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Search Results: 1 - 10 of 11338 matches for " Joseph Leena "
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Cytomegalovirus infection with lissencephaly
Joseph Leena,Pushpalatha,Kuruvilla Sarah
Indian Journal of Pathology and Microbiology , 2008,
Abstract: Lissencephaly is a malformation of the brain in which the brain surface is smooth, rather than convoluted. Among the various causes of lissencephaly, infection by a virus during pregnancy plays an important role. Cytomegalovirus (CMV) is an important pathogen causing this anomaly. We present this case of a young female with 24-week-gestation diagnosed on ultrasound as carrying an anomalous fetus with lissencephalic features. At autopsy, there were multiple intra-nuclear CMV inclusions in the brain and the kidneys. This case is presented for its rarity and for the documentation of the tissue localization of CMV inclusions at autopsy.
Candida dubliniensis: An Appraisal of Its Clinical Significance as a Bloodstream Pathogen
Ziauddin Khan,Suhail Ahmad,Leena Joseph,Rachel Chandy
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0032952
Abstract: A nine-year prospective study (2002–2010) on the prevalence of Candida dubliniensis among Candida bloodstream isolates is presented. The germ tube positive isolates were provisionally identified as C. dubliniensis by presence of fringed and rough colonies on sunflower seed agar. Subsequently, their identity was confirmed by Vitek2 Yeast identification system and/or by amplification and sequencing of the ITS region of rDNA. In all, 368 isolates were identified as C. dubliniensis; 67.1% came from respiratory specimens, 11.7% from oral swabs, 9.2% from urine, 3.8% from blood, 2.7% from vaginal swabs and 5.4% from other sources. All C. dubliniensis isolates tested by Etest were susceptible to voriconazole and amphotericin B. Resistance to fluconazole (≥8 μg/ml) was observed in 2.5% of C. dubliniensis isolates, 7 of which occurred between 2008–2010. Of note was the diagnosis of C. dubliniensis candidemia in 14 patients, 11 of them occurring between 2008–2010. None of the bloodstream isolate was resistant to fluconazole, while a solitary isolate showed increased MIC to 5-flucytosine (>32 μg/ml) and belonged to genotype 4. A review of literature since 1999 revealed 28 additional cases of C. dubliniensis candidemia, and 167 isolates identified from blood cultures since 1982. In conclusion, this study highlights a greater role of C. dubliniensis in bloodstream infections than hitherto recognized.
Role of scrape cytology in ovarian neoplasms
Rao Shalinee,Sadiya N,Joseph Leena,Rajendiran S
Journal of Cytology , 2009,
Abstract: Aim: The present study was done to evaluate the role of scrape cytology in the diagnosis of ovarian neoplasm and its utilization for teaching pathology residents. Materials and Methods: This was a prospective study on 50 solid/solid-cystic ovarian neoplasms sent in 10% buffered formalin. Scrapings obtained from the fresh cut surface of tumors were smeared uniformly on to glass slides, immediately fixed in 95% ethyl alcohol and stained with hematoxylin and eosin stain. Results: The overall diagnostic accuracy of scrape cytology has been satisfactory with 92% of cases correlating with the final diagnosis. Characteristic cytological pattern was noted in various types of surface epithelial, sex cord stromal and germ cell tumors. The technique had limited value in mucinous tumors to distinguish borderline cases from invasive carcinoma. Two mucinous carcinomas were diagnosed as borderline mucinous tumor and two endometrioid carcinomas were misinterpreted as cystadenocarcinoma on scrape cytology. Formalin did not interfere or produce any remarkable changes in cytomorphology. Conclusions: Scrape cytology is a simple, rapid, accurate, inexpensive adjunctive cytodiagnostic technique and its routine utilization in ovarian lesions could aid in expanding the cytological knowledge of ovarian neoplasms.
Cytologic features of pulmonary blastoma
Sai Shalini C,Joseph Leena,Abraham Georgi,Prathiba D
Journal of Cytology , 2009,
Abstract: Pulmonary blastomas are rare lung neoplasms constituting 0.5% of all lung tumors. This tumor has an aggressive course and needs to be recognized on cytology. A preoperative diagnosis of pulmonary blastoma is difficult to obtain by cytopathologic methods. A diagnosis of biphasic pulmonary blastoma should be considered when there is a dimorphic population of cells on cytology. A 30-year-old male presented with gradually progressing breathlessness and left-sided chest pain for the past one month. Chest radiograph and computed tomography of thorax revealed an anterior mediastinal mass that was subjected to ultrasound-guided fine-needle aspiration cytology. Aspiration cytology showed a highly cellular lesion with a dimorphic population of tumor cells in a necrotic background. The possibility of a non-small cell carcinoma was suggested. Subsequent histopathology revealed the tumor to be a pulmonary blastoma. The importance of recognizing the dimorphic population of cells in cytology is discussed.
Papillary lesions of breast - An introspect of cytomorphological features
Prathiba D,Rao Shalinee,Kshitija Kasthuri,Joseph Leena
Journal of Cytology , 2010,
Abstract: Background : True papillary lesions of the breast have a significantly high error rate on fine needle aspiration cytology (FNAC), as many other nonpapillary breast lesions exhibit overlapping features on cytosmears. Aim : To evaluate the utility of individual morphological features in offering a more precise cytodiagnosis in papillary lesions of the breast. Materials and Methods : Cytology smears reported as papillary lesions on nipple discharge / FNAC and histopathology over a period of two years were studied and correlated. A subjective assessment of morphological features, namely, the cellular yield, presence of three-dimensional papillary clusters, stromal bare nuclei, presence of cyst macrophages and cellular atypia was carried out on cytosmears. Results : Fourteen cases of papillary lesions were identified. Thirty-six per cent of the cases were found to be true positive, 43% false negative and 21% false positive with a sensitivity of 42% for papillary lesions. Eight of nine papillary lesions showed cyst macrophages. Stromal bare nuclei were seen in three of four malignant papillary lesions. However, the number of stromal bare nuclei was less compared to benign lesions. None of the malignant nonpapillary lesions showed stromal bare nuclei. Conclusions : Cytomorphological features alone are inadequate for the precise diagnosis of papillary lesions of the breast.
