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Search Results: 1 - 10 of 288732 matches for " Juana I.; Benítez López "
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Actividad antiartrítica del jarabe de Allium sativum L
Tillán Capó,Juana I.; Benítez López,Annia; Hernández Paderni,Ivette; Carrillo,Carmen;
Revista Cubana de Plantas Medicinales , 2007,
Abstract: allium sativum l is widely used by cuban people in folk and natural medicine to alliviate inflammatory processes and specially in rheumatoid arthritis; however, its activity hasn’t scientifically enough demonstrated to stablish a clinical assay for its registration and industrial production. in present paper, action of a allium sativum syrup on experimental rheumatoid arthritis was assessed, using models of leg edema and pleurisy in wistar rats, based on passive reaction of arthus. in two models, placebo and doses of 45, 90, and 180 mg/kg of body weight were assayed based on total solids in a.sativum syrup. as positive controls ibuprofen and prednisone were used at dosis of 200 and 10 mg/kg, respectively. positive controls and assayed dosis of allium sativum l syrup decreased inflammatory process triggered by antigen-antibody reaction achieved by means of passive reaction of arthus, by means of egg albumin antiserum, and bovine albumin antiserum for leg edema and development of pleurisy, recpectively.
Actividad antiartrítica del jarabe de Allium sativum L Antiarthritic activity of Allium sativum L syrup
Juana I. Tillán Capó,Annia Benítez López,Ivette Hernández Paderni,Carmen Carrillo
Revista Cubana de Plantas Medicinales , 2007,
Abstract: Allium sativum L. es ampliamente utilizado por la población cubana en la medicina tradicional y natural para aliviar procesos inflamatorios y en especial en la artritis reumatoide; sin embargo, su actividad no ha sido demostrada científicamente como para poder establecer un ensayo clínico para su registro y producción industrial. En el presente trabajo se evaluó la acción de un jarabe de Allium sativum L. sobre la artritis reumatoide experimental, empleando los modelos de edema de la pata y pleuresía en ratas Wistar, basados en la reacción pasiva de Arthus. En los dos modelos, se ensayaron placebo y dosis de 45, 90 y 180 mg/kg de peso corporal, en base a sólidos totales contenido en el jarabe de A. sativum. Como controles positivos se utilizó ibuprofeno y prednisona a las dosis de 200 y 10 mg/kg respectivamente. Tanto los controles positivos, como las dosis de jarabe de Allium sativum L. ensayadas disminuyeron el proceso inflamatorio desencadenado por la reacción antígeno anticuerpo que se logra mediante la reacción pasiva de Arthus, el antisuero de albúmina de huevo y antisuero de albúmina bovina para el edema de la pata y el desarrollo de pleuresía respectivamente. Allium sativum L is widely used by Cuban people in folk and natural medicine to alliviate inflammatory processes and specially in rheumatoid arthritis; however, its activity hasn’t scientifically enough demonstrated to stablish a clinical assay for its registration and industrial production. In present paper, action of a Allium sativum syrup on experimental rheumatoid arthritis was assessed, using models of leg edema and pleurisy in Wistar rats, based on passive reaction of Arthus. In two models, placebo and doses of 45, 90, and 180 mg/kg of body weight were assayed based on total solids in A.sativum syrup. As positive controls Ibuprofen and Prednisone were used at dosis of 200 and 10 mg/kg, respectively. Positive controls and assayed dosis of Allium sativum L syrup decreased inflammatory process triggered by antigen-antibody reaction achieved by means of passive reaction of Arthus, by means of egg albumin antiserum, and bovine albumin antiserum for leg edema and development of pleurisy, recpectively.
Actividad analgésica y antipirética de un extracto fluido de Pimenta dioica L. y evaluación de su toxicidad aguda oral
Benítez López,Ania; Tillán Capó,Juana; Cabrera González,Yolanda;
Revista Cubana de Farmacia , 1998,
Abstract: the analgesic and antipyretic activity of the pimenta dioica l. fluid extract was studied in experimental animals, as well as its acute oral toxicity. the analgesic effect was evaluated at doses of 825, 1 320 and 1 650 mg/kg by the technique of contorsions induced by chemical agents (witkin et. al., 1961), whereas antipyresis was tested in rabbits at doses of 206 and 406 mg/kg against an endotoxin of e. coli. the results obtained in both studies were compared with ibuprofen 200 mg/kg, and it was proved that the oral administration of the extract at doses of 1 650 mg/kg -analgesia- and 406 mg/kg -antipyresis- has an efectivity similar to that of ibuprofen. the toxicological study was conducted in mice and it was obtained a dl50 of 2.56 g/kg, which allows to classify the extract as non toxic.
