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Search Results: 1 - 10 of 2319 matches for " Jovanovi? Svetlana "
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Resistance of nerve cells to oxidative injury
Jovanovi? Zorica,JovanoviSvetlana
Medicinski Pregled , 2011, DOI: 10.2298/mpns1108386j
Abstract: Introduction. Reactive oxygen species are particularly active in the brain and neuronal tissue, and they are involved in numerous cellular functions, including cell death and survival. Brain and oxidative stress. A high metabolic rate and an abundant supply of the transition metals make the brain an ideal target for a free radical attack. In addition, the brain has a high susceptibility to oxidative stress due to the high lipid content and relatively lower regenerative capacity in comparison with other tissues. Vulnerability of nerve cells to oxidative stress. The neurons are more vulnerable to oxidative stress than other brain cell types. In addition to the two conventional enzymes, catalase and glutathione peroxidase, peroxiredoxins remove intracellular hydrogen peroxide by reducing it to water. The recent work increasingly supports the hypothesis that peroxiredoxins are not only antioxidant proteins, but they also play a role in cell signaling by controlling hydrogen peroxide and alkyl hydroperoxide levels. The accumulating evidence demonstrates that microglia can become deleterious and damage neurons. The overactivated microglia release reactive oxygen species that cause neuronal damage in neurodegenerative diseases. Conclusion. The defense of nerve cells against reactive oxygen species - mediated oxidative damage is essential for maintaining the functionality of nerve cells. The ongoing studies show that neuron-glial compartmentalization of antioxidants is critical for the neuronal signaling by hydrogen peroxide as well as the neuronal protection.
Oral health in individuals with psychotic disorders
JovanoviSvetlana,Gaji? Ivanka
Stomatolo?ki Glasnik Srbije , 2008, DOI: 10.2298/sgs0803180j
Abstract: Mental disorders are an important problem in every national health care service. The importance of psychotic disorders is not only their frequency but also their long-term character, recurrence, association with other diseases, costs and consequences for the family and society. Psychotic disorders (schizophrenia, schizoaffective disorder, bipolar disorders and depression) and their treatment may result in serious oral diseases. These disorders and medications used to treat them may lead to a series of oral complications and side effects, predominantly high prevalence of carious and extracted teeth, periodontal disease, inadequate oral hygiene, xerostomia, burning mouth syndrome, bad breath and gustatory sense dysfunction. Psychotic disorders affect oral and dental health in two ways. Behavioural changes affect the oral hygiene maintenance and lead to bad habits and attitudes towards oral health. Antipsychotic therapy has adverse effects on oral health. Literature data suggest that oral health in patients with psychotic disorders is poor and highlight the need to develop specific preventive programmes, which would be aimed at improving behaviour of this population at risk in the oral health care system.
Oral health in individuals with psychotic disorders
JovanoviSvetlana,Gaji? Ivanka
Stomatolo?ki Glasnik Srbije , 2008, DOI: 10.2298/sgs0802115j
Abstract: Mental disorders are an important problem in every national health care service. The importance of psychotic disorders is not only their frequency but also their long-term character, recurrence, association with other diseases, costs and consequences for the family and society. Psychotic disorders (schizophrenia, schizoaffective disorder, bipolar disorders and depression) and their treatment may result in serious oral diseases. These disorders and medications used to treat them may lead to a series of oral complications and side effects, predominantly high prevalence of carious and extracted teeth, periodontal disease, inadequate oral hygiene, xerostomia, burning mouth syndrome, bad breath and gustatory sense dysfunction. Psychotic disorders affect oral and dental health in two ways. Behavioral changes affect the oral hygiene maintenance and lead to bad habits and attitudes towards oral health. Antipsychotic therapy has adverse effects on oral health. Literature data suggest that oral health in patients with psychotic disorders is poor and highlight the need to develop specific preventive programmes, which would be aimed at improving behavior of this population at risk in the oral health care system.
Health habits, attitudes and behavior towards oral health of children with epilepsy
JovanoviSvetlana,Gaji? Ivanka
Srpski Arhiv za Celokupno Lekarstvo , 2007, DOI: 10.2298/sarh0704167j
Abstract: Introduction: Children suffering from epilepsy are high at risk of oral diseases primarily due to their underlying medical condition which can have an impact on the maintenance level of oral hygiene, but also due to adverse effects of antiepileptic drugs. Objective. The aim of this paper was to identify habits, attitudes and behavior of children with epilepsy and parents in respect to oral health. Method. The experimental group consisted of 50 children with epilepsy, 24 boys and 26 girls, 7-14 years old, mean age 11.2±2.2 years. The control group consisted of healthy children, matched by age and gender. The instruments of investigation consisted of the structured interview of children and parents concerning oral health habits, attitudes and behavior. We used medical records of children with epilepsy as a source of information on their diagnosis, duration of the illness and current therapy. Statistical analysis was performed by chi-squared test, nonparametric correlation, Wilcoxon’s signed rank test and logistic regression. Results. Results showed that more children with epilepsy and their parents had inappropriate habits and attitudes towards oral health, as well as nutrition habits (p<0.001). Compared to healthy controls, children with epilepsy washed their teeth less often and shorter, they had less knowledge about causes of oral diseases and about influence of oral diseases on general health, and they had worse self-rating of teeth and gum condition. In addition, significantly more children with epilepsy used an incorrect technique of teeth brushing (p<0.001). Characteristics of children’s epilepsy and educational degree of parents had no influence on these differences. Conclusion. Study results showed that children with epilepsy and their parents had worse habits, attitudes and behavior towards oral health than healthy controls and their parents. This difference can be explained primarily by worse parental estimation of oral health and behavior towards oral health in comparison to parents of healthy controls. .