Osteoclastoma-like anaplastic carcinoma of the thyroid
Joseph Leena,Ravi A,Rekha A,Rao Shalinee
Journal of Cytology , 2008,
Abstract: Anaplastic carcinoma is a highly malignant tumor that is partially or totally undifferentiated. The use of fine needle aspiration cytology (FNAC) to diagnose anaplastic carcinoma with osteoclast-like giant cells, has been rarely reported. We report here a case of osteoclastoma - anaplastic carcinoma - that was diagnosed on cytology in a 58 year-old female patient, who presented with a progressively increasing swelling over the anterior aspect of the neck. Multinucleated giant cells resembling osteoclasts are rarely seen in the giant cell variant of anaplastic carcinoma.
Primitive neuroectodermal tumor of the maxilla
Joseph Leena,Kumar Ravi,Senthil Kannan,Ravindran C
Journal of Oral and Maxillofacial Pathology , 2008,
Abstract: Primitive neuroectodermal tumor (PNET) of the maxilla is a soft tissue sarcoma classically described under small round blue cell tumors. This tumor is commonly seen in the chest, pelvis, abdomen, and extremities; and rarely in dura, ovaries, cervix, etc. These tumors are rare in the head and neck area. We report a case of a 3-year-old girl presenting with a PNET of the maxilla.
Collaborative Meeting as an Integrative Mechanism in a Multinational Investment Project  [PDF]
Leena Pekkinen, Jaakko Kujala
Technology and Investment (TI) , 2014, DOI: 10.4236/ti.2014.51006

In multinational and complex projects that are often implemented by multiple organizations, the entire projects need to be divided into manageable subprojects. At the same time, all subprojects are needed to be kept aligned with the project goals and targets by integration and coordination. The purpose of this article is to study the role of a particular, work-shop type, collaborative meeting by utilizing the characteristics of an integrative information processing framework. A single case study method was used to observe the practices of collaborative meetings. This study contributes to the project management research by analysing how collaborative meeting practice can be used as a mechanism to reduce uncertainty and equivocality in a large investment project. The results of this study are two folds: Firstly, the case project’s collaborative meetings are described in detail; secondly, the perceived features and procedures of the collaborative meetings in the case project are illustrated showing the role of the collaborative meetings as an integrative tool. Moreover, the perceived integrative characteristics of the collaborative meetings reducing uncertainty and equivocality are presented. This study indicates that collaborative meeting is an integrative mechanism reducing uncertainty and equivocality in a large investment project context.

Risk Management in Project Networks: An Information Processing View  [PDF]
Leena Pekkinen, Kirsi Aaltonen
Technology and Investment (TI) , 2015, DOI: 10.4236/ti.2015.61005
Abstract: Increasingly, projects are executed by networks of organizations. The networked form of organization has many important implications for project risk management. Information processing theories introduce mechanisms for processing information inside organizations as well as among organizations to reduce the uncertainty and equivocality inherently present in international projects. This study aims to examine the risk management practices involved at a project network level through an empirical analysis of one complex large project network executed in a challenging institutional environment. With regard to network level risk management, the paper identifies eight formal information processing mechanisms for implementing risk management: (1) established rules and criteria for the selection of subcontractors at a global level, (2) specification of responsibilities in the contract, (3) formal risk sheet, (4) progress follow-up tool, (5) database for project information, (6) customer reporting system, (7) updated project plan after the project is delayed, and (8) country study team. Personal relationships between parties, personal commitment, experienced individuals, and face-to-face meetings are identified as informal information processing mechanisms used as measures of project risk management to reduce equivocality. We also elaborate the fitness of the mechanisms used for the contextual situations of the project network settings.
Use of Masonry Construction & Demolition Waste in Concrete  [PDF]
Tahir Kibriya, Leena Tahir
World Journal of Engineering and Technology (WJET) , 2017, DOI: 10.4236/wjet.2017.52017
Abstract: Massive amounts of brick waste are obtained from demolition of old buildings and structures around the world. With the increased stress on sustainable construction, and environmentally friendly materials and greener concreting practices, a large proportion of such waste bricks are crushed and mixed with normal aggregates for use in concrete. The performance of concrete containing waste brick aggregates partially replacing normal aggregates have not been investigated for their performance. This paper covers investigations carried out on concrete with such aggregates obtained from demolition waste and mixed with varying proportions of normal aggregates to produce concrete. Two types of crushed brick aggregates were mixed with gravel in the ratios of 30:70 and 40:60 by weight and specimen were cast for investigations. Two w/c ratios were investigated. Various tests were carried out to assess the compressive strength of cubes and cylinders of mixed aggregates concrete along with f1exural strength, stress/strain behavior, moduli of elasticity, ultrasonic pulse velocity determination, densities, surface absorption, shrinkage and frost resistance. The values obtained from these tests were compared with the values of concrete with normal aggregates (gravel) with similar w/c ratios. While the strength tests and durability tests more or less gave satisfactory results however the larger moisture absorption by the waste brick aggregates reduces the frost resistance capacity somewhat thereby care needs to be exercised in using these mixes in regions/areas susceptible to frost.
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