Actividad analgésica y antipirética de un extracto fluido de Pimenta dioica L. y evaluación de su toxicidad aguda oral
Ania Benítez López,Juana Tillán Capó,Yolanda Cabrera González
Revista Cubana de Farmacia , 1998,
Abstract: Se estudió la actividad analgésica y antipirética del extracto fluido de Pimenta dioica L. en animales de experimentación, así como su toxicidad aguda oral. Se evaluó el efecto analgésico a las dosis 825, 1 320 y 1 650 mg/kg mediante la técnica de contorsiones inducidas por agentes químicos (Witkin y col, 1961), y la antipiresia fue testada en conejos a las dosis 206 y 406 mg/kg, frente a una endotoxina de E. coli. Se compararon los resultados obtenidos en ambos estudios con ibuprofeno 200 mg/kg, y se demostró que el extracto administrado por vía oral, a las dosis de 1 650 mg/kg -analgesia- y 406 mg/kg -antipiresia- posee una efectividad similar al ibuprofeno. Se realizó el estudio toxicológico en ratones, y se obtuvo una DL50 de 2,56 g/kg, lo que permite clasificar al extracto como no tóxico. The analgesic and antipyretic activity of the Pimenta dioica L. fluid extract was studied in experimental animals, as well as its acute oral toxicity. The analgesic effect was evaluated at doses of 825, 1 320 and 1 650 mg/kg by the technique of contorsions induced by chemical agents (Witkin et. al., 1961), whereas antipyresis was tested in rabbits at doses of 206 and 406 mg/kg against an endotoxin of E. coli. The results obtained in both studies were compared with ibuprofen 200 mg/kg, and it was proved that the oral administration of the extract at doses of 1 650 mg/kg -analgesia- and 406 mg/kg -antipyresis- has an efectivity similar to that of ibuprofen. The toxicological study was conducted in mice and it was obtained a DL50 of 2.56 g/kg, which allows to classify the extract as non toxic.
Leguminosas naturalizadas en el Valle del Cauto, Cuba Naturalized legumes in the Cauto Valley, Cuba
I Gómez,E Cordoví,D. G Benítez,R. C López
Pastos y Forrajes , 2010,
Abstract: Con el objetivo de evaluar la dinámica de crecimiento de 24 accesiones del género Brachiaria spp., se desarrolló la presente investigación en la región de Barrancabermeja, Santander, Colombia. Se utilizó un dise o experimental completamente aleatorizado, en 72 parcelas de 21 m2 cada una y tres réplicas (parcelas) para cada tratamiento. Las accesiones fueron agrupadas según los hábitos de crecimiento en: estoloníferas, decumbentes y erectas, y se determinó la tasa de crecimiento en función de la altura del pasto. Las accesiones con mejor crecimiento durante la investigación fueron: de las estoloníferas, B. dictyoneura CIAT-6133; de las de hábito decumbente, B. decumbens CIAT-606; y de las de crecimiento erecto, B. brizantha CIAT-16113, CIAT-26110, CIAT-26318 y CIAT-16322. Algunas accesiones no tuvieron un buen comportamiento, al parecer por las condiciones edafoclimáticas a las que fueron sometidas. Entre ellas se encuentran B. dictyoneura CIAT-16871, B. ruziziensis CIAT-26180 y B. brizantha CIAT-16212, 26124 y 26427. With the objective of prospect and collect the naturalized legumes for livestock production usage in the Cauto Valley, Cuba, two searches were made in representative zones of the region. The first search was conducted in the territory located west of Bayamo city, where there are different soils and rainfall regimes, and the second one on soils affected by salinity. In prospection number 1 the presence of 17 genera was determined and within them a total of 22 species, among which the following prevailed: Galactia spiciformis, Centrosema molle, Desmodium triflorum and Teramnus uncinatum; the existence of an important number of species was also known on vertisol soils with deficient drainage, which edaphic grouping constitutes the most extended in the region, and on the other hand, the associability degree of each legume with other species of the spontaneous vegetation present in the search areas, was characterized. In prospection number 2 four and five genera were found on areas with weak and moderate fertility levels, respectively, and Desmanthus virgatus stood out due to the abundance in the number of individuals. It is concluded that under the conditions these prospections were made, there is a rich potential of naturalized legumes with multiplication and usage possibilities in the region.
