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Search Results: 1 - 10 of 11119 matches for " Joseph Anupama "
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Osteoporosis and osteopenia in India: A few more observations
Babu Abraham,Ikbal Faizal,Noone Manjula,Joseph Anupama
Indian Journal of Medical Sciences , 2009,
Risk factors among patients with acute coronary syndrome in rural Kerala
Babu Abraham,Haneef Mohammed,Joseph Anupama,Noone Manjula
Indian Journal of Community Medicine , 2010,
Heavy-tailed Independent Component Analysis
Joseph Anderson,Navin Goyal,Anupama Nandi,Luis Rademacher
Computer Science , 2015,
Abstract: Independent component analysis (ICA) is the problem of efficiently recovering a matrix $A \in \mathbb{R}^{n\times n}$ from i.i.d. observations of $X=AS$ where $S \in \mathbb{R}^n$ is a random vector with mutually independent coordinates. This problem has been intensively studied, but all existing efficient algorithms with provable guarantees require that the coordinates $S_i$ have finite fourth moments. We consider the heavy-tailed ICA problem where we do not make this assumption, about the second moment. This problem also has received considerable attention in the applied literature. In the present work, we first give a provably efficient algorithm that works under the assumption that for constant $\gamma > 0$, each $S_i$ has finite $(1+\gamma)$-moment, thus substantially weakening the moment requirement condition for the ICA problem to be solvable. We then give an algorithm that works under the assumption that matrix $A$ has orthogonal columns but requires no moment assumptions. Our techniques draw ideas from convex geometry and exploit standard properties of the multivariate spherical Gaussian distribution in a novel way.
Prediction of Effective Elastic Modulus of Biphasic Composite Materials  [PDF]
Anupama Upadhyay, Ramvir Singh
Modern Mechanical Engineering (MME) , 2012, DOI: 10.4236/mme.2012.21002
Abstract: Two semi-empirical approaches for prediction of elastic modulus of biphasic composites have been proposed. Developed relations are for pore free matrix and pore free filler and found to depend on nonlinear contribution of volume fraction of constituents as well as ratio of elastic properties of individual phases. These relations are applied for the calculation of effective elastic modulus mainly for Al2O3-NiAl, SiC-Al, Alumina-Zirconia, Al-Al2O3, W-glass and Flax-Resin composite materials. Theoretical predictions using developed relations are compared with experimental data. It is found that the predicted values of effective elastic modulus using modified relations are quite close to the experimental results.
The Turkish Online Journal of Distance Education , 2009,
Abstract: In teacher training programme (B.Ed) period of teaching practice is considered as very demanding, hectic and exhaustive. Yet the essence of teacher training lies in it. Every year student teachers are sent for teaching practice to different schools. This period extends approximately for 21-25 days. On returning to department, as per practice, student teachers share their views, concerns, experiences and gains with their lecturers in evaluation session. This feedback proves beneficial while making plans for next session. For last four years, some problems, experiences, impediments remain same for most of the students. This paper takes into account the various predicaments faced by student teachers and ways to strengthen the teaching practice so that reflective teaching practice can be encouraged.
Early phase studies in India: Are we too early to explore?
Ramkumar Anupama
Indian Journal of Pharmacology , 2008,
In Silico Studies on Development of Novel Virostatic Agents against Bluetongue Virus
Pandrangi Anupama
ISRN Virology , 2014, DOI: 10.1155/2014/450361
Abstract: The core of BTV is organized into three concentric structures of which VP7 protein forms the major core protein. The subcore consists of VP3 protein and the innermost part of the core is made of three minor proteins: VP1, VP4, and VP6. Earlier it was reported that core-like particles (CLPs) composed of viral VP7 and VP3 proteins were produced in order to study role of VP7 protein in intermolecular interactions in the BTV assembly process. Site specific mutational studies revealed that substitution of the single lysine residue of VP7 (Lys-255) by leucine abrogated CLP formation, indicating a critical role for this lysine. In the present study, homology modeling, mutagenesis, and docking studies were carried out in order to design potent leads in modulation of VP7 protein in abrogating CLP formation. 1. Introduction Bluetongue is an infectious noncontagious virus disease of ruminants caused by bluetongue virus of genus Orbivirus within the family Reoviridae. It is transmitted by biting midges of the Culicoides genus (Diptera: Ceratopogonidae). In addition to biting midges, BTV has been isolated from some arthropods, for example, sheep ked (Melophagus ovinus) [1] or some species of ticks [2, 3] and mosquitoes [4]. However, these are mechanical vectors with only a negligible role in disease epidemiology [5]. It can be directly transmitted from one animal to another through semen and transplacentally [6]. Bluetongue can also be spread by live attenuated vaccines against BTV or even by vaccines against other antigens contaminated with BTV [7, 8]. To date 26 distinct internationally recognized serotypes (based on the lack of cross-neutralization) of the virus have been identified. Cattle and goats are major hosts of the virus, but in these species infection is usually asymptomatic despite high virus levels, allowing the disease to circulate in the absence of any symptoms. Sheep and deer are usually the only species to exhibit symptoms of infection. The manifestations of bluetongue range from an unapparent to a fatal outcome depending on the serotype and strain of the virus, the species, breed, and age of the infected animal; older animals are generally more susceptible [9]. The worldwide economic losses due to bluetongue have not been expressed in exact numbers, but the estimate is 3 billion US$ a year [10]. The losses are both direct (death, abortions, weight loss, or reduced milk yield and meat efficiency) and, what is more important, indirect as a result of export restrictions for live animals, their semen, and some products such as fetal bovine serum.
