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Search Results: 1 - 10 of 1472 matches for " Joy Gardner "
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A Quantitative Assessment of the Morphology of the Piriform Aperture as an Indicator of Race  [PDF]
Seth Gardner
Forensic Medicine and Anatomy Research (FMAR) , 2015, DOI: 10.4236/fmar.2015.31002
Abstract: Piriform apertures from skulls in the Bass Collection at the University of Tennessee were examined. The morphology of the perform aperture from digital images was captured using Adobe Measuring Tool 9.0 and data analyzed with SPSS 17.0. Twenty-four linear measurements from a central point of the aperture as well as the perimeter were evaluated to quantify a difference between Black and White populations. The statistical analyses employed Discriminate Functional Analysis followed by Stepwise analysis. Discriminate functions were generated to predict to which group a skull belonged. A discriminate function produced an accuracy of 77.4%. Step-wise discriminate function analysis, using only three variables, produced an accuracy of 79.0%.
Unusual Drainage of the Right Testicular Vein: A Case Report  [PDF]
Seth Gardner
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.46046
Abstract:
Routine dissection was carried out on a 75-year-old male cadaver and the drainage pattern of the testicular veins was identified and photographed. Dissection showed that the right testicular vein demonstrated an abnormal drainage pattern by terminating into the right renal vein. The left testicular vein demonstrated a normal drainage pattern by terminating into the left renal vein. The unusual drainage of the right testicular vein into the right renal vein may complicate hemodynamics thus causing a varicocele. Complications of a varicocele could lead to testis atrophy and/or infertility. Knowing the anatomical variants of the testicular veins drainage pattern may help the surgeon avoid potential complications during routine laparoscopic procedures and may also uncover a reason for male infertility.
A Human Skull with a Tripartite Inca Bone: A Case Report  [PDF]
Seth Gardner
Forensic Medicine and Anatomy Research (FMAR) , 2016, DOI: 10.4236/fmar.2016.43007
Abstract: An adult human skull was discovered in a college osteological collection presenting with two Inca bones. Inca bones or interparietal (supernumerary) bones are rarely seen among dry human skulls. Their frequency of presentation is much less than that of sutural or Wormian bones. Inca bones or interparietal (supernumerary) bones are accepted as normal variants most often found in the occipitoparietal region of the skull. Their characteristic shape, a triangle, resembles a monument design of the Inca tribe of South America and Latin America. The significance of the presence of these variants is that Inca bones or interparietal bones may be mistaken for a skull fracture. They may also be very useful in forensic identification of an unknown individual.
Ticks Associated with Macquarie Island Penguins Carry Arboviruses from Four Genera
Lee Major, May La Linn, Robert W. Slade, Wayne A. Schroder, Alex D. Hyatt, Joy Gardner, Jeff Cowley, Andreas Suhrbier
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004375
Abstract: Macquarie Island, a small subantarctic island, is home to rockhopper, royal and king penguins, which are often infested with the globally distributed seabird tick, Ixodes uriae. A flavivirus, an orbivirus, a phlebovirus, and a nairovirus were isolated from these ticks and partial sequences obtained. The flavivirus was nearly identical to Gadgets Gully virus, isolated some 30 year previously, illustrating the remarkable genetic stability of this virus. The nearest relative to the orbivirus (for which we propose the name Sandy Bay virus) was the Scottish Broadhaven virus, and provided only the second available sequences from the Great Island orbivirus serogroup. The phlebovirus (for which we propose the name Catch-me-cave virus) and the previously isolated Precarious Point virus were distinct but related, with both showing homology with the Finnish Uukuniemi virus. These penguin viruses provided the second and third available sequences for the Uukuniemi group of phleboviruses. The nairovirus (for which we propose the name Finch Creek virus) was shown to be related to the North American Tillamook virus, the Asian Hazara virus and Nairobi sheep disease virus. Macquarie Island penguins thus harbour arboviruses from at least four of the seven arbovirus-containing genera, with related viruses often found in the northern hemisphere.
Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells
Stefan W. Metz,Joy Gardner,Corinne Geertsema,Thuy T. Le,Lucas Goh,Just M. Vlak,Andreas Suhrbier,Gorben P. Pijlman
PLOS Neglected Tropical Diseases , 2013, DOI: 10.1371/journal.pntd.0002124
Abstract: The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful production of CHIKV virus-like particles (VLPs) in insect cells using recombinant baculoviruses. This well-established expression system is rapidly scalable to volumes required for epidemic responses and proved well suited for processing of CHIKV glycoproteins and production of enveloped VLPs. Herein we show that a single immunization with 1 μg of non-adjuvanted CHIKV VLPs induced high titer neutralizing antibody responses and provided complete protection against viraemia and joint inflammation upon challenge with the Réunion Island CHIKV strain in an adult wild-type mouse model of CHIKV disease. CHIKV VLPs produced in insect cells using recombinant baculoviruses thus represents as a new, safe, non-replicating and effective vaccine candidate against CHIKV infections.
