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Search Results: 1 - 10 of 11011 matches for " Joseph McEvoy "
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Limitación del riesgo cardiovascular generado por la clozapina
Carolina Aponte Urdaneta,Joseph P McEvoy
Revista Colombiana de Psiquiatría , 2008,
La construcción de la imagen heroica a través del discurso periodístico: El caso de la activista peruana María Elena Moyano
Historia Crítica , 2008,
Abstract: this work tries to demonstrate that the social construction of the national hero/heroine as a symbol of courage and resistance generally arises within a period of social, political, and economic crisis. the national hero is a construction that is created in a moment characterized by the loss of public trust and the failure of government leaders to act. the creation of the heroic image functions as a socio-political tool. the article suggests that there is a close relationship between the history and the construction of heroic figures. using the death of peruvian activist maría elena moyano as a concrete example, it demonstrates that journalistic discourse has the ability to create an heroic image around a person who has been given the traditional role that the hero has played in society since antiquity.
La construcción de la imagen heroica a través del discurso periodístico. El caso de la activista peruana María Elena Moyano.
Gabriela McEvoy.
Historia Crítica , 2008,
Abstract: This work tries to demonstrate that the social construction of the national hero/heroine as a symbol of courage and resistance generally arises within a period of social, political, and economic crisis. The national hero is a construction that is created in a moment characterized by the loss of public trust and the failure of government leaders to act. The creation of the heroic image functions as a sociopolitical tool. The article suggests that there is a close relationship between the history and the construction of heroic fgures. Using the death of Peruvian activist María Elena Moyano as a concrete example, it demonstrates that journalistic discourse has the ability to create an heroic image around a person who has been given the traditional role that the hero has played in society since Antiquity.
No una sino muchas repúblicas: una aproximación a las bases teóricas del republicanismo peruano, 1821-1834
McEvoy, Carmen
Revista de Indias , 2011,
Abstract: The article seeks to explore three strands of Peruvian republicanism between 1821 and 1834. One of these was the patria científica [scientific homeland] which flourished within the heart of the Sociedad Patriótica de Lima. This was represented by a group of scientific men, headed by Hipólito Unanue and among whom José Gregorio Paredes played a leading role. The second strand was of a legal-philosophical character due to its emphasis on concepts like freedom and sovereignty, and was forged in discussions over the possibility of either a constitutional monarchy or a strictly republican regime whose main spokesman was the Trujillo lawyer José Faustino Sánchez Carrión. Militarized republicanism, the third category of thought discussed in this article, arose as a response to the problem of the war against the Spanish empire and was the brainchild of soldiers of the Republic like Domingo Nieto. El artículo se propone explorar tres de las vertientes del republicanismo peruano entre 1821 y 1834. La primera, la patria científica que floreció en el seno de la Sociedad Patriótica de Lima y está representada por un grupo de hombres de ciencia liderados por Hipólito Unanue, entre los que destacó José Gregorio Paredes. La segunda vertiente, de corte jurídico- filosófico por su énfasis en conceptos como los de libertad y soberanía, se irá gestando en la discusión entre la opción de una monarquía constitucional y otra de carácter estrictamente republicano, siendo su vocero el abogado trujillano José Faustino Sánchez Carrión. El republicanismo militarizado, que es la última categoría que se discute en este trabajo, surge como una respuesta al problema de la guerra contra el imperio espa ol y es construida por soldados de la República como Domingo Nieto.
Homeostatic Imbalance of Purine Catabolism in First-Episode Neuroleptic-Na?ve Patients with Schizophrenia
Jeffrey K. Yao,George G. Dougherty Jr.,Ravinder D. Reddy,Matcheri S. Keshavan,Debra M. Montrose,Wayne R. Matson,Joseph McEvoy,Rima Kaddurah-Daouk
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009508
Abstract: Purine catabolism may be an unappreciated, but important component of the homeostatic response of mitochondria to oxidant stress. Accumulating evidence suggests a pivotal role of oxidative stress in schizophrenia pathology.
