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ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACTS OF LEAF AND BARK OF NARINGI CRENULATA (ROXB.) NICOLSON
K. Sarada , R. Jothibai Margret and V. R. Mohan *
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Ethanol extracts of Naringi crenulata leaf and bark were evaluated for its anti-inflammatory activity at the dose levels of 250mg kg-1 and 500mg kg-1 body weight using a Carrageenan induced paw oedema method (acute inflammation). Results showed that both leaf and bark ethanol extracts had potent and significant anti-inflammatory activity. These results were also comparable with reference drug indomethacin used in this study.
ANITIDIABETIC, ANTIHYPERLIPIDAEMIC AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT OF FERONIA ELEPHANTUM CORREA LEAF AND BARK IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS
Muthulakshmi A,Jothibai Margret R,Mohan V.R
International Research Journal of Pharmacy , 2013,
Abstract: The aim of the present study was to evaluate the antidiabetic Potential of ethanol extract of Feronia elephantum Correa leaf and bark in normal and alloxan induced diabetic rats. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150 mg/kg). The ethanol extract of F. elephantum leaf and bark at a dose of 400mg/kg of body weight was administered separately at a single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of F. elephantum leaf and bark on blood glucose, serum lipid profile, the levels of lipid peroxides and antioxidant enzymes, such as catalase, superoxide dismutase, glutathione peroxidase and reduced glutathione were examined. Oral administration of F. elephantum leaf and bark extract to diabetic rats for 14 days significantly reduced the levels of blood glucose, lipid parameters except HDL-C and lipid peroxidation, but increased the activities of plasma insulin and antioxidant enzymes. Ethanol extract of F. elephantum supplementation is useful in controlling the blood glucose level, improves the plasma insulin and lipid metabolism. It is beneficial in preventing diabetic complication from lipid peroxidation and antioxidant system in experimental diabetic rats; therefore, it could be useful for prevention or early treatment of diabetes mellitus.
FORMULATION AND EVALUATION OF ISONIAZID AND ETHAMBUTOL HYDROCHLORIDE COMBINATION TABLETS
Margret Chandira R,Jayakar B,Palanisamy P.
International Research Journal of Pharmacy , 2012,
Abstract: Ethambutol hydrochloride and Isoniazid Drugs are used as Antituberculosis agents. It is mainly used in the initial Treatment of pulmonary tuberculosis. Here in present study compressed tablet of Ethambutol hydrochloride and Isoniazid prepared by using HPMC, HPC, and PVPK -30 as binders. Compressed tablets of Ethambutol hydrochloride and Isoniazid were prepared by wet granulation method. Among different trials of F1 to F9 with wet granulation, the trial F1 showed satisfactory in-vitro drug release profile as compared to that of innovator for formulation. The cumulative percentage of drug release of formulation F1 (Isoniazid) And F1 (Ethambutol) were 99.53 and 99.43 respectively. The result of stability studies of batch F1 indicate that it is stable at 40°C ± 2°C / 75% RH ± 5 % relative humidity as there was no significant differences observe for dissolution and assay after two months.
FORMULATION AND EVALUATION OF BILAYERED FLOATING TABLETS OF METFORMIN HYDROCHLORIDE
R.Margret Chandira,P.Palanisamy,B.Jayakar
International Research Journal of Pharmacy , 2012,
Abstract: Diabetes is a chronic metabolic disease characterized by high glucose levels in the blood. Sustained release gastro retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of gastrointestinal tract and improve the bioavailability of medication that is characterized by narrow absorption window. Gastro retentive floating drug delivery systems (GFDDS) of Metformin HCl, an antidiabetic drug with an oral bioavailbility of only 50% (because of its poor absorption from lower gastrointestinal tract) have been designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of floating bilayer matrix tablet by direct compression technique, by using HPMC as release retardant, and NaHCO3 as gas generating agent to reduce floating lag time. Bilayer Floating tablets were evaluated for Hardness, Friability, Weight Variation, Drug content, Floating properties and In-vitro release pattern. The In-vitro drug release followed Zero order Kinetics and drug release was found to be diffusion controlled.
Role of nanotechnology in novel drug delivery system
Debjit bhowmik,Chiranjib,Margret chandira.R,Jayakar.B
Journal of Pharmaceutical Science and Technology , 2009,
Abstract: Nanotechnology is the engineering of functional systems at the molecular scale. This covers both current work and concepts that are more advanced. nanotechnology enhanced materials will enable a weightreduction accompanied by an increase in stability and an improved functionality. biomedical nanotechnology, bionanotechnology, and nanomedicine are used to describe this hybrid field. The pace ofnew discoveries in biotechnology and health care and even the appearance of whole new fields of endeavour in recent years have made for an exciting and challenging time for pharmacists.The increasingdemands of understanding how modern medicines work at the molecular level, the shift towards predictive, preventive and personalised health care and challenges from nanotechnology and stem cell technology have added to the need for pharmacists to remain the experts in medicines.Nanotechnology is on its way to make a big impact in Biotech, Pharmaceutical and Medical diagnostics sciences. A dynamic collaboration is observed within the Researchers, Government, Pharmaceutical - Biomedical companies and educational institutions all over the world in developing the nanotechnology applications in advanced medicine and patient care. It is expected that the forthcoming generations of nano products will have target specificity,may carry multiple drugs, and could potentially release the payloads at varying time intervalsThe prefix "nano" refers to one-billionth. When applied in the metric scale of linear measurements, a nanometer is one-billionth of a meter. The term "nanotechnology" is now commonly used to refer to the creation of new objects with nanoscale dimensions between 1.0 and 100.0 nm.Functionalities can be added to nanomaterialsby interfacing them with biological molecules or structures. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications. Thus far, the integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug delivery vehicles. Nanotechnology is also opening up new opportunities in implantable delivery systems, which are often preferable to the use of injectable drugs, because the latter frequently display firstorder kinetics (the blood concentration goes up rapidly, but drops exponentially over time). This rapid risemay cause difficulties with toxicity, and drug efficacy can diminish as the drug concentration falls below
A guided tour: Pollen tube orientation in flowering plants
Margret Sauter
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0329-6
Abstract: Sexual reproduction in flowering plants requires that two sperm cells are delivered to the embryo sac where double fertilization of an egg cell and of a central cell results in the formation of a diploid embryo and of the triploid nutritional endosperm tissue. The immobile male gametes are delivered to the immobile female gametophyte by a single cell, the pollen tube. The pollen tube must be able to germinate on a genetically appropriate stigma and it must be directed through the transmitting tract of the style from where it must target an ovule. Moreover, the pollen tube must enter the ovule at a defined opening, the micropyle, grow toward one of the two synergids and release the two sperm cells upon contact. This complex process requires recognition events with chemically based or physically supported cell-cell communication as well as directional cues for the growing pollen tube. A number of molecules and mechanisms have been implicated in pollen tube guidance which are summarized in this review.
