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Search Results: 1 - 10 of 174888 matches for " Juan F. Medrano "
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Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse: A review
Pablo M Corva, Juan F Medrano
Genetics Selection Evolution , 2001, DOI: 10.1186/1297-9686-33-2-105
Abstract: (To access the full article, please see PDF)
Comparison of gene coverage of mouse oligonucleotide microarray platforms
Ricardo A Verdugo, Juan F Medrano
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-58
Abstract: A MySQL relational database was created to store the mapping information for 25,416 mouse genes and for the probes in five microarray platforms (gene coverage level in parenthesis): Affymetrix430 2.0 (75.6%), ABI Genome Survey (81.24%), Agilent (79.33%), Codelink (78.09%), Sentrix (90.47%); and four array-ready oligosets: Sigma (47.95%), Operon v.3 (69.89%), Operon v.4 (84.03%), and MEEBO (84.03%). The differences in coverage between platforms were highly conserved across chromosomes. Differences in the number of redundant and unspecific probes were also found among arrays. The database can be queried to compare specific genomic regions using a web interface. The software used to create, update and query the database is freely available as a toolbox named ArrayGene.The software developed here allows researchers to create updated custom databases by using public or proprietary information on genes for any organisms. ArrayGene allows easy comparisons of gene coverage between microarray platforms for any region of the genome. The comparison presented here reveals that the commercial microarray Sentrix, which is based on the MEEBO public oligoset, showed the best mouse genome coverage currently available. We also suggest the creation of guidelines to standardize the minimum set of information that vendors should provide to allow researchers to accurately evaluate the advantages and disadvantages of using a given platform.The wide use of DNA microarrays to query expression of genes has created the need for updated, consistent and meaningful annotations on the probes included in the microarrays. We refer to gene annotation as a recognizable label or gene id identifying the gene that is targeted by a given probe. Gene ids should be stable, widely used and allow reliable associations among genomic databases. Several microarray annotation systems are available for investigators, aiming to address specific user demands. For instance, the KARMA [1] web server provides periodic
Characterization of Bacteria in Biopsies of Colon and Stools by High Throughput Sequencing of the V2 Region of Bacterial 16S rRNA Gene in Human
Yukihide Momozawa,Valérie Deffontaine,Edouard Louis,Juan F. Medrano
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016952
Abstract: The characterization of the human intestinal microflora and their interactions with the host have been identified as key components in the study of intestinal disorders such as inflammatory bowel diseases. High-throughput sequencing has enabled culture-independent studies to deeply analyze bacteria in the gut. It is possible with this technology to systematically analyze links between microbes and the genetic constitution of the host, such as DNA polymorphisms and methylation, and gene expression.
Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains
Charles R Farber, Pablo M Corva, Juan F Medrano
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-102
Abstract: The first speed congenic panel was developed by introgressing four overlapping donor regions spanning MMU2 in its entirety onto both HG and B6 backgrounds, for a total of eight strains. Phenotypic characterization of the MMU2 panel confirmed the segregation of multiple growth and obesity QTL and strongly suggested that a subset of these loci modify the effects of the hg deletion. The second panel consisted of individual donor regions on an HG background for each QTL on MMU1, 5, 8, 9, 11 and 17. Of the six developed strains, five were successfully characterized and displayed significant differences in growth and/or obesity as compared to controls. All five displayed phenotypes similar to those originally attributed to each QTL, however, novel phenotypes were unmasked in several of the strains including sex-specific effects.The speed congenic strains developed herein constitute an invaluable genomic resource and provide the foundation to identify the specific nature of genetic variation influencing growth and obesity.The use of mouse models has provided valuable insight into the etiology of monogenic syndromes caused by single gene mutations. However, such models do not mimic the genetic complexity of disease traits commonly seen in the human population. Complex traits, such as polygenic growth and obesity are influenced by the small to moderate direct effects of quantitative trait loci (QTL), epistasis between QTL alleles, environmental perturbations and QTL-environment interactions.To date numerous mouse growth and obesity QTL have been localized [1,2], however, little progress has been made in determining the specific nature of the underlying genetic variants. One resource used to fine map QTL are congenic strains which are designed to convert a complex polygenic trait into one that is mono- or oligogenic. This is accomplished by eliminating segregating genetic variation outside the locus of interest and reducing the environmental variation influencing a trait by c
Boticarium I.
Juan Medrano
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2011,
Abstract: Sin resumen.
La importancia de la ropa (II). Lencería, complementos y zapatería.
Juan Medrano
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2011,
Abstract: Sin resumen.
Reflexiones nerviosas. Fútbol
Juan Medrano
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2012,
Abstract: Sin resumen.
Documentos en la red
Juan Medrano
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2012,
Abstract: Sin resumen.
Para leer.
Juan Medrano
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2011,
Abstract: Sin resumen.
Reflexiones nerviosas: la importancia de la ropa (I) pacientes y médicos.
Juan Medrano
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2011,
Abstract: Sin resumen.
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