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Search Results: 1 - 10 of 378309 matches for " Juan C. Jaramillo E "
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Conceptions about mental health in the field of public health
Diego A. Restrepo O,Juan C. Jaramillo E
Revista Facultad Nacional de Salud Pública , 2012,
Abstract: In the field of public health, mental health has had a great deal of relevance. This concept has been used extensively in the professional, academic, and political fields. Despite that, the different definitions of mental health face significant epistemological and practical problems. These difficulties are encountered by those who try to specify the meaning of "mental", the relationship between "health" and "mental", and, consequently, how research and intervention actions are to be carried out in the field of mental health. In practice, the orientation of actions and research involving mental health is not based on “universal” definitions in the field of public health. It is rather based on conceptions constructed from different approaches to the health-disease issue. This paper discusses the conceptions of mental health that have been configured from the biomedical, behavioral, and socio-economic approaches, the notions of "mind" underlying these conceptions, and their implications for intervention in the field of public health.
Antitumor activity against murine lymphoma L5178Y model of proteins from cacao (Theobroma cacao L.) seeds in relation with in vitro antioxidant activity
Ana M Preza, María E Jaramillo, Ana M Puebla, Juan C Mateos, Rodolfo Hernández, Eugenia Lugo
BMC Complementary and Alternative Medicine , 2010, DOI: 10.1186/1472-6882-10-61
Abstract: Differential extraction of proteins from unfermented and semi-fermented-dry cacao seeds was performed and characterized by SDS-PAGE and FPLC size-exclusion chromatography. Antitumor activity was evaluated against murine lymphoma L5178Y in BALB/c mice (6 × 104 cells i.p.), with a treatment oral dose of 25 mg/kg/day of each protein fraction, over a period of 15 days. Antioxidant activity was evaluated by the ABTS+ and ORAC-FL assays.Albumin, globulin and glutelin fractions from both cacao seed type were obtained by differential solubility extraction. Glutelins were the predominant fraction. In the albumin fraction, polypeptides of 42.3 and 8.5 kDa were found in native conditions, presumably in the form of two peptide chains of 21.5 kDa each one. The globulin fraction presented polypeptides of 86 and 57 kDa in unfermented cacao seed that produced the specific-cacao aroma precursors, and after fermentation the polypeptides were of 45 and 39 kDa. The glutelin fraction presented proteins >200 kDa and globulins components <100 KDa in lesser proportion. Regarding the semifermented-dry cacao seed, it was observed that the albumin fraction showed antitumoral activity, since it caused significant decreases (p < 0.05) in the ascetic fluid volume and packed cell volume, inhibiting cell growth in 59.98 ± 13.6% at 60% of the population; while the greatest antioxidant capacity due to free radical scavenging capacity was showed by the albumin and glutelin fraction in both methods assayed.This study is the first report on the biological activity of semifermented-dry cacao protein fractions with their identification, supporting the traditional use of the plant. The albumin fraction showed antitumor and free radical scavenging capacity, however both activities were not correlated. The protein fractions could be considered as source of potential antitumor peptides.In living systems, as a part of metabolism pathways, free radicals are generated on an ongoing basis. Free radicals in biolo
Cognition, social cognition and social functioning in schizophrenia
Paola Jaramillo,Inmaculada Fuentes,Juan C. Ruiz
Psychology, Society & Education , 2009,
Abstract: The discoveries continually being made in the study of schizophrenia have shown the complexity of this serious mental disorder. Research has enabled intervention to be redirected to focus on areas of maximum impact and efficacy. Currently, studies concur that the majority of people with schizophrenia exhibit deficits in non-social cognitive functioning, in performance in social cognition tasks and clearly in social functioning. This article aims to give a concise overview of developments made in these three areas and the importance of the subsequent relations between them.
