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Search Results: 1 - 10 of 26988 matches for " Ju-Won Kim "
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Magnetic Flux Leakage Sensing-Based Steel Cable NDE Technique
Seunghee Park,Ju-Won Kim,Changgil Lee,Jong-Jae Lee
Shock and Vibration , 2014, DOI: 10.1155/2014/929341
Abstract: Nondestructive evaluation (NDE) of steel cables in long span bridges is necessary to prevent structural failure. Thus, an automated cable monitoring system is proposed that uses a suitable NDE technique and a cable-climbing robot. A magnetic flux leakage- (MFL-) based inspection system was applied to monitor the condition of cables. This inspection system measures magnetic flux to detect the local faults (LF) of steel cable. To verify the feasibility of the proposed damage detection technique, an 8-channel MFL sensor head prototype was designed and fabricated. A steel cable bunch specimen with several types of damage was fabricated and scanned by the MFL sensor head to measure the magnetic flux density of the specimen. To interpret the condition of the steel cable, magnetic flux signals were used to determine the locations of the flaws and the levels of damage. Measured signals from the damaged specimen were compared with thresholds that were set for objective decision-making. In addition, the measured magnetic flux signals were visualized as a 3D MFL map for intuitive cable monitoring. Finally, the results were compared with information on actual inflicted damages, to confirm the accuracy and effectiveness of the proposed cable monitoring method. 1. Introduction Recently, there have been increasing demands on structural health monitoring (SHM) and nondestructive testing (NDT) in the fields of civil, mechanical, and aerospace engineering. Especially, local monitoring methodologies for specific critical members have been studied to overcome the limitation of global monitoring techniques for whole structures [1–4]. Steel cables in long span bridges are also critical members that suspend almost all of the dead load of the structure. However, cross-sectional damage can occur in a steel cable due to corrosion and fracture, which can lead to stress concentrations. Cross-sectional damage can be a direct cause of structural failure. Therefore, nondestructive evaluation (NDE) is necessary to detect the initial stages of cross-sectional damage in a cable. However, it is difficult to monitor the condition of most cables, as the damage can be invisible and inaccessibly located. To overcome these drawbacks, we propose an automated cable monitoring system, which uses a suitable NDE technique and a cable-climbing robot that can approach the damaged point, which is shown in Figure 1. Figure 1: The cable-climbing robot with suitable NDE equipment. Meanwhile, NDE techniques available for incorporation into cable-climbing robots have been widely researched. In this study,
Phosphokinase Antibody Arrays on Dendron-Coated Surface
Ju-Won Kwak, Hyobin Jeong, Sun-Ho Han, Youngkyu Kim, Sung Min Son, Inhee Mook-Jung, Daehee Hwang, Joon Won Park
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096456
Abstract: Monitoring protein phosphorylation at the cellular level is important to understand the intracellular signaling. Among the phosphoproteomics methods, phosphokinase antibody arrays have emerged as preferred tools to measure well-characterized phosphorylation in the intracellular signaling. Here, we present a dendron-coated phosphokinase antibody array (DPA) in which the antibodies are immobilized on a dendron-coated glass slide. Self-assembly of conically shaped dendrons well-controlled in size and structure resulted in precisely controlled lateral spacing between the immobilized phosphosite-specific antibodies, leading to minimized steric hindrance and improved antigen-antibody binding kinetics. These features increased sensitivity, selectivity, and reproducibility in measured amounts of protein phosphorylation. To demonstrate the utility of the DPA, we generated the phosphorylation profiles of brain tissue samples obtained from Alzheimer's disease (AD) model mice. The analysis of the profiles revealed signaling pathways deregulated during the course of AD progression.
The effect of dimiristoylphosphatidylethanol on the rotational mobility of n-(9-Anthroyloxy) stearic acid in neuronal and model membranes  [PDF]
Young-Sik Park, No-Soo Park, Jun-Bong Seo, Soo-Kyoung Bae, You-Kwang kim, Ki-Soo Seong, Young-Jun Kim, Ju-Won Park, Joung-Moung Shin, Young-Chan Jeon, In-Kyo Chung, Moon-Kyoung Bae, Hye-Ock Jang, Il Yun
Journal of Biophysical Chemistry (JBPC) , 2010, DOI: 10.4236/jbpc.2010.13016
Abstract: The aim of this study was to provide a basis for examining the molecular mechanism for the pharmacological action of ethanol. We studied di¬myristoyl¬phosphatidylethanol (DMPEt)’s effects on specific locations of n-(9-anthroyloxy) palmitic acid or stearic acid (n-AS) within phos¬pholipids of synaptosomal plasma membrane vesicles isolated from bovine cerebral cortex (SPMV) and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from SPMV. DMPEt increased rotational mobility (increased disordering) of hydrocarbon interior, but it decreased mobility (increased ordering) of membrane interface, in native and model membranes. The degree of rotational mobility in accordance with the carbon atom numbers of phospholipids comprising neuronal membranes was in the order at the 16, 12, 9, 6 and 2 position of aliphatic chain present in phospholipids. The sensitivity of increasing or decreasing effect of rotational mobility of hydrocarbon interior or surface region by DMPEt differed depending on the neuronal and model membranes in the descending order of SPMV, SPMVPL and SPMVTL.
