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Search Results: 1 - 10 of 31717 matches for " Juan Beloscar "
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Perfil lipídico en ni?os y adolescentes de una población escolar
Rosillo,Irene; Pituelli,Norma; Corbera,Mirtha; Lioi,Susana; Miryan,Turco; D′Arrigo,Mabel; Gastaldi,Liliana; Beloscar,Juan;
Archivos argentinos de pediatr?-a , 2005,
Abstract: introduction. the relationship between lipid metabolism disorders and cardiovascular risk, associated to other conditions as obesity, resulted in considering the importance of studying the lipid profile since early ages. the aim of the present work was to study the lipid profile in children and adolescents to provide data according to age and sex, and comparing them with those reported by other authors. population, material and methods. a cross-sectional descriptive study of a sample (n= 960) of children and adolescents of different public schools of rosario and surroundings, with a median or low socioeconomical status was analyzed. males and females aged 5 to 8 years without known pathological conditions were included. overweighted participants were excluded (6.6%). results. the obtained values were: cholesterol: 164.9 ± 23.6 mg/dl; triglycerides: 72.3 ± 31.7 mg/dl; ldl cholesterol: 96.1 ± 23.6 mg/dl; hdl cholesterol: 55.1 ± 5.6mg/dl; non-hdl cholesterol: 110.1 ± 25.4 mg/dl; cholesterol/hdl cholesterol: 3.03 ± 0.59 mg/dl; ldl cholesterol/hdl cholesterol: 1.77± 0.59. non statistically significant differences between the parameters comparing females and males in the studied sample were observed, in any age groups except for triglycerides (significantly higher in females aged 5 to 11 year p< 0.001). conclusions. the comparison of our results with those of other authors allowed us to point out differences with a different level of significance. the benefit yielded by the lipid profile study in a population of children and adolescents might be a useful reference to identify modifiable risk factors as well as the necessity of interventions leading to the implementation of prevention measures at early ages.
Chagasic Thymic Atrophy Does Not Affect Negative Selection but Results in the Export of Activated CD4+CD8+ T Cells in Severe Forms of Human Disease
Alexandre Morrot ,Eugênia Terra-Granado,Ana Rosa Pérez,Suse Dayse Silva-Barbosa,Novica M. Mili?evi?,Désio Aurélio Farias-de-Oliveira,Luiz Ricardo Berbert,Juliana De Meis,Christina Maeda Takiya,Juan Beloscar,Xiaoping Wang,Vivian Kont,P?rt Peterson,Oscar Bottasso,Wilson Savino
PLOS Neglected Tropical Diseases , 2011, DOI: 10.1371/journal.pntd.0001268
Abstract: Extrathymic CD4+CD8+ double-positive (DP) T cells are increased in some pathophysiological conditions, including infectious diseases. In the murine model of Chagas disease, it has been shown that the protozoan parasite Trypanosoma cruzi is able to target the thymus and induce alterations of the thymic microenvironment and the lymphoid compartment. In the acute phase, this results in a severe atrophy of the organ and early release of DP cells into the periphery. To date, the effect of the changes promoted by the parasite infection on thymic central tolerance has remained elusive. Herein we show that the intrathymic key elements that are necessary to promote the negative selection of thymocytes undergoing maturation during the thymopoiesis remains functional during the acute chagasic thymic atrophy. Intrathymic expression of the autoimmune regulator factor (Aire) and tissue-restricted antigen (TRA) genes is normal. In addition, the expression of the proapoptotic Bim protein in thymocytes was not changed, revealing that the parasite infection-induced thymus atrophy has no effect on these marker genes necessary to promote clonal deletion of T cells. In a chicken egg ovalbumin (OVA)-specific T-cell receptor (TCR) transgenic system, the administration of OVA peptide into infected mice with thymic atrophy promoted OVA-specific thymocyte apoptosis, further indicating normal negative selection process during the infection. Yet, although the intrathymic checkpoints necessary for thymic negative selection are present in the acute phase of Chagas disease, we found that the DP cells released into the periphery acquire an activated phenotype similar to what is described for activated effector or memory single-positive T cells. Most interestingly, we also demonstrate that increased percentages of peripheral blood subset of DP cells exhibiting an activated HLA-DR+ phenotype are associated with severe cardiac forms of human chronic Chagas disease. These cells may contribute to the immunopathological events seen in the Chagas disease.