Secondary Syphilis in Cali, Colombia: New Concepts in Disease Pathogenesis
Adriana R. Cruz,Allan Pillay,Ana V. Zuluaga,Lady G. Ramirez,Jorge E. Duque,Gloria E. Aristizabal,Mary D. Fiel-Gan,Roberto Jaramillo,Rodolfo Trujillo,Carlos Valencia,Linda Jagodzinski,David L. Cox,Justin D. Radolf,Juan C. Salazar
PLOS Neglected Tropical Diseases , 2010, DOI: 10.1371/journal.pntd.0000690
Abstract: Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18–68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia. To be eligible for participation, study subjects were required to have cutaneous lesions consistent with SS, a reactive Rapid Plasma Reagin test (RPR-titer ≥1:4), and a confirmatory treponemal test (Fluorescent Treponemal Antibody Absorption test- FTA-ABS). Most subjects enrolled were women (64.9%), predominantly Afro-Colombian (38.6%) or mestizo (56.1%), and all were of low socio-economic status. Three (5.3%) subjects were newly diagnosed with HIV infection at study entry. The duration of signs and symptoms in most patients (53.6%) was less than 30 days; however, some patients reported being symptomatic for several months (range 5–240 days). The typical palmar and plantar exanthem of SS was the most common dermal manifestation (63%), followed by diffuse hypo- or hyperpigmented macules and papules on the trunk, abdomen and extremities. Three patients had patchy alopecia. Whole blood (WB) samples and punch biopsy material from a subset of SS patients were assayed for the presence of Tp DNA polymerase I gene (polA) target by real-time qualitative and quantitative PCR methods. Twelve (46%) of the 26 WB samples studied had quantifiable Tp DNA (ranging between 194.9 and 1954.2 Tp polA copies/ml blood) and seven (64%) were positive when WB DNA was extracted within 24 hours of collection. Tp DNA was also present in 8/12 (66%) skin biopsies available for testing. Strain typing analysis was attempted in all skin and WB samples with detectable Tp DNA. Using arp repeat size analysis and tpr RFLP patterns four different strain types were identified (14d, 16d, 13d and 22a). None of the WB samples had sufficient DNA for typing. The clinical and microbiologic observations presented herein, together with recent Cali syphilis seroprevalence data, provide additional evidence that venereal syphilis is highly endemic in this region of Colombia, thus underscoring the need for health care providers in the region to be acutely aware of the clinical manifestations of SS. This study also provides, for the first time, quantitative evidence that a significant proportion of untreated SS patients have substantial numbers of circulating spirochetes. How Tp is able to persist in the blood and skin of SS patients, despite the known presence of circulating treponemal opsonizing
Luna Azul , 2010,
Abstract: the purpose of this writing is to explore the levinasian no-place metaphor, in order to clarify its meanings as well as to critically evaluate its pertinence under the light of contemporary reflections. in order to do this, we will contextualize the levinasian proposal around the no-place, especially under the concepts of sensitivity, proximity, and infinite; we will reconstruct some levinas's critiques which we will call "philosophies of the coming back home", and finally we will suggest some aspects in which the jew philosopher theses might be pertinent. this last purpose will be accompanied by a social research carried out about this issue.
Factores de crecimiento IV: Factor de crecimiento epidérmico,Factores estimuladores de colonias, Neurotropinas Growth factors: epidermal growth factor, colony stimulating factors and neurotropins
Juan Guillermo Maldonado E.,Hilda Norha Jaramillo Londo?o
Iatreia , 1999,
Abstract: En esta cuarta entrega sobre los factores de crecimiento se revisan el factor de crecimiento epidérmico (EGF), los factores estimuladores de colonias (CSF) y las neurotropinas. Como se ha venido presentando en las anteriores entregas, se hace referencia a su estructura bioquímica, su mecanismo de acción, sus efectos biológicos y sus interacciones. Las neurotropinas y el EGF, por tratarse de factores que actúan predominantemente en el microambiente tisular, no pueden manejarse en el contexto de concentraciones circulantes, situación que sí es factible para los CSF. De otro lado, se revisan los mecanismos de las neurotropinas en el sistema nervioso. In this fourth review of growth factors we summarize, as in previous papers, topics related to biochemical structure, mechanisms of action, biological effects and cross-interactions for epidermal growth factor (EGF), colony stimulating factors (CSF) and neurotropins. Since the effects of EGF and neurotropins are exerted predominantly at the microenvironment level, they can not be evaluated by means of its circulating levels, a fact that could be possible for CSFs.