Clinical profile of presumed and definitive ocular sarcoidosis
JovanoviSvetlana,Zlatanovi? Gordana,Jovanovi? Zorica,Radoti? Filip
Srpski Arhiv za Celokupno Lekarstvo , 2013, DOI: 10.2298/sarh1302013j
Abstract: Introduction. Sarcoidosis is an antigen-mediated disease of unknown cause defined by granulomatous inflammation of different organs. Objective. The aim of this study was to analyze the clinical picture in 26 patients with a definitive and presumed ocular sarcoidosis. Methods. The following tests were conducted: angiotensin-converting enzyme, tuberculin skin test, liver enzymes and calcium in urine and serum. Enlarged hilar lymph glands were diagnosed using X-ray tomography or computed tomography of the mediastinum. A biopsy of lymph glands was performed either transbronchially or transmediastinally. Ophthalmic examination included biomicroscopic examination, intraocular pressure measurement, photofundus, fluorescein angiography, optical coherence tomography and computerized perimetry. Results. The average follow-up period of the disease was 6.1 years. The average age was 52.0 years. There were 62.5% female patients, with bilateral incidence of 69.2%. The clinical picture included: panuveitis (in 30.8% of patients), anterior uveitis (26.9%), posterior uveitis (26.9%), intermediate uveitis (7.7%) and vitritis in (7.7%). The following complications were observed: cataract (in 34.6% of patients), cystoid macular edema (23.1%), glaucoma (15.4%), macroaneurysms (15.4%), neovascularization (7.7%) and band keratopathy (3.8%). There was a statistically significant difference in the visual acuity (p=0.033) and severity of clinical symptoms (p=0.02) between the groups of patients with retinal vasculitis associated with “candle-wax” phenomenon and the group of patients with multiple chorioretinal lesions - “white dot” syndrome. Conclusion. To our consideration, the differences observed between the two groups are the result of retinal vasculitis and subsequent macular edema, which is significantly more frequent in the group with “candle-wax” phenomenon.
AGE DIFFERENCES IN OCCUPATIONAL INJURIES IN THE CONSTRUCTION INDUSTRY
Jovica Jovanovi,Milan Jovanovi,Mirjana Arandjelovi?,Svetlana Adamovi?
Acta Medica Medianae , 2004,
Abstract: Occupational injuries at construction sites are identified as a major problem throughout the world. The purposes of this study are to estimate the number and average annual rate of occupational traumatic injuries and to estimate the age differences in transition period between 1993s and 2003s in construction industry. The most prevalence of injuries was registered in 1994 (4.55%) and in 2003 s (4.38%). The number of injured workers under the 20 years of age decreased in the examined period (from 22.2% in 1993s to 4.6% in the 2003s). The number of injured worker over the 51 years of age increased in the examined period (from 0.9% in 1993s to 17.8% in 2003 s). Closed fractures (24.1%), open fractures (14.6%) and dislocated fractures (10.9%) were the most common type of injuries in the examined period. These types of injuries were the most frequently presented at the workers over the 51 years of age. Falls from height, falls on same level and traffic accidents were the most common causes of occupational injuries in the examined period. Falls from height and falls on the same level were the most common presented at the workers over the 51 years of age. Traffic accidents were the most common cause of occupational injuries among the workers under the 30 years of age. Severity ratio of occupational injuries raised by the age of injured workers. Severity ratio of injuries raised in the examined period (from 60.6 in 1993s to 82.7 in the 2003s). Traumatic occupational injuries are a specific and significant problem in construction industry in the transition period.