Induction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivo
Lee D. Major, Thomas S. Partridge, Joy Gardner, Stephen J. Kent, Robert de Rose, Andreas Suhrbier, Wayne A. Schroder
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057343
Abstract: SerpinB2, also known as plasminogen activator inhibitor type 2, is a major product of activated monocytes/macrophages and is often strongly induced during infection and inflammation; however, its physiological function remains somewhat elusive. Herein we show that SerpinB2 is induced in peripheral blood mononuclear cells following infection of pigtail macaques with CCR5-utilizing (macrophage-tropic) SIVmac239, but not the rapidly pathogenic CXCR4-utilizing (T cell-tropic) SHIVmn229. To investigate the role of SerpinB2 in lentiviral infections, SerpinB2?/? mice were infected with EcoHIV, a chimeric HIV in which HIV gp120 has been replaced with gp80 from ecotropic murine leukemia virus. EcoHIV infected SerpinB2?/? mice produced significantly lower anti-gag IgG1 antibody titres than infected SerpinB2+/+ mice, and showed slightly delayed clearance of EcoHIV. Analyses of published microarray studies showed significantly higher levels of SerpinB2 mRNA in monocytes from HIV-1 infected patients when compared with uninfected controls, as well as a significant negative correlation between SerpinB2 and T-bet mRNA levels in peripheral blood mononuclear cells. These data illustrate that SerpinB2 can be induced by lentiviral infection in vivo and support the emerging notion that a physiological role of SerpinB2 is modulation of Th1/Th2 responses.
Formation of (2E)-4-Hydroxy-2-nonenal and (2E)-4-Hydroxy-2-hexenal by Plant Enzymes: A Review Suggests a Role in the Physiology of Plants  [PDF]
Harold W. Gardner
Advances in Enzyme Research (AER) , 2016, DOI: 10.4236/aer.2016.42006
Abstract: It is demonstrated that (3Z)-nonenal (NON) and (3Z)-hexenal (HEX) are oxidized in a cascade by lipoxygenase (LOX) and hydroperoxide peroxygenase (HP peroxygenase) into (2E)-4-hydroxy-2- nonenal (HNE) and (2E)-4-hydroxy-2-hexenal (HHE), respectively. In turn, HNE inactivates LOX terminating the cascade. The hydroxy-alkenals produced serve to inhibit plant pathogens, which initiated the cascade. In addition to LOX, other unknown oxygenases may be involved in the cascade.
Online or Face-to-Face Microbiology Laboratory Sessions? First Year Higher Education Student Perspectives and Preferences  [PDF]
Susan Salter, Christine Gardner
Creative Education (CE) , 2016, DOI: 10.4236/ce.2016.714189
Abstract: Reducing the number of face-to-face laboratory sessions and supplementing with virtual/online alternatives are critical to managing the combined pressures of increasing first-year student numbers and decreasing university budgets. Most of the research studies about online practicals are hypothesis generating rather than hypothesis testing thus only providing initial support and direction for the generation of pedagogically sound online laboratory teaching. This pilot study investigated the effectiveness of using a combination of online and face-to-face practical sessions to enable students in a Microbiology unit, offered to students completing several health science courses, to connect discipline-specific theory and practical application. Quantitative and qualitative data were gathered using a paper-based questionnaire from 72 first-year students. Results showed that 65 percent of students preferred a combination of face-to-face and online sessions. Furthermore, determinants for engagement with online sessions varied with student gender.
Macroeconomic Link to Indian Capital Market: A Post-Liberalization Evidence  [PDF]
Hirak Ray, Joy Sarkar
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.54028
Abstract:

The present paper attempts to investigate the dynamic relation between the stock market and the select macroeconomic variables at log-levels, in India, for the period 1991:01 to 2008:04. Findings of the study show that the long-run stock market behavior is positively related to output and exchange rate, and negatively related to short- and long-term interests, money supply and inflation. The results of the causality and innovation analysis suggest that the stock market influences the economic activities, more specifically the industrial activities and the market is expected to be more sensitive to the shocks of itself over the projected period of the study.

Gauging Risk Stability: A Simple Test Using Patterns of Workers’ Compensation Claims  [PDF]
Richard J. Butler, B. Delworth Gardner, Harold H. Gardner
Journal of Financial Risk Management (JFRM) , 2012, DOI: 10.4236/jfrm.2012.13005
Abstract: In financial risk management, whether for national and international entities, or within a firm, it is important to be able to decide what risks are altered by past experience (or intervention of a central banker at the national level, or a firm’s risk manager at the employer level) and what risks do not vary over time (risks from intrinsic heterogeneity). Policies aimed at changing intrinsic risk will obviously not be cost effective, though tools for identifying such unchanging risks may help to minimize losses associated with those risks. This paper outlines a simple test that allows the researcher to distinguish these alternative risk types. We present our test in the context of patterns of workers’ compensation lost day claims to test whether past experience explains repeated claims for some individuals, or whether some individuals exhibit an innate heterogeneity in claims-filing propensities. We find that a previous claim significantly increases claim probabilities in the future using easy to estimate and interpret “runs” tests on the claims. This suggests, for the risk management problem examined here, that early intervention to limit the effects of the first lost time claim may produce significant disability-cost savings with respect to future claims.
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