Nanotechnology for Early Cancer Detection
Young-Eun Choi,Ju-Won Kwak,Joon Won Park
Sensors , 2010, DOI: 10.3390/s100100428
Abstract: Vast numbers of studies and developments in the nanotechnology area have been conducted and many nanomaterials have been utilized to detect cancers at early stages. Nanomaterials have unique physical, optical and electrical properties that have proven to be very useful in sensing. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon nanotubes, gold nanowires and many other materials have been developed over the years, alongside the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. Proteins, antibody fragments, DNA fragments, and RNA fragments are the base of cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future, we might be able to detect cancer at a very early stage, providing a much higher chance of treatment.
Glycyrrhizin Alleviates Neuroinflammation and Memory Deficit Induced by Systemic Lipopolysaccharide Treatment in Mice
Jeong-Ho Song,Ju-Won Lee,Beomsoo Shim,Chang-Yeol Lee,Sooyong Choi,Chulhun Kang,Nak-Won Sohn,Jung-Won Shin
Molecules , 2013, DOI: 10.3390/molecules181215788
Abstract: The present study investigated the effects of glycyrrhizin (GRZ) on neuroinflammation and memory deficit in systemic lipopolysaccharide (LPS)-treated C57BL/6 mice. Varying doses of GRZ was orally administered (10, 30, or 50 mg/kg) once a day for 3 days before the LPS (3 mg/kg) injection. At 24 h after the LPS injection, GRZ significantly reduced TNF-α and IL-1β mRNA at doses of 30 and 50 mg/kg. COX-2 and iNOS protein expressions were significantly reduced by GRZ at doses of 30 and 50 mg/kg. In the Morris water maze test, GRZ (30 mg/kg) significantly prolonged the swimming time spent in the target and peri-target zones. GRZ also significantly increased the target heading and memory score numbers. In the hippocampal tissue, GRZ significantly reduced the up-regulated Iba1 protein expression and the average cell size of Iba1-expressing microglia induced by LPS. The results indicate that GRZ ameliorated the memory deficit induced by systemic LPS treatment and the effect of GRZ was found to be mediated through the inhibition of pro-inflammatory mediators and microglial activation in the brain tissue. This study supports that GRZ may be a putative therapeutic drug on neurodegenerative diseases associated with cognitive deficits and neuroinflammation such as Alzheimer’s disease.
Differences in body components and electrical characteristics between youth soccer players and non-athletes  [PDF]
Seung-Min Yang, Won-Deok Lee, Ju-Hyun Kim, Mee-Young Kim, Junghwan Kim
Health (Health) , 2013, DOI: 10.4236/health.2013.56134
Abstract:

Many previous studies have focused on youth soccer player injuries without body component analysis compared to non-athletes. Only a few studies which have investigated body components of youth soccer players, and studies that look at electrical characteristics used by rheobase and chronaxie as well as body components are even scarcer. Therefore, we feel that there is a need for a study investigating objective clinical analysis of the body components (body structure and body composition) and electrical characteristics of both youth soccer players and non-athletes. Sixty subjects participated in our study, comprising of thirty youth soccer players and thirty non-athletes. The Inbody 520 was used to measure and analyze body composition and the Duo 500 was employed to measure electrical characteristics. It was observed that the soccer players showed markedly lower total impedance compared to the non-athletes. In both legs, it was particularly noted that there were significant differences between the right and left sides. The soccer players showed a higher skeletal muscle mass and lean/ideal lean × 100% compared to the non-athletes. Furthermore, the soccer players had a lower rheobase and higher chronaxie. A comparison of the genders showed a similar pattern. In this study, we were able to separate the differences in body components and electrical characteristics between the subject groups using a systemic approach. Future studies on diverse types of athletes would contribute further to the development of clinical physiotherapy and sports rehabilitation.