Associations between Purine Metabolites and Clinical Symptoms in Schizophrenia
Jeffrey K. Yao, Ruth Condray, George G. Dougherty, Matcheri S. Keshavan, Debra M. Montrose, Wayne R. Matson, Joseph McEvoy, Rima Kaddurah-Daouk, Ravinder D. Reddy
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042165
Abstract: Background The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology of schizophrenia. Methodology/Principal Findings Breakdown products in purine pathway were measured using high-pressure liquid chromatography coupled with a coulometric multi-electrode array system for 25 first-episode neuroleptic-na?ve patients with schizophrenia at baseline and at 4-weeks following initiation of treatment with antipsychotic medication. Associations between these metabolites and clinical and neurological symptoms were examined at both time points. The ratio of uric acid and guanine measured at baseline predicted clinical improvement following four weeks of treatment with antipsychotic medication. Baseline levels of purine metabolites also predicted clinical and neurological symtpoms recorded at baseline; level of guanosine was associated with degree of clinical thought disturbance, and the ratio of xanthosine to guanosine at baseline predicted degree of impairment in the repetition and sequencing of actions. Conclusions/Significance Findings suggest an association between optimal levels of purine byproducts and dynamics in clinical symptoms and adjustment, as well as in the integrity of sensory and motor processing. Taken together, alterations in purine catabolism may have clinical relevance in schizophrenia pathology.
Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics
Joseph McEvoy, Rebecca A. Baillie, Hongjie Zhu, Peter Buckley, Matcheri S. Keshavan, Henry A. Nasrallah, George G. Dougherty, Jeffrey K. Yao, Rima Kaddurah-Daouk
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068717
Abstract: There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks. This information could provide valuable insights about disease mechanisms, trajectory of disease progression, and diagnostic biomarkers. We used a lipidomics platform to measure individual lipid species in 20 drug-na?ve patients with a first episode of schizophrenia (FE group), 20 patients with chronic schizophrenia that had not adhered to prescribed medications (RE group), and 29 race-matched control subjects without schizophrenia. Lipid metabolic profiles were evaluated and compared between study groups and within groups before and after treatment with atypical antipsychotics, risperidone and aripiprazole. Finally, we mapped lipid profiles to n3 and n6 fatty acid synthesis pathways to elucidate which enzymes might be affected by disease and treatment. Compared to controls, the FE group showed significant down-regulation of several n3 polyunsaturated fatty acids (PUFAs), including 20:5n3, 22:5n3, and 22:6n3 within the phosphatidylcholine and phosphatidylethanolamine lipid classes. Differences between FE and controls were only observed in the n3 class PUFAs; no differences where noted in n6 class PUFAs. The RE group was not significantly different from controls, although some compositional differences within PUFAs were noted. Drug treatment was able to correct the aberrant PUFA levels noted in FE patients, but changes in re patients were not corrective. Treatment caused increases in both n3 and n6 class lipids. These results supported the hypothesis that phospholipid n3 fatty acid deficits are present early in the course of schizophrenia and tend not to persist throughout its course. These changes in lipid metabolism could indicate a metabolic vulnerability in patients with schizophrenia that occurs early in development of the disease.