A Meta-Analysis Approach for Characterizing Pan-Cancer Mechanisms of Drug Sensitivity in Cell Lines
Kendric Wang, Raunak Shrestha, Alexander W. Wyatt, Anupama Reddy, Joseph Lehár, Yuzhou Wang, Anna Lapuk, Colin C. Collins
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0103050
Abstract: Understanding the heterogeneous drug response of cancer patients is essential to precision oncology. Pioneering genomic analyses of individual cancer subtypes have begun to identify key determinants of resistance, including up-regulation of multi-drug resistance (MDR) genes and mutational alterations of drug targets. However, these alterations are sufficient to explain only a minority of the population, and additional mechanisms of drug resistance or sensitivity are required to explain the remaining spectrum of patient responses to ultimately achieve the goal of precision oncology. We hypothesized that a pan-cancer analysis of in vitro drug sensitivities across numerous cancer lineages will improve the detection of statistical associations and yield more robust and, importantly, recurrent determinants of response. In this study, we developed a statistical framework based on the meta-analysis of expression profiles to identify pan-cancer markers and mechanisms of drug response. Using the Cancer Cell Line Encyclopaedia (CCLE), a large panel of several hundred cancer cell lines from numerous distinct lineages, we characterized both known and novel mechanisms of response to cytotoxic drugs including inhibitors of Topoisomerase 1 (TOP1; Topotecan, Irinotecan) and targeted therapies including inhibitors of histone deacetylases (HDAC; Panobinostat) and MAP/ERK kinases (MEK; PD-0325901, AZD6244). Notably, our analysis implicated reduced replication and transcriptional rates, as well as deficiency in DNA damage repair genes in resistance to TOP1 inhibitors. The constitutive activation of several signaling pathways including the interferon/STAT-1 pathway was implicated in resistance to the pan-HDAC inhibitor. Finally, a number of dysregulations upstream of MEK were identified as compensatory mechanisms of resistance to the MEK inhibitors. In comparison to alternative pan-cancer analysis strategies, our approach can better elucidate relevant drug response mechanisms. Moreover, the compendium of putative markers and mechanisms identified through our analysis can serve as a foundation for future studies into these drugs.
An Approach to Human Adaptability towards its Built Environment: A Review  [PDF]
Richa Tiwari, Mukesh Pandey, Anupama Sharma
Energy and Power Engineering (EPE) , 2010, DOI: 10.4236/epe.2010.22013
Abstract: This paper deals with the human adaptability to its built environment. The built environment as we know it rarely finds itself adapting to its surrounding context, whether it be on the level of interaction with humans or the climate. Humans and nature both are in a constant state of flux; moving, changing, sensing, and reacting to their context and information they gather and perceive. A barrier is formed between the built environment and humans and nature due to the fact that their inherent characteristics are utterly contrasting. It is commonly estimated that persons in urban areas spend at least 80% of their time indoors. This suggests that the quality of the indoor environment can have a significant impact on comfort, health, and overall sense of well being. The indoor environment of buildings should thus be designed and controlled, as to provide a comfortable and healthy space for occupants. In order to maintain the quality of the indoor environment, we mechanically condition our buildings to achieve constant, uniform and comfortable environments. The maintenance of thermal equilibrium between the human body and its environment is one of the primary requirements. History of thermal comfort and climate design shows a definite relation between them and research is needed to know “What are comfort conditions?” and “How buildings could adapt themselves to these conditions”.
Nanoparticle Paclitaxel (Nanoxel) as a Safe and Cost-Effective Radio-Sensitizer in Locally Advanced Head and Neck Carcinoma  [PDF]
Akshay Nigam, Anupama Sharma, Sanjeev Kumar Singh
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.31006
Abstract: Squamous cell carcinoma of the head and neck (SCCHN) is a common malignancy. It is the 7th most common malignancy. Approximately 45,000 new cases are diagnosed each year in the USA. In present study 10 patients were selected of age group between 40 - 60 years from Gwalior-Chambal region, among them 3 were females and 7 were males. 3 patients were suffering from tonsilitis, 4 from Laryngeal carcinoma, 2 from carcinoma in maxillary antrum and 1 patient was suffering from carcinoma of whole tongue. The aim of present study is to evaluate the safety of nanoparticle paclitaxel (Nanoxel, a plant alkaloid) in combination with radiation in the treatment of locally advanced head and neck carcinoma. Further the patients were divided in 2 groups. The 1st group received nanoxel (plant alkaloid) administered concomitantly with radiation therapy. 2nd group received gemcitabine administered in combination with radiation therapy. 9 patients showed response for the therapy. The adverse effects in arm A, 2 patients showed anemia less than 8 gm of Hemoglobin, 2 patient showed leucopenia and 1 patient showed diarrhoea, Nausea/vomiting were shown by 4 patients, in arm B, 1 patient showed leucopenia, 1 patient showed anemia less than 9 gm hemoglobin and 5 patient showed sensory neuropathy. Nanoxel (plant alkaloid) showed best results in the case of head and neck carcinoma. The dose of 30 mg/kg b.w showed best safety with best clinical effect in term of less time of patient admission (hardly 30 mins) with less side effects with greater clinical effects in our study.
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