Rotation of the optical polarization angle associated with the 2008 γ-ray flare of blazar w comae
Marco Sorcia,Erika Benítez,David Hiriart,José M. López,José I. Cabrera,Raúl Mújica
Physics , 2014, DOI: 10.1088/0004-637X/794/1/54
Abstract: An $R$--band photopolarimetric variability analysis of the TeV bright blazar W Comae, between 2008 February 28 and 2013 May 17, is presented. The source showed a gradual tendency to decrease its mean flux level with a total change of ~3~mJy. A maximum and minimum brightness states in the $R$-band of 14.25$\pm$0.04 and 16.52$\pm$0.1~mag respectively were observed, corresponding to a maximum variation of $\Delta$F = 5.40 mJy. We estimated a minimum variability timescale of $\Delta$t=3.3 days. A maximum polarization degree $P$=33.8\%$\pm$1.6\%, with a maximum variation of $\Delta$P = 33.2\%, was found. One of our main results is the detection of a large rotation of the polarization angle from 78\degr to 315\degr ($\Delta\theta\sim$237\degr) that coincides in time with the $\gamma$-ray flare observed in 2008 June. This result indicates that both optical and $\gamma$-ray emission regions could be co-spatial. During this flare, a correlation between the $R$-band flux and polarization degree was found with a correlation coefficient of $r_{F-p}=0.93\pm$0.11. From the Stokes parameters we infer the existence of two optically thin synchrotron components that contribute to the polarized flux. One of them is stable with a constant polarization degree of 11\%. Assuming a shock-in jet model during the 2008 flare, we estimated a maximum Doppler factor $\delta_D\sim 27$ and a minimum of $\delta_D\sim 16$; a minimum viewing angle of the jet $\sim$2\degr.0; and a magnetic field $B \sim$ 0.12~G.
Leguminosas naturalizadas en el Valle del Cauto, Cuba
Gómez,I; Cordoví,E; Benítez,D. G; López,R. C; Nuviola,Y; Olivera,Yuseika;
Pastos y Forrajes , 2010,
Abstract: with the objective of prospect and collect the naturalized legumes for livestock production usage in the cauto valley, cuba, two searches were made in representative zones of the region. the first search was conducted in the territory located west of bayamo city, where there are different soils and rainfall regimes, and the second one on soils affected by salinity. in prospection number 1 the presence of 17 genera was determined and within them a total of 22 species, among which the following prevailed: galactia spiciformis, centrosema molle, desmodium triflorum and teramnus uncinatum; the existence of an important number of species was also known on vertisol soils with deficient drainage, which edaphic grouping constitutes the most extended in the region, and on the other hand, the associability degree of each legume with other species of the spontaneous vegetation present in the search areas, was characterized. in prospection number 2 four and five genera were found on areas with weak and moderate fertility levels, respectively, and desmanthus virgatus stood out due to the abundance in the number of individuals. it is concluded that under the conditions these prospections were made, there is a rich potential of naturalized legumes with multiplication and usage possibilities in the region.