Hans Erich Troje: Gegenpositionen. Aspekte zur Zukunft von Ehe und Familie. K ln u.a.: B hlau Verlag 2009.
Margret Karsch
querelles-net , 2010,
Abstract: Der Sammelband ist in der Reihe Rechtsgeschichte und Geschlechterforschung“ des B hlau Verlags erschienen. Er enth lt Aufs tze des emeritierten Rechtswissenschaftlers aus den Jahren 1975 bis 1999, die in ideologischer und polemischer Form Positionen zu Familien- und Gleichstellungspolitik formulieren, wie sie in der Geschlechterforschung l ngst überholt sind. The collected volume appeared in B hlau Verlag’s series “Legal History and Gender Research.” It contains essays by the retired legal scholar from the years 1975 to 1999 that in ideological and polemic form formulate positions on family and equity politics akin to those that have long been overhauled by gender research.
Paula Villa, Barbara Thiessen (Hg.): Mütter – V ter: Diskurse, Medien, Praxen. Münster: Verlag Westf lisches Dampfboot 2009.
Margret Karsch
querelles-net , 2010,
Abstract: Die vielseitigen Beitr ge des Sammelbandes lassen deutlich werden, dass die Bilder von Geschlechterrollen und Elternschaft sowie die medialen Angebote hierzu und die Alltagspraxis von Frauen und M nnern sich gegenseitig beeinflussen, aber keinesfalls deckungsgleich sind. Im Gegenteil, die mannigfaltigen Widersprüche treten umso deutlicher hervor, je mehr die gesellschaftlichen und individuellen Anforderungen auseinanderklaffen, die sich aus den unterschiedlichen Konstruktionen von Elternschaft ergeben. Zwar haben sich die Geschlechterrollen ver ndert, so dass die individuellen Gestaltungsm glichkeiten gewachsen sind, ein struktureller gesellschaftlicher Wandel aber hat sich noch nicht vollzogen. The versatile contributions of this collected volume clearly show that the images of gender roles and parenthood also in the media and the daily practice of women and men mutually affect one another, but are absolutely not identical. On the contrary, the diverse contradictions stand out the more that societal and individual standards diverge, which result from the different constructions of parenthood. Although gender roles have changed so that individual possibilities for shaping these have grown, a transformation of society at a structural level has not yet been completed.
Soziale Mission und Emanzipation. Zwei Pionierinnen der weiblichen Sozialarbeit Social Mission and Emancipation: Two Pioneers of Female Social Work
Margret Nitsche
querelles-net , 2006,
Abstract: In einer umfangreichen Doppelbiographie beschreibt Anja Schüler Leben und Werk der beiden frühen Sozialreformerinnen und Feministinnen Jane Addams (1860-1935) und Alice Salomon (1872-1948) und die wechselseitige Rezeption ihrer jeweiligen sozialpolitischen Arbeit im transatlantischen Dialog. Anja Schüler describes in an expansive double biography the life and work of two early social reformers and feminists Jane Addams (1860-1935) and Alice Salomon (1972-1948) and the reciprocal reception of their sociopolitical work in transatlantic dialogue.
Gewaltph nomene und Geschlechterverh ltnisse in Gegenwartsliteratur Violent Phenomena and Gender Relations in Contemporary Literature
Margret Karsch
querelles-net , 2006,
Abstract: Andrea Geiers umfangreiche Studie Gewalt“ und Geschlecht“ wirft ein neues Licht auf literarische Darstellungen von Gewalt und deren vielf ltige Bezugnahmen auf Muster von M nnlichkeit“ und Weiblichkeit”. Geier untersucht sieben deutschsprachige Prosatexte, die von sechs Autorinnen stammen und in den 1980er und 1990er Jahren erschienen sind. Die Verfasserin spürt den narrativen Verfahren nach, mit denen verschiedene literarische und au erliterarische Diskurse verknüpft werden und die spezifische Konstellationen des Verh ltnisses von Gewalt und Geschlecht bilden. Andrea Geier’s comprehensive study “Violence” and “Gender” places literary presentations of violence and their diverse references to models of “masculinity” and “femininity” in a new light. Geier examines seven German-language prose texts written by six authors and published in the 1980s and 1990s. The author traces the narrative modes connecting different literary and extra-literary discourses, discourses that create specific constellations for the relationship between violence and gender.
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