Early Double-Negative Thymocyte Export in Trypanosoma cruzi Infection Is Restricted by Sphingosine Receptors and Associated with Human Chagas Disease
Ailin Lepletier,Liliane de Almeida,Leonardo Santos,Luzia da Silva Sampaio,Bruno Paredes,Florencia Belén González,Célio Geraldo Freire-de-Lima,Juan Beloscar,Oscar Bottasso,Marcelo Einicker-Lamas,Ana Rosa Pérez,Wilson Savino,Alexandre Morrot
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0003203
Abstract: The protozoan parasite Trypanosoma cruzi is able to target the thymus and induce alterations of the thymic microenvironmental and lymphoid compartments. Acute infection results in severe atrophy of the organ and early release of immature thymocytes into the periphery. To date, the pathophysiological effects of thymic changes promoted by parasite-inducing premature release of thymocytes to the periphery has remained elusive. Herein, we show that sphingosine-1-phosphate (S1P), a potent mediator of T cell chemotaxis, plays a role in the exit of immature double-negative thymocytes in experimental Chagas disease. In thymuses from T. cruzi-infected mice we detected reduced transcription of the S1P kinase 1 and 2 genes related to S1P biosynthesis, together with increased transcription of the SGPL1 sphingosine-1-lyase gene, whose product inactivates S1P. These changes were associated with reduced intrathymic levels of S1P kinase activity. Interestingly, double-negative thymocytes from infected animals expressed high levels of the S1P receptor during infection, and migrated to lower levels of S1P. Moreover, during T. cruzi infection, this thymocyte subset expresses high levels of IL-17 and TNF-α cytokines upon polyclonal stimulation. In vivo treatment with the S1P receptor antagonist FTY720 resulted in recovery the numbers of double-negative thymocytes in infected thymuses to physiological levels. Finally, we showed increased numbers of double-negative T cells in the peripheral blood in severe cardiac forms of human Chagas disease.
Summary on the Studies of the Unearthed Bamboo Medical Books for the Past Forty Years
—Take Prescriptions of Fifty-Two Diseases and Han Medical Books of Wuwei for Example

Juan Hu
Chinese Studies (ChnStd) , 2016, DOI: 10.4236/chnstd.2016.51001
Abstract: For the past forty years, the study of the unearthed bamboo medical books has always been a very valid concern and many important achievements have yet been achieved. However, the lack of standard handwriting in addition to seriously being destroyed when unearthed, it’s not that easy to read them. The purpose of this article is to sort through and correct some commonly occurred interpretation mistakes from the previous studies.
“Association between Feelings about Competition and Self-Reported Happiness: Do Racial Differences Matter?” Evidence from the World Value Surveys  [PDF]
Juan Barrios
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.45026
Abstract: Drawing on individual data from the World Values Surveys, this paper estimates the importance of racial differences in the relation between individual feelings about competition and self-reported happiness. Racial or ethnic characteristics are split as Asians, Blacks and Whites. In general, people who think competition is good are associated to the same (high) level of happiness as do people who think competition is harmful. Blacks, however, appear to shy away from competition probably because they are not the winners in the competitive process of capitalism. Results among blacks within different countries show similar patterns. These findings are different than and complement previous research which shows a positive or negative relation between competition and well-being. The paper improves over previous research in that it approximates competitive environment by using individual-level measures and considers the relevance of cultural differences. Instrumental variable analysis suggests that there may be a relation of causality stemming from competition to happiness. The paper conjectures about the reasons why individuals who find competition as harmful report higher levels of happiness but do not attempt to establish causality directions.
Mainland China and Hong Kong Closer Economic Partnership Arrangement Effect Analysis  [PDF]
Juan Yang
Chinese Studies (ChnStd) , 2016, DOI: 10.4236/chnstd.2016.53008
Abstract: Based on gravity model, this paper analyzes the impact of Mainland China and Hong Kong Closer Economic Partnership Arrangement by using the data from 2004 to 2013. The result shows that, closer economic partnership arrangement has not promoted the goods export of Hong Kong; the effects on services trade and investment are limited. The main reasons may be the disappearance foundation of the cooperation between the two sides and the limited openness of Mainland China market.