Reliability of upright posture measurements in primary school children
Maureen P McEvoy, Karen Grimmer
BMC Musculoskeletal Disorders , 2005, DOI: 10.1186/1471-2474-6-35
Abstract: Sagittal plane photographs of usual, relaxed upright standing posture of 38 boys and girls aged 5–12 years were taken twice within an hour. Reflective markers were placed over the canthus, tragus, C7 spinous process, greater trochanter and lateral malleolus. Digitising software was used to calculate the x,y plane coordinates, from which five postural angles were calculated (trunk, neck, gaze, head on neck, lower limb). Height, weight, motor control estimates (as measured by the Brace Tests) and presence of recent pain were recorded for each child, and the association between the first test measure of posture angles and these factors was assessed using linear regression and ANOVA models. Multiple ANOVA models were applied to analyse the effect of repeated testing, and significant predictors on the angles.Four of the five postural angles (trunk, neck, head on neck, lower limb) were significantly influenced by age. As age was strongly associated with height (r2 = 0.84) and moderately associated with weight and motor control (r2 = 0.67, 0.56 respectively), these developmental parameters may well explain the age effect on angles. There was no relationship between age and pain reported on either the testing day, or recently, and there was no gender influence on any angle. There was no significant effect of repeated testing on any angle (ICC>0.93). None of the hypothesized predictors were associated with differences in angles from repeated testing.This study outlined the variability of relaxed upright standing posture of children aged 5–12 years, when measured twice in an hour. Age influenced the size of the angles but not the variability. While the subject numbers in this study are small, the findings provide useful information on which further studies in posture and its development in pre-adolescent children can be based.Posture reflects the relationship between spinal segments, and the influence of the environment on spinal segments [1]. Correct upright posture is consi
Associated Production of Non-Standard Higgs Bosons at the LHC
David E. Kaplan,Matthew McEvoy
Physics , 2011, DOI: 10.1103/PhysRevD.83.115004
Abstract: We discuss the feasibility of seeing a Higgs boson which decays to four partons through a pair of (pseudo-)scalars at the LHC. We restrict our search to Higgs bosons produced in association with a W/Z boson at high transverse momentum. We argue that subjet analysis techniques are a good discriminant between such events and W/Z plus jets and top-antitop production. For light scalar masses (below 30 GeV), we find evidence that a flavor-independent search for such a non-standard Higgs boson is plausible with 100 fb^-1 of data, while a Higgs decaying to heavier scalars is only likely to be visible in models where scalar decays to b quarks dominate.
Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya
Colin Ohrt, Peter Obare, Ampon Nanakorn, Christine Adhiambo, Ken Awuondo, Wendy O'Meara, Shon Remich, Kurt Martin, Earnest Cook, Jean-Paul Chretien, Carmen Lucas, Joseph Osoga, Peter McEvoy, Martin Owaga, James Odera, Bernhards Ogutu
Malaria Journal , 2007, DOI: 10.1186/1475-2875-6-79
Abstract: A twelve-day "long" and a four-day "short" training course consisting of supervised laboratory practicals, lectures, group discussions, demonstrations, and take home assignments were developed. Well characterized slides were developed and training materials iteratively improved. Objective pre- and post-course evaluations consisted of 30 slides (19 negative, 11 positive) with a density range of 50–660 parasites/μl, a written examination (65 questions), a photographic image examination (30 images of artifacts and species specific characteristics), and a parasite counting examination.To date, 209 microscopists have participated from 11 countries. Seventy-seven experienced microscopists participated in the "long" courses, including 47 research microscopists. Sensitivity improved by a mean of 14% (CI 9–19%) from 77% baseline (CI 73–81 %), while specificity improved by a mean of 17% (CI 11–23%) from 76% (CI 70–82%) baseline. Twenty-three microscopists who had been selected for a four-day refresher course showed continued improvement with a mean final sensitivity of 95% (CI 91–98%) and specificity of 97% (CI 95–100%). Only 9% of those taking the pre-test in the "long" course achieved a 90% sensitivity and 95% specificity, which increased to 61% of those completing the "short" course. All measures of performance improved substantially across each of the five organization types and in each course offered.The data clearly illustrated that false positive and negative malaria smears are a serious problem, even with research microscopists. Training dramatically improved performance. Quality microscopy can be provided by the Centre of Excellence concept. This concept can be extended to other diagnostics of public health importance, and comprehensive disease control strategies.Quality of laboratory medicine has always been a barrier to effective health care in the developing world. The issues and potential solutions have been recently illustrated by Petti, Bates and colleagues [1,
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