Growth factors: first part Factores de crecimiento I
Juan Guillermo Maldonado E.,Hilda Norha Jaramillo Londo?o
Iatreia , 1996,
Abstract: Los factores de crecimiento tienen como función activar o inhibir la transcripción génica; es así como la cascada enzimática que se inicia con la activación de los receptores de la membrana citoplasmática, ya sean de tipo segundo mensajero o catalíticos, tiene como efecto final la fosforilación de proteínas, las cuales pueden ser: 1) enzimas que intervienen en las vías metabólicas; 2) proteínas promotoras de la transcripción de genes o, por el contrario, represoras de los mismos (31,32); en algunos casos el efecto final consiste en la transcripción de protooncogenes (33) cuyos productos pueden ser otro factor de crecimiento o receptores para éstos (16); 3) algunos factores de crecimiento ejercen sus efectos sobre los eventos postranscripcionales y postraslacionales (23). Los Factores de Crecimiento, incluyendo las citoquinas, representan un número muy grande de polipéptidos, glucoproteínas y otras moléculas relacionadas. Todos ellos promueven la proliferación, la diferenciación y las funciones especializadas de casi cualquier tipo de célula. Juegan un papel importante mediando los modos paracrino, autocrino y endocrino de comunicación. En esta primera parte de una serie se definen y clasifican los factores de crecimiento; para la clasificación se proponen diversos sistemas basados en el período de desarrollo del individuo en que actúan, en el punto crítico del ciclo celular sobre el que ejercen su acción y en los efectos fisiológicos que producen; se discuten, además, someramente, la composición química, los mecanismos de acción y las funciones de estas sustancias.
Growth factors II: insuline-like growth binging proteins (GFBPs) Factores de crecimiento II: factores insulinoides de crecimiento
Hilda Norha Jaramillo Londo?o,Juan Guillermo Maldonado E.
Iatreia , 1996,
Abstract: This review summarizes recent knowledge concerning Insulin.like growth factors I and II, with emphasis on their biochemical structure, concentrations, binding proteins, receptors, mechanisms of action, biological effects, and alterations of their concentrations in biological fluids. Se revisan los Factores Insulinoides de Crecimiento, también denominados ";Factores de Crecimiento Similares a la Insulina";, sobre los cuales se dispone de abundante información. Se sintetizan conocimientos recientes sobre dichos factores con énfasis en los siguientes aspectos: estructura bioquímica, concentraciones y sus cambios en los líquidos biológicos, proteínas fijadoras, receptores, mecanismos de acción y efectos biológicos.
Growth factors III part: transforming growth factors (TGF) Factores de crecimiento III: factores transformadores del crecimiento (TGF)
Juan Guillermo Maldonado E.,Hilda Norha Jaramillo Londo?o
Iatreia , 1996,
Abstract: A review is presented on the basic concepts of Transforming Growth Factors both a and p; it includes general considerations, biochemical structure, concentrations, binding proteins, receptors, mechanisms of action, and biological effects. Se presenta una revisión de los conceptos básicos sobre los factores transformadores del crecimiento, tanto alfa como beta, incluyendo los siguientes aspectos: consideraciones generales, estructura bioquímica, concentraciones, proteínas transportadoras, receptores, mecanismos de acción y efectos biológicos.
Luna Azul , 2010,
Abstract: The purpose of this writing is to explore the Levinasian no-place metaphor, in order to clarify its meanings as well as to critically evaluate its pertinence under the light of contemporary reflections. In order to do this, we will contextualize the Levinasian proposal around the no-place, especially under the concepts of sensitivity, proximity, and infinite; we will reconstruct some Levinas’s critiques which we will call “philosophies of the coming back home”, and finally we will suggest some aspects in which the Jew philosopher theses might be pertinent. This last purpose will be accompanied by a social research carried out about this issue.
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