Risk factors for oral changes in children with epilepsy: Informative article
JovanoviSvetlana,Gaji? Ivanka,Radivojevi? Vlada
Stomatolo?ki Glasnik Srbije , 2009, DOI: 10.2298/sgs0901033j
Abstract: Epilepsy is the most common neurological disorder in people of all ages. Based on the data regarding the prevalence of epilepsy in other countries, about 12,000 individuals under the age of 18 are estimated to suffer from active epilepsy. Children with epilepsy are a high risk group for oral diseases primarily due to psychiatric and psycho-social consequences of the primary disorder as well as the adverse effects of anti-epileptic therapy. Due to the primary disorder, children with epilepsy have reduced motivation for a number of activities, reduced mental and physical abilities, neglected social contacts, more difficult adoption of knowledge, skills, positive attitudes and behavior as well as general and oral healthcare. In children with epilepsy, there is an additional risk for oral diseases due to the adverse effects of anti-epileptic therapy such as gingival hyperplasia. Studies in other countries and in Serbia showed higher prevalence and frequency of oral diseases compared to the control group of healthy children of the same age. This paper emphasizes the need for dental educational work with children with epilepsy and their parents as well as doctors who treat the primary disorder.
Injury risk to young car drivers in traffic on territory of republic of Serbia
Dragan JOVANOVI,Svetlana BA?I?,Jelena MITROVI?
Transport Problems : an International Scientific Journal , 2010,
Abstract: Percentage of young drivers who were involved in traffic accident with fatalities and injuries is very high. In nearly each fourth accident with fatalities was participated one driver younger than 25 years. Young drivers take part in 26% of all accident with serious consequences (died and serious injuries).In the paper we prepared analysis of casualty among the young car drivers 18-24 years old who participated in traffic on the territory of the Republic of Serbia during the period of 2002. to 2006. According to collected data of casualties we carried out analysis by time and type of accident in which young car drivers were involved. The main aim is to give some traffic safety measures to reduce the accident risks of young car drivers on the road in Serbia.
The influence of organic and inorganic Fe supplementation on red blood picture, immune response and quantity of iron in organs of broiler chickens
Milanovi? Svetlana,Lazarevi? M.,Joki? ?.,Jovanovi? I.
Acta Veterinaria , 2008, DOI: 10.2298/avb0803179m
Abstract: The aim of this study was to investigate the influence of organic and inorganic Fe supplementation on red blood picture, immune response and quantity of iron in organs of broiler chickens. The trial was conducted on 200 'Arbor Acres' chickens randomly alloted in four equal groups. Birds from all groups were fed standard broiler feed, supplemented with 40 mg/kg of Fe originating from different sources: Group I (FeSO4), Group II (Fe bounded to yeast), Group III (ferrous ascorbate) and Group IV (iron chelate). From each group, 10 birds were sacrificed on 21st, 35th and 42nd day and the following parameters were measured: erythrocyte count, hematocrite value, hemoglobin concentration, concentration of nonheme iron in spleen, liver and bone marrow (femur), degree of cutaneous hypersensitivity to PHA and titers of antibodies to Gumboro virus following vaccination. Addition of organic iron supplements resulted in increased erythrocyte count, hemoglobin concentration and hematocrite value on the 21st day. Different iron forms did not change the concentration of nonheme iron in the liver on the 21st and 42nd day. On the 35th day, the group supplemented with ferrous ascorbate had lower liver iron concentration. Also, concentrations of nonheme iron in the spleen were lower in groups supplemented with organic iron forms. The concentration of iron in the bone marrow decreased with age and the lowest values were recorded in the ferrous ascorbate supplemented group. The degree of cutaneous hypersensitivity to PHA was higher in groups supplemented with organic iron forms on the 21st and 35th day. Titers of anti-Gumboro antibodies were higher in the group supplemented with iron helate on the 35th day, but later (day 42) no significant differences were observed among groups. .
Comparison of Biochemical Markers of Bone Turnover in Patients on Continuous Ambulatory Peritoneal Dialysis and Maintenance Hemodialysis
Neda Novakovi , Svetlana Pejanovi , Dijana Jovanovi , Nada Majki -Singh
Journal of Medical Biochemistry , 2007, DOI: 10.2478/v10011-007-0025-5
Abstract: The aim of this study was to compare the biochemical markers of bone formation - bone isoenzyme alkaline phosphatase, /BALP/ bone resorption - tartarat resistant acid phosphatase /TRAP/ and parameters of bone turnover (Ca, P and iPTH) between 108 patients on continuous ambulatory peritoneal dialysis (CAPD) and 112 patients on hemodialysis (HD). Parameters were determined by spectrophotometry (TRAP, Ca, P), electrochemiluminiscent method (iPTH) and electrophoresis (BALP). There was significant correlation between BALP levels of CAPD patients and Ca values of HD patients (r = 0.216, p < 0.05), but comparison of P, iPTH and BALP showed no significant difference between the groups. We found significant correlation between BALP and TRAP (r = 0.570, p < 0.01) and BALP and iPTH values (r = 0.551, p < 0.01) in HD patients. Also, significant correlations in CAPD patients between BALP and TRAP (r = 0.194, p < 0.05) and BALP and iPTH values (r = 0.283, p < 0.01) were found. Our results suggest that the effect of CAPD and HD on bone turnover may be monitored most conclusively via BALP levels. This biochemical marker is a very good index of bone turnover in patients undergoing dialysis and it could indicate an early stage of decreased bone turnover.
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