The Hubble Field vs Dark Energy  [PDF]
Juan Lartigue
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.712145
Abstract: The Hubble equation was considered valid enough to calculate the recession velocity of galaxies, until further observations showed that there would be an accelerated recession in the Hubble flow, necessarily tied to an accelerated expansion of the Universe. So, this paper postulates the existence of a Hubble field as a possible cause for such an accelerated expansion, with some conditions: it must be a scalar field whose intensity should be a constant in respect to distance and whose Poisson equation should not be zero nor a function of mass; such field could rather be a property of the space-time. The obvious expression for acceleration should be the derivative of the Hubble equation respect to time, which gives two opposed-signs terms whose substitution by the De-Sitter equation drives to a permanent negative acceleration, similarly to that obtained by the 2nd Friedmann equation. Otherwise, the inclusion of the ? term in the gravitational Einstein equation has led to a two opposed-signs terms expression, resembled to a non-published Newton equation. The negative term expresses the gravitational attraction and the positive one expresses the accelerated expansion as a ? function, which usually is attributed to dark energy. In this paper it is shown that Λ is proportional to the squared Hubble parameter and that the uncertain dark energy may be substituted by the calculable Hubble field intensity to obtain an equation for the net Universe acceleration. Equations for the Hubble parameter as functions of time and radius are also deduced. A relation is shown between the various assumed masses of the Universe and its critical radius. Additional Universe parameters are estimated such as the deceleration factor and a solution for the Poisson equation in the Hubble field. A brief comment t on high-standard candles is included.
“The Trinity”: Synergy Innovation Mechanism of Science and Technology—A Case Study Based on Nantong Industrial Technology Institute  [PDF]
Juan Zhang
Technology and Investment (TI) , 2017, DOI: 10.4236/ti.2017.81004
Abstract: “The trinity” is that NITI focuses on the universal, critical and forward-looking technology which is from enterprises in Nantong, and uses the strategic, service, and benefit synergy, to integrate the research of scientific institutes, the incubation of incubators, and industrialization of industry bases to be an organic entirety which produces collaborative innovation. It is a science and technology innovation chain. The case proves that the scientific and technological transfer efficiency of “the Trinity” is higher than others, and has both social and economic benefits. To a certain extent, it is “1 + 1 + 1 > 3”. At present, China’s scientific and technological innovation has not been widely into fast development. On the back of the local strong financial strength and in the intention of enhancing the level of local science and technology innovation, “the Trinity” is a kind of convenient form.
Agency Cost and Uncontrollable Risks in Hiding Fortune Overseas—Offshore Companies, Ownership of the Cannes Villa and Money Laundering in the Criminal Case of Bo Xilai  [PDF]
Juan Fang
Chinese Studies (ChnStd) , 2018, DOI: 10.4236/chnstd.2018.72011
Abstract: The Jinan Intermediate People’s Court adjudicated the charges of bribery, embezzlement and abuse of power against Mr. Bo Xilai, the former Communist Party Chief of Chongqing from August 22 to 26, 2013. Bo was charged of accepting a luxury villa located in Cannes from a tycoon named Xu Ming. A conspiracy named the Montage scheme, which used offshore companies in the purpose of committing bribery and covering the beneficiary of the property abroad, emerged during the trial. With focus on the role of the offshore companies played in financing function, fake business transactions, ownership structure related to the Cannes villa, this paper is trying to answer a couple of questions: what’s the time of accepting cash bribe paralleling with money laundering through a group of offshore companies, the time when the money was firstly transferred from the bribe-giver to the bribe-taker or the time when the bribe-taker became the beneficiary or controller of the assets purchased with the money? In finding out the beneficiary of a property under the name of an offshore company, is it legally required and technically possible to prove the consistence between the owner of a property and that of an offshore company?
Stability and Risk of Financial Holding Companies—Taking the Chinese CITIC Group as Example  [PDF]
Juan Zhang
Journal of Service Science and Management (JSSM) , 2019, DOI: 10.4236/jssm.2019.122017
Abstract: With the development of financial mixed operation, in order to enhance the financial competitiveness, more and more countries are accelerating the pace of from separate operation to mixed operation. Except bringing the advantages, financial holding company has also faced great challenges at the same time. Therefore, establishing the corresponding mixed supervision system and improving the competitiveness of the financial holding company have become the most important tasks for China’s financial industry. Taking the Chinese CITIC International Financial Holdings Limited as an example, we focus on comparing economies of scale, economies of scope as well as the study of stability and risk, based on theoretical analysis and empirical analysis methods. The results show that most of the China Financial Holding Company Limited did not reach the greatest economies of scale and scope because of the restrictions on their own management and management experience. Secondly, the higher risk of securities will not increase the risk of major financial institutions such as banks. Thirdly, the risk of subsidiaries in financial holding companies is relatively low, compared with others in separated operation. In addition, we analyze the transmission mechanism and internal transaction risk of the financial holding company, innovatively propose “Incentive Conflict Concept” in subsidiary of internal and external risk control. Finally, the paper suggests that the financial holding companies should attach great importance to internal risk control, improve their management and integrated resource ability. More importantly, the external supervision mechanism needs to improve supervision mechanism design for the mixed supervision, as much as possible to achieve regulatory objectives of incentive compatibility.
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