in vitro anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages.
Cembranoids with 3,14-Ether Linkage and a Secocembrane with Bistetrahydrofuran from the Dongsha Atoll Soft Coral Lobophytum sp.
Mohamed Elamir F. Hegazy,Jui-Hsin Su,Ping-Jyun Sung,Jyh-Horng Sheu
Marine Drugs , 2011, DOI: 10.3390/md9071243
Abstract: Four new cembranoids, lobophylins A–D ( 1– 4), and one novel secocembrane, lobophylin E ( 5) were isolated from a soft coral Lobophytum sp. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods. Among these metabolites, 1– 4 are rarely found cembranoids possessing a tetrahydrofuran moiety with a 3,14-ether linkage. In addition, 5 is the first secocembrane possessing two tetrahydrofuran moieties with 3,14- and 4,7-ether linkages.
Two New Cembrane-Based Diterpenoids from the Marine Soft Coral Sinularia crassa
Yun-Sheng Lin,Nai-Lun Lee,Mei-Chin Lu,Jui-Hsin Su
Molecules , 2012, DOI: 10.3390/molecules17055422
Abstract: Two new cembrane diterpenes, sicrassarines A and B (compounds 1 and 2), were isolated from the Taiwanese soft coral Sinularia crassa. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy.
A New Cubitane Diterpenoid from the Soft Coral Sinularia crassa
Ching-Hsiao Cheng,Yun-Sheng Lin,Zhi-Hong Wen,Jui-Hsin Su
Molecules , 2012, DOI: 10.3390/molecules170910072
Abstract: A new cubitane diterpenoid, crassalone A (1), was isolated from the marine soft coral Sinularia crassa. The structure was determined by extensive spectroscopic analyses. Compound 1 is not cytotoxic (IC50 > 20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).
Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
Ching-Chyuan Su,Bing-Sang Wong,Chuen Chin,Yu-Jen Wu,Jui-Hsin Su
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14024317
Abstract: Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1– 5, including two new metabolites, 11-acetylsinuflexolide ( 1) and 11-acetyldihydrosinuflexolide ( 2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR ( 1H– 1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
4-Methylenesterols from a Sponge Theonella swinhoei
Jheng-Kun Guo,Ching-Ying Chiang,Mei-Chin Lu,Wen-Been Chang,Jui-Hsin Su
Marine Drugs , 2012, DOI: 10.3390/md10071536
Abstract: Three new 4-methylenesterols, theonellasterol K ( 1), acetyltheonellasterol ( 2) and acetyldehydroconicasterol ( 3), along with two known sterols, theonellasterol ( 4) and theonellasterone ( 5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.
A New Spatane Diterpenoid from the Cultured Soft Coral Sinularia leptoclados
Tsung-Chang Tsai,Yu-Jen Wu,Jui-Hsin Su,Wei-Tung Lin,Yun-Sheng Lin
Marine Drugs , 2013, DOI: 10.3390/md11010114
Abstract: A new spatane diterpenoid, leptoclalin A ( 1), along with two previously reported known norcembranoid diterpenes ( 2 and 3), were isolated from a cultured soft coral Sinularia leptoclados . The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. Metabolite 1 is rarely found in spatane skeletons reported from soft corals. In addition, compound 1 exhibited weak cytotoxicity towards human tumor cell lines T-47 D and K-562.
An Investigation into the Cytotoxic Effects of 13-Acetoxysarcocrassolide from the Soft Coral Sarcophyton crassocaule on Bladder Cancer Cells
Ching-Chyuan Su,Jui-Hsin Su,Jen-Jie Lin,Cheng-Chi Chen,Wen-Ing Hwang,Han Hsiang Huang,Yu-Jen Wu
Marine Drugs , 2011, DOI: 10.3390/md9122622
Abstract: Active compounds from natural products have been widely studied. The anti-tumor effects of 13-acetoxysarcocrassolide isolated from Formosan soft coral Sarcophyton crassocaule on bladder cancer cells were examined in this study. An MTT assay showed that 13-acetoxysarcocrassolide was cytotoxic to bladder female transitional cancer (BFTC) cells. We determined that the BFTC cells underwent cell death through apoptosis by flow cytometry. Due to the highly-migratory nature of the BFTC cells, the ability of 13-acetoxysarcocrassolide to stop their migration was assessed by a wound healing assay. To determine which proteins were affected in the BFTC cells upon treatment, a comparative proteomic analysis was performed. By LC-MS/MS analysis, we identified that 19 proteins were up-regulated and eight were down-regulated. Seven of the proteins were confirmed by western blotting analysis. This study reveals clues to the potential mechanism of the cytotoxic effects of 13-acetoxysarcocrassolide on BFTC cells. Moreover, it suggests that PPT1 and hnRNP F could be new biomarkers for bladder cancer. The results of this study are also helpful for the diagnosis, progression monitoring and therapeutic strategies of transitional cell tumors.
Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.
Yu-Chia Chang,Shang-Wei Tseng,Li-Lian Liu,Yalan Chou,Yuan-Shing Ho,Mei-Chin Lu,Jui-Hsin Su
Marine Drugs , 2012, DOI: 10.3390/md10050987
Abstract: One new pentacyclic sesterterpene, hippospongide A ( 1), and one new scalarane sesterterpenoid, hippospongide B ( 2), along with six previously reported known scalarane–type sesterterpenes ( 3– 8), were isolated from a sponge Hip pospongia sp . The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3– 5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines.
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