DNA Microarray Analysis of Gene Expression in Eutopic Endometrium from Patients with Endometriosis  [PDF]
Kyu Ri Hwang, Young Min Choi, Jin Ju Kim, Hye Won Jeon, Min A. Hong
Advances in Reproductive Sciences (ARSci) , 2017, DOI: 10.4236/arsci.2017.54009
Abstract: Pathogenesis of the endometriosis is complex and the etiology is still unclear. The objective of this study was to examine that endometrial gene expression in late secretory phase endometrium differs between patients with and without endometriosis. Five patients with proven advanced-stage endometriosis and 5 controls underwent endometrial biopsy in the late secretory phase. Analysis of eutopic endometrial gene expression was performed using Affymetrix gene arrays and differentially expressed genes were assigned to gene ontology groups based on overrepresented analysis using Database for Annotation, Visualization, and Integrated Discovery software. Four hundred sixty two genes were identified as up-regulated such as matrix metalloproteinase 10, cytochrome P450 family 24 subfamily A polypeptide 1, matrix metalloproteinase 3, chemokine (C-C motif) ligand 20, Rho family GTPase 1, interleukin 1-beta, and insulin-like growth factor binding protein 1. Six hundred forty three genes were down-regulated in all endometriotic samples. A lot of genes related with metabolic process, cellular ketone metabolic process and ncRNA metabolic processing were included. Expression patterns of selected five genes were validated by quantitative real time PCR. The results of this analysis support that the eutopic endometrium from patients with advanced-stage endometriosis has distinct gene expression profile from eutopic endometrium of control without endometriosis.
1-Chloromethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid amide, a derivative of tetrahydroisoquinoline, induces granulocytic differentiation of the human leukemic HL-60 cells via G0/G1 phase arrest  [PDF]
Sung-Min Ju, Hyun-Ock Pae, Won-Sin Kim, Chai-Ho Lee, Byung-Hun Jeon
Health (Health) , 2013, DOI: 10.4236/health.2013.55A001
Abstract:

Tetrahydroisoquinolines are known to have various biological effects, including antitumor activity. This study investigated the effect of 1-chloromethyl-6, 7-dimethoxy-3, 4-dihydro-1H-isoquinoline-2-sulfonic acid amide (CDST), a newly synthesized anticancer agent, on cellular differentiation and proliferation in HL-60 cells. Differentiation and proliferation of HL-60 cells were determined through expression of CD11b and CD14 surface antigens using flow cytometry and nitroblue tetrazolium (NBT) assay, and through analysis of cell cycle using propidium iodide staining, western blot analysis and immunoprecipitation, respectively. CDST induced the differentiation of HL-60, as shown by increased expression of differentiation surface antigen CD11b (but no significant change in CD14 expression) and increased NBT-reducing functional activity. DNA flow cytometry analysis indicated that CDST markedly induced a G0/G1 phase arrest of HL-60 cells. Subsequently, we examined the expre-ssion of G0/G1 phase cell cycle-related proteins, including cyclin-dependent kinases (CDKs), cyclins and cyclin dependent kinase inhibitors (CKIs), during the differentiation of HL-60. The levels of CDK2, CDK6, cyclin E and cyclin A were decreased, whereas steady-state levels of CDK4 and cyclin D1 were unaffected. The expression of the p27Kip1 was markedly increased by CDST, but not p21WAF1/Cip1. Moreover, CDST markedly enhanced the binding of p27Kip1 with CDK2 and CDK6, resulting in the reduced activity of

The Number of Chains of Subgroups in the Lattice of Subgroups of the Dicyclic Group
Ju-Mok Oh,Yunjae Kim,Kyung-Won Hwang
Discrete Dynamics in Nature and Society , 2012, DOI: 10.1155/2012/760246
Abstract: We give an explicit formula for the number of chains of subgroups in the lattice of subgroups of the dicyclic group 4 of order 4 by finding its generating function of multivariables.
Exact soluble two-dimensional charged wormhole
Ji Young Han,Won Tae Kim,Hee Ju Yee
Physics , 2003, DOI: 10.1103/PhysRevD.69.027501
Abstract: We present an exactly soluble charged wormhole model in two dimensions by adding infalling chiral fermions on the static wormhole. The infalling energy due to the infalling charged matter requires the classical back reaction of the geometry, which is solved by taking into account of the nontrivial nonchiral exotic energy. Finally, we obtain the exact expression for the size of the throat depending on the total amount of the infalling net energy and discuss the interesting transition from the AdS spacetime to the wormhole geometry.
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