Long-term optical polarization variability of the tev blazar 1es~1959+650
Marco Sorcia,Erika Benítez,David Hiriart,José M. López,José I. Cabrera,Raúl Mújica,Jochen Heidt,Ivan Agudo,Kari Nilsson,Michael Mommert
Physics , 2013, DOI: 10.1088/0067-0049/206/2/11
Abstract: A detailed analysis of the optical polarimetric variability of the TeV blazar 1ES 1959+650 from 2007 October 18 to 2011 May 5 is presented. The source showed a maximum and minimum brightness states in the R-band of 14.08$\pm$0.03 mag and 15.20$\pm$0.03 mag, respectively, with a maximum variation of 1.12 mag, and also a maximum polarization degree of $P=$(12.2$\pm$0.7)%, with a maximum variation of 10.7%. From August to November 2009, a correlation between the optical $R$-band flux and the degree of linear polarization was found, with a correlation coefficient $r_{pol}$=0.984$\pm$0.025. The source presented a preferential position angle of optical polarization of $\sim153^{\circ}$, with variations of $10\degr$-$50\degr$, that is in agreement with the projected position angle of the parsec scale jet found at 43 GHz. From the Stokes parameters we infer the existence of two optically-thin synchrotron components that contribute to the polarized flux. One of them is stable, with a constant polarization degree of 4%. Assuming a stationary shock for the variable component, we estimated some parameters associated with the physics of the relativistic jet: the magnetic field, $B\sim$0.06 G, the Doppler factor, $\delta_{0}\sim$23, the viewing angle, $\Phi\sim2.4\degr$, and the size of the emission region $r_b\sim5.6\times10^{17}$ cm. Our study is consistent with the spine-sheath model to explain the polarimetric variability displayed by this source during our monitoring.
Consecutive Low Doses of Cyclosporine A Induce Pro-Inflammatory Cytokines and Accelerate Allograft Skin Rejection
Roberto López-Flores,Rafael Bojalil,José C. Benítez,Yadira Ledesma-Soto,César A. Terrazas,Miriam Rodríguez-Sosa,Luis I. Terrazas
Molecules , 2011, DOI: 10.3390/molecules16053969
Abstract: Cyclosporine A (CsA) is a fungus-derived molecule with potent immunosuppressive activity that has been largely used to downregulate cell-mediated immune responses during transplantation. However, previous data have indicated that CsA shows immunomodulatory activity that relays on the antigen concentration and the dose of CsA used. To test the hypothesis that minimal doses of CsA may show different outcomes on grafts, we used an experimental model for skin transplants in mice. ICR outbred mice received skin allografts and were either treated daily with different doses of CsA or left untreated. Untreated mice showed allograft rejection within 14 days, with graft necrosis, infiltration of neutrophils and macrophages and displayed high percentages of CD8+ T cells in the spleens, which were associated with high serum levels of IL-12, IFN-g and TNF-α. As expected, mice treated with therapeutic doses of CsA (15 mg/kg) did not show allograft rejection within the follow-up period of 30 days and displayed the lowest levels of IL-12, IFN-g and TNF-α as well as a reduction in CD8+ lymphocytes. In contrast, mice treated with consecutive minimal doses of CsA (5 × 10?55 mg/kg) displayed an acute graft rejection as early as one to five days after skin allograft; they also displayed necrosis and strong inflammatory infiltration that was associated with high levels of IL-12, IFN-g and TNF-α. Moreover, the CD4+ CD25hiFoxP3+ subpopulation of cells in the spleens of these mice was significantly inhibited compared with animals that received the therapeutic treatment of CsA and those treated with placebo. Our data suggest that consecutive, minimal doses of CsA may affect Treg cells and may stimulate innate immunity.
GRUPOS DE SUELOS Y SU DISTRIBUCIóN EN LAS áREAS DEL INGENIO CENTRAL MOTZORONGO, VERACRUZ, MéXICO
Gómez,I. A; Hernández,A; Ascanio,M. O; Sánchez,M. E; Benítez,Ledya; Villegas,R; López,M; Durán,J. L; Ponce de León,D;
Cultivos Tropicales , 2010,
Abstract: this report is one of the results from some studies performed in the raw material supply area of central motzorongo mill, veracruz, mexico, which consisted of knowing soil characteristics, classification and distribution. starting from a photo-interpretation work and drilling 1310 observation points, sugarcane-growing soils were mapped. afterwards, the study was enlarged and the world reference base classification was applied to the entire area. due to the complexity and interaction between formation factors, different formation processes have been shown in the studied area and soils of the humid tropical regions were found together with some younger ones. then, 12 referential groups of soils were identified and characterized. among these groups, acrisols, nitisols, phaeozems and luvisols